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1. 发明申请

WO2002072140A2 MHC-I-RESTRICTED PRESENTATION OF HIV-1 VIRION ANTIGENS WITHOUT VIRAL REPLICATION. APPLICATION TO THE STIMULATION OF CTL AND VACCINATION IN VIVO; ANALYSIS OF VACCINATING COMPOSITION IN VITRO 审中-公开
标题翻译：没有病毒复制的HIV-1毒素抗体的MHC-I限制性介绍。应用于血液中的CTL和疫苗刺激; VITRO中吸入组合物的分析
公开(公告)号：WO2002072140A2
公开(公告)日：2002-09-19
申请号：PCT/EP2002/002620
申请日：2002-02-26
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , SCHWARTZ, Olivier , BUSEYNE, Florence , MARSAC, Delphine , MICHEL, Marie-Louise , RIVIERE, Yves , HEARD, Jean-Michel
发明人： SCHWARTZ, Olivier , BUSEYNE, Florence , MARSAC, Delphine , MICHEL, Marie-Louise , RIVIERE, Yves , HEARD, Jean-Michel
IPC分类号： A61K39/21
CPC分类号： G01N33/567 , A61K39/12 , A61K39/21 , A61K2039/5258 , A61K2039/53 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N2740/16023 , C12N2740/16034 , C12N2740/16062 , C12N2740/16122 , C12N2740/16222 , C12N2740/16234 , C12N2760/20222 , C12N2760/20234 , G01N33/505 , G01N33/5082 , G01N2333/16
摘要： Dendritic cells and macrophages can process extracellular antigens for presentation by MHC-I molecules. HIV-1 epitopes derived from incoming virions are presented through the exogenous MHC-I pathway in primary human dendritic cells, and to a lower extent in macrophages, leading to cytotoxic T lymphocyte activation in the absence of viral protein neosynthesis. Exogenous antigen presentation required adequate virus-receptor interactions and fusion of viral and cellular membranes. These results provide new insights about how anti-HIV cytotoxic T lymphocytes can be activated and are useful for anti-HIV vaccine design.
摘要翻译：树突细胞和巨噬细胞可以处理细胞外抗原以供MHC-1分子表达。来源于病毒粒子的HIV-1表位通过原代人树突状细胞中的外源性MHC-1途径呈现，并且在巨噬细胞中呈现较低程度，导致在没有病毒蛋白质新合成的情况下导致细胞毒性T淋巴细胞活化。外源性抗原呈递需要足够的病毒 - 受体相互作用和病毒和细胞膜的融合。这些结果提供了关于抗HIV细胞毒性T淋巴细胞如何被激活并可用于抗HIV疫苗设计的新见解。

2. 发明申请

WO1998000753A1 MOVING PICTURE CAMERA AND DEVICE FOR RECEIVING FILM REELS 审中-公开
标题翻译：移动图像摄像机和用于接收胶片的设备
公开(公告)号：WO1998000753A1
公开(公告)日：1998-01-08
申请号：PCT/FR1997001159
申请日：1997-06-27
申请人： AATON , BEAUVIALA, Jean-Pierre , RIVIERE, Yves
发明人： AATON
IPC分类号： G03B17/26
CPC分类号： G03B17/265
摘要： The invention concerns a device (20) for receiving coaxial moving picture film reels, to be associated with an optical block (10) of a filming camera, comprising: a plate (21) for receiving the reels and for defining a space for means (15, 16, 24, 25) to guide the film in loops between the reels and a rear presser (12) to be located opposite a filming window (13) of the optical block (10), each reel comprising two circular spool heads for axially holding the film around a take-up core; one main spindle (22) to co-operate with the take-up cores; two secondary spindles (29, 30) each bearing a cylinder (42, 43) for returning the film and means for spacing the spool heads, and means (34, 35, 36, 37) for creating a relative motion between the secondary spindles (29, 30) and the reels, between an off-position where the secondary spindles (29, 30) are radially distant from the reels and an operative position where the spacing means move apart the periphery of the spool heads (91) in a determined region, fixed with respect to the receiving device (20; 20').
摘要翻译：本发明涉及一种用于接收与成像相机的光学块（10）相关联的同轴运动图像胶卷盘的装置（20），包括：用于接收卷轴并用于限定装置空间的板（21） 15,16,24,25），以将薄膜引导到卷轴和后压脚（12）之间的环中，以与光学块（10）的成膜窗（13）相对定位，每个卷轴包括两个圆形卷轴头，用于将胶片轴向保持在卷绕芯周围; 一个主轴（22）与卷取芯配合; 两个次级主轴（29,30）各自承载用于返回胶片的圆筒（42,43）和用于间隔卷轴头的装置，以及用于在次主轴之间产生相对运动的装置（34,35,36,37）在所述次主轴（29,30）从所述卷轴径向远离的偏离位置和所述间隔装置以确定的所述卷轴头（91）的周边移动的操作位置之间的所述卷轴区域，相对于接收装置（20; 20'）固定。

