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1. 发明申请

WO2006116039A3 METHOD AND APPARATUS FOR AUTOMATED RAPID IMMUNOHISTOCHEMISTRY 审中-公开
公开(公告)号：WO2006116039A3
公开(公告)日：2006-11-02
申请号：PCT/US2006/015023
申请日：2006-04-21
申请人： CELERUS DIAGNOSTICS, INC. , ERICKSON, Page A. , EVERMAN, Michael R. , BELL, Michael S. , EDBERG, Kevin S. , BOTKE, Matthew M. , SAWATZKY, Brian D.
发明人： ERICKSON, Page A. , EVERMAN, Michael R. , BELL, Michael S. , EDBERG, Kevin S. , BOTKE, Matthew M. , SAWATZKY, Brian D.
IPC分类号： G01N35/00 , G01N33/50 , G01N21/00 , G01N33/48
摘要： A sample processing system that may be configured to achieve parallel or coincidental sample processing such as histochemical processing may involve a plurality of samples arranged for coincidental movement perhaps by use of angular microscopic slide movements to cause processing activity that may include repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges. Through refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened from a more common 60 to 120 minutes to perhaps less than 15 minutes so as to permit use of such a system in an intraoperative or surgical environment such as recommended by the College of American Pathologists intraoperative guidelines or the like. Patients may thus avoid a need to be subjected to an additional surgical procedure when lab results become available to see if tumors or the like were fully removed in a prior procedure.

2. 发明申请

WO2010033758A1 AUTOMATED VACUUM ASSISTED VALVE PRIMING SYSTEM AND METHODS OF USE 审中-公开
标题翻译：自动真空辅助阀预灌装系统及其使用方法
公开(公告)号：WO2010033758A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/057403
申请日：2009-09-18
申请人： NORDSON CORPORATION , CROWELL, Cutler , FISKE, Erik , QUINONES, Horatio , SAWATZKY, Brian
发明人： CROWELL, Cutler , FISKE, Erik , QUINONES, Horatio , SAWATZKY, Brian
IPC分类号： B67D7/08
CPC分类号： G05D16/20 , B05C5/0225 , B05C11/1005 , B05C11/1034 , Y10T137/0396 , Y10T137/85986
摘要： An automated system (10) and methods (11) for priming a fluid chamber (12) of a fluid dispensing valve (14) with fluid (16) from fluid material source that includes a vacuum source (46), a valve priming station (32), a vacuum switch (54), and a controller (62). The valve priming station (32) has a boot (40), a vacuum chamber (36), and a vacuum channel (42) in the boot (40). The vacuum channel (42) connects with the vacuum source (46) via the vacuum chamber (36). The boot (40) sealingly engages a valve nozzle (28) of the fluid dispensing valve (14) so that the vacuum chamber (36) connects the vacuum source (46) with the fluid chamber (12). The vacuum switch (54) couples with the vacuum channel (42) via the vacuum chamber (36) and has an opened and closed position based upon a vacuum level in the vacuum chamber (36). The controller (62) is electrically connected with the vacuum source (46) and vacuum switch (54) and controls priming of the fluid dispensing valve (14) based upon whether the vacuum switch (54) is opened or closed.
摘要翻译：一种自动化系统（10）和方法（11），用于利用来自流体材料源的流体（16）起动流体分配阀（14）的流体室（12），流体材料源包括真空源（46），阀启动站 32），真空开关（54）和控制器（62）。阀门启动台（32）具有一个罩（40），一个真空室（36）和一个位于靴子（40）中的真空通道（42）。真空通道（42）通过真空室（36）与真空源（46）连接。护罩（40）密封地接合流体分配阀（14）的阀喷嘴（28），使得真空室（36）将真空源（46）与流体室（12）连接。真空开关（54）经由真空室（36）与真空通道（42）联接，并且基于真空室（36）中的真空水平具有打开和关闭位置。基于真空开关（54）是打开还是关闭，控制器（62）与真空源（46）和真空开关（54）电连接并控制流体分配阀（14）的启动。

3. 发明申请

WO2006116039A2 METHOD AND APPARATUS FOR AUTOMATED RAPID IMMUNOHISTOCHEMISTRY 审中-公开
标题翻译：自动快速免疫组织化学方法与装置
公开(公告)号：WO2006116039A2
公开(公告)日：2006-11-02
申请号：PCT/US2006015023
申请日：2006-04-21
申请人： CELERUS DIAGNOSTICS INC , ERICKSON PAGE A , EVERMAN MICHAEL R , BELL MICHAEL S , EDBERG KEVIN S , BOTKE MATTHEW M , SAWATZKY BRIAN D
发明人： ERICKSON PAGE A , EVERMAN MICHAEL R , BELL MICHAEL S , EDBERG KEVIN S , BOTKE MATTHEW M , SAWATZKY BRIAN D
IPC分类号： C12M3/00
CPC分类号： G01N35/00029 , G01N1/312 , G01N35/00009 , G01N2035/00039 , Y10T436/11 , Y10T436/112499 , Y10T436/113332
摘要： A sample processing system that may be configured to achieve parallel or coincidental sample processing such as histochemical processing may involve a plurality of samples arranged for coincidental movement perhaps by use of angular microscopic slide movements to cause processing activity that may include repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges. Through refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened from a more common 60 to 120 minutes to perhaps less than 15 minutes so as to permit use of such a system in an intraoperative or surgical environment such as recommended by the College of American Pathologists intraoperative guidelines or the like. Patients may thus avoid a need to be subjected to an additional surgical procedure when lab results become available to see if tumors or the like were fully removed in a prior procedure.
摘要翻译：可以被配置为实现平行或重复的样品处理（例如组织化学处理）的样品处理系统可以涉及可以通过使用角度显微镜幻灯片移动来布置为巧合运动的多个样品，以引起处理活动，所述处理活动可以包括反复消除和重新应用流体物质可能通过毛细管运动的作用，以便刷新邻近样品的微环境，例如活组织检查或其它这样的样品。可以包括抗体和其他物质，以减轻操作者的行为，并允许通过包括单容器多腔多重流体物质杂志，线性放置的多物质源和一级抗体盒来允许位置特异性物质应用。通过刷新微环境，避免了微环境的消耗，并且幻灯片处理所需的时间可能会从更常见的60到120分钟到可能少于15分钟的时间急剧缩短，以便允许在术中或术中使用这样的系统手术环境如美国病理学家推荐的术中指南等。因此，当实验室结果变得可用时，患者可能避免需要进行额外的外科手术，以便在先前的手术中是否完全移除肿瘤等。

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