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1. 发明申请

WO2008096180A3 RIGID FOAM AND PROCESS FOR THE PRODUCTION THEREOF 审中-公开
公开(公告)号：WO2008096180A3
公开(公告)日：2008-08-14
申请号：PCT/GB2008/050083
申请日：2008-02-11
申请人： SUSTAINABLE RESOURCE SUPPLIES LIMITED , LYNN, Mark Thomas , RUSSELL, Stephen J
发明人： LYNN, Mark Thomas , RUSSELL, Stephen J
IPC分类号： B29C44/12 , C08J9/00
摘要： The present invention provides a rigid foam comprising a foamed proteinaceous material and a fibrous particulate dispersed therein, wherein the fibrous particulate has a mean fibre length of less than 10 mm and comprises one or more wool or nylon fibres. A process for the production of said foam is also provided. The disclosed foam may be used as a thermal or an acoustic insulation board.

2. 发明申请

WO2008096180A2 RIGID FOAM AND PROCESS FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：刚性泡沫及其生产方法
公开(公告)号：WO2008096180A2
公开(公告)日：2008-08-14
申请号：PCT/GB2008050083
申请日：2008-02-11
申请人： SUSTAINABLE RESOURCE SUPPLIES , LYNN MARK THOMAS , RUSSELL STEPHEN J
发明人： LYNN MARK THOMAS , RUSSELL STEPHEN J
IPC分类号： B29C44/12 , C08J9/00
CPC分类号： B29C44/12 , C08J9/0085 , C08J2205/10 , C08J2389/00 , E04B1/90 , E04B2001/742 , E04B2001/743 , E04B2001/8457 , Y02A30/246
摘要： The present invention provides a rigid foam comprising a foamed proteinaceous material and a fibrous particulate dispersed therein, wherein the fibrous particulate has a mean fibre length of less than 10 mm and comprises one or more wool or nylon fibres. A process for the production of said foam is also provided. The disclosed foam may be useful as thermal or acoustic insulation board.
摘要翻译：本发明提供一种包含发泡蛋白质材料和分散在其中的纤维状颗粒的硬质泡沫，其中纤维颗粒的平均纤维长度小于10mm，并且包含一种或多种羊毛或尼龙纤维。还提供了用于生产所述泡沫的方法。所公开的泡沫可用作热或隔音板。

3. 发明申请

WO2003093431A3 ABLATED SLAM-DEPENDENT ENTRY 审中-公开
公开(公告)号：WO2003093431A3
公开(公告)日：2003-11-13
申请号：PCT/US2003/013679
申请日：2003-05-02
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , RUSSELL, Stephen, J. , NAKAMURA, Takafumi , CATTANEO, Roberto , VONGPUNSAWAD, Sompong
发明人： RUSSELL, Stephen, J. , NAKAMURA, Takafumi , CATTANEO, Roberto , VONGPUNSAWAD, Sompong
IPC分类号： C07K14/005
摘要： The invention provides nucleic acids, polypeptides, and viruses containing nucleic acids and/or polypeptides. The invention also provides methods for using viruses to treat cancer patients. Specifically, the invention provides nucleic acid molecules encoding viral hemagglutinin (H) polypeptides, viral H polypeptides, and viruses containing nucleic acids and/or H polypeptides. Such viruses are useful for treating cancer patients without causing immune suppression.

