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1. 发明申请

WO2012046825A1 4- (METHYLAMINOPHENOXY) PYRDIN- 3 - YL - BENZAMIDE DERIVATIVES FOR TREATING CANCER 审中-公开
标题翻译： 4-（甲基氨基苯氧基）PYRDIN-3-YL-治疗癌症的苯甲酰胺衍生物
公开(公告)号：WO2012046825A1
公开(公告)日：2012-04-12
申请号：PCT/JP2011/073165
申请日：2011-10-03
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , NAKAGAWA, Takashi , SAKAMOTO, Makoto , YAMAGUCHI, Kazuya , TERAUCHI, Yuki , SHIRAKURA, Masamichi , HARADA, Yasuo , KOJIMA, Yutaka , SUMIDA, Takumi
发明人： NAKAGAWA, Takashi , SAKAMOTO, Makoto , YAMAGUCHI, Kazuya , TERAUCHI, Yuki , SHIRAKURA, Masamichi , HARADA, Yasuo , KOJIMA, Yutaka , SUMIDA, Takumi
IPC分类号： A61K31/44 , C07D213/75 , A61P35/00
CPC分类号： C07D213/75 , C07D213/76
摘要： The present invention provides a novel compound having an excellent antitumor effect, stability and metabolic stability. The compound of the present invention is represented by the following general formula (1) wherein R 1 represents a halogen atom, an aryl group, an aryloxy group or a lower alkyl group optionally substituted with one or more halogen atoms; R 2 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; and; m represents an integer of 1 to 3; provided that when m represents 2 or 3, R 1 s are the same or different.
摘要翻译：本发明提供了具有优异的抗肿瘤效果，稳定性和代谢稳定性的新型化合物。本发明化合物由以下通式（1）表示，其中R 1表示卤素原子，芳基，芳氧基或任选被一个或多个卤素原子取代的低级烷基; R2表示氢原子，卤素原子，低级烷基或低级烷氧基; 和; m表示1〜3的整数，条件是当m表示2或3时，R 1相同或不同。

2. 发明申请

WO1997023354A1 OPTICAL RECORDING MATERIAL AND OPTICAL RECORDING MEDIUM 审中-公开
标题翻译：光学记录材料和光记录介质
公开(公告)号：WO1997023354A1
公开(公告)日：1997-07-03
申请号：PCT/JP1996003753
申请日：1996-12-24
申请人： TOYO INK MANUFACTURING CO., LTD. , KIMURA, Shuichi , OGAWA, Tadashi , SAKAMOTO, Makoto
发明人： TOYO INK MANUFACTURING CO., LTD.
IPC分类号： B41M05/26
CPC分类号： C09B47/085 , G11B7/248 , Y10S428/913 , Y10S430/146 , Y10T428/21
摘要： An optical recording material represented by formula (1) and an optical recording medium which has a recording layer containing the same and is excellent in recording sensitivity, light resistance, and durability. In said formula X1 to X4 each represents hydrogen, alkyl, aryl, alicyclic residue, aralkyl, heterocycle, alkoxy, aryloxy, alkylthio, or arylthio; Y1 to Y4 each represents hydrogen, halogeno, nitro, phthalimidomethyl, or sulfonamido; R1 and R2 each represents hydrogen, halogeno, hydroxy, alkyl, aryl, aralkyl, alkoxy, aryloxy, alkylthio, arylthio, alkylamino, dialkylamino, arylamino, or diarylamino; M represents Al, Ga, In, Si, Ge, or Sn; Z represents azo compound, anthraquinone compound, or metal complex compound; n1 to n4 each is 1 to 4; m1 to m4 each is 0 to 4; and k is 1 or 2 and 1 is 0 or 1, provided that (k+1) is 1 or 2.
摘要翻译：由式（1）表示的光学记录材料和具有包含该记录材料的记录层，记录灵敏度，耐光性和耐久性优异的记录介质。所述式X 1至X 4各自表示氢，烷基，芳基，脂环族残基，芳烷基，杂环，烷氧基，芳氧基，烷硫基或芳硫基; Y1至Y4各自表示氢，卤代，硝基，苯二甲酰亚氨基甲基或亚磺酰氨基; R 1和R 2各自表示氢，卤素，羟基，烷基，芳基，芳烷基，烷氧基，芳氧基，烷硫基，芳硫基，烷基氨基，二烷基氨基，芳基氨基或二芳基氨基; M表示Al，Ga，In，Si，Ge或Sn; Z表示偶氮化合物，蒽醌化合物或金属络合物; n1〜n4分别为1〜4; m1〜m4分别为0〜4; 并且k为1或2且1为0或1，条件是（k + 1）为1或2。

