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1. 发明申请

WO2004011499A1 NOVEL ALBUMINS 审中-公开
标题翻译：新的阿尔卑斯
公开(公告)号：WO2004011499A1
公开(公告)日：2004-02-05
申请号：PCT/GB2003/003199
申请日：2003-07-28
申请人： UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH , DELTA BIOTECHNOLOGY LIMITED , BEREZENKO, Stephen , SADLER, Peter, John , STEWART, Alan, James , BLINDAUER, Claudia
发明人： BEREZENKO, Stephen , SADLER, Peter, John , STEWART, Alan, James , BLINDAUER, Claudia
IPC分类号： C07K14/765
CPC分类号： C07K14/765
摘要： The present invention relates to mutated forms of serum albumin, which display altered metal binding and/or other characteristics with respect to a native albumin from which the mutant has been derived, as well as uses of such mutant albumins in the medical field or in growth of cells in culture.
摘要翻译：本发明涉及突变形式的血清白蛋白，其相对于衍生突变体的天然白蛋白显示改变的金属结合和/或其它特征，以及在医学领域或生长中使用这种突变蛋白的细胞。

2. 发明申请

WO2011131925A2 OSMIUM (II) ARENE AZO ANTI-CANCER COMPLEXES 审中-公开
标题翻译： OSMIUM（II）ARENE AZO抗癌复合物
公开(公告)号：WO2011131925A2
公开(公告)日：2011-10-27
申请号：PCT/GB2011/000591
申请日：2011-04-15
申请人： UNIVERSITY OF WARWICK , FU, Ying , SADLER, Peter, John , HABTEMARIAM, Abraha
发明人： FU, Ying , SADLER, Peter, John , HABTEMARIAM, Abraha
IPC分类号： C07F15/00 , C07F17/02 , A61P35/00 , A61K31/00
CPC分类号： C07F15/002
摘要： The present invention relates to the use of certain osmium containing complexes such as cytotoxic agents particularly for the treatment of cancer. There is also provided novel osmium containing complexes, as well as pharmaceutical formulations comprising such complexes.
摘要翻译：本发明涉及某些含锇复合物如细胞毒剂特别用于治疗癌症的用途。还提供了新颖的含锇络合物，以及包含这种复合物的药物制剂。

3. 发明申请

WO2004005304A1 RUTHENIUM ANTICANCER COMPLEXES 审中-公开
标题翻译： RENHENIUM ANTICANCER复合物
公开(公告)号：WO2004005304A1
公开(公告)日：2004-01-15
申请号：PCT/GB2003/002879
申请日：2003-07-04
申请人： THE UNIVERSITY COURT, THE UNIVERSITY OF EDINBURGH , SADLER, Peter, John , FERNÁNDEZ LAÍNEZ, Rafael , HABTEMARIAM, Abraba , MELCHART, Michael , JODRELL, Duncan, Ian
发明人： SADLER, Peter, John , FERNÁNDEZ LAÍNEZ, Rafael , HABTEMARIAM, Abraba , MELCHART, Michael , JODRELL, Duncan, Ian
IPC分类号： C07F15/00
CPC分类号： C07F17/02
摘要： Ruthenium (II) compounds of formula (I) are useful in the treatment and/or prevention of cancer, wherein formula (I) is :
摘要翻译：式（I）的钌（II）化合物可用于治疗和/或预防癌症，其中式（I）是：

4. 发明申请

WO1994020863A1 DETECTION OF ALBUMIN IN PHYSIOLOGICAL FLUIDS 审中-公开
标题翻译：生物流体中ALBUM的检测
公开(公告)号：WO1994020863A1
公开(公告)日：1994-09-15
申请号：PCT/GB1994000425
申请日：1994-03-04
申请人： BIRKBECK COLLEGE , SADLER, Peter, John , VILES, John, Howard , TUCKER, Alan , PATEL, Sunil, Unka
发明人： BIRKBECK COLLEGE
IPC分类号： G01R33/46
CPC分类号： G01R33/465
摘要： A method of detecting albumin or one or more amino acid residues thereof, in a physiological fluid containing albumin and other proteins, and optionally free amino acids, which comprises subjecting a sample of the fluid to 'H NMR spectroscopy which is single pulse or 2 dimensional spectroscopy, in which the resolution is enhanced.
摘要翻译：在含有白蛋白和其它蛋白质的生理液体中，检测白蛋白或其一个或多个氨基酸残基的方法和任选的游离氨基酸，其包括使流体样品进行1脉冲或2维的1 H NMR光谱光谱学，其中分辨率得到增强。

