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1. 发明申请

WO2013055517A1 FILTER SYSTEMS FOR SEPARATING MICROCARRIERS FROM CELL CULTURE SOLUTIONS 审中-公开
标题翻译：用于从细胞培养物解决方案中分离微生物的过滤系统
公开(公告)号：WO2013055517A1
公开(公告)日：2013-04-18
申请号：PCT/US2012/056917
申请日：2012-09-24
申请人： HYCLONE LABORATORIES, INC. , LARSEN, Jeremy, K. , COLEMAN, Jon, Q. , ROWLEY, David, S.
发明人： LARSEN, Jeremy, K. , COLEMAN, Jon, Q. , ROWLEY, David, S.
IPC分类号： C12M47/02 , C12M23/26
CPC分类号： C12M29/04 , B01D29/13 , B01D29/27 , B01D35/027 , C12M23/14 , C12M23/26 , C12M25/16 , C12M33/14 , C12M47/02
摘要： A filter assembly for separating microcarriers from a fluid medium includes a collapsible container bounding a sterile compartment adapted to hold a fluid. An inlet port is attached to the container through which fluid flows into the compartment. An outlet port is attached to the container through which fluid flows out of the compartment. A filter is disposed within the compartment, the filter dividing the compartment into an inlet chamber that is fluidly coupled with the inlet port and an outlet chamber that is fluidly coupled with the outlet port, the filter allowing a medium to pass therethrough but preventing microcarriers disposed in the medium from passing therethrough.
摘要翻译：用于将微载体与流体介质分离的过滤器组件包括界定适于保持流体的无菌隔室的可折叠容器。入口连接到容器，流体通过该入口进入隔室。出口端口连接到容器，流体通过该出口流出隔室。过滤器设置在隔室内，过滤器将隔室分隔成与入口端口流体连接的入口室和与出口端口流体连接的出口室，过滤器允许介质通过，但防止布置的微载体在介质中通过。

2. 发明申请

WO2009050446A1 VIRAL THERAPEUTIC 审中-公开
标题翻译：病毒治疗
公开(公告)号：WO2009050446A1
公开(公告)日：2009-04-23
申请号：PCT/GB2008/003479
申请日：2008-10-15
申请人： KING'S COLLEGE LONDON , BAYLOR COLLEGE OF MEDICINE , VYAKARNAM, Annapurna , ROWLEY, David, R.
发明人： VYAKARNAM, Annapurna , ROWLEY, David, R.
IPC分类号： C07K16/38 , A61K39/395 , A61K31/7088 , C07K14/81 , A61P31/16 , A61P31/18 , C07K14/705
CPC分类号： C07K16/38 , A61K31/7088 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K2317/76 , G01N33/56988
摘要： The invention provides a method of inhibiting viral infection of a mammalian cell, said method comprising reducing or inhibiting ps20 polypeptide expressed by said cell. Suitably ps20 is inhibited by contacting said cell with an antibody capable of binding to ps20 polypeptide. Suitably said antibody is ps20 neutralising antibody. The invention also provides antibody capable of binding ps20 polypeptide, siRNA targeted to a transcript encoding ps20 polypeptide, or antisense ps20 polynucleotide for use as a medicament for viral infection. The invention also provides a method of identifying an agent for inhibiting a viral infection, comprising determining level of ps20 expression in first and second samples, the first contacted with test agent; and comparing the level of ps20 expression in said first and second samples; wherein lower level of ps20 expression in said first sample relative to said second sample identifies test agent as an agent for inhibiting a viral infection.
摘要翻译：本发明提供了抑制哺乳动物细胞病毒感染的方法，所述方法包括减少或抑制由所述细胞表达的ps20多肽。通过使所述细胞与能够结合ps20多肽的抗体接触来适当地抑制ps20。适当地说抗体是ps20中和抗体。本发明还提供能够结合ps20多肽的抗体，靶向编码ps20多肽的转录物的siRNA或反义ps20多核苷酸用作病毒感染的药物。本发明还提供鉴定用于抑制病毒感染的试剂的方法，包括测定第一和第二样品中ps20表达的水平，首先与测试试剂接触; 以及比较所述第一和第二样品中ps20表达水平; 其中所述第一样品中相对于所述第二样品的较低水平的ps20表达鉴定了作为抑制病毒感染的试剂的试验剂。