3. 发明申请

WO2009057811A2 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF 审中-公开
标题翻译：杂环化合物及其药物组合物
公开(公告)号：WO2009057811A2
公开(公告)日：2009-05-07
申请号：PCT/JP2008/070153
申请日：2008-10-29
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , SUMIDA, Takumi , TABUSA, Fujio , SEKIGUCHI, Kazuo , KODAMA, Takeshi , YASUMURA, Koichi , KOJIMA, Yutaka , MOTOYAMA, Masaaki , MIYAJIMA, Keisuke , YOSHIDA, Kenji , KAN, Keizo , SAKAMOTO, Makoto , TAKASU, Hideki , NAKAGAWA, Takashi , OHI, Naoto , HARADA, Yasuo , HASHIMOTO, Norikazu , MATSUYAMA, Hironori , IIDA, Masatoshi , FUJITA, Shigekazu , FUKUSHIMA, Tae
发明人： SUMIDA, Takumi , TABUSA, Fujio , SEKIGUCHI, Kazuo , KODAMA, Takeshi , YASUMURA, Koichi , KOJIMA, Yutaka , MOTOYAMA, Masaaki , MIYAJIMA, Keisuke , YOSHIDA, Kenji , KAN, Keizo , SAKAMOTO, Makoto , TAKASU, Hideki , NAKAGAWA, Takashi , OHI, Naoto , HARADA, Yasuo , HASHIMOTO, Norikazu , MATSUYAMA, Hironori , IIDA, Masatoshi , FUJITA, Shigekazu , FUKUSHIMA, Tae
IPC分类号： C07D401/12 , C07D403/12 , A61K31/444 , A61K31/506 , A61P1/16
CPC分类号： C07D401/12 , C07D403/12
摘要： The present invention provides a heterocyclic compound represented by General Formula (1): wherein R 1 is a group R 5 -Z 1 -, etc., Z 1 is a lower alkylene group, etc., and R 5 is a group represented by General Formula; wherein R 13 is a hydrogen atom, etc., m is an integer from 1 to 5; R 2 is a hydrogen atom: Y is CH or N: A 1 is a heterocyclic ring selected from the group consisting of indolediyl groups, wherein the heterocyclic ring may have at least one substituent: T is a group -CO-, etc.: R 3 is a hydrogen atom, etc.: R 4 is a lower alkyl group optionally substituted by one or more hydroxy groups, etc.: R 3 and R 4 , together with the nitrogen atom to which they bind, may bind to each other and form a 5- to 10-membered saturated heterocyclic ring, wherein the heterocyclic ring may have at least one substituent. The heterocyclic compound of the present invention has excellent effects of suppressing the production of collagen and/or treating tumors.
摘要翻译：本发明提供了由通式（1）表示的杂环化合物：其中R 1是基团R 5 -Z 1， 1 - 等，Z 1是低级亚烷基等，R 5是由通式表示的基团; 其中R 13为氢原子等，m为1至5的整数; R 2是氢原子：Y是CH或N：A 1是选自吲哚二基的杂环，其中该杂环可至少具有一个取代基：T为基团-CO-等：R 3为氢原子等：R 4为任选被一个或两个取代基取代的低级烷基或更多的羟基等：R 3和R 4与它们所结合的氮原子一起可以相互连接并形成5至10元环，其中杂环可以具有至少一个取代基。本发明的杂环化合物具有抑制胶原产生和/或治疗肿瘤的优异效果。

