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1. 发明申请

WO2012126879A1 NOVEL OPRF/I FUSION PROTEINS, THEIR PREPARATION AND USE 审中-公开
标题翻译：新型OPRF / I融合蛋白，其制备和使用
公开(公告)号：WO2012126879A1
公开(公告)日：2012-09-27
申请号：PCT/EP2012/054783
申请日：2012-03-19
申请人： INTERCELL AG , SCHLEGL, Robert
发明人： SCHLEGL, Robert
IPC分类号： C07K14/21 , C07K19/00 , A61K39/104 , C07K16/12
CPC分类号： C07K16/1214 , A61K39/104 , C07K14/21 , C07K2319/00 , C07K2319/02 , C07K2319/21
摘要： The present invention relates to a novel trimeric OprF/I fusion protein comprising a portion of the Pseudomonas aeruginosa outer membrane protein F which is fused with its carboxy terminal end to a portion of the amino terminal end of the Pseudomonas aeruginosa out membrane protein I, wherein said portion of the Pseudomonas aeruginosa outer membrane protein F comprises the amino acids 190-342 of SEQ ID NO: 1 and wherein said portion of the Pseudomonas aeruginosa outer membrane protein I comprises the amino acids 21-83 of SEQ ID NO: 2, and further to a novel Opr F/I fusion protein which contains a disulphide bond pattern, preferably selected from the group consisting of (a) Cys18-Cys27-bond, (b) Cys18-Cys27-bond and Cys33-Cys47-bond, and (c) Cys18-Cys47 and Cys27-Cys33-bond, and to immunogenic variants thereof having at least 85% identity to the amino acid sequence of SEQ ID NO: 3. The present invention also relates to a novel method for producing said OprF/I fusion proteins and to their use for the preparation of a pharmaceutical composition and for the preparation of antibodies or antibody derivatives which specifically bind said novel OprF/I fusion proteins.
摘要翻译：本发明涉及一种新颖的三聚体OprF / I融合蛋白，其包含铜绿假单胞菌外膜蛋白F的一部分，其与其羧基末端与铜绿假单胞菌膜蛋白I的氨基末端的一部分稠合，其中绿脓假单胞菌外膜蛋白F的所述部分包含SEQ ID NO：1的氨基酸190-342，并且其中铜绿假单胞菌外膜蛋白I的所述部分包含SEQ ID NO：2的氨基酸21-83，和进一步涉及含有二硫键型图案的新型Opr F / I融合蛋白，优选选自（a）Cys18-Cys27-键，（b）Cys18-Cys27-键和Cys33-Cys47-键，和（ c）Cys18-Cys47和Cys27-Cys33-键，以及其与SEQ ID NO：3的氨基酸序列具有至少85％同一性的免疫原性变体。本发明还涉及一种用于产生所述OprF / I 融合蛋白质和蛋白质用于制备药物组合物和用于制备特异性结合所述新型OprF / I融合蛋白的抗体或抗体衍生物。

2. 发明申请

WO2011101465A1 IC31 NANOPARTICLES 审中-公开
标题翻译： IC31纳米粒子
公开(公告)号：WO2011101465A1
公开(公告)日：2011-08-25
申请号：PCT/EP2011/052496
申请日：2011-02-21
申请人： INTERCELL AG , WIZEL, Benjamin , RIEDL, Karin , LINGNAU, Karen , SCHLOSSER, Ursula , WRUSS, Jürgen , SCHLEGL, Robert , WEBER, Michael , REINISCH, Christoph , PAUCZ, Ljubomir , KLADE, Christoph , LOOK, Jee, Loon , RUIZ, Christian , SEID, Robert
发明人： WIZEL, Benjamin , RIEDL, Karin , LINGNAU, Karen , SCHLOSSER, Ursula , WRUSS, Jürgen , SCHLEGL, Robert , WEBER, Michael , REINISCH, Christoph , PAUCZ, Ljubomir , KLADE, Christoph , LOOK, Jee, Loon , RUIZ, Christian , SEID, Robert
IPC分类号： A61K39/12 , A61K39/39 , A61P31/00 , A61K9/10
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/08 , A61K9/10 , A61K9/14 , A61K9/51 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K39/092 , A61K39/118 , A61K39/12 , A61K39/145 , A61K39/40 , A61K39/42 , A61K48/00 , A61K2039/55516 , A61K2039/55555 , A61K2039/55561 , A61K2039/70 , C12N7/00 , C12N2760/16134 , C12N2760/16171 , C12N2760/16234 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396 , Y02A50/401 , Y02A50/412 , Y02A50/47
摘要： The invention discloses pharmaceutical compositions in liquid form comprising a peptide with the amino acid sequence KLKL 5 KLK and an oligodeoxynucleotide with the nucleic acid sequence (dIdC) 13 and wherein the peptide and the oligodeoxynucleotide are present as sterile-filterable nanoparticles in the composition, thereby forming a suspension, characterized in that the mean particle size of the solid particles is less than 1 μm.
摘要翻译：本发明公开了液体形式的药物组合物，其包含具有氨基酸序列KLKL5KLK的肽和具有核酸序列（dIdC）13的寡脱氧核苷酸的肽，并且其中肽和寡脱氧核苷酸作为无菌可过滤纳米粒子存在于组合物中，由此形成悬浮液，其特征在于固体颗粒的平均粒径小于1μm。

