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1. 发明申请

WO2008148751A1 TARGETED INDUCTION OF AGGREGATION OF PROTEINS WITH CROSS BETA STRUCTURES 审中-公开
标题翻译：有针对性地诱导蛋白质与交叉结构的结合
公开(公告)号：WO2008148751A1
公开(公告)日：2008-12-11
申请号：PCT/EP2008/056825
申请日：2008-06-03
申请人： VIB VZW , VRIJE UNIVERSITEIT BRUSSEL , SCHYMKOWITZ, Joost , ROUSSEAU, Frederic
发明人： SCHYMKOWITZ, Joost , ROUSSEAU, Frederic
IPC分类号： C07K1/32 , C12N15/62 , A61K38/00
CPC分类号： C07K1/32 , A61K38/00 , C07K14/36 , C07K2319/00 , C12N9/0004 , C12N15/62
摘要： The present invention belongs to the field of protein aggregation. The invention discloses a method for interfering with the function of a target protein and uses a non-naturally, user-designed molecule, designated as aggregator, that has a specificity for a target protein and which induces aggregation upon contact with said target protein. The present invention also discloses such aggregator molecules and their use in therapeutic and diagnostic applications.
摘要翻译：本发明属于蛋白质聚集领域。本发明公开了一种用于干扰靶蛋白功能的方法，并使用非靶向蛋白质特异性的非天然用户设计的分子，称为聚集体，其与靶蛋白接触时诱导聚集。本发明还公开了这样的聚集剂分子及其在治疗和诊断应用中的用途。

2. 发明申请

WO2008028939A1 MEANS AND METHODS FOR THE PRODUCTION OF AMYLOID OLIGOMERS 审中-公开
标题翻译：用于生产AMYLOID低聚物的方法和方法
公开(公告)号：WO2008028939A1
公开(公告)日：2008-03-13
申请号：PCT/EP2007/059327
申请日：2007-09-06
申请人： VIB VZW , VRIJE UNIVERSITEIT BRUSSEL , KATHOLIEKE UNIVERSITEIT LEUVEN - K.U.LEUVEN R & D , ROUSSEAU, Frederic , SCHYMKOWITZ, Joost , DA ROCHA MARTINS, Ivo , DE STROOPER, Bart
发明人： ROUSSEAU, Frederic , SCHYMKOWITZ, Joost , DA ROCHA MARTINS, Ivo , DE STROOPER, Bart
IPC分类号： C07K14/47 , G01N33/68
CPC分类号： C07K14/4711 , G01N33/6896 , G01N2333/4709 , G01N2500/02 , G01N2500/10
摘要： The present invention relates to the field of amyloid disorders, more particularly to the field of diseases where protein misfolding leads to the generation of insoluble amyloid fibers in tissues and organs. The invention provides methods for the production of soluble, toxic amyloid oligomers. The invention further provides assays using said amyloid oligomers to screen for molecules that interfere with the toxicity of said oligomers.
摘要翻译：本发明涉及淀粉样蛋白病症的领域，更具体地涉及蛋白质错折叠导致在组织和器官中产生不溶性淀粉样蛋白纤维的疾病领域。本发明提供了生产可溶性有毒淀粉样低聚物的方法。本发明进一步提供了使用所述淀粉样寡聚物筛选干扰所述低聚物的毒性的分子的测定法。

