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    • 1. 发明申请
    • PARTICLE SENSOR WITH WIDE LINEAR RANGE
    • 具有宽线性范围的粒子传感器
    • WO2009017721A2
    • 2009-02-05
    • PCT/US2008009144
    • 2008-07-28
    • BUGLAB LLCDEBRECZENY MARTIN PROMERO JAIMEPETERSEN ETHAN
    • DEBRECZENY MARTIN PROMERO JAIMEPETERSEN ETHAN
    • G01N15/02G01N21/49
    • G01N21/51G01N15/06G01N2021/4709
    • This invention provides a novel methods and devices for measurement of particle concentration or changes in particle concentration over a wide linear range. The invention comprises one or more radiation sources and one or more detectors contained in a housing which is interfaced to a medium containing particulate matter. The one or more radiation sources are directed into the medium, scattered or transmitted by the particulate matter, and then some portion of the radiation is detected by the one or more detectors. Methods for confining the measurement to a specific volume within the medium are described. Algorithms are provided for combining the signals generated by multiple source-detector pairs in a manner that results in a wide linear range of response to changes in particle concentration. In one embodiment the sensor provides non¬ invasive measurements of biomass in a bioreactor. In another embodiment an immersible probe design is described, which may be suited for one-time use. In an addition embodiment, a sensor is provided which is well suited to the rapid sequential measurement of particle concentration in multiple vessels, such as assessment of biomass in series of shake flasks.
    • 本发明提供了用于在宽线性范围内测量颗粒浓度或颗粒浓度变化的新颖方法和装置。 本发明包括一个或多个辐射源和一个或多个包含在与包含微粒物质的介质接口的外壳中的检测器。 一个或多个辐射源被引导到介质中,被颗粒物质散射或透射,然后由一个或多个检测器检测到辐射的一部分。 描述了将测量限制在介质内的特定体积的方法。 提供算法用于以对颗粒浓度变化的响应具有宽线性范围的方式组合由多个源 - 检测器对产生的信号。 在一个实施例中,传感器提供生物反应器中生物质的非侵入性测量。 在另一个实施例中,描述了可浸入式探针设计,其可适合于一次性使用。 在另外的实施例中,提供了一种传感器,该传感器非常适合于快速顺序测量多个容器中的颗粒浓度,例如评估一系列摇瓶中的生物质。