3. 发明申请

WO02072140A3 MHC-I-RESTRICTED PRESENTATION OF HIV-1 VIRION ANTIGENS WITHOUT VIRAL REPLICATION. APPLICATION TO THE STIMULATION OF CTL AND VACCINATION IN VIVO; ANALYSIS OF VACCINATING COMPOSITION IN VITRO 审中-公开
标题翻译：没有病毒复制的HIV-1病毒抗体的MHC-I限制性介绍。应用于血液中的CTL和疫苗刺激; VITRO中吸入组合物的分析
公开(公告)号：WO02072140A3
公开(公告)日：2003-08-21
申请号：PCT/EP0202620
申请日：2002-02-26
申请人： PASTEUR INSTITUT , INST NAT SANTE RECH MED , CENTRE NAT RECH SCIENT , SCHWARTZ OLIVIER , BUSEYNE FLORENCE , MARSAC DELPHINE , MICHEL MARIE-LOUISE , RIVIERE YVES , HEARD JEAN-MICHEL
发明人： SCHWARTZ OLIVIER , BUSEYNE FLORENCE , MARSAC DELPHINE , MICHEL MARIE-LOUISE , RIVIERE YVES , HEARD JEAN-MICHEL
IPC分类号： A01N63/00 , A61K39/21 , A61K48/00 , C07H21/04 , C07K14/16 , C12N7/04 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , C12Q1/68 , C12Q1/70 , G01N33/50 , G01N33/567 , C07K14/15 , C07K14/155
CPC分类号： G01N33/567 , A61K39/12 , A61K39/21 , A61K2039/5258 , A61K2039/53 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N2740/16023 , C12N2740/16034 , C12N2740/16062 , C12N2740/16122 , C12N2740/16222 , C12N2740/16234 , C12N2760/20222 , C12N2760/20234 , G01N33/505 , G01N33/5082 , G01N2333/16
摘要： Dendritic cells and macrophages can process extracellular antigens for presentation by MHC-I molecules. HIV-1 epitopes derived from incoming virions are presented through the exogenous MHC-I pathway in primary human dendritic cells, and to a lower extent in macrophages, leading to cytotoxic T lymphocyte activation in the absence of viral protein neosynthesis. Exogenous antigen presentation required adequate virus-receptor interactions and fusion of viral and cellular membranes. These results provide new insights about how anti-HIV cytotoxic T lymphocytes can be activated and are useful for anti-HIV vaccine design.
摘要翻译：树突细胞和巨噬细胞可以处理细胞外抗原以供MHC-1分子表达。来源于病毒粒子的HIV-1表位通过原代人树突状细胞中的外源性MHC-1途径呈现，并且在巨噬细胞中呈现较低程度，导致在没有病毒蛋白质新合成的情况下导致细胞毒性T淋巴细胞活化。外源性抗原呈递需要足够的病毒 - 受体相互作用和病毒和细胞膜的融合。这些结果提供了关于抗HIV细胞毒性T淋巴细胞如何被激活并可用于抗HIV疫苗设计的新见解。

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