3. 发明申请

WO2012130785A1 METHODS FOR SCREENING INHIBITORS OF TUMOUR ASSOCIATED PROTEIN AGGREGATION 审中-公开
标题翻译：筛选肿瘤相关蛋白聚集抑制剂的方法
公开(公告)号：WO2012130785A1
公开(公告)日：2012-10-04
申请号：PCT/EP2012/055291
申请日：2012-03-26
申请人： VIB VZW , VRIJE UNIVERSITEIT BRUSSEL , KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D , SCHYMKOWITZ, Joost , ROUSSEAU, Frederic , XU, Jie , DE SMET, Frederik
发明人： SCHYMKOWITZ, Joost , ROUSSEAU, Frederic , XU, Jie , DE SMET, Frederik
IPC分类号： G01N33/50
CPC分类号： G01N33/5008 , C12Q1/68 , G01N33/5011 , G01N2333/4748 , G01N2500/10
摘要： The present invention relates to the fields of protein aggregation diseases including cancer. More specifically, it concerns a screening method for identifying compounds that inhibit or disrupt co-aggregation of one or more member proteins of a disease-related protein aggregome, in particular a tumor-associated protein aggregome. Further, the invention encompasses agents and compounds identified by the screening method which can be applied to prevent or to treat protein aggregation diseases, such as cancer.
摘要翻译：本发明涉及包括癌症在内的蛋白质聚集疾病的领域。更具体地，涉及用于鉴定抑制或破坏疾病相关蛋白聚集体，特别是肿瘤相关蛋白聚集体的一种或多种成员蛋白的共聚集的化合物的筛选方法。此外，本发明包括通过筛选方法鉴定的药剂和化合物，其可以用于预防或治疗诸如癌症的蛋白质聚集疾病。

4. 发明申请

WO2012123419A1 MOLECULES AND METHODS FOR INHIBITION AND DETECTION OF PROTEINS 审中-公开
标题翻译：蛋白质的抑制和检测的分子和方法
公开(公告)号：WO2012123419A1
公开(公告)日：2012-09-20
申请号：PCT/EP2012/054285
申请日：2012-03-12
申请人： VIB VZW , VRIJE UNIVERSITEIT BRUSSEL , KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D , UNIVERSITEIT GENT , SCHYMKOWITZ, Joost , ROUSSEAU, Frederic
发明人： SCHYMKOWITZ, Joost , ROUSSEAU, Frederic
IPC分类号： A61L27/00 , C07K14/00 , A61L31/08 , A61L31/16 , C07K14/40
CPC分类号： C07K14/40 , A61L27/00 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/25 , A61L2300/404 , C07K2319/21 , C07K2319/42 , C07K2319/43
摘要： The present application belongs to the field of functional peptides and more particularly to the field of controlled protein aggregation. The invention discloses molecules of a peptide structure as defined in the claims and methods of using such molecules for therapeutic applications and for diagnostic uses, as well as in other applications such as in the agbio field and in industrial biotechnology. The molecules can be used for curing and/or stabilizing infections such as bacterial,fungal and viral diseases, but are also useful in non-infectious human and veterinary diseases. The molecules can also be used for the detection of protein biomarkers and for the prognosis and diagnosis of a variety of diseases.
摘要翻译：本申请属于功能性肽领域，更具体地涉及受控蛋白质聚集领域。本发明公开了如权利要求中所定义的肽结构的分子以及使用这些分子用于治疗应用和诊断用途的方法，以及在其它应用中，例如在agbio领域和工业生物技术中。这些分子可用于固化和/或稳定感染例如细菌，真菌和病毒性疾病，但也可用于非传染性的人和兽医疾病。这些分子也可用于检测蛋白质生物标志物以及各种疾病的预后和诊断。

