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    • 1. 发明申请
    • METHOD AND APPARATUS FOR AUTOMATED RAPID IMMUNOHISTOCHEMISTRY
    • 自动快速免疫组织化学方法与装置
    • WO2006116039A2
    • 2006-11-02
    • PCT/US2006015023
    • 2006-04-21
    • CELERUS DIAGNOSTICS INCERICKSON PAGE AEVERMAN MICHAEL RBELL MICHAEL SEDBERG KEVIN SBOTKE MATTHEW MSAWATZKY BRIAN D
    • ERICKSON PAGE AEVERMAN MICHAEL RBELL MICHAEL SEDBERG KEVIN SBOTKE MATTHEW MSAWATZKY BRIAN D
    • C12M3/00
    • G01N35/00029G01N1/312G01N35/00009G01N2035/00039Y10T436/11Y10T436/112499Y10T436/113332
    • A sample processing system that may be configured to achieve parallel or coincidental sample processing such as histochemical processing may involve a plurality of samples arranged for coincidental movement perhaps by use of angular microscopic slide movements to cause processing activity that may include repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges. Through refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened from a more common 60 to 120 minutes to perhaps less than 15 minutes so as to permit use of such a system in an intraoperative or surgical environment such as recommended by the College of American Pathologists intraoperative guidelines or the like. Patients may thus avoid a need to be subjected to an additional surgical procedure when lab results become available to see if tumors or the like were fully removed in a prior procedure.
    • 可以被配置为实现平行或重复的样品处理(例如组织化学处理)的样品处理系统可以涉及可以通过使用角度显微镜幻灯片移动来布置为巧合运动的多个样品,以引起处理活动,所述处理活动可以包括反复消除和重新应用 流体物质可能通过毛细管运动的作用,以便刷新邻近样品的微环境,例如活组织检查或其它这样的样品。 可以包括抗体和其他物质,以减轻操作者的行为,并允许通过包括单容器多腔多重流体物质杂志,线性放置的多物质源和一级抗体盒来允许位置特异性物质应用。 通过刷新微环境,避免了微环境的消耗,并且幻灯片处理所需的时间可能会从更常见的60到120分钟到可能少于15分钟的时间急剧缩短,以便允许在术中或术中使用这样的系统 手术环境如美国病理学家推荐的术中指南等。 因此,当实验室结果变得可用时,患者可能避免需要进行额外的外科手术,以便在先前的手术中是否完全移除肿瘤等。
    • 3. 发明申请
    • PARALLEL PROCESSING FLUIDIC METHOD AND APPARATUS FOR AUTOMATED RAPID IMMUNOHISTOCHEMISTRY
    • 自动化快速免疫化学方法的平行加工流体法及装置
    • WO2006116199A3
    • 2007-12-13
    • PCT/US2006015269
    • 2006-04-21
    • CELERUS DIAGNOSTICS INCERICKSON PAGE AEVERMAN MICHAEL RBELL MICHAEL SEDBERG KEVIN SBOTKE MATTHEW M
    • ERICKSON PAGE AEVERMAN MICHAEL RBELL MICHAEL SEDBERG KEVIN SBOTKE MATTHEW M
    • C12M1/36C12M1/38C12M3/00
    • G01N35/00029G01N1/312G01N35/00009G01N2035/00039Y10T436/11Y10T436/112499Y10T436/113332
    • A sample processing system that may be configured to achieve parallel or coincidental sample processing such as histochemical processing may involve a plurality of samples arranged for coincidental movement perhaps by use of angular microscopic slide movements to cause processing activity that may include repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges. Through refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened from a more common 60 to 120 minutes to perhaps less than 15 minutes so as to permit use of such a system in an intraoperative or surgical environment such as recommended by the College of American Pathologists intraoperative guidelines or the like. Patients may thus avoid a need to be subjected to an additional surgical procedure when lab results become available to see if tumors or the like were fully removed in a prior procedure.
    • 可以被配置为实现平行或重合的样品处理(例如组织化学处理)的样品处理系统可以涉及可以通过使用角度显微镜幻灯片移动来布置为巧合运动的多个样品,以引起处理活动,所述处理活动可包括重复消除和重新应用 流体物质可能通过毛细血管运动的作用,以便刷新邻近诸如活组织检查或其它样品的样品的微环境。 可以包括抗体和其他物质,以减轻操作者的行为,并允许位置特异性物质应用,包括单容器多腔多重流体物质杂志,线性放置的多物质源和一级抗体盒。 通过刷新微环境,避免了微环境的消耗,并且幻灯片处理所需的时间可以从更常见的60分钟到120分钟到可能少于15分钟的时间急剧缩短,以便允许在术中或术中使用这样的系统 手术环境如美国病理学家推荐的术中指南等。 因此,当实验室结果变得可用时,患者可以避免需要进行额外的外科手术,以便在先前的手术中是否完全移除肿瘤等。
    • 4. 发明申请
    • WICKING CASSETTE METHOD AND APPARATUS FOR AUTOMATED RAPID IMMUNOHISTOCHEMISTRY
    • 自动快速免疫组织化学检测方法及装置
    • WO2006116035A2
    • 2006-11-02
    • PCT/US2006015017
    • 2006-04-21
    • CELERUS DIAGNOSTICS INCERICKSON PAGE AEVERMAN MICHAEL RBELL MICHAEL SEDBERG KEVIN SBOTKE MATTHEW W
    • ERICKSON PAGE AEVERMAN MICHAEL RBELL MICHAEL SEDBERG KEVIN SBOTKE MATTHEW W
    • G02B6/04
    • G01N35/00029G01N1/312G01N35/00009G01N2035/00039Y10T436/11Y10T436/112499Y10T436/113332
    • A sample processing system that may be configured to achieve parallel or coincidental sample processing such as histochemical processing may involve a plurality of samples arranged for coincidental movement perhaps by use of angular microscopic slide movements to cause processing activity that may include repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges. Through refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened from a more common 60 to 120 minutes to perhaps less than 15 minutes so as to permit use of such a system in an intraoperative or surgical environment such as recommended by the College of American Pathologists intraoperative guidelines or the like. Patients may thus avoid a need to be subjected to an additional surgical procedure when lab results become available to see if tumors or the like were fully removed in a prior procedure.
    • 可以被配置为实现平行或重复的样品处理(例如组织化学处理)的样品处理系统可以涉及可以通过使用角度显微镜幻灯片移动来布置为巧合运动的多个样品,以引起处理活动,所述处理活动可以包括反复消除和重新应用 流体物质可能通过毛细管运动的作用,以便刷新邻近样品的微环境,例如活组织检查或其它这样的样品。 可以包括抗体和其他物质,以减轻操作者的行为,并允许通过包括单容器多腔多重流体物质杂志,线性放置的多物质源和一级抗体盒来允许位置特异性物质应用。 通过刷新微环境,避免了微环境的消耗,并且幻灯片处理所需的时间可能会从更常见的60到120分钟到可能少于15分钟的时间急剧缩短,以便允许在术中或术中使用这样的系统 手术环境如美国病理学家推荐的术中指南等。 因此,当实验室结果变得可用时,患者可能避免需要进行额外的外科手术,以便在先前的手术中是否完全移除肿瘤等。