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1. 发明申请

WO2009050444A1 DIAGNOSTIC METHODS FOR HIV INFECTION 审中-公开
标题翻译： HIV感染的诊断方法
公开(公告)号：WO2009050444A1
公开(公告)日：2009-04-23
申请号：PCT/GB2008/003477
申请日：2008-10-15
申请人： KING'S COLLEGE LONDON , BAYLOR COLLEGE OF MEDICINE , VYAKARNAM, Annapurna , ROWLEY, David, R.
发明人： VYAKARNAM, Annapurna , ROWLEY, David, R.
IPC分类号： G01N33/68 , G01N33/569
CPC分类号： C07K16/38 , A61K31/7088 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K2317/76 , G01N33/56988
摘要： The invention relates to a method of aiding the diagnosis of a human immunodeficiency virus infection in a subject, said method comprising (i) providing a sample from the subject (ii) determining the level of ps20 in said sample (iii) comparing the level of ps20 of (ii) with the level of ps20 in an uninfected reference sample, wherein a higher level of ps20 in the sample from the subject compared to the uninfected reference sample indicates an increased likelihood of human immunodeficiency virus infection in said subject. The invention also relates to methods for assessing susceptibility of a subject to human immunodeficiency virus infection. Most suitably the ps20 level is determined via binding by an anti-ps20 antibody such as the IG7 antibody. The invention also relates to kits for use in said methods.
摘要翻译：本发明涉及帮助受试者中人类免疫缺陷病毒感染的诊断的方法，所述方法包括（i）提供来自受试者的样品（ii）确定所述样品中的ps20的水平（iii）（ii）中的ps20与未感染参考样品中ps20的水平相比，其中与未感染的参考样品相比，来自受试者的样品中较高水平的ps20表明在所述受试者中人类免疫缺陷病毒感染的可能性增加。本发明还涉及用于评估受试者对人类免疫缺陷病毒感染的易感性的方法。最合适的是通过抗-PS20抗体如IG7抗体的结合来确定ps20水平。本发明还涉及用于所述方法的试剂盒。

2. 发明申请

WO2009050446A1 VIRAL THERAPEUTIC 审中-公开
标题翻译：病毒治疗
公开(公告)号：WO2009050446A1
公开(公告)日：2009-04-23
申请号：PCT/GB2008/003479
申请日：2008-10-15
申请人： KING'S COLLEGE LONDON , BAYLOR COLLEGE OF MEDICINE , VYAKARNAM, Annapurna , ROWLEY, David, R.
发明人： VYAKARNAM, Annapurna , ROWLEY, David, R.
IPC分类号： C07K16/38 , A61K39/395 , A61K31/7088 , C07K14/81 , A61P31/16 , A61P31/18 , C07K14/705
CPC分类号： C07K16/38 , A61K31/7088 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K2317/76 , G01N33/56988
摘要： The invention provides a method of inhibiting viral infection of a mammalian cell, said method comprising reducing or inhibiting ps20 polypeptide expressed by said cell. Suitably ps20 is inhibited by contacting said cell with an antibody capable of binding to ps20 polypeptide. Suitably said antibody is ps20 neutralising antibody. The invention also provides antibody capable of binding ps20 polypeptide, siRNA targeted to a transcript encoding ps20 polypeptide, or antisense ps20 polynucleotide for use as a medicament for viral infection. The invention also provides a method of identifying an agent for inhibiting a viral infection, comprising determining level of ps20 expression in first and second samples, the first contacted with test agent; and comparing the level of ps20 expression in said first and second samples; wherein lower level of ps20 expression in said first sample relative to said second sample identifies test agent as an agent for inhibiting a viral infection.
摘要翻译：本发明提供了抑制哺乳动物细胞病毒感染的方法，所述方法包括减少或抑制由所述细胞表达的ps20多肽。通过使所述细胞与能够结合ps20多肽的抗体接触来适当地抑制ps20。适当地说抗体是ps20中和抗体。本发明还提供能够结合ps20多肽的抗体，靶向编码ps20多肽的转录物的siRNA或反义ps20多核苷酸用作病毒感染的药物。本发明还提供鉴定用于抑制病毒感染的试剂的方法，包括测定第一和第二样品中ps20表达的水平，首先与测试试剂接触; 以及比较所述第一和第二样品中ps20表达水平; 其中所述第一样品中相对于所述第二样品的较低水平的ps20表达鉴定了作为抑制病毒感染的试剂的试验剂。

3. 发明申请

WO2009049406A1 USE OF PS20 /WFDC1 AND INTERFERONS TO DIAGNOSE, MONITOR AND TREAT VIRAL DISEASES 审中-公开
标题翻译：使用PS20 / WFDC1和干扰物进行诊断，监测和治疗病毒性疾病
公开(公告)号：WO2009049406A1
公开(公告)日：2009-04-23
申请号：PCT/CA2008/001800
申请日：2008-10-15
申请人： UNIVERSITY HEALTH NETWORK , KING'S COLLEGE LONDON , FISH, Eleanor, N. , BAIG, Ehtesham , VYAKARNAM, Annapurna
发明人： FISH, Eleanor, N. , BAIG, Ehtesham , VYAKARNAM, Annapurna
IPC分类号： A61K38/21 , A61K31/7088 , A61K31/7105 , A61K39/395 , A61K48/00 , A61P31/14 , A61P31/16 , C12Q1/68 , G01N33/53 , G01N33/569 , G01N33/68
CPC分类号： G01N33/56983 , A61K31/7088 , A61K31/7105 , A61K38/21 , C12N15/1131 , C12N2310/11 , C12N2310/14 , G01N33/6866 , A61K2300/00
摘要： Methods for detecting, diagnosing or monitoring viral diseases in a subject are described comprising measuring ps20 polypeptides or ps20 polynucleotides and interferons and interferon polynucleotides in a sample from the subject. The invention also contemplates therapeutic applications for viral diseases employing modulators of ps20 polypeptides and ps20 polynucleotides in combination with interferon or interferon polynucleotides.
摘要翻译：描述了用于检测，诊断或监测受试者中的病毒性疾病的方法，包括在来自受试者的样品中测量ps20多肽或ps20多核苷酸和干扰素和干扰素多核苷酸。本发明还考虑了使用ps20多肽和ps20多核苷酸与干扰素或干扰素多核苷酸组合的调节剂的病毒性疾病的治疗应用。

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