4. 发明申请

WO2007066784A3 DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS 审中-公开
标题翻译：二甲苯衍生物作为抗菌剂
公开(公告)号：WO2007066784A3
公开(公告)日：2007-10-25
申请号：PCT/JP2006324610
申请日：2006-12-04
申请人： OTSUKA PHARMA CO LTD , MATSUYAMA HIRONORI , OHNISHI KENJI , NAKAGAWA TAKASHI , TAKASU HIDEKI , SAKAMOTO MAKOTO , HIGUCHI KUMI , MIYAJIMA KEISUKE , YAMADA SATOSHI , MOTOYAMA MASAAKI , KOJIMA YUTAKA , YASUMURA KOICHI , KODAMA TAKESHI , OTSUJI SHUN , KAN KEIZO , SUMIDA TAKUMI
发明人： MATSUYAMA HIRONORI , OHNISHI KENJI , NAKAGAWA TAKASHI , TAKASU HIDEKI , SAKAMOTO MAKOTO , HIGUCHI KUMI , MIYAJIMA KEISUKE , YAMADA SATOSHI , MOTOYAMA MASAAKI , KOJIMA YUTAKA , YASUMURA KOICHI , KODAMA TAKESHI , OTSUJI SHUN , KAN KEIZO , SUMIDA TAKUMI
IPC分类号： A61K31/495 , A61K31/496 , A61P35/00
CPC分类号： A61K31/496 , A61K31/495
摘要： An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X 1 represents a nitrogen atom or a group -CH=, R 1 represents a group -Z-R 6 , in which Z represents a group -CO-, a group -CH(OH)- or the like, R 6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R 2 represents a hydrogen atom or a halogen atom, Y represents a group -O-, a group -CO-, a group -CH(OH)- or a lower alkylene group, and A represents [Formula 2] wherein R 3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R 4 represents an imidazolyl lower alkyl group or the like.
摘要翻译：本发明的目的在于提供一种抗肿瘤活性大大提高的安全性药物。根据本发明，提供了含有下列通式（1）表示的化合物或其盐作为有效成分的药物：[1]其中X 1代表氮原子或基团-CH =，R 1表示基团-ZR 6，其中Z表示基团-CO-，基团-CH（OH） - 或 R 6表示具有1至4个氮原子，氧原子或硫原子的5至15元单环，二环或三环饱和或不饱和杂环基，R 2， SUP>表示氢原子或卤素原子，Y表示-O-基团，-CO-基团，-CH（OH）基或低级亚烷基，A表示[式2]其中R ^{3 表示氢原子，低级烷氧基等，p表示1或2，R 4表示咪唑基低级烷基等。}

5. 发明申请

WO2007066784A2 MEDICINAL DRUG 审中-公开
标题翻译：药物药物
公开(公告)号：WO2007066784A2
公开(公告)日：2007-06-14
申请号：PCT/JP2006/324610
申请日：2006-12-04
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , MATSUYAMA, Hironori , OHNISHI, Kenji , NAKAGAWA, Takashi , TAKASU, Hideki , SAKAMOTO, Makoto , HIGUCHI, Kumi , MIYAJIMA, Keisuke , YAMADA, Satoshi , MOTOYAMA, Masaaki , KOJIMA, Yutaka , YASUMURA, Koichi , KODAMA, Takeshi , OTSUJI, Shun , KAN, Keizo , SUMIDA, Takumi
发明人： MATSUYAMA, Hironori , OHNISHI, Kenji , NAKAGAWA, Takashi , TAKASU, Hideki , SAKAMOTO, Makoto , HIGUCHI, Kumi , MIYAJIMA, Keisuke , YAMADA, Satoshi , MOTOYAMA, Masaaki , KOJIMA, Yutaka , YASUMURA, Koichi , KODAMA, Takeshi , OTSUJI, Shun , KAN, Keizo , SUMIDA, Takumi
CPC分类号： A61K31/496 , A61K31/495
摘要： An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X 1 represents a nitrogen atom or a group -CH=, R 1 represents a group -Z-R 6 , in which Z represents a group -CO-, a group -CH(OH)- or the like, R 6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R 2 represents a hydrogen atom or a halogen atom, Y represents a group -O-, a group -CO-, a group -CH(OH)- or a lower alkylene group, and A represents [Formula 2] wherein R 3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R 4 represents an imidazolyl lower alkyl group or the like.
摘要翻译：本发明的目的在于提供一种抗肿瘤活性大大提高，安全性优异的药用药物。根据本发明，提供了含有下述通式（1）表示的化合物或其盐作为活性成分的药物：[1]其中X 1代表氮原子或基团-CH =，R 1表示基团-ZR 6，其中Z表示基团-CO-，基团-CH（OH） - 或 R 6表示具有1至4个氮原子，氧原子或硫原子的5至15元单环，二环或三环饱和或不饱和杂环基，R 2， SUP>表示氢原子或卤素原子，Y表示-O-基团，-CO-基团，-CH（OH）基或低级亚烷基，A表示[式2]其中R ^{3表示氢原子，低级烷氧基等，p表示1或2，R 4表示咪唑基低级烷基等。}

