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1. 发明申请

WO2010084408A3 PTA089 PROTEIN 审中-公开
标题翻译： PTA089蛋白质
公开(公告)号：WO2010084408A3
公开(公告)日：2010-09-30
申请号：PCT/IB2010000102
申请日：2010-01-21
申请人： OXFORD BIOTHERAPEUTICS LTD , ROHLFF CHRISTIAN
发明人： ROHLFF CHRISTIAN
IPC分类号： C07K16/28 , G01N33/574
CPC分类号： C07K16/28 , A61K47/6849 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6863 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , G01N33/57407 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57438
摘要： The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of bladder cancer, colorectal cancer, head and neck cancer, kidney cancer, liver cancer, lung cancer, prostate cancer or skin cancer, for monitoring the effectiveness of bladder cancer, colorectal cancer, head and neck cancer, kidney cancer, liver cancer, lung cancer, prostate cancer or skin cancer treatment, and for drug development.
摘要翻译：本发明提供了用于监测膀胱癌的有效性的膀胱癌，结直肠癌，头颈部癌，肾癌，肝癌，肺癌，前列腺癌或皮肤癌的治疗，筛选，诊断和预后的方法和组合物，结直肠癌，头颈癌，肾癌，肝癌，肺癌，前列腺癌或皮肤癌治疗，以及用于药物开发。

2. 发明申请

WO2013003625A2 ANTIBODIES 审中-公开
标题翻译：抗体
公开(公告)号：WO2013003625A2
公开(公告)日：2013-01-03
申请号：PCT/US2012044703
申请日：2012-06-28
申请人： OXFORD BIOTHERAPEUTICS LTD , ROHLFF CHRISTIAN , TERRETT JONATHAN ALEXANDER
发明人： ROHLFF CHRISTIAN , TERRETT JONATHAN ALEXANDER
IPC分类号： C07K16/28
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/30 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/77
摘要： The invention provides antibodies which bind to the ADP-ribosyl cyclase 2. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided. The antibodies may be used for the treatment of human cancers, including acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer and pancreatic cancer and human inflammatory diseases, including asthma, gout, crohns, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, diabetes and atherosclerotic.
摘要翻译：本发明提供了结合ADP-核糖基环化酶2的抗体。还提供了编码抗体的核酸分子，表达载体，宿主细胞和用于表达抗体的方法。抗体可用于治疗人类癌症，包括急性骨髓性白血病（AML），B细胞慢性淋巴细胞白血病，乳腺癌，结肠直肠癌，肾癌，头颈癌，肺癌，卵巢癌和胰腺癌，以及人类炎症性疾病，包括哮喘，痛风，克罗恩病，狼疮，多发性硬化，类风湿性关节炎，牛皮癣，糖尿病和动脉粥样硬化。

3. 发明申请

WO2009150513A3 EPHRIN TYPE-A RECEPTOR 7 PROTEIN 审中-公开
标题翻译： EPHRIN型A受体7蛋白
公开(公告)号：WO2009150513A3
公开(公告)日：2010-07-08
申请号：PCT/IB2009005884
申请日：2009-06-09
申请人： OXFORD BIOTHERAPEUTICS LTD , ROHLFF CHRISTIAN
发明人： ROHLFF CHRISTIAN
IPC分类号： G01N33/574
CPC分类号： G01N33/57407 , G01N2333/9121
摘要： The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of bladder cancer, breast cancer, colorectal cancer, gastric cancer, head and neck cancer, kidney cancer, lung cancer, osteosarcoma, pancreatic cancer, prostate cancer, skin cancer, thyroid cancer or uterine cancer, including metastatic cancer, for monitoring the effectiveness of treatment of bladder cancer, breast cancer, colorectal cancer, gastric cancer, head and neck cancer, kidney cancer, lung cancer, osteosarcoma, pancreatic cancer, prostate cancer, skin cancer, thyroid cancer or uterine cancer, including metastatic cancer, and for drug development.
摘要翻译：本发明提供了膀胱癌，乳腺癌，结肠直肠癌，胃癌，头颈癌，肾癌，肺癌，骨肉瘤，胰腺癌，前列腺癌，皮肤癌等的治疗，筛选，诊断和预后的方法和组合物。甲状腺癌或子宫癌，包括转移性癌症，用于监测膀胱癌，乳腺癌，结肠直肠癌，胃癌，头颈癌，肾癌，肺癌，骨肉瘤，胰腺癌，前列腺癌，皮肤癌的治疗效果，甲状腺癌或子宫癌，包括转移性癌症和药物开发。

