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1. 发明申请

WO2008042939A2 MOLDED CONTAINER WITH RAISED NIPPLE AND METHOD FOR USE 审中-公开
标题翻译：具有增加的NIPPLE的模制容器和使用的方法
公开(公告)号：WO2008042939A2
公开(公告)日：2008-04-10
申请号：PCT/US2007080267
申请日：2007-10-03
申请人： SCHERER TECHNOLOGIES INC R P , POYNTER RICHARD Q , DECOSTE PETER J
发明人： POYNTER RICHARD Q , DECOSTE PETER J
IPC分类号： B65D1/04
CPC分类号： B65D51/002 , A61J1/1406 , A61J1/201 , A61J1/2055 , A61J1/2089 , B65D1/0238
摘要： This invention container comprises a container shell comprising a body portion, adjoining cap portion and enclosed stopper, and an engineered separation site to facilitate separation of body and cap. The stopper has a raised nipple on the stopper, positioned such that a portion of the stopper is enclosed within the body portion and a portion of the stopper is enclosed within the cap portion. When the cap portion is removed from the body portion, a portion of the nipple therefore extends out of the body portion, allowing easy access to the stopper for cleaning or contents removal. In addition, there is an engineered separation site which includes a partial attenuation of the thickness of part of the container wall. Raised gussets are provided to enhance the cooperation between the instant invention and various needle-free connectors known in the art.
摘要翻译：本发明的容器包括容器壳体，其包括主体部分，邻接的盖部分和封闭的塞子，以及用于分离主体和盖子的工程分离部位。止动器在止动器上具有凸起的接头，定位成使得止动件的一部分被封闭在主体部分内，止动件的一部分被封闭在帽部内。当帽部从主体部分移除时，乳头的一部分因此延伸出主体部分，允许容易地进入止动器以进行清洁或内容物移除。此外，还有一个工程分离部位，其中包括部分容器壁厚部分衰减。提供凸起角撑板以增强本发明与本领域已知的各种无针连接器之间的协作。

2. 发明申请

WO2007047313A2 CHILD RESISTANT MEDICAMENT STORAGE AND DISTRIBUTION BACK CARD AND SEALED BLISTER CARD 审中-公开
标题翻译：抗儿童药物储存和分发卡和密封卡
公开(公告)号：WO2007047313A2
公开(公告)日：2007-04-26
申请号：PCT/US2006039746
申请日：2006-10-11
申请人： SCHERER TECHNOLOGIES INC R P , GHERDAN VICTOR , CHADWICK DENNIS , BARNDT DAVID , CRAIG TIMOTHY F
发明人： GHERDAN VICTOR , CHADWICK DENNIS , BARNDT DAVID , CRAIG TIMOTHY F
IPC分类号： B65D83/04
CPC分类号： B65D83/0463 , B65D2215/00
摘要： A child-resistant medicament storage and distribution back card for senior-friendly and child-resistant distribution of a medicament. The back card is incorporated into a medication package where it protects the area of the package that is most susceptible to attacks on the integrity of the package. The back card has a card opening feature bounded by a perimeter that includes at least two cuts and at least two lands, often thought of as perforations. The cuts extend through the back card, and the lands connect the back card to the card opening feature. Each cut has a cut length and each land has a land length. The ratio of any land length to any cut length is between approximately 0.25 and approximately 0.80, which has been found to substantially prevent removal of the card opening feature from the back card by picking at any of the cuts with a fingernail.
摘要翻译：儿童耐药药物储存和分发背卡，用于药物的高级友好和防止儿童分布。背卡被结合到药物包装中，以保护包装的最易受到包装完整性攻击的区域。后卡具有由周边限定的卡片开口特征，该周边包括至少两个切口和至少两个通常被认为是穿孔的平台。切口延伸穿过背面卡，并且背面卡将背面卡连接至卡打开特征。每个切割有一个切割长度，每个土地都有一个土地长度。任何陆地长度与任何切割长度的比率在大约0.25和大约0.80之间，已经发现通过用指甲在任何切口处拾取，基本上防止了卡片开口特征从背面卡片上被移除。

