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1. 发明申请

WO2007087448A1 SPIRO IMIDAZOLE DERIVATIVES AS PPAR MODULATORS 审中-公开
标题翻译： SPIRO咪唑唑衍生物作为PPAR调节剂
公开(公告)号：WO2007087448A1
公开(公告)日：2007-08-02
申请号：PCT/US2007/002315
申请日：2007-01-25
申请人： IRM LLC , EPPLE, Robert , RUSSO, Ross , AZIMIOARA, Mihai , COW, Christopher , MOLTENI, Valentina , LI, Xiaolin , CHIANELLI, Donatella
发明人： EPPLE, Robert , RUSSO, Ross , AZIMIOARA, Mihai , COW, Christopher , MOLTENI, Valentina , LI, Xiaolin , CHIANELLI, Donatella
IPC分类号： C07D471/10 , A61K31/435 , A61P3/00 , A61P9/00 , A61P11/00
CPC分类号： C07D471/10
摘要： The invention provides compounds (Ia), (Ib) and (Ic), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.
摘要翻译：本发明提供化合物（Ia），（Ib）和（Ic），包含这些化合物的药物组合物和使用这些化合物治疗或预防与过氧化物酶体增殖物激活受体（PPAR）家族的活性相关的疾病或病症的方法。

2. 发明申请

WO2007056497A1 COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS 审中-公开
标题翻译：化合物和组合物作为PPAR调节剂
公开(公告)号：WO2007056497A1
公开(公告)日：2007-05-18
申请号：PCT/US2006/043587
申请日：2006-11-07
申请人： IRM LLC , EPPLE, Robert , XIE, Yongping , WANG, Xing , RUSSO, Ross , COW, Christopher , AZIMIOARA, Mihai
发明人： EPPLE, Robert , XIE, Yongping , WANG, Xing , RUSSO, Ross , COW, Christopher , AZIMIOARA, Mihai
IPC分类号： C07D413/04 , A61K31/422 , A61P3/00 , A61P9/00 , A61P3/10 , A61P25/28
CPC分类号： C07D413/04
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.
摘要翻译：本发明提供了化合物，包含此类化合物的药物组合物以及使用此类化合物治疗或预防与过氧化物酶体增殖物激活受体（PPAR）家族活性有关的疾病或病症的方法。

3. 发明申请

WO2008121570A1 COMPOUNDS AND METHODS FOR MODULATING G PROTEIN-COUPLED RECEPTORS 审中-公开
标题翻译：化合物和调节G蛋白偶联受体的方法
公开(公告)号：WO2008121570A1
公开(公告)日：2008-10-09
申请号：PCT/US2008/057622
申请日：2008-03-20
申请人： IRM LLC , EPPLE, Robert , AZIMIOARA, Mihai , COW, Christopher , RUSSO, Ross , NIKULIN, Victor , LELAIS, Gerald
发明人： EPPLE, Robert , AZIMIOARA, Mihai , COW, Christopher , RUSSO, Ross , NIKULIN, Victor , LELAIS, Gerald
IPC分类号： A61K31/192 , A61P3/04 , A61P3/06
CPC分类号： A61K31/192
摘要： The invention provides methods for modulating G protein-coupled receptor 20 (GPR20), and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated GPR20.
摘要翻译：本发明提供调节G蛋白偶联受体20（GPR20）的方法，以及使用这些化合物治疗，改善或预防与异常或失调的GPR20有关的病症的方法。

4. 发明申请

WO2005116000A1 COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS 审中-公开
标题翻译：化合物和组合物作为PPAR调节剂
公开(公告)号：WO2005116000A1
公开(公告)日：2005-12-08
申请号：PCT/US2005/018167
申请日：2005-05-24
申请人： IRM LLC , EPPLE, Robert , COW, Christopher , XIE, Yongping , WANG, Xing , RUSSO, Ross , AZIMIOARA, Mihai , SAEZ, Enrique
发明人： EPPLE, Robert , COW, Christopher , XIE, Yongping , WANG, Xing , RUSSO, Ross , AZIMIOARA, Mihai , SAEZ, Enrique
IPC分类号： C07D277/24
CPC分类号： C07D277/24 , C07D277/16 , C07D277/36 , C07D417/04 , C07D417/14
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR.
摘要翻译：本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与过氧化物酶体增殖物激活受体（PPAR）家族的活性相关的疾病或病症的方法，特别是PPAR的活性。

5. 发明申请

WO2008051763A1 CATHEPSIN PROTEASES INHIBITORS 审中-公开
标题翻译： CATHEPSIN蛋白抑制剂
公开(公告)号：WO2008051763A1
公开(公告)日：2008-05-02
申请号：PCT/US2007/081635
申请日：2007-10-17
申请人： IRM LLC , RUSSO, Ross , EPPLE, Robert
发明人： EPPLE, Robert
IPC分类号： C07D498/08 , A61K31/395 , A61P11/06 , A61P19/02 , A61P19/10 , A61P35/00 , A61P37/00
CPC分类号： C07D498/08
摘要： The invention provides compounds (I) and pharmaceutical compositions thereof, and more particularly, bicyclic carbamates, which are useful as cathepsin inhibitors, and methods for using such compounds or pharmaceutically acceptable salts thereof, wherein X is 0 or S; R 1 is OR 2 , halo, (CR 2 ) n R 3 , nitro, cyano, amino, aniido, sulfonamide, or an optionally substituted C 1-6 alkyl, C 2-6 alkenyl, or C 3-6 alkynyl;R 2 is H, (CR 2 )nR 3 , or an optionally substituted C 1-6 alkyl, C 2-6 alkenyl or C 3-6 alkynyl; R 3 is an optionally substituted aryl, heteroaryl, carbocyciic ring or heterocyclic ring; m is 1-3; and n is 0-4.
摘要翻译：本发明提供了可用作组织蛋白酶抑制剂的化合物（I）及其药物组合物，更具体地是双环氨基甲酸酯，以及使用这些化合物或其药学上可接受的盐的方法，其中X为0或S; R 1是OR 2，卤素，（CR 2）n R 3，R 3，，硝基，氰基，氨基，脒基，磺酰胺或任选取代的C 1-6烷基，C 2-6链烯基或C 3-6烯基， R 2是H，（CR 2）n R 3或任选取代的C 1-6烷基， C 1-6烷基，C 2-6烯基或C 3-6亚炔基; R 3是任选取代的芳基，杂芳基，碳环或杂环; m为1-3; n为0-4。