5. 发明申请

WO2009115552A3 MANAGEMENT OF THE IDENTITIES OF USERS IN A SYSTEM 审中-公开
标题翻译：管理系统中用户的身份
公开(公告)号：WO2009115552A3
公开(公告)日：2009-11-26
申请号：PCT/EP2009053200
申请日：2009-03-18
申请人： EADS SECURE NETWORKS , ROUSSEAU FREDERIC , ELOY STEPHANE
发明人： ROUSSEAU FREDERIC , ELOY STEPHANE
IPC分类号： H04L29/06 , H04L9/32 , H04N1/44 , H04W12/02
CPC分类号： H04L63/08 , H04L63/0407 , H04L63/0492 , H04L63/102 , H04W12/06 , H04W12/08 , H04W88/02
摘要： The invention comprises managing the identity of a user to be associated with a terminal (11) adapted for communication in a communication network that provides a service based on the identity of the user. A contactless transaction is established at the terminal with an identification entity (12). During the transaction, a piece of information on the identity of the user stored in the identification entity is received. Finally, the identity of the user obtained from said information is stored. It is also provided that the identity of the user is erased at the terminal when the terminal is subjected to a specific action.
摘要翻译：本发明包括管理与适于在通信网络中进行通信的终端（11）相关联的用户的身份，该通信网络基于用户的身份提供服务。在具有识别实体（12）的终端处建立非接触交易。在交易期间，接收关于存储在识别实体中的用户的身份的一条信息。最后，存储从所述信息获得的用户的身份。还提供了当终端受到特定动作时，在终端处擦除用户的身份。

6. 发明申请

WO2007071789A1 MEANS AND METHODS FOR MEDIATING PROTEIN INTERFERENCE 审中-公开
标题翻译：介导蛋白质干扰的方法和方法
公开(公告)号：WO2007071789A1
公开(公告)日：2007-06-28
申请号：PCT/EP2006/070184
申请日：2006-12-22
申请人： VIB VZW , SCHYMKOWITZ, Joost , ROUSSEAU, Frederic
发明人： SCHYMKOWITZ, Joost , ROUSSEAU, Frederic
IPC分类号： A61K38/16
CPC分类号： A61K38/1866 , A61K38/16 , A61K47/48246 , A61K47/64 , C07K2319/735 , C12N15/8216 , C12N15/8257
摘要： The present invention belongs to the field of functional proteomics and more particularly to the field of protein aggregation. The invention discloses a method for interfering with the function of a target protein and uses a non-naturally, user-designed molecule, designated as interferor, that has a specificity for a target protein and which induces aggregation upon contact with said target protein. The present invention also discloses such interferor molecules and their use in therapeutic applications.
摘要翻译：本发明属于功能蛋白质组学领域，更具体地涉及蛋白质聚集领域。本发明公开了一种用于干扰靶蛋白功能的方法，并使用非靶向蛋白质特异性的非天然用户设计的分子（称为干扰素），并与靶蛋白接触时诱导聚集。本发明还公开了这样的干扰素分子及其在治疗应用中的用途。

7. 发明申请

WO2009136061A3 COLUMN WITH HEAT AND/OR MATERIAL EXCHANGE PACKING 审中-公开
标题翻译：具有热和/或材料交换包装的柱
公开(公告)号：WO2009136061A3
公开(公告)日：2010-04-08
申请号：PCT/FR2009050596
申请日：2009-04-07
申请人： AIR LIQUIDE , LECLERCQ FRANCOIS , ROUSSEAU FREDERIC
发明人： LECLERCQ FRANCOIS , ROUSSEAU FREDERIC
IPC分类号： B01J19/32 , F25J3/04
CPC分类号： B01J19/32 , B01J2219/3221 , B01J2219/32213 , B01J2219/32234 , B01J2219/32272 , B01J2219/32408 , F25J3/04412 , F25J3/04909 , F25J3/04921
摘要： A column with a packing for the exchange of heat and/or of material between a descending liquid and an ascending gas, of the type which comprises at least one exchange section (5, 9, 10, 11) either between two distributors or comprising at least two and at most twenty superposed portions, this exchange section comprising a lower portion (9A, 10A, 11A) and, above the latter, another portion (5B, 9B, 10B, 11B), the lower packing portion (9A, 10A, 11A) of at least one exchange section (9, 10, 11) comprising at least one packing module which has a number of transfer units less than that of at least one packing module of the other packing portion (9B, 10B, 11B) of the same exchange section. Application to air distillation columns.
摘要翻译：一种具有用于在下降液体和上升气体之间交换热量和/或材料的填料的列，其包括在两个分配器之间的至少一个交换部分（5,9,10,11），或者包括在所述交换部包括下部（9A，10A，11A），并且在所述交换部的上方具有另一部分（5B，9B，10B，11B），所述下部包装部（9A，10A，11A）至少一个交换部分（9,10,11）包括至少一个包装模块，所述至少一个包装模块具有比另一个包装部分（9B，10B，11B）的至少一个包装模块的传送单元少同一交换区。应用于空气蒸馏塔。