3. 发明申请

WO2006121621A2 CHILD-RESISTANT BLISTER PACKAGE WITH TEAR TAB 审中-公开
标题翻译：具有茶几的儿童防晒包装
公开(公告)号：WO2006121621A2
公开(公告)日：2006-11-16
申请号：PCT/US2006015873
申请日：2006-04-27
申请人： SCHERER TECHNOLOGIES INC R P , BATES RONALD R JR
发明人： BATES RONALD R JR
IPC分类号： B65D75/36 , B65D75/58
CPC分类号： B65D75/367 , B65D75/5833 , B65D2215/04 , B65D2575/362
摘要： A blister package for housing a medicament having a base layer and a blister layer, joined together in-part. Each layer has a tab creation separation line allowing a user to initiate a predetermined sequence of steps required to access the medicament. The tab creation separation lines are located interior to the perimeter of each associated layer. The tab creation separation lines selectively reduce the strength of the associated layer thereby allowing a user to "punch out," or create, a tab for use in accessing the medicament. A number of predetermined manipulations must be completed to access the medicament. These manipulations include applying a force to create a tab, removing the tab thereby creating a sinistral wing and a dextral wing, and rotating the sinistral wing and the dextral wing in opposite directions to cause a tear that exposes the medicament.
摘要翻译：一种用于容纳具有基底层和泡罩层的药物的泡罩包装，其部分地结合在一起。每个层具有标签创建分离线，允许用户启动访问药物所需的步骤的预定顺序。标签创建分隔线位于每个关联层的周边的内部。选项卡创建分隔线选择性地降低相关层的强度，从而允许用户“冲出”或创建用于访问药物的标签。必须完成许多预定的操作来接近药物。这些操作包括施加力以产生翼片，移除翼片从而产生左侧翼和右翼，以及沿相反方向旋转左侧翼和右翼，引起暴露药物的撕裂。

4. 发明申请

WO2006017462A2 PEELABLE POUCH CONTAINING A SINGLE OR MULTIPLE DOSAGE FORMS AND PROCESS OF MAKING SAME 审中-公开
标题翻译：包含单个或多个剂型的可剥离皮包及其制造方法
公开(公告)号：WO2006017462A2
公开(公告)日：2006-02-16
申请号：PCT/US2005027341
申请日：2005-08-02
申请人： SCHERER TECHNOLOGIES INC R P , ALVATER PAUL HAMILTON , FILLIS THOMAS JOHN
发明人： ALVATER PAUL HAMILTON , FILLIS THOMAS JOHN
IPC分类号： B65D33/00 , B65D30/00 , B65D30/08 , B65D30/22 , B65D33/16
CPC分类号： B65D81/3266 , B65D75/5805 , B65D75/5855
摘要： A peelable pouch (50) for containing a single dosage product (P) having a top layer (100) joined to a bottom layer (200) by at least one seal (500) thereby creating a primary compartment (300). The primary compartment (300) houses the product (P), sealed from the exterior environment. The peelable pouch (50) includes a tear promoting surface condition (600) on the top layer (100) and the bottom layer (200) intersected by a fold-over line (700). When the pouch (50) is folded about the fold-over line (700) the tear promoting surface condition (600) permits a user to easily tear off a portion of the pouch (50) and expose a portion of the primary compartment (300) allowing the product (P) to be removed from the pouch (50). Alternative embodiments incorporate a product retention edge (350) that requires supplemental separation of the top (100) and bottom (200) layers to gain access to the product (P), as well as a secondary compartment (400) formed between the top (100) and bottom (200) layers.
摘要翻译：一种用于容纳具有通过至少一个密封件（500）连接到底层（200）的顶层（100）的单一剂量产品（P）的可剥离袋（50），由此形成初级隔室（300）。主室（300）容纳从外部环境密封的产品（P）。可剥离袋（50）包括顶层（100）上的撕裂促进表面状态（600）和与折叠线（700）相交的底层（200）。当袋（50）围绕折叠线（700）折叠时，撕裂促进表面状态（600）允许使用者容易地撕掉袋（50）的一部分并暴露主隔室（300）的一部分），使产品（P）从袋（50）中移出。替代实施例包括产品保留边缘（350），其需要顶部（100）和底部（200）层的补充分离以获得对产品（P）的访问，以及形成在顶部（100） 100）和底部（200）层。

