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    • 8. 发明申请
    • USE OF PHENYLETHYLAMINE DERIVATIVES FOR THE ANITMICROBIAL TREATMENT OF SURFACES
    • 苯乙烯衍生物用于治疗表面抗微生物剂的用途
    • WO0162082A3
    • 2002-05-02
    • PCT/EP0101561
    • 2001-02-13
    • CIBA SC HOLDING AGHAAP WOLFGANGHOELZL WERNEROCHS DIETMARPUCHTLER KARINSCHNYDER MARCEL
    • HAAP WOLFGANGHOELZL WERNEROCHS DIETMARPUCHTLER KARINSCHNYDER MARCEL
    • A61K8/30A01N33/10A01N35/04A01N37/34A01N37/36A01N37/38A01N39/00A01N39/02A01N39/04A61K8/00A61K8/41A61K8/44A61K31/138A61K31/225A61K31/24A61K31/277A61P1/02A61P17/00A61Q1/00A61Q1/04A61Q1/06A61Q1/10A61Q1/12A61Q3/02A61Q3/04A61Q5/02A61Q5/04A61Q5/08A61Q5/10A61Q9/04A61Q11/00A61Q15/00A61Q17/02C07C213/06C07C217/60C07C253/30C07C255/54C09D11/00C09D201/00C11D3/48D06M13/328D21H21/36
    • A01N39/00A01N33/10A01N37/38A01N39/02A01N39/04C07C217/60C07C255/54C07C2601/08
    • The use of compounds of formula (1) is described, in which compounds R1, R2 and R3 are each independently of the others hydrogen; C1-C20alkyl; C3-C7cycloalkyl; C2-C20alkenyl; C4-C7cycloalkenyl; C2-C20alkynyl; C4-C7cycloalkynyl; or unsubstituted or C1-C5alkyl-, C3-C7cylcoalkyl-, C1-C5alkoxyl-, C3-C7cycloakoxy-, halo-, oxo-, carboxy-, carboxy-C1-C7alkyl ester-, carboxy-C3-C7cylcloalkyl ester-, cyano-, trifluoromethyl-, pentafluoroethyl-, amino-, N,N-mono- or di-C1-C20alkylamino- or nitro-substituted phenyl-C1-C5alkyl, naphthyl-C1-C5alkyl, phenylcarbonyl-C1-C5alkyl, naphthylcarbonyl-C1-C5alkyl, pyrrolylalkyl, furanylalkyl, thiophenylalkyl, pyrazolylalkyl, imidazolylalkyl, oxazolylalkyl, thiazolylalkyl, isoxazolylalkyl, isothiazolylalkyl, 1,2,3-triazolylalkyl, 1,2,4-triazolylalkyl, 1,2,3-oxadiazolylalkyl, 1,3,4-oxadiazolylalkyl, 1,2,3-thiadiazolylalkyl, 1,3,4-thiadiazolylalkyl, indolylalkyl, pyridylalkyl, pyridazinylalkyl, pyrimidinylalkyl, pyridazinylalkyl, quinolinylalkyl, isoquinolinylalkyl, pyrrolyl, furanyl, thiophenyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,3-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,3-thiadiazolyl, 1,3,4-thiadiazolyl, indolyl, pyridyl, pyridazinyl, pyrimidinyl, pyridazinyl, quinolinyl or isoquinolinyl; R4, R5, R6 and R7 are each independently of the others hydrogen; C1-C20alkyl; C3-C7 cycloalky; C2-C20 alkenyl; C4-C7 cycloalkenyl; C2-C20 alkynyl; or C4-C7 cycloalkynyl; and m and n are each independently of the other 0 or 1, for antimicrobial treatment of surfaces. The compounds exhibit a pronounced activity against pathogenic gram-positive and gram-negative bacteria, and also against yeasts and moulds. They are accordingly suitable for the antimicrobial treatment, especially preservation and disinfection, of surfaces.
    • 描述了式(1)化合物的用途,其中化合物R1,R2和R3各自独立地为氢; C1-C20烷基; C3-C7环烷基; C2-C20alkenyl; C4-C7cycloalkenyl; C2-C20alkynyl; C4-C7cycloalkynyl; 或未取代的或C 1 -C 5烷基 - ,C 3 -C 7烷基烷基 - ,C 1 -C 5烷氧基 - ,C 3 -C 7环烷氧基 - ,卤代 - ,氧代 - ,羧基 - ,羧基-C 1 -C 7烷基酯 - ,羧基-C 3 -C 7环烷基酯 - 氰基 - 三氟甲基 - ,五氟乙基 - ,氨基 - ,N,N-单或二-C 1 -C 20烷基氨基或硝基取代的苯基-C 1 -C 5烷基,萘基-C 1 -C 5烷基,苯基羰基-C 1 -C 5烷基,萘基羰基-C 1 -C 5烷基 ,吡咯基烷基,呋喃基烷基,噻吩基烷基,吡唑基烷基,咪唑基烷基,恶唑基烷基,噻唑烷基,异恶唑基烷基,异噻唑基烷基,1,2,3-三唑基烷基,1,2,4-三唑基烷基,1,2,3-恶二唑基烷基,1,3,4-恶二唑基烷基 1,2,3-噻二唑基烷基,1,3,4-噻二唑基烷基,吲哚基烷基,吡啶基烷基,哒嗪基烷基,嘧啶基烷基,哒嗪基烷基,喹啉基烷基,异喹啉基烷基,吡咯基,呋喃基,噻吩基,吡唑基,咪唑基,恶唑基,噻唑基,异恶唑基,异噻唑基, ,2,3-三唑基,1,2,4-三唑基,1,2,3-恶二唑基,1,3,4-恶二唑基,1,2,3-噻二唑基,1,3,4-噻二唑基,吲哚基, 吡啶基,哒嗪基,嘧啶基,哒嗪基,喹啉基或异喹啉基; R4,R5,R6和R7各自独立地为氢; C1-C20烷基; C3-C7环状; C2-C20烯基; C4-C7环烯基; C2-C20炔基; 或C 4 -C 7环炔基; m和n各自独立地为0或1,用于表面的抗微生物处理。 该化合物对病原性革兰氏阳性菌和革兰氏阴性细菌以及酵母和霉菌均表现出明显的活性。 因此它们适用于表面的抗菌处理,特别是保存和消毒。