5. 发明申请

WO2007135410A1 RUTHENIUM II COMPOUNDS 审中-公开
标题翻译：二氢化钌
公开(公告)号：WO2007135410A1
公开(公告)日：2007-11-29
申请号：PCT/GB2007/001874
申请日：2007-05-21
申请人： THE UNIVERSITY COURT OF THE UNVERSITY OF EDINBURGH , HABTEMARIAM, Abraha , BUGARCIC, Tijana , SADLER, Peter John
发明人： HABTEMARIAM, Abraha , BUGARCIC, Tijana , SADLER, Peter John
IPC分类号： A61K31/00 , A61P35/00
CPC分类号： C07F17/02
摘要： A ruthenium (II) compound of formula (I), or a solvate form thereof for use in a method of therapy, wherein: R 1 R 2 R 3 R 4 R 5 and R 6 are independently selected from H, C 1-7 alkyl, C 5-20 aryl, C 3-20 heterocyclyl, halo, ester, amido, acyl, sulfo, sulfonamido, ether, thioether, azo and amino, or R 1 and R 2 together with the ring to which they are attached form a saturated or unsaturated carbocyclic or heterocyclic group containing up to three 3- to 8- membered carbocyclic or heterocyclic rings, wherein each carbocyclic or heterocyclic ring may be fused to one or more other carbocyclic or heterocyclic rings; X is halo or a neutral or negatively charged O, N- or S- donor ligand; m is -1, 0, 1 or 2; q is 1, 2 or 3; R C1 and R C2 independently represent one or more optional substituents selected from hydroxy, C 1-7 alkoxy, C 5-20 aryloxy, C 1-7 alkyl, carboxy, C 1-7 alkyl ester and C 5-20 aryl ester; R N1 and R N2 are independently selected from hydroxy, C 1-7 alkoxy, C 5-20 aryloxy, C 1-7 alkyl, carboxy, C 1-7 alkyl ester and C 5-20 aryl ester; or R N1 and R N2 together with the pyridine rings to which they are bound form an tricyclic heteraromatic moiety, where the ring formed by R N1 and R N2 together may be optionally substituted by one or more substituents represented by R C3 selected from: hydroxy, C 1-7 alkoxy, C 5-20 aryloxy, C 1-7 alkyl, carboxy, C 1-7 alkyl ester and C 5-20 aryl ester.
摘要翻译：用于治疗方法的式（I）的钌（II）化合物或其溶剂化物形式，其中：R 1 R 2 R 3 R 4 R 5和R 6独立地选自H，C 1-7烷基 C 5-20芳基，C 3-20杂环基，卤素，酯，酰胺基，酰基，磺基，亚磺酰氨基，醚，硫醚，偶氮和氨基，它们所连接的环与它们所连接的环一起形成含有至多三个3-至8-元碳环或杂环的饱和或不饱和碳环或杂环基，其中每个碳环或杂环可以与一个或多个其它碳环或杂环稠合; X是卤素或中性或带负电荷的O，N-或S-供体配体; m为-1,0,1或2; q为1,2或3; R C1和R C2独立地表示一个或多个任选的选自羟基，C 1-7 - 烷氧基，C 5-20的取代基芳氧基，C 1-7烷基，羧基，C 1-7 - 烷基酯和C 5-20-20芳基酯; R N1和R N2独立地选自羟基，C 1-7 - 烷氧基，C 5-20芳氧基 C 1-7烷基，羧基，C 1-7烷基酯和C 5-20-20芳基酯; 或R N1和R N2与它们所连接的吡啶环一起形成三环杂芳基部分，其中由R 1，R 2，和R“N 2”可以任选被一个或多个选自以下的取代基取代：选自羟基，C 1-7 - 烷氧基，C 5-20芳氧基，C 1-7 - 烷基，羧基，C 1-7 - 烷基酯和C 5-20 - 芳基酯。