5. 发明申请

WO0185102A8 OIL-IN-WATER EMULSION FORMULATION CONTAINING HYDROQUINONE AND RETINOL 审中-公开
标题翻译：含有水合物和维生素的水包油乳液制剂
公开(公告)号：WO0185102A8
公开(公告)日：2003-11-20
申请号：PCT/US0114434
申请日：2001-05-03
申请人： SCHERER TECHNOLOGIES INC R P , SINGH SANDHYA B , BEAUSOLEIL MARIE-HELENE , SAXENA SUBHASH J
发明人： SINGH SANDHYA B , BEAUSOLEIL MARIE-HELENE , SAXENA SUBHASH J
IPC分类号： A61K8/04 , A61K8/06 , A61K8/34 , A61K8/67 , A61K8/81 , A61Q19/02 , A61K7/00 , A61K7/48
CPC分类号： A61K8/062 , A61K8/0275 , A61K8/0279 , A61K8/347 , A61K8/671 , A61K8/8117 , A61K8/8152 , A61K2800/56 , A61Q19/02
摘要： An oil-in-water emulsion formulation containing hydroquinone and retinol, which comprises an oil-in-water emulsion containing hydroquinone entrapped in absorbent micro-agglomerates or impregnated in porous microparticles and retinol-impregnated microparticles.
摘要翻译：一种含有氢醌和视黄醇的水包油乳液制剂，其包含含有氢醌的水包油乳液，其中包含吸收性微团聚物或浸渍在多孔微粒和视黄醇浸渍的微粒中。

6. 发明申请

WO2009108775A3 PROCESS TO MINIMIZE POLYMORPHISM 审中-公开
标题翻译：最小化多态性的过程
公开(公告)号：WO2009108775A3
公开(公告)日：2009-12-03
申请号：PCT/US2009035276
申请日：2009-02-26
申请人： SCHERER TECHNOLOGIES INC R P , HOWES SIMON A M , MCLAUGHLIN ROSIE , JORDAN ANDREW , TIAN WEI
发明人： HOWES SIMON A M , MCLAUGHLIN ROSIE , JORDAN ANDREW , TIAN WEI
IPC分类号： A61K9/20 , A61M36/14
CPC分类号： A61K31/5517 , A61K9/06 , A61K9/10 , A61K31/551 , A61K47/42
摘要： The commercial formulation of fast dispersing dosage forms (FDDF) requires substantial holding times during which large quantities of pharmaceutically active substance are formed into individual dosage units. During this holding time, pharmaceutical agents with a propensity to polymorphism in an aqueous environment may crystallize into various, and sometimes unpredictable forms. These crystalline forms may affect the efficacy of the pharmaceutical agent. Previous attempts to control this process have included attempts to direct crystallization into a stable form. The instant invention acts to suppress crystallization, by utilizing a combination of standard molecular weight fish gelatin and a low processing temperature, to suppress crystallization to a degree that is not accomplished by either the use of standard molecular weight fish gelatin or low processing temperatures individually.
摘要翻译：快速分散剂型（FDDF）的商业制剂需要大量的保持时间，在此期间大量的药物活性物质形成为单独的剂量单位。在此期间，在水性环境中具有多态性倾向的药剂可能会结晶成各种有时不可预测的形式。这些结晶形式可能影响药剂的功效。以前尝试控制该方法的尝试包括将结晶直接导入稳定形式的尝试。本发明通过利用标准分子量鱼明胶和低加工温度的组合来抑制结晶，以将结晶抑制到不能通过使用标准分子量鱼明胶或单独的低加工温度来实现的程度。