6. 发明申请

WO2009057811A3 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF 审中-公开
标题翻译：杂环化合物及其药物组合物
公开(公告)号：WO2009057811A3
公开(公告)日：2009-07-09
申请号：PCT/JP2008070153
申请日：2008-10-29
申请人： OTSUKA PHARMA CO LTD , SUMIDA TAKUMI , TABUSA FUJIO , SEKIGUCHI KAZUO , KODAMA TAKESHI , YASUMURA KOICHI , KOJIMA YUTAKA , MOTOYAMA MASAAKI , MIYAJIMA KEISUKE , YOSHIDA KENJI , KAN KEIZO , SAKAMOTO MAKOTO , TAKASU HIDEKI , NAKAGAWA TAKASHI , OHI NAOTO , HARADA YASUO , HASHIMOTO NORIKAZU , MATSUYAMA HIRONORI , IIDA MASATOSHI , FUJITA SHIGEKAZU , FUKUSHIMA TAE
发明人： SUMIDA TAKUMI , TABUSA FUJIO , SEKIGUCHI KAZUO , KODAMA TAKESHI , YASUMURA KOICHI , KOJIMA YUTAKA , MOTOYAMA MASAAKI , MIYAJIMA KEISUKE , YOSHIDA KENJI , KAN KEIZO , SAKAMOTO MAKOTO , TAKASU HIDEKI , NAKAGAWA TAKASHI , OHI NAOTO , HARADA YASUO , HASHIMOTO NORIKAZU , MATSUYAMA HIRONORI , IIDA MASATOSHI , FUJITA SHIGEKAZU , FUKUSHIMA TAE
IPC分类号： C07D401/12 , A61K31/444 , A61K31/506 , A61P1/16 , C07D403/12
CPC分类号： C07D401/12 , C07D403/12
摘要： The present invention provides a heterocyclic compound represented by General Formula (1): wherein R1 is a group R5-Z1-, etc., Z1 is a lower alkylene group, etc., and R5 is a group represented by General Formula; wherein R13 is a hydrogen atom, etc., m is an integer from 1 to 5; R2 is a hydrogen atom: Y is CH or N: A1 is a heterocyclic ring selected from the group consisting of indolediyl groups, wherein the heterocyclic ring may have at least one substituent: T is a group -CO-, etc.: R3 is a hydrogen atom, etc.: R4 is a lower alkyl group optionally substituted by one or more hydroxy groups, etc.: R3 and R4, together with the nitrogen atom to which they bind, may bind to each other and form a 5- to 10-membered saturated heterocyclic ring, wherein the heterocyclic ring may have at least one substituent. The heterocyclic compound of the present invention has excellent effects of suppressing the production of collagen and/or treating tumors.
摘要翻译：本发明提供由通式（1）表示的杂环化合物：其中R1为R5-Z1-基团等，Z1为低级亚烷基等，R5为通式所示的基团。其中R 13为氢原子等，m为1至5的整数; R2是氢原子：Y是CH或N：A1是选自吲哚二基的杂环，其中杂环可以具有至少一个取代基：T是-CO-等：R3是氢原子等：R4是任选被一个或多个羟基取代的低级烷基等：R 3和R 4与它们所结合的氮原子一起可以彼此结合形成5- 10元饱和杂环，其中杂环可以具有至少一个取代基。本发明的杂环化合物具有抑制胶原蛋白的生成和/或治疗肿瘤的优异效果。

