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1. 发明申请

WO0005253A9 ANTAGONISTS SPECIFIC FOR THE CORTICOTROPIN-RELEASING FACTOR RECEPTOR TYPE 2 (CRFR2) 审中-公开
标题翻译： CORTICOTROPIN-REXTOR因子受体2型（CRFR2）特异性拮抗剂
公开(公告)号：WO0005253A9
公开(公告)日：2000-07-27
申请号：PCT/EP9905297
申请日：1999-07-23
申请人： MAX PLANCK GESELLSCHAFT , SPIESS JOACHIM , RUEHMANN ANDREAS
发明人： SPIESS JOACHIM , RUEHMANN ANDREAS
IPC分类号： A61K38/00 , A61K38/16 , A61K39/395 , C07K14/435 , C07K14/575 , C07K16/18 , C12N15/12 , C12N15/63 , G01N33/53 , G01N33/68
CPC分类号： C07K14/57509 , A61K38/00
摘要： The present invention relates to an antagonist of the ligand of the Corticotropin-Releasing Factor Receptor, type 2 (CRFR2) lacking the 8 to 10 N-terminal amino acids of native sauvagine. The present invention also relates to an antagonist of the ligand of the Corticotropin-Releasing Factor Receptor, type 2 (CRFR2) lacking the 11 N-terminal amino acids of native sauvagine, wherein the N-terminal amino acid of said antagonist is a charged amino acid. Furthermore, the present invention relates to a polynucleotide encoding the antagonist of the present invention, a vector comprising the polynucleotide of the present invention, and a host comprising the polynucleotide or the vector of the present invention. Also described are a method for producing the antagonist of the present invention, antibodies directed the antagonist of the present invention, as well as anti-idiotypic antibodies directed against the antibody of the present invention. The present invention also relates to pharmaceutical and diagnostic compositions comprising the antagonist, the polynucleotide, the vector, the antibody, and/or the anti-idiotypic antibody of the present invention. Furthermore, the present invention relates to a kit comprising one or more of the above mentioned compounds of the present invention and to the use of one or more of these compounds for the preparation of a pharmaceutical composition for preventing and/or treating a Corticotropin-Releasing Factor Receptor, type 2 (CRFR2)-associated disease.
摘要翻译：本发明涉及不含天然sauvagine的8至10个N-末端氨基酸的促性激素释放因子受体2型（CRFR2）的配体的拮抗剂。本发明还涉及缺乏天然sauvagine的11个N-末端氨基酸的促肾上腺皮质激素释放因子受体2型（CRFR2）的配体的拮抗剂，其中所述拮抗剂的N-末端氨基酸是带电氨基酸。此外，本发明涉及编码本发明拮抗剂的多核苷酸，包含本发明多核苷酸的载体和包含本发明的多核苷酸或载体的宿主。还描述了制备本发明拮抗剂的方法，针对本发明拮抗剂的抗体以及针对本发明抗体的抗独特型抗体。本发明还涉及包含本发明的拮抗剂，多核苷酸，载体，抗体和/或抗独特型抗体的药物和诊断组合物。此外，本发明涉及一种试剂盒，其包含一种或多种上述本发明化合物，以及这些化合物中的一种或多种用于制备用于预防和/或治疗促肾上腺皮质激素释放的药物组合物因子受体2型（CRFR2）相关疾病。

2. 发明申请

WO0005253A2 ANTAGONISTS SPECIFIC FOR THE CORTICOTROPIN-RELEASING FACTOR RECEPTOR TYPE 2 (CRFR2) 审中-公开
标题翻译： 2型促分裂素释放因子受体特异性拮抗剂（CRFR2）
公开(公告)号：WO0005253A2
公开(公告)日：2000-02-03
申请号：PCT/EP9905297
申请日：1999-07-23
申请人： MAX PLANCK GESELLSCHAFT , SPIESS JOACHIM , RUEHMANN ANDREAS
发明人： SPIESS JOACHIM , RUEHMANN ANDREAS
IPC分类号： A61K38/00 , A61K38/16 , A61K39/395 , C07K14/435 , C07K14/575 , C07K16/18 , C12N15/12 , C12N15/63 , G01N33/53 , G01N33/68
CPC分类号： C07K14/57509 , A61K38/00
摘要： The present invention relates to an antagonist of the ligand of the Corticotropin-Releasing Factor Receptor, type 2 (CRFR2) lacking the 8 to 10 N-terminal amino acids of native sauvagine. The present invention also relates to an antagonist of the ligand of the Corticotropin-Releasing Factor Receptor, type 2 (CRFR2) lacking the 11 N-terminal amino acids of native sauvagine, wherein the N-terminal amino acid of said antagonist is a charged amino acid. Furthermore, the present invention relates to a polynucleotide encoding the antagonist of the present invention, a vector comprising the polynucleotide of the present invention, and a host comprising the polynucleotide or the vector of the present invention. Also described are a method for producing the antagonist of the present invention, antibodies directed the antagonist of the present invention, as well as anti-idiotypic antibodies directed against the antibody of the present invention. The present invention also relates to pharmaceutical and diagnostic compositions comprising the antagonist, the polynucleotide, the vector, the antibody, and/or the anti-idiotypic antibody of the present invention. Furthermore, the present invention relates to a kit comprising one or more of the above mentioned compounds of the present invention and to the use of one or more of these compounds for the preparation of a pharmaceutical composition for preventing and/or treating a Corticotropin-Releasing Factor Receptor, type 2 (CRFR2)-associated disease.
摘要翻译：本发明涉及缺乏天然苏维A的8至10个N端氨基酸的2型促肾上腺皮质激素释放因子受体（CRFR2）配体的拮抗剂。本发明还涉及缺乏天然苏维A的11个N-末端氨基酸的2型促肾上腺皮质激素释放因子受体（CRFR2）的配体的拮抗剂，其中所述拮抗剂的N-末端氨基酸是带电荷的氨基酸酸。此外，本发明涉及编码本发明拮抗剂的多核苷酸，包含本发明多核苷酸的载体和包含本发明多核苷酸或载体的宿主。还描述了生产本发明拮抗剂的方法，针对本发明拮抗剂的抗体以及针对本发明抗体的抗独特型抗体。本发明还涉及包含本发明的拮抗剂，多核苷酸，载体，抗体和/或抗独特型抗体的药物和诊断组合物。此外，本发明涉及包含一种或多种上述本发明化合物的试剂盒以及这些化合物中的一种或多种在制备用于预防和/或治疗促肾上腺皮质激素释放的药物组合物中的用途因子受体，2型（CRFR2）相关疾病。

3. 发明申请

WO9718238A2 CRF ANALOGS 审中-公开
标题翻译： CRF模拟
公开(公告)号：WO9718238A2
公开(公告)日：1997-05-22
申请号：PCT/EP9605010
申请日：1996-11-14
申请人： MAX PLANCK GESELLSCHAFT , SPIESS JOACHIM , RUEHMANN ANDREAS
发明人： SPIESS JOACHIM , RUEHMANN ANDREAS
IPC分类号： A61K38/00 , C07K14/575 , A61K38/22 , G01N33/74
CPC分类号： C07K14/57509 , A61K38/00
摘要： The present invention relates to lipophilic CRF analogs which are useful as active ingredients in pharmaceutical or diagnostic compositions.
摘要翻译：本发明涉及用作药物或诊断组合物中的活性成分的亲脂性CRF类似物。

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