3. 发明申请

WO2003047440A2 FIXING DEVICE AND APPLICATOR THEREFOR 审中-公开
标题翻译：固定装置和适用于此的装置
公开(公告)号：WO2003047440A2
公开(公告)日：2003-06-12
申请号：PCT/GB2002/005477
申请日：2002-12-04
申请人： THE UNIVERSITY OF DUNDEE , DREW, Tim , ALLCOCK, Paul , ROWLEY, David
发明人： DREW, Tim , ALLCOCK, Paul , ROWLEY, David
IPC分类号： A61B17/68
CPC分类号： A61B17/686 , A61B17/88 , F16B13/001 , F16B13/061 , F16B13/124
摘要： A fixing device is disclosed which is primarily for use in orthopaedics. In one disclosed embodiment the fixing device includes an elongate body having a throughbore, wherein the elongate body has a number of spiral slots in the surface thereof. In use, the fixing device is inserted into an aperture in a bone and a screw is tightened within the throughbore of the elongate body, causing the body to expand and the slots to be closed in order to secure the fixing device in place within the aperture in the bone. An applicator device is also disclosed which in use holds the fixing device in place when a screw is tightened therein.
摘要翻译：公开了一种主要用于矫形外科的固定装置。在一个公开的实施例中，固定装置包括具有通孔的细长主体，其中细长主体在其表面中具有多个螺旋槽。在使用中，将固定装置插入到骨中的孔中，并且将螺钉拧紧在细长体的通孔内，使得主体扩张并且将狭缝关闭以便将固定装置固定在孔内在骨头里。还公开了一种涂抹器装置，其在使用时将固定装置在其中拧紧时保持在适当位置。

4. 发明申请

WO1995035311A1 3-AMINO-2-OXO-1-PIPERIDINEACETIC DERIVATIVES AS ENZYME INHIBITORS 审中-公开
标题翻译： 3-氨基-2-氧代-1-哌嗪基衍生物作为酶抑制剂
公开(公告)号：WO1995035311A1
公开(公告)日：1995-12-28
申请号：PCT/US1995007661
申请日：1995-06-19
申请人： CORVAS INTERNATIONAL, INC. , SEMPLE, Joseph, Edward , ARDECKY, Robert, J. , NUTT, Ruth, F. , RIPKA, William, Charles , ROWLEY, David, C. , LIM-WILBY, Marguerita, S., L. , BRUNCK, Terrence, K.
发明人： CORVAS INTERNATIONAL, INC.
IPC分类号： C07K05/06
CPC分类号： C07K5/06139 , A61K38/05 , C07K5/06191
摘要： The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
摘要翻译：本发明公开了肽醛，其是凝血酶的有效和特异性抑制剂，其药学上可接受的盐，药学上可接受的组合物，以及将其用作以异常血栓形成为特征的哺乳动物的疾病状态的治疗剂。

5. 发明申请

WO2007127391A3 FACILITATING E-COMMERCE INVOLVING DIGITAL ASSETS 审中-公开
公开(公告)号：WO2007127391A3
公开(公告)日：2007-11-08
申请号：PCT/US2007/010281
申请日：2007-04-27
申请人： SNOCAP, INC. , AYDAR, Ali , ROWLEY, David , MENDELSON, Jordan , FLETCHER, Richard , RACINELLI, Daniel , TOFFALETTI, Jason
发明人： AYDAR, Ali , ROWLEY, David , MENDELSON, Jordan , FLETCHER, Richard , RACINELLI, Daniel , TOFFALETTI, Jason
IPC分类号： G06Q30/00
摘要： A transactional computer-implemented system, method and computer program product are provided. In use, information is received from a plurality of entities which each has an interest in at least one corresponding digital asset (302). Utilizing the information, a plurality of interfaces, each associated with at least one of the entities, are populated, for facilitating transactions involving the at least one corresponding digital asset (304).

6. 发明申请

WO2006013389A1 BIOPSY APPARATUS AND METHOD 审中-公开
标题翻译：生物仪器和方法
公开(公告)号：WO2006013389A1
公开(公告)日：2006-02-09
申请号：PCT/GB2005/003100
申请日：2005-08-05
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE , ROWLEY, David , DREW, Tim
发明人： ROWLEY, David , DREW, Tim
IPC分类号： A61B10/00
CPC分类号： A61B10/025 , A61B2010/0208 , A61B2090/0801
摘要： A biopsy apparatus (10) has a needle (18) and a driver assembly (20), which exerts a drive force on the needle (18) to drive it into tissue to take a tissue sample. In one embodiment the apparatus (10) has a driver (34) mounted for movement within a bore (36), which is driven by the force of a compressed spring (48) to impact the needle (18) and drive it forwards into the tissue to be sampled. A method for taking a tissue sample by driving a needle into tissue is also described.
摘要翻译：活检装置（10）具有针（18）和驱动器组件（20），其在针（18）上施加驱动力以将其驱动到组织中以取出组织样本。在一个实施例中，装置（10）具有安装用于在孔（36）内运动的驱动器（34），该孔由压缩弹簧（48）的力驱动以冲击针（18）并将其向前驱动要采样的组织。还描述了通过将针驱动到组织中来取出组织样本的方法。