4. 发明申请

WO02077154A3 GENE DELIVERY DEVICE AND GENE DELIVERY METHOD 审中-公开
标题翻译：基因输送装置和基因递送方法
公开(公告)号：WO02077154A3
公开(公告)日：2002-11-28
申请号：PCT/US0143608
申请日：2001-11-20
申请人： MAYO FOUNDATION , KHURANA GAUTAM , RUSSELL STEPHEN J , KATUSIC ZVONIMIR S
发明人： KHURANA GAUTAM , RUSSELL STEPHEN J , KATUSIC ZVONIMIR S
IPC分类号： A61K48/00 , A61M31/00 , A01N53/04
CPC分类号： A61K48/0075
摘要： A gene delivery device for localizing and enhancing the efficacy of gene transfer that provides a contact surface for contacting with a tissue site. By applying a pharmaceutical composition comprising a nucleic acid to a contact surface and contacting the contact surface to a tissue site, a greater than 10-fold increase in transduction efficiency is achieved. In one embodiment of the invention, the device comprises a housing in communication with a contact surface having multiple contact elements, and the pharmaceutical composition is applied to the contact elements through a lumen in the device.
摘要翻译：用于定位和增强基因转移功能的基因递送装置，其提供与组织部位接触的接触表面。通过将包含核酸的药物组合物应用于接触表面并使接触表面与组织部位接触，实现了转导效率提高了10倍以上。在本发明的一个实施例中，该装置包括与具有多个接触元件的接触表面连通的壳体，并且该药物组合物通过装置中的内腔施加到接触元件。

5. 发明申请

WO2023086995A2 GENETICALLY MODIFIED UNGULATE CELLS AND THEIR USES IN CANCER THERAPY 审中-公开
公开(公告)号：WO2023086995A2
公开(公告)日：2023-05-19
申请号：PCT/US2022/079820
申请日：2022-11-14
申请人： IMANIS LIFE SCIENCES, LLC , RUSSELL, Stephen J. , FIOS THERAPEUTICS LLC
发明人： MCGREGOR, Christopher G. A. , KROTOVA, Karina
IPC分类号： C12N15/85 , A61K35/12
摘要： Provided herein are genetically modified ungulate cells expressing a chimeric antigen receptor. Also provided herein are transgenic ungulate cells that can be used as cell carriers for the delivery of oncolytic viruses in cancer therapy. Also provided are transgenic ungulates comprising these cells, methods of making these cells, and methods of treating cancer by administering these cells to a subject in need thereof. Also provided are transgenic ungulate cells that express a chimeric antigen receptor and uses thereof.

6. 发明申请

WO2008008917A3 HYDROXYAPATITE PARTICLES 审中-公开
公开(公告)号：WO2008008917A3
公开(公告)日：2008-01-17
申请号：PCT/US2007/073397
申请日：2007-07-12
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , RUSSELL, Stephen J. , PENG, Kah-whye , ONG, Hooi Tin
发明人： RUSSELL, Stephen J. , PENG, Kah-whye , ONG, Hooi Tin
IPC分类号： A61L27/54 , A61L27/56 , A61F2/28
摘要： This document provides methods and materials related to hydroxyapatite particles. For example, hydroxyapatite particles, methods for making hydroxyapatite particles, and methods for using hydroxyapatite particles are provided herein.

7. 发明申请

WO2008008917A2 HYDROXYAPATITE PARTICLES 审中-公开
标题翻译：羟基磷灰石
公开(公告)号：WO2008008917A2
公开(公告)日：2008-01-17
申请号：PCT/US2007073397
申请日：2007-07-12
申请人： MAYO FOUNDATION , RUSSELL STEPHEN J , PENG KAH-WHYE , ONG HOOI TIN
发明人： RUSSELL STEPHEN J , PENG KAH-WHYE , ONG HOOI TIN
CPC分类号： A61K51/0489 , A61F2/28 , A61F2310/00293 , A61K51/1027 , A61K51/1244
摘要： This document provides methods and materials related to hydroxyapatite particles. For example, hydroxyapatite particles, methods for making hydroxyapatite particles, and methods for using hydroxyapatite particles are provided herein.
摘要翻译：本文件提供了与羟基磷灰石颗粒相关的方法和材料。例如，提供羟基磷灰石颗粒，制备羟基磷灰石颗粒的方法，以及使用羟基磷灰石颗粒的方法。