8. 发明申请

WO2010058142A3 HEAT EXCHANGER 审中-公开
标题翻译：热交换器
公开(公告)号：WO2010058142A3
公开(公告)日：2012-11-15
申请号：PCT/FR2009052269
申请日：2009-11-24
申请人： AIR LIQUIDE , CRAYSSAC FREDERIC , ROUSSEAU FREDERIC , WAGNER MARC
发明人： CRAYSSAC FREDERIC , ROUSSEAU FREDERIC , WAGNER MARC
IPC分类号： F25J3/00 , B01D1/22 , F25J3/04 , F25J5/00 , F28D9/00 , F28F3/02 , F28F27/02
CPC分类号： F28F3/025 , F25J3/04412 , F25J5/005 , F25J2250/04 , F25J2290/32 , F28D9/0068 , F28F9/026
摘要： The invention relates to a heat exchanger (2) for vaporising a liquid by exchanging heat with a second fluid, including a parallelepiped body made up of an assembly of parallel vertical plates (4) defining a multitude of flat passages (9) therebetween and lateral bars (7) closing the passages to the outside, a means for sending the liquid into a first assembly of passages (9) and the second fluid into the remaining passages, an insert (1, 3) for distributing the liquid at the top end of the passages (9) of said first assembly, across the entire horizontal length thereof, by fine distribution along the entire length of said passages, at least one of the lateral bars having a rounded profile along most of the length thereof and a flat profile on a portion of the length thereof, and one edge of the insert engaging the portion of the length of said bar where the profile is flat.
摘要翻译：本发明涉及一种用于通过与第二流体交换热量来蒸发液体的热交换器（2），所述第二流体包括平行六面体，所述平行六面体由平行的垂直板（4）组成，所述平行垂直板（4）在其间限定多个平坦通道（9）关闭通向外部的通道的杆（7），用于将液体输送到通道（9）的第一组件和第二流体进入剩余通道的装置，用于在顶端分配液体的插入件（1,3）的所述第一组件的通道（9）穿过其整个水平长度，沿着所述通道的整个长度的精细分布，所述侧杆中的至少一个沿着其大部分长度具有圆形轮廓，并且具有平坦轮廓在其长度的一部分上，并且插入件的一个边缘接合所述条的长度的部分，其中轮廓是平坦的。

9. 发明申请

WO2009136067A3 MANAGING SECURE USE OF A TERMINAL 审中-公开
标题翻译：管理终端的安全使用
公开(公告)号：WO2009136067A3
公开(公告)日：2010-03-11
申请号：PCT/FR2009050604
申请日：2009-04-07
申请人： EADS SECURE NETWORKS , ROUSSEAU FREDERIC
发明人： ROUSSEAU FREDERIC
IPC分类号： H04L9/32
CPC分类号： H04L9/3273 , H04L2209/805
摘要： A terminal exhibits at least one functionality made secure on the basis of a security item. A security entity stores said security item as well as first authentication parameters. The terminal stores second authentication parameters. At the level of the terminal, an authentication of the security entity is performed (11) on the basis of the first and second authentication parameters. Next, a secure contactless link is established (12) with the security entity. Finally, the security item stored on said security entity is received (23) in the course of said secure link.
摘要翻译：终端基于安全项目显示至少一个安全的功能。安全实体存储所述安全项目以及第一认证参数。终端存储第二认证参数。在终端的级别，基于第一和第二认证参数来执行安全实体的认证（11）。接下来，与安全实体建立安全的非接触链路（12）。最后，在所述安全链路的过程中接收（23）存储在所述安全实体上的安全项目。

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