6. 发明申请

WO1985005554A1 NMR CONTRAST AGENTS 审中-公开
标题翻译： NMR对比剂
公开(公告)号：WO1985005554A1
公开(公告)日：1985-12-19
申请号：PCT/GB1985000234
申请日：1985-05-31
申请人： AMERSHAM INTERNATIONAL PLC , SADLER, Peter, John , HARDING, Charles, Thomas
发明人： AMERSHAM INTERNATIONAL PLC
IPC分类号： A61K49/00
CPC分类号： A61K49/128 , A61K49/085 , G01R33/5601
摘要： An agent for modifying H2O relaxation times in NMR diagnosis comprises a polysaccharide having chemically linked to it an organic complexant to which is complexed a paramagnetic metal ion. Polysaccharides include cellulose, starch, sepharose and dextran. Organic complexants include EDTA, DTPA and aminoethyl diphosphonate. A preferred metal ion is Gadolinium (III). The agents can be administered orally or parenterally.
摘要翻译：用于在NMR诊断中修饰H 2 O松弛时间的试剂包括与其化学连接的有机络合物的多糖，其与顺磁性金属离子络合。多糖包括纤维素，淀粉，琼脂糖凝胶和葡聚糖。有机络合剂包括EDTA，DTPA和氨基乙基二膦酸盐。优选的金属离子是钆（III）。所述试剂可以口服或肠胃外给药。

7. 发明申请

WO2008017855A1 OSMIUM COMPOUNDS 审中-公开
标题翻译： OSMIUM化合物
公开(公告)号：WO2008017855A1
公开(公告)日：2008-02-14
申请号：PCT/GB2007/003042
申请日：2007-08-10
申请人： THE UNIVERSITY OF WARWICK , SADLER, Peter, John , PEACOCK, Anna, Frances, Acushla , VAN RIJT, Sabine, Helena , HABTEMARIAM, Abraha
发明人： SADLER, Peter, John , PEACOCK, Anna, Frances, Acushla , VAN RIJT, Sabine, Helena , HABTEMARIAM, Abraha
IPC分类号： C07F17/02 , A61K31/00 , A61P35/00
CPC分类号： C07F17/02
摘要： The present invention relates to osmium compounds of formula [I), their preparation and use in methods of treatment, particularly for cancer treatment.
摘要翻译：本发明涉及式[I]的锇化合物，其在治疗方法中的制备和用途，特别是用于癌症治疗。

8. 发明申请

WO2004096819A1 RUTHENIUM (II) COMPLEXES FOR THE TREATMENT OF TUMORS 审中-公开
标题翻译： RUTHENIUM（II）用于治疗肿瘤的复合物
公开(公告)号：WO2004096819A1
公开(公告)日：2004-11-11
申请号：PCT/GB2004/001837
申请日：2004-04-29
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH , HABTEMARIAM, Abraha , SADLER, Peter, John
发明人： HABTEMARIAM, Abraha , SADLER, Peter, John
IPC分类号： C07F17/02
CPC分类号： C07F17/02
摘要： Ruthenium (II) compounds of formula (I) are useful in the treatment and/or prevention of cancer.
摘要翻译：式（I）的钌（II）化合物可用于治疗和/或预防癌症。