3. 发明申请

WO2003031465A1 METHOD FOR RECONSTITUTING A RECOMBINANT PROTEIN TO ITS BIOLOGICALLY ACTIVE FORM 审中-公开
标题翻译：将重组蛋白重新生成生物活性物质的方法
公开(公告)号：WO2003031465A1
公开(公告)日：2003-04-17
申请号：PCT/EP2002/010992
申请日：2002-10-01
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , NECINA, Roman , SCHLEGL, Robert , JUNGBAUER, Alois , MACHOLD, Christine
发明人： NECINA, Roman , SCHLEGL, Robert , JUNGBAUER, Alois , MACHOLD, Christine
IPC分类号： C07K1/113
CPC分类号： C07K1/1136 , C07K1/1133 , C07K1/16 , C07K1/36
摘要： In a method for reconstituting a recombinant protein from a denatured state to its active form, a feed solution containing the recombinant protein in its denatured and/or biologically inactive intermediate forms is subjected to a chromatographic separation process, in which the protein is reconstituted under conditions that promote refolding of the protein and the intermediate forms are separated from the refolded protein. The denatured form and/or the inactive intermediate forms of the protein are separated from the refolded protein in a continuous or quasi-continuous manner and optionally recycled to the feed solution.
摘要翻译：在将重组蛋白从变性状态重建为其活性形式的方法中，将含有其变性和/或生物惰性中间体形式的重组蛋白的进料溶液进行色谱分离过程，其中蛋白质在条件促进蛋白质的重折叠和中间体形式与重折叠的蛋白质分离。将蛋白质的变性形式和/或无活性中间体形式以连续或准连续方式与重折叠蛋白质分离，并任选地再循环至饲料溶液中。

4. 发明申请

WO2013135274A1 ALUMINIUM COMPOUNDS FOR USE IN THERAPEUTICS AND VACCINES 审中-公开
标题翻译：用于治疗和疫苗的铝化合物
公开(公告)号：WO2013135274A1
公开(公告)日：2013-09-19
申请号：PCT/EP2012/054387
申请日：2012-03-13
申请人： INTERCELL AG , MÖHLEN, Michael , SCHLEGL, Robert , WEBER, Michael , WRUSS, Jürgen
发明人： MÖHLEN, Michael , SCHLEGL, Robert , WEBER, Michael , WRUSS, Jürgen
IPC分类号： A61K39/12 , A61K39/39
CPC分类号： A61K39/12 , A61K2039/55505 , C12N2770/24134 , Y02A50/388 , Y02A50/39 , Y02A50/466
摘要： The invention relates to means and methods for preparing aqueous composition comprising aluminium and a protein. The invention further relates to aqueous compositions comprising a protein and an aluminium-salt, said composition comprising less than 350 ppb heavy metal based on the weight of the aqueous composition.
摘要翻译：本发明涉及制备包含铝和蛋白质的水性组合物的方法和方法。本发明还涉及包含蛋白质和铝盐的含水组合物，所述组合物基于水性组合物的重量包含小于350ppb的重金属。

5. 发明申请

WO2012084272A1 OPRF/I AGENTS AND THEIR USE IN HOSPITALIZED AND OTHER PATIENTS 审中-公开
标题翻译： OPRF / I药剂及其在医院和其他患者中的使用
公开(公告)号：WO2012084272A1
公开(公告)日：2012-06-28
申请号：PCT/EP2011/054127
申请日：2011-03-18
申请人： INTERCELL AG , KLADE, Christoph , SCHLEGL, Robert , WESTRITSCHNIG, Kerstin
发明人： KLADE, Christoph , SCHLEGL, Robert , WESTRITSCHNIG, Kerstin
IPC分类号： C07K14/21 , C07K19/00 , C07K16/12 , A61K39/104 , A61K39/40
CPC分类号： A61K39/104 , C07K14/21
摘要： The present invention relates to a new use of a vaccine comprising a fusion protein that comprises the Pseudomonas aeruginosa outer membrane protein I (OprI or OMPI) which is fused with its amino terminal end to the carboxy-terminal end of a carboxy-terminal portion of the Pseudomonas aeruginosa outer membrane protein F (OprF or OMPF), as well as to a new use of a monoclonal or polyclonal antibody against this fusion protein or a pharmaceutical composition thereof.
摘要翻译：本发明涉及包含融合蛋白的疫苗的新用途，所述融合蛋白包含铜绿假单胞菌外膜蛋白I（OprI或OMPI），其与其氨基末端与羧基末端部分的羧基末端稠合铜绿假单胞菌外膜蛋白F（OprF或OMPF），以及针对该融合蛋白的单克隆或多克隆抗体或其药物组合物的新用途。

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