4. 发明申请

WO2010026473A3 PTA072 PROTEIN 审中-公开
标题翻译： PTA072蛋白
公开(公告)号：WO2010026473A3
公开(公告)日：2010-05-27
申请号：PCT/IB2009006747
申请日：2009-09-03
申请人： OXFORD BIOTHERAPEUTICS LTD , ROHLFF CHRISTIAN
发明人： ROHLFF CHRISTIAN
IPC分类号： C07K16/30 , C07K14/47 , G01N33/574
CPC分类号： C07K16/30 , C07K14/4748 , C07K2317/56
摘要： The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of B-cell non-Hodgkin's lymphoma, breast cancer, colorectal cancer, kidney cancer, pancreatic cancer or prostate cancer, for monitoring the effectiveness of B-cell non-Hodgkin's lymphoma, breast cancer, colorectal cancer, kidney cancer, pancreatic cancer or prostate cancer treatment, and for drug development.
摘要翻译：本发明提供了用于监测B细胞非霍奇金淋巴瘤，乳腺癌，结肠直肠癌，肾癌，胰腺癌或前列腺癌的治疗，筛选，诊断和预后的方法和组合物，用于监测B细胞非霍奇金淋巴瘤淋巴瘤，乳腺癌，结肠直肠癌，肾癌，胰腺癌或前列腺癌治疗，以及药物开发。

5. 发明申请

WO2013003625A4 ANTIBODIES TO ADP-RIBOSYL CYCLASE 2 审中-公开
标题翻译： ADP-RIBOSYL CYCLASE的抗体2
公开(公告)号：WO2013003625A4
公开(公告)日：2013-11-21
申请号：PCT/US2012044703
申请日：2012-06-28
申请人： OXFORD BIOTHERAPEUTICS LTD , ROHLFF CHRISTIAN , TERRETT JONATHAN ALEXANDER
发明人： ROHLFF CHRISTIAN , TERRETT JONATHAN ALEXANDER
IPC分类号： C07K16/28
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/30 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/77
摘要： The invention provides antibodies which bind to the ADP-ribosyl cyclase 2. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided. The antibodies may be used for the treatment of human cancers, including acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer and pancreatic cancer and human inflammatory diseases, including asthma, gout, crohns, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, diabetes and atherosclerotic.
摘要翻译：本发明提供了结合ADP-核糖基环化酶2的抗体。还提供了编码抗体的核酸分子，表达载体，宿主细胞和用于表达抗体的方法。抗体可用于治疗人类癌症，包括急性骨髓性白血病（AML），B细胞慢性淋巴细胞白血病，乳腺癌，结肠直肠癌，肾癌，头颈癌，肺癌，卵巢癌和胰腺癌，以及人类炎症性疾病，包括哮喘，痛风，克罗恩病，狼疮，多发性硬化，类风湿性关节炎，牛皮癣，糖尿病和动脉粥样硬化。

6. 发明申请

WO2009087462A3 EPHRIN TYPE-A RECEPTOR 10 PROTEIN 审中-公开
标题翻译： EPHRIN型A受体10蛋白
公开(公告)号：WO2009087462A3
公开(公告)日：2009-09-03
申请号：PCT/IB2008003634
申请日：2008-12-24
申请人： OXFORD BIOTHERAPEUTICS LTD , ROHLFF CHRISTIAN , STAMPS ALASDAIR
发明人： ROHLFF CHRISTIAN , STAMPS ALASDAIR
IPC分类号： C07K16/28 , C12Q1/68 , G01N33/574
CPC分类号： C07K16/28 , C12Q1/6886 , C12Q2600/136 , G01N33/57492 , G01N33/74 , G01N2333/71
摘要： The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of bladder cancer, breast cancer, colorectal cancer, head and neck cancer, kidney cancer, lung cancer or pancreatic cancer, for monitoring the effectiveness of bladder cancer, breast cancer, colorectal cancer, head and neck cancer, kidney cancer, lung cancer or pancreatic cancer treatment, and for drug development based on Ephrin Type-A Receptor 10 Protein.
摘要翻译：本发明提供膀胱癌，乳腺癌，结肠直肠癌，头颈癌，肾癌，肺癌或胰腺癌的治疗，筛选，诊断和预后的方法和组合物，用于监测膀胱癌，乳腺癌，结直肠癌，头颈癌，肾癌，肺癌或胰腺癌治疗，以及基于Ephrin A型受体10蛋白的药物开发。

7. 发明申请

WO2013001369A3 THERAPEUTIC AND DIAGNOSTIC TARGET 审中-公开
公开(公告)号：WO2013001369A3
公开(公告)日：2013-05-16
申请号：PCT/IB2012001680
申请日：2012-06-28
申请人： OXFORD BIOTHERAPEUTICS LTD , ROHLFF CHRISTIAN , STAMPS ALASDAIR
发明人： ROHLFF CHRISTIAN , STAMPS ALASDAIR
IPC分类号： A61K39/00 , C07K16/28 , C07K16/30 , C12Q1/68 , G01N33/574
CPC分类号： C07K16/18 , A61K39/0011 , C07K14/435 , C07K16/005 , C07K16/2896 , C07K16/30 , C07K2317/55 , C07K2317/732 , C07K2317/77 , C12Q1/6886 , C12Q2600/158 , G01N33/566 , G01N33/57426 , G01N2500/04 , H01M2/0473 , H01M2/263 , H01M2/30 , H01M10/058
摘要： The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer or pancreatic cancer, for monitoring the effectiveness of acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer or pancreatic cancer treatment, and for drug development. The present invention also provides methods and compositions for depletion of immune cells to treat inflammatory diseases.