6. 发明申请

WO2007089667A1 COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS 审中-公开
公开(公告)号：WO2007089667A1
公开(公告)日：2007-08-09
申请号：PCT/US2007/002316
申请日：2007-01-25
申请人： IRM LLC , EPPLE, Robert , RUSSO, Ross , AZIMIOARA, Mihai
发明人： EPPLE, Robert , RUSSO, Ross , AZIMIOARA, Mihai
IPC分类号： C07D513/04 , A61K31/435
CPC分类号： C07D513/04
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.

7. 发明申请

WO2008103500A1 THIAZOLE DERIVATIVES AS MODULATORS OF G PROTEIN-COUPLED RECEPTORS 审中-公开
标题翻译：作为G蛋白偶联受体的调节剂的噻唑衍生物
公开(公告)号：WO2008103500A1
公开(公告)日：2008-08-28
申请号：PCT/US2008/050434
申请日：2008-01-07
申请人： IRM LLC , EPPLE, Robert , AZIMIOARA, Mihai , COW, Christopher , RUSSO, Ross , NIKULIN, Victor , LELAIS, Gerald
发明人： EPPLE, Robert , AZIMIOARA, Mihai , COW, Christopher , RUSSO, Ross , NIKULIN, Victor , LELAIS, Gerald
IPC分类号： C07D417/10 , C07D417/14 , A61K31/427 , A61P3/10
CPC分类号： C07D417/10 , C07D417/14
摘要： The invention provides compounds of formula (IA) or (IB) and pharmaceutical compositions thereof, which are useful for modulating G protein-coupled receptor 120 (GPR120), and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated GPR120.
摘要翻译：本发明提供了可用于调节G蛋白偶联受体120（GPR120）的式（IA）或（IB）化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常相关的病症的方法或放松管制的GPR120。

8. 发明申请

WO2007056366A3 COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS 审中-公开
公开(公告)号：WO2007056366A3
公开(公告)日：2007-05-18
申请号：PCT/US2006/043342
申请日：2006-11-07
申请人： IRM LLC , EPPLE, Robert , COW, Christopher , AZIMIOARA, Mihai , RUSSO, Ross , XIE, Yongping , WANG, Xing
发明人： EPPLE, Robert , COW, Christopher , AZIMIOARA, Mihai , RUSSO, Ross , XIE, Yongping , WANG, Xing
IPC分类号： C07D263/32 , C07D263/46 , C07D277/22 , C07D277/36 , C07D417/12 , A61K31/421 , A61K31/426
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.

9. 发明申请

WO2008103501A1 COMPOUNDS AND METHODS FOR MODULATING G PROTEIN-COUPLED RECEPTORS 审中-公开
标题翻译：化合物和调节G蛋白偶联受体的方法
公开(公告)号：WO2008103501A1
公开(公告)日：2008-08-28
申请号：PCT/US2008/050507
申请日：2008-01-08
申请人： IRM LLC , EPPLE, Robert , AZIMIOARA, Mihai , COW, Christopher , RUSSO, Ross , NIKULIN, Victor , LELAIS, Gerald
发明人： EPPLE, Robert , AZIMIOARA, Mihai , COW, Christopher , RUSSO, Ross , NIKULIN, Victor , LELAIS, Gerald
IPC分类号： C07D263/32 , C07D263/60 , C07D277/30 , C07D513/04 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/429 , A61P3/00
CPC分类号： C07D263/32 , C07D263/60 , C07D277/30 , C07D513/04
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating G protein-coupled receptor 20 (GPR20), and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated GPR20.
摘要翻译：本发明提供了可用于调节G蛋白偶联受体20（GPR20）的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调的GPR20有关的病症的方法。

10. 发明申请

WO2007056496A1 OXAZOLE AND THIAZOLE PPAR MODULATOR 审中-公开
标题翻译：奥沙唑和噻唑PPAR调节剂
公开(公告)号：WO2007056496A1
公开(公告)日：2007-05-18
申请号：PCT/US2006/043586
申请日：2006-11-07
申请人： IRM LLC , EPPLE, Robert , COW, Christopher , AZIMIOARA, Mihai , RUSSO, Ross
发明人： EPPLE, Robert , COW, Christopher , AZIMIOARA, Mihai , RUSSO, Ross
IPC分类号： C07D263/48 , C07D277/42 , A61K31/422 , A61K31/427 , A61P3/00 , A61P9/00 , A61P17/00 , A61P25/28 , A61P29/00
CPC分类号： C07D263/48 , C07D277/42
摘要： The invention provides compounds (I) pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPARδ.
摘要翻译：本发明提供化合物（I）包含这些化合物的药物组合物和使用这些化合物治疗或预防与过氧化物酶体增殖物激活受体（PPAR）家族的活性相关的疾病或病症的方法，特别是PPARd的活性。

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