8. 发明申请

WO9744474A3 VIRAL PARTICLES WHICH ARE MASKED OR UNMASKED WITH RESPECT TO A CELL RECEPTOR 审中-公开
标题翻译：与细胞受体相关的病毒颗粒被隐藏或被忽略
公开(公告)号：WO9744474A3
公开(公告)日：1998-03-05
申请号：PCT/FR9700870
申请日：1997-05-16
申请人： CENTRE NAT RECH SCIENT , COSSET FRANCOIS LOIC , VALSESIA SANDRINE , RUSSELL STEPHEN J
发明人： COSSET FRANCOIS-LOIC , VALSESIA SANDRINE , RUSSELL STEPHEN J
IPC分类号： C12N15/09 , A61K31/70 , A61K31/7088 , A61K31/711 , A61K47/42 , A61K47/48 , A61K48/00 , C07K1/107 , C07K14/15 , C07K14/485 , C12N7/00 , C12N7/04 , C12N15/62 , C12N15/867 , C12N15/87 , C12N15/86 , C12N7/15
CPC分类号： C07K14/005 , A61K47/6901 , A61K48/00 , C07K1/1075 , C07K14/485 , C07K2319/00 , C12N7/00 , C12N15/62 , C12N15/86 , C12N15/87 , C12N2740/13022 , C12N2740/13043 , C12N2740/13045 , C12N2740/13062 , C12N2810/60 , C12N2810/6018 , C12N2810/6054 , C12N2810/80 , C12N2810/851 , C12N2810/852 , C12N2810/854
摘要： The invention features the use of a peptide for transferring genes in a eukaryotic target cell, which peptide has about 10 to about 200, in particular about 15 to about 150 amino acids, and advantageously about 20 amino acids, in which 30 % at least of the amino acids are constituted by proline radicals, which proline radicals are regularly arranged so as to induce polypeptide chain turnings at about 180° ('β-turn' or 'reverse-turn'), these turns being regularly spaced and gathering in a polyproline β-turn helix, in a polypeptide construction containing, on the said peptide N-terminal side (upstream), an N-terminal (upstream) proteinic domain capable of recognising a targeted surface molecule or an antigen expressed on a cellular surface, in particular an appropriate receptor (targeted receptor) located on the said eukaryotic cell, and on the said peptide C-terminal side (downstream), a C-terminal (downstream) protein domain capable of recognising an appropriate receptor (auxiliary receptor) located on the said eukaryotic cell, which peptide is capable of facilitating or inhibiting interaction between the C-terminal (downstream) protein domain and the auxiliary receptor, the inhibition of this interaction taking place so long as the N-terminal (upstream) protein domain has not interacted with the targeted receptor, and the facilitating of the interaction between the C-terminal (downstream) protein domain and the auxiliary receptor taking place when the N-terminal (upstream) protein domain has interacted with the targeted receptor.