8. 发明申请

WO2013001369A2 THERAPEUTIC AND DIAGNOSTIC TARGET 审中-公开
标题翻译：治疗和诊断目标
公开(公告)号：WO2013001369A2
公开(公告)日：2013-01-03
申请号：PCT/IB2012001680
申请日：2012-06-28
申请人： OXFORD BIOTHERAPEUTICS LTD , ROHLFF CHRISTIAN , STAMPS ALASDAIR
发明人： ROHLFF CHRISTIAN , STAMPS ALASDAIR
IPC分类号： A61K39/00
CPC分类号： C07K16/18 , A61K39/0011 , C07K14/435 , C07K16/005 , C07K16/2896 , C07K16/30 , C07K2317/55 , C07K2317/732 , C07K2317/77 , C12Q1/6886 , C12Q2600/158 , G01N33/566 , G01N33/57426 , G01N2500/04 , H01M2/0473 , H01M2/263 , H01M2/30 , H01M10/058
摘要： The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer or pancreatic cancer, for monitoring the effectiveness of acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer or pancreatic cancer treatment, and for drug development. The present invention also provides methods and compositions for depletion of immune cells to treat inflammatory diseases.
摘要翻译：本发明提供了治疗，筛选，诊断和预后急性骨髓性白血病（AML），B细胞慢性淋巴细胞白血病，乳腺癌，结直肠癌，肾癌，头颈癌，肺癌，卵巢癌或用于监测急性骨髓性白血病（AML），B细胞慢性淋巴细胞性白血病，乳腺癌，结肠直肠癌，肾癌，头颈癌，肺癌，卵巢癌或胰腺癌治疗以及药物开发的有效性的胰腺癌。本发明还提供了消耗免疫细胞以治疗炎性疾病的方法和组合物。

9. 发明申请

WO2009020645A3 MATRIPTASE PROTEIN AND USES THEREOF 审中-公开
标题翻译： MATRIPTASE蛋白及其用途
公开(公告)号：WO2009020645A3
公开(公告)日：2009-05-07
申请号：PCT/US2008009512
申请日：2008-08-07
申请人： OXFORD GENOME SCIENCES UK LTD , MEDAREX INC , ROHLFF CHRISTIAN , TERRETT JONATHAN ALEXANDER
发明人： ROHLFF CHRISTIAN , TERRETT JONATHAN ALEXANDER
IPC分类号： G01N33/573 , A61K39/395 , A61K47/48 , A61K48/00 , A61K51/10 , A61P35/00 , C07K16/40 , C12N5/00 , C12N9/50 , C12N15/13 , C12N15/32 , C12Q1/37 , C12Q1/68 , G01N33/532 , G01N33/574
CPC分类号： G01N33/573 , C12Q1/37 , G01N33/574 , G01N2333/96433
摘要： The present invention provides methods and compositions for treatment, screening, diagnosis, prognosis and therapy of breast cancer, colorectal cancer, esophageal cancer, gastric cancer, prostate cancer and uterine cancer, for monitoring the effectiveness of breast cancer, colorectal cancer, esophageal cancer, gastric cancer, prostate cancer and uterine cancer treatment, and for drug development.
摘要翻译：本发明提供用于乳腺癌，结直肠癌，食管癌，胃癌，前列腺癌和子宫癌的治疗，筛选，诊断，预后和治疗的方法和组合物，用于监测乳腺癌，结肠直肠癌，食管癌，胃癌，前列腺癌和子宫癌治疗，以及用于药物开发。

10. 发明申请

WO2008104806A2 PROTEIN 审中-公开
标题翻译：蛋白
公开(公告)号：WO2008104806A2
公开(公告)日：2008-09-04
申请号：PCT/GB2008050127
申请日：2008-02-26
申请人： OXFORD GENOME SCIENCES UK LTD , ROHLFF CHRISTIAN , STAMPS ALASDAIR
发明人： ROHLFF CHRISTIAN , STAMPS ALASDAIR
CPC分类号： A61K39/39558 , C07K14/705 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3061 , C07K16/3069 , C07K2317/734 , C12Q1/6886 , G01N33/57407 , G01N33/57419 , G01N33/57423 , G01N33/57426 , G01N33/57438 , G01N33/57449 , Y10T436/143333
摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of colorectal cancer, kidney cancer, liver cancer, lung cancer, lymphoid leukaemia (particularly chronic lymphocytic leukaemia), ovarian cancer or pancreatic cancer, for monitoring the effectiveness of colorectal cancer, kidney cancer, liver cancer, lung cancer, lymphoid leukaemia (particularly chronic lymphocytic leukaemia), ovarian cancer or pancreatic cancer treatment, and for drug development.
摘要翻译：本发明提供了用于筛选，诊断和预后的结肠直肠癌，肾癌，肝癌，肺癌，淋巴白血病（特别是慢性淋巴细胞性白血病），卵巢癌或胰腺癌的方法和组合物，用于监测结直肠癌，肾脏的有效性癌症，肝癌，肺癌，淋巴白血病（特别是慢性淋巴细胞性白血病），卵巢癌或胰腺癌治疗以及药物开发。

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