7. 发明申请

WO2005084558A1 APPARATUS FOR USE IN ORTHOPAEDIC SURGERY 审中-公开
标题翻译：用于手术治疗的装置
公开(公告)号：WO2005084558A1
公开(公告)日：2005-09-15
申请号：PCT/GB2005/000901
申请日：2005-03-09
申请人： IMP (HOLDINGS) LIMITED , DAVIS, Kenneth, P. , MOLLON, David, L. , DREW, Timothy, S. , PATERSON, David, W. , ROWLEY, David, I. , SMITH, Roy
发明人： DAVIS, Kenneth, P. , MOLLON, David, L. , DREW, Timothy, S. , PATERSON, David, W. , ROWLEY, David, I. , SMITH, Roy
IPC分类号： A61B17/15
CPC分类号： A61B17/155 , A61B2017/0023
摘要： A kit of parts for use in resectioning an end of a bone during orthopaedic surgery, comprising a cutting jig (12) and a alignment tool (10, 11), the cutting jig comprising a generally parallel pipedal member having a top face (20a) a bottom face and four side faces(20b, 20c), the bottom face being recessed in order to receive the end of the bone to be resectioned, means defining a plurality of slots (24, 25, 27, 29, 30) through the member (12) for receiving a cutting implement, a generally medial opening (33) extending from the . bottom face for receiving the alignment tool (10, 11) and having a shaped cross section whereby to mate with the alignment tool (10, 11) in a predetermined orientation, and a plurality of firing elements (31) in at least two side walls (20b) arranged to enable fixing the cutting jig (12) to the bone. The alignment tool comprises an elongate metal rod (10) and a separate alignment member (11) arranged to have a bore for receiving the rod and a flange (11a) provided on the main member and extending in opposite directions therefrom to facilitate fixing of the alignment member to the end of the bone to be resectioned. Preferably, the cutting jig is of plastics material in which case the slots are lined with metal.
摘要翻译：一种用于在矫形手术期间切除骨头末端的部件套件，包括切割夹具（12）和对准工具（10,11），所述切割夹具包括具有顶面（20a）的大致平行的管状部件，底面和四个侧面（20b，20c），所述底面凹入以接收要切除的骨的端部，所述装置限定通过所述切口的多个狭槽（24,25,27,29,30）用于接收切割工具的构件（12），从所述切割工具延伸的大致内侧的开口（33）。底面，用于接收对准工具（10,11）并且具有成形横截面，从而与预定取向的对准工具（10,11）配合;以及在至少两个侧壁中的多个击发元件（31）（20b），其布置成能够将切割夹具（12）固定到骨骼上。对准工具包括细长的金属杆（10）和设置成具有用于容纳杆的孔的单独对准构件（11）和设置在主构件上并沿其相反方向延伸的凸缘（11a），以便于固定对准构件到要切除的骨的末端。优选地，切割夹具是塑料材料，在这种情况下，槽被金属衬里。