9. 发明申请

WO2003017993A1 PHOTOREACTIVE COMPOUNDS AND COMPOSITIONS 审中-公开
标题翻译：光敏化合物和组合物
公开(公告)号：WO2003017993A1
公开(公告)日：2003-03-06
申请号：PCT/GB2002/003939
申请日：2002-08-27
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH , SADLER, Peter, John , MÜLLER, Philippe
发明人： SADLER, Peter, John , MÜLLER, Philippe
IPC分类号： A61K31/00
CPC分类号： A61K33/24 , A61K31/28 , A61K31/555 , C07F15/0093
摘要： The present invention provides a compound of formula (I): Pt IV (N 3 ) 2 X 1 X 2 Y 1 Y 2 , wherein X 1 and X 2 are the same or different and each one is a group NR 1 R 2 R 3 wherein R 1 , R 2 and R 3 are the same or different and each can be any one of H and optionally substituted alkyl, aryl, aralkyl, acyl, cycloalkyl, heterocyclyl, alkenyl, aralkenyl, alkinyl, cycloalkenyl, or X 1 and X 2 together represent a group R 1 R 2 NR 4 NR 1 R 2 wherein R 1 and R 2 have the same meaning as before, and R 4 represents an optionally substituted divalent, saturated or unsaturated, alkyl chain, an optionally substituted divalent, saturated or unsaturated cycloalkyl or an optionally substituted divalent aryl, or R 4 or two or more of R 1 , R 2 , R 3 and R 4 and the respective N atom(s) to which they are linked, represent an optionally substituted heterocyclyl having at least one ring containing said N atom(s); and Y 1 and Y 2 are the same or different or when cis together represent a divalent moiety Y 3 , wherein at least one of Y 1 and Y 2 , or Y 3 , is a substantially labile ligand in the analogous Pt(II) complex without the azide groups, whilst being substantially resistant, in vivo , to hydrolysis and physiological reducing agents. One or more of R 1 , R 2 , R 3 and R 4 , may further represent a covalently bonded link to at least one further complex of formula (I) to form a dimer or oligomer, or to a targeting moiety having affinity for a predetermined tissue or cell type.
摘要翻译：本发明提供了式（I）化合物：其中X 1和X 2相同或不同，其中X 1和X 2都相同或不同，不同，每个是NR 1 R 2 R 3基团，其中R 1，R 2和R 3相同或不同，并且各自可以是H中的任何一个和任选取代的烷基，芳基，芳烷基，酰基，环烷基，杂环基，烯基，芳烯基，炔基，环烯基或X 1和X 2一起表示基团R 1，R 2 NR 4 NR 1 R 2其中R 1和R 2具有与之前相同的含义，并且R 4表示任选取代的二价，饱和或不饱和的烷基链，任选取代的二价饱和或不饱和环烷基或或R 4或R 1，R 2，R 3和R 4中的两个或多个，以及与它们相连的各自的N原子代表一个任选取代的具有至少一个含有所述N原子的环的杂环基; Y 1和Y 2相同或不同，或者当顺式一起代表二价基团Y 3时，其中Y 1和Y 2或Y 3中的至少一个是在类似的Pt（II）络合物中没有叠氮基团的基本上不稳定的配体，同时在体内基本上对水解和生理还原剂具有抗性。 R 1，R 2，R 3和R 4中的一个或多个可以进一步代表与至少一个另外的式（I）的络合物的共价连接的连接基以形成二聚体或低聚物，或涉及对预定组织或细胞类型具有亲和性的靶向部分。

10. 发明申请

WO1987001594A1 CONTRAST AGENT FOR NMR IMAGING 审中-公开
标题翻译： NMR成像对比剂
公开(公告)号：WO1987001594A1
公开(公告)日：1987-03-26
申请号：PCT/GB1986000540
申请日：1986-09-11
申请人： AMERSHAM INTERNATIONAL PLC , SADLER, Peter, John , HARDING, Charles, Thomas
发明人： AMERSHAM INTERNATIONAL PLC
IPC分类号： A61K49/00
CPC分类号： A61K49/20 , Y10T436/24
摘要： A polysaccharide chemically joined to a nitroxyl spin label (NSL) compound has use for the preparation of an NMR diagnostic composition. An agent for modifying H2O relaxation times in NMR diagnosis may comprise a polysaccharide to which is chemically linked both an NSL compound and an organic complexing agent to which is complexed a paramagnetic metal ion, such as Gd(III) or Cu(II). Polysaccharides include dextran, starch and cellulose. The preferred NSL compound is 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl.
摘要翻译：化学连接到硝酰自旋标记（NSL）化合物的多糖可用于制备NMR诊断组合物。用于在NMR诊断中修饰H 2 O松弛时间的试剂可以包含多糖，其与化学连接的是NSL化合物和与顺磁性金属离子如Gd（III）或Cu（II）络合的有机络合剂。多糖包括葡聚糖，淀粉和纤维素。优选的NSL化合物是4-氨基-2,2,6,6-四甲基哌啶-1-氧基。

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