7. 发明申请

WO2006014012A3 AROMATIC COMPOUNDS 审中-公开
标题翻译：芳香化合物
公开(公告)号：WO2006014012A3
公开(公告)日：2006-12-07
申请号：PCT/JP2005014611
申请日：2005-08-03
申请人： OTSUKA PHARMA CO LTD , FUKUSHIMA TAE , MATSUMURA SHUJI , TAKEMURA NORIAKI , SATOU HIDEAKI , ITO NOBUAKI , SHITSUTA TAKUYA , TSUTSUI HIRONORI , TANAKA MICHINORI , KAN KEIZO , NAGAO HITOSHI , WATANABE KENJI , TAI KUNINORI , NAKAGAWA TAKASHI , TAKASU HIDEKI , SAKAMOTO MAKOTO , MIYAJIMA KEISUKE , YAMADA SATOSHI , KOJIMA YUTAKA , YASUMURA KOICHI , OHI NAOTO , OKUNO MITSUHIRO , SUGIYAMA KAZUHISA , KIYONO KUNIHIKO , SUZUKI TAKASHI , AKAMATSU SEIJI , KODAMA TAKESHI , YANAGIHARA YASUO , SUMIDA TAKUMI
发明人： FUKUSHIMA TAE , MATSUMURA SHUJI , TAKEMURA NORIAKI , SATOU HIDEAKI , ITO NOBUAKI , SHITSUTA TAKUYA , TSUTSUI HIRONORI , TANAKA MICHINORI , KAN KEIZO , NAGAO HITOSHI , WATANABE KENJI , TAI KUNINORI , NAKAGAWA TAKASHI , TAKASU HIDEKI , SAKAMOTO MAKOTO , MIYAJIMA KEISUKE , YAMADA SATOSHI , KOJIMA YUTAKA , YASUMURA KOICHI , OHI NAOTO , OKUNO MITSUHIRO , SUGIYAMA KAZUHISA , KIYONO KUNIHIKO , SUZUKI TAKASHI , AKAMATSU SEIJI , KODAMA TAKESHI , YANAGIHARA YASUO , SUMIDA TAKUMI
IPC分类号： C07D295/192 , C07C233/67 , C07D211/46 , C07D211/58 , C07D211/62 , C07D211/70 , C07D213/75 , C07D239/42 , C07D241/20 , C07D295/185 , C07D317/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14
CPC分类号： C07C229/18 , C07C205/38 , C07C217/90 , C07C233/45 , C07C233/75 , C07C271/58 , C07C275/34 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D211/46 , C07D211/58 , C07D211/62 , C07D211/70 , C07D213/75 , C07D239/42 , C07D241/20 , C07D295/185 , C07D295/192 , C07D317/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X 1 represents a nitrogen atom or a group -CH=; R 1 represents a group -Z-R 6 , wherein Z represents a group -CO-, a group -CH(OH)-, or the like, and R 6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R 2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group -O-, a group -CO-, a group -CH(OH)-, a lower alkylene group, or the like; and (A) represents a group or the like, wherein R 3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R 4 represents an imidazolyl lower alkyl group or the like.
摘要翻译：本发明提供了一种新颖的化合物，其具有优异的抑制胶原产生的效果和较少的副作用。本发明的化合物由下列通式（1）表示：其中X 1表示氮原子或基团-CH =; R 1表示基团-ZR 6，其中Z表示-CO-基团，-CH（OH） - 基等基团，R“ 6表示具有1至4个氮原子，氧原子或硫原子的5至15元单环，二环或三环饱和或不饱和杂环基; R 2表示氢原子，卤素原子或低级亚烷基; Y表示基团-O-，基团-CO-，基团-CH（OH） - ，低级亚烷基基团等; 和（A）表示基团等，其中R 3表示氢原子，低级烷氧基等，p表示1或2，R 4 O >表示咪唑基低级烷基等。