7. 发明申请

WO2007047533A3 CHILD RESISTANT AND SENIOR FRIENDLY MEDICAMENT PACKAGE 审中-公开
标题翻译：儿童抗衰老和高级友好药物包装
公开(公告)号：WO2007047533A3
公开(公告)日：2007-07-26
申请号：PCT/US2006040267
申请日：2006-10-13
申请人： SCHERER TECHNOLOGIES INC R P , GHERDAN VICTOR , BARNDT DAVID , CRAIG TIMOTHY F
发明人： GHERDAN VICTOR , BARNDT DAVID , CRAIG TIMOTHY F
IPC分类号： B65D83/04 , B65D85/42
CPC分类号： B65D83/0463 , B65D2215/04 , B65D2575/363
摘要： A child resistant senior friendly medication storage and distribution package including a blister portion and a blocking substrate sandwiched between a dispensing substrate and a backing substrate. The procedure to access the medicament is easy for an adult to understand and accomplish, yet difficult for most children. The blister portion contains a base layer and a blister layer. The blister layer includes an article receiving blister designed for holding the medicament. The dispensing substrate has a dispensing substrate blister receiver. The blister receiver is configured to cooperate with the blister so it extends through the dispensing substrate. The blocking substrate includes a gate that initially covers a portion of the blister. The gate must be moved, or slid, out of the way in order to eject the medicament. The user applies a force to the gate causing it to translate between the backing substrate and the dispensing substrate.
摘要翻译：一种抗儿童药物储存和分配包装，包括夹在分配衬底和背衬衬底之间的泡罩部分和阻挡衬底。成人进入药物的步骤很容易理解和完成，但对大多数儿童而言是困难的。泡罩部分包含基层和泡罩层。泡罩层包括设计用于保持药物的接收泡罩的物品。分配衬底具有分配衬底吸塑接收器。泡罩接收器被配置为与泡罩配合，使得其延伸穿过分配衬底。阻挡衬底包括初始覆盖泡罩的一部分的浇口。门必须移动或滑动，以便弹出药物。使用者向门施加力使其在背衬基底和分配衬底之间平移。

8. 发明申请

WO2005123541A2 CHILD RESISTANT PRODUCT DISPENSER 审中-公开
标题翻译：儿童防护产品分配器
公开(公告)号：WO2005123541A2
公开(公告)日：2005-12-29
申请号：PCT/US2005020626
申请日：2005-06-10
申请人： SCHERER TECHNOLOGIES INC R P , ARNOLD WILLIAM
发明人： ARNOLD WILLIAM
IPC分类号： B65D83/04
CPC分类号： B65D83/0463 , B65D75/327 , B65D2215/04 , B65D2575/3236
摘要： A child resistant product dispenser includes a blister card having compartments for holding a product, a housing, and a blister cover, for use in covering the blister card compartments. The blister cover may include a dispensing area for each compartment of the blister card. To remove a product from the product dispenser the user presses a dispensing area against either a compartment thereby forcing the product through a frangible area on the blister card and through a frangible area in the housing or against a peelable area on the blister card and a frangible area in the housing. This creates an opening through which the product is removed.
摘要翻译：防儿童产品分配器包括具有用于容纳产品的隔室的吸塑卡，壳体和泡罩盖，用于覆盖泡罩卡隔间。吸塑罩可以包括用于泡罩卡的每个隔室的分配区域。为了从产品分配器中移除产品，用户将分配区域压向隔室，从而迫使产品通过泡罩卡片上的易碎区域并通过壳体中的易碎区域或者泡沫卡片上的可剥离区域，并且易碎房屋面积这将创建产品被移除的开口。