9. 发明申请

WO1997044474A2 VIRAL PARTICLES WHICH ARE MASKED OR UNMASKED WITH RESPECT TO A CELL RECEPTOR 审中-公开
标题翻译：与细胞受体相关的病毒颗粒被隐藏或被忽略
公开(公告)号：WO1997044474A2
公开(公告)日：1997-11-27
申请号：PCT/FR1997000870
申请日：1997-05-16
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , COSSET, François-Loîc , VALSESIA, Sandrine , RUSSELL, Stephen, J.
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C12N15/86
CPC分类号： C07K14/005 , A61K47/6901 , A61K48/00 , C07K1/1075 , C07K14/485 , C07K2319/00 , C12N7/00 , C12N15/62 , C12N15/86 , C12N15/87 , C12N2740/13022 , C12N2740/13043 , C12N2740/13045 , C12N2740/13062 , C12N2810/60 , C12N2810/6018 , C12N2810/6054 , C12N2810/80 , C12N2810/851 , C12N2810/852 , C12N2810/854
摘要： The invention features the use of a peptide for transferring genes in a eukaryotic target cell, which peptide has about 10 to about 200, in particular about 15 to about 150 amino acids, and advantageously about 20 amino acids, in which 30 % at least of the amino acids are constituted by proline radicals, which proline radicals are regularly arranged so as to induce polypeptide chain turnings at about 180 DEG (" beta -turn" or "reverse-turn"), these turns being regularly spaced and gathering in a polyproline beta -turn helix, in a polypeptide construction containing, on the said peptide N-terminal side (upstream), an N-terminal (upstream) proteinic domain capable of recognising a targeted surface molecule or an antigen expressed on a cellular surface, in particular an appropriate receptor (targeted receptor) located on the said eukaryotic cell, and on the said peptide C-terminal side (downstream), a C-terminal (downstream) protein domain capable of recognising an appropriate receptor (auxiliary receptor) located on the said eukaryotic cell, which peptide is capable of facilitating or inhibiting interaction between the C-terminal (downstream) protein domain and the auxiliary receptor, the inhibition of this interaction taking place so long as the N-terminal (upstream) protein domain has not interacted with the targeted receptor, and the facilitating of the interaction between the C-terminal (downstream) protein domain and the auxiliary receptor taking place when the N-terminal (upstream) protein domain has interacted with the targeted receptor.
摘要翻译：本发明的特征在于使用肽在真核靶细胞中转移基因，该肽具有约10至约200，特别是约15至约150个氨基酸，并且有利地约20个氨基酸，其中至少30％氨基酸由脯氨酸基团构成，脯氨酸自由基被规则排列，以便在约180°（“β转”或“反转”）处诱导多肽链转角，这些转动规则地间隔开并聚集在聚脯氨酸特别是在所述肽N-末端侧（上游）上含有能够识别目标表面分子或表达于细胞表面的抗原的N末端（上游）蛋白质结构域的多肽构建体中，β转角螺旋位于所述真核细胞上的适当受体（靶向受体）和所述肽C-末端侧（下游），能够识别合适受体的C末端（下游）蛋白结构域（a 位于所述真核细胞上的所述肽，所述肽能够促进或抑制C-末端（下游）蛋白质结构域和辅助受体之间的相互作用，只要N末端（上游）蛋白质结构域没有与靶向受体相互作用，并且当N-末端（上游）蛋白质结构域与靶向受体相互作用时，C末端（下游）蛋白质结构域和辅助受体之间的相互作用的促进发生。

10. 发明申请

WO2005007962A1 NONWOVEN SPACER FABRIC 审中-公开
标题翻译：非织造布面料
公开(公告)号：WO2005007962A1
公开(公告)日：2005-01-27
申请号：PCT/GB2004/003001
申请日：2004-07-09
申请人： UNIVERSITY OF LEEDS , RUSSELL, Stephen, J. , POURMOHAMMADI, Ali , MAO, Ningtao , AHMED, Idris, A. , RATHOD, Manoj, K.
发明人： RUSSELL, Stephen, J. , POURMOHAMMADI, Ali , MAO, Ningtao , AHMED, Idris, A. , RATHOD, Manoj, K.
IPC分类号： D04H13/00
CPC分类号： A61F13/5323 , A61F13/15699 , A61F13/15707 , A61F13/539 , A61F2013/15829 , A61F2013/15983 , A61F2013/53975 , C11D17/049 , D04H1/425 , D04H1/4266 , D04H1/4326 , D04H1/46 , D04H1/732 , D04H3/037 , D04H5/03 , D04H13/00 , Y10T428/24562 , Y10T428/24744 , Y10T428/2481 , Y10T442/643 , Y10T442/654 , Y10T442/659 , Y10T442/666 , Y10T442/668 , Y10T442/689 , Y10T442/699
摘要： The invention provides a non-woven fabric comprising at least two separate but interconnected layers, each of the layers being provided with discrete interconnections so as to provide discrete voids between the two layers of fabric.
摘要翻译：本发明提供了一种包括至少两个单独但互连的层的无纺织物，每个层具有分立的互连，从而在两层织物之间提供离散的空隙。

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