8. 发明申请

WO2006014012A2 AROMATIC COMPOUND 审中-公开
标题翻译：芳香化合物
公开(公告)号：WO2006014012A2
公开(公告)日：2006-02-09
申请号：PCT/JP2005/014611
申请日：2005-08-03
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , FUKUSHIMA, Tae , MATSUMURA, Shuji , TAKEMURA, Noriaki , SATOU, Hideaki , ITO, Nobuaki , SHITSUTA, Takuya , TSUTSUI, Hironori , TANAKA, Michinori , KAN, Keizo , NAGAO, Hitoshi , WATANABE, Kenji , TAI, Kuninori , NAKAGAWA, Takashi , TAKASU, Hideki , SAKAMOTO, Makoto , MIYAJIMA, Keisuke , YAMADA, Satoshi , KOJIMA, Yutaka , YASUMURA, Koichi , OHI, Naoto , OKUNO, Mitsuhiro , SUGIYAMA, Kazuhisa , KIYONO, Kunihiko , SUZUKI, Takashi , AKAMATSU, Seiji , KODAMA, Takeshi , YANAGIHARA, Yasuo , SUMIDA, Takumi
发明人： FUKUSHIMA, Tae , MATSUMURA, Shuji , TAKEMURA, Noriaki , SATOU, Hideaki , ITO, Nobuaki , SHITSUTA, Takuya , TSUTSUI, Hironori , TANAKA, Michinori , KAN, Keizo , NAGAO, Hitoshi , WATANABE, Kenji , TAI, Kuninori , NAKAGAWA, Takashi , TAKASU, Hideki , SAKAMOTO, Makoto , MIYAJIMA, Keisuke , YAMADA, Satoshi , KOJIMA, Yutaka , YASUMURA, Koichi , OHI, Naoto , OKUNO, Mitsuhiro , SUGIYAMA, Kazuhisa , KIYONO, Kunihiko , SUZUKI, Takashi , AKAMATSU, Seiji , KODAMA, Takeshi , YANAGIHARA, Yasuo , SUMIDA, Takumi
IPC分类号： C07D295/192 , C07D317/58 , C07D211/46 , C07D211/58 , C07D213/75
CPC分类号： C07C229/18 , C07C205/38 , C07C217/90 , C07C233/45 , C07C233/75 , C07C271/58 , C07C275/34 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D211/46 , C07D211/58 , C07D211/62 , C07D211/70 , C07D213/75 , C07D239/42 , C07D241/20 , C07D295/185 , C07D295/192 , C07D317/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X 1 represents a nitrogen atom or a group -CH=; R 1 represents a group -Z-R 6 , wherein Z represents a group -CO-, a group -CH(OH)-, or the like, and R 6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R 2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group -O-, a group -CO-, a group -CH(OH)-, a lower alkylene group, or the like; and (A) represents a group or the like, wherein R 3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R 4 represents an imidazolyl lower alkyl group or the like.
摘要翻译：本发明提供了一种新颖的化合物，其具有优异的抑制胶原产生的效果和较少的副作用。本发明的化合物由下列通式（1）表示：其中X 1表示氮原子或基团-CH =; R 1表示基团-ZR 6，其中Z表示-CO-基团，-CH（OH） - 基等基团，R“ 6表示具有1至4个氮原子，氧原子或硫原子的5至15元单环，二环或三环饱和或不饱和杂环基; R 2表示氢原子，卤素原子或低级亚烷基; Y表示基团-O-，基团-CO-，基团-CH（OH） - ，低级亚烷基基团等; 和（A）表示基团等，其中R 3表示氢原子，低级烷氧基等，p表示1或2，R 4 O >表示咪唑基低级烷基等。

9. 发明申请

WO1994021612A1 CARBOSTYRIL DERIVATIVES AS MATRIX METALLOPROTEINASES INHIBITORS 审中-公开
标题翻译： CARBOSTYRIL衍生物作为基质金属蛋白酶抑制剂
公开(公告)号：WO1994021612A1
公开(公告)日：1994-09-29
申请号：PCT/JP1994000434
申请日：1994-03-17
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , SAKAMOTO, Makoto , IMAOKA, Takeshi , MOTOYAMA, Masaaki , YAMAMOTO, Yoshihito , TAKASU, Hideki
发明人： OTSUKA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D215/38
CPC分类号： C07D215/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D491/04
摘要： This invention provides a carbostyril derivative of formula (1), where R , R , R , R , R , R and n are as defined, or its salt. This carbostyril derivative or its salt possess an excellent matrix metalloproteinases inhibitory action.
摘要翻译：本发明提供式（1）的喹诺酮衍生物，其中R 1，R 2，R 3，R 4，R 5，R 6和n如上所定义，或其盐。该喹诺酮衍生物或其盐具有优异的基质金属蛋白酶抑制作用。

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