9. 发明申请

WO02076398A3 IMPROVED FORMS OF PHARMACEUTICALLY ACTIVE AGENTS AND METHOD FOR MANUFACTURE THEREOF 审中-公开
标题翻译：药物活性剂的改进形式及其制备方法
公开(公告)号：WO02076398A3
公开(公告)日：2003-02-20
申请号：PCT/US0209165
申请日：2002-03-27
申请人： SCHERER TECHNOLOGIES INC R P , XU XINMIN SAMUEL , ERKOBONI DAVID F , LEBO DAVID B , FAVARA ANDREW
发明人： XU XINMIN SAMUEL , ERKOBONI DAVID F , LEBO DAVID B , FAVARA ANDREW
IPC分类号： A61K45/00 , A61K9/16 , A61K31/192 , A61K47/02 , A61P29/00 , A61K9/20 , A61K9/46
CPC分类号： A61K47/02 , A61K9/1611 , A61K31/192
摘要： A pharmaceutical composition comprising a pharmaceutically active agent and a salt of said pharmaceutically active agent with the proviso that said composition does not contain hydrolyzed cellulose, wherein said pharmaceutical active agent is a weak acid or weak base. The present invention is also directed to a new ibuprofen form having, when potassium is present in said form as a counter ion, an IR peak at 1706 cm shifted and broadened in absorbance relative to racemic ibuprofen free acid, the form's characteristic absorbance profile from 1000 to 650 cm and broadened in absorbance relative to racemic ibuprofen free acid, the form's characteristic absorbance profile from 1000 to 650 cm and D-spacings of 21.1, 7.1, and 3.4 ANGSTROM by X-ray diffraction.
摘要翻译：该药物组合物包含药物活性剂和所述药物活性剂的盐，条件是所述组合物不含水解纤维素，其中所述药物活性剂是弱酸或弱碱。本发明还涉及一种新的布洛芬形式，当以所述形式存在钾作为抗衡离子时，在1706cm -1处的IR峰相对于外消旋布洛芬游离酸在吸光度上移动和扩大，形式的特征吸光度分布从1000到650 cm -1，吸光度相对于外消旋布洛芬游离酸扩大，形式的特征吸光度分布为1000至650 cm -1，D间距为21.1,7.1和3.4 ANGSTROM的X 射线衍射。

10. 发明申请

WO0185102A3 OIL-IN-WATER EMULSION FORMULATION CONTAINING HYDROQUINONE AND RETINOL 审中-公开
标题翻译：含有水合物和维生素的水包油乳液制剂
公开(公告)号：WO0185102A3
公开(公告)日：2002-08-29
申请号：PCT/US0114434
申请日：2001-05-03
申请人： SCHERER TECHNOLOGIES INC R P , SINGH SANDHYA B , BEAUSOLEIL MARIE-HELENE , SAXENA SUBHASH J
发明人： SINGH SANDHYA B , BEAUSOLEIL MARIE-HELENE , SAXENA SUBHASH J
IPC分类号： A61K8/04 , A61K8/06 , A61K8/34 , A61K8/67 , A61K8/81 , A61Q19/02 , A61K7/00 , A61K7/48
CPC分类号： A61K8/062 , A61K8/0275 , A61K8/0279 , A61K8/347 , A61K8/671 , A61K8/8117 , A61K8/8152 , A61K2800/56 , A61Q19/02
摘要： An oil-in-water emulsion formulation containing hydroquinone and retinol, which comprises an oil-in-water emulsion containing hydroquinone entrapped in absorbent micro-agglomerates or impregnated in porous microparticles and retinol-impregnated microparticles.
摘要翻译：一种含有氢醌和视黄醇的水包油乳液制剂，其包含含有氢醌的水包油乳液，其中包含吸收性微团聚物或浸渍在多孔微粒和视黄醇浸渍的微粒中。

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