8. 发明申请

WO1997028839A1 STEERABLE CATHETER HAVING DISPOSABLE MODULE AND STERILIZABLE HANDLE AND METHOD OF CONNECTING SAME 审中-公开
标题翻译：具有可切换模块和无菌手柄的可转向导管及其连接方法
公开(公告)号：WO1997028839A1
公开(公告)日：1997-08-14
申请号：PCT/US1997001667
申请日：1997-02-06
申请人： CATHETER IMAGING SYSTEMS, INC. , SNOKE, P., Jack , MARC, Michael, J. , ROWLEY, David, Scott
发明人： CATHETER IMAGING SYSTEMS, INC.
IPC分类号： A61M25/01
CPC分类号： A61M25/0147 , A61B1/00105 , A61B1/0052 , A61M25/0136 , A61M2025/015
摘要： A catheter and methods are provided for inserting at least portions thereof into a vessel, cavity, or tissue of a human body to thereby provide manipulation of a distal portion of the catheter when positioned within a vessel, cavity, or tissue. The catheter preferably has a module which includes an elongate tube having at least one lumen extending from a distal end to a proximal end of the tube, a module interface connected to the proximal end of the tube, and a deflector connected to the tube for deflecting the distal portion of the elongate tube. A handle detachably connects to the module and is configured to be readily held in the hand of a user. The handle has a body which includes a wall positioned in and extending transversely across distal portions of the body. The wall has an outer surface thereof defining an exterior portion of the body and a first cavity formed within the body. Preferably, the body detachably and coextensively connects to the module interface through the outer surface of the wall. A controller is connected to the body and detachably connects to the deflector of the module for responsively controlling the deflector to thereby manipulate distal portions of the elongate tube. The controller and the deflector connect to define a unitary catheter manipulator extending from the first cavity, through the wall, and to the tube for manipulating a distal portion of the catheter when positioned within a vessel, cavity, or tissue.
摘要翻译：提供导管和方法用于将其至少部分插入人体的容器，空腔或组织中，从而当定位在容器，空腔或组织内时提供导管的远端部分的操纵。导管优选地具有模块，该模块包括细长管，其具有从管的远端延伸到近端的至少一个内腔，连接到管的近端的模块接口以及连接到管的用于偏转的导流器细长管的远端部分。手柄可拆卸地连接到模块并且被构造成容易地保持在使用者的手中。手柄具有主体，该主体包括位于主体的远侧部分并横向延伸穿过主体的远侧部分的壁。该壁具有限定主体的外部部分的外表面和形成在主体内的第一腔体。优选地，主体通过壁的外表面可拆卸地并共同地连接到模块接口。控制器连接到主体并且可拆卸地连接到模块的偏转器，用于响应地控制偏转器，从而操纵细长管的远端部分。控制器和偏转器连接以限定从第一腔延伸穿过壁，并且当定位在容器，空腔或组织内时用于操纵导管的远端部分的导管操纵器。

9. 发明申请

WO1997020930A1 UROGENITAL SINUS DERIVED GROWTH FACTOR NUCLEOTIDE AND AMINO ACID SEQUENCES 审中-公开
标题翻译：致癌基因衍生生长因子核苷酸和氨基酸序列
公开(公告)号：WO1997020930A1
公开(公告)日：1997-06-12
申请号：PCT/US1996019365
申请日：1996-12-06
申请人： BAYLOR COLLEGE OF MEDICINE , ROWLEY, David, R.
发明人： BAYLOR COLLEGE OF MEDICINE
IPC分类号： C12N15/12
CPC分类号： C07K14/81 , A61K38/00 , C07K14/4703 , C07K14/811 , Y10S530/834
摘要： The present invention relates to a urogenital sinus derived growth inhibitory factor, ps20. The amino acid and nucleotide sequences for ps20 are provided. Also provided in the present invention are antibodies which bind to ps20. Additionally, ps20 is shown to be a member of the WAP-type for disulfide core domain family and to possess protease inhibitory function.
摘要翻译：本发明涉及泌尿生殖窦衍生的生长抑制因子ps20。提供ps20的氨基酸和核苷酸序列。本发明还提供了结合ps20的抗体。此外，ps20显示为二硫键核心家族的WAP型成员，并具有蛋白酶抑制功能。

10. 发明申请

WO1994025950A1 ILLUMINATING DISPLAY DEVICE 审中-公开
标题翻译：照明显示设备
公开(公告)号：WO1994025950A1
公开(公告)日：1994-11-10
申请号：PCT/GB1994000927
申请日：1994-04-29
申请人： LOUGHBOROUGH UNIVERSITY OF TECHNOLOGY , ROWLEY, David, Michael
发明人： LOUGHBOROUGH UNIVERSITY OF TECHNOLOGY
IPC分类号： G09F13/04
CPC分类号： G09F13/04 , B60Q3/18
摘要： There is disclosed an illuminating display device (11) comprising a legend-bearing face layer (13) which is part of a deep transparent member (14) in a lamp housing, the deep transparent member (14) being of uniform or substantially uniform refractive index throughout ist depth whereby to avoid internal reflections.
摘要翻译：公开了一种照明显示装置（11），其包括作为灯壳体中的深透明构件（14）的一部分的图例支承面层（13），所述深透明构件（14）具有均匀或基本均匀的折射指数在整个深度上，以避免内部反射。

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