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1. 发明申请

WO2005009499A1 COMPLIANT OSTEOSYNTHESIS FIXATION PLATE 审中-公开
标题翻译：合适的骨质疏松板
公开(公告)号：WO2005009499A1
公开(公告)日：2005-02-03
申请号：PCT/US2004/022840
申请日：2004-07-15
申请人： KENSEY NASH CORPORATION , RINGEISEN, Timothy, A.
发明人： RINGEISEN, Timothy, A.
IPC分类号： A61L31/04
CPC分类号： A61B17/8061 , A61B17/80 , A61B17/8085 , A61B2017/00004 , A61L31/04 , A61L31/125 , A61L31/146 , A61L31/148 , A61L31/16 , A61L31/18 , A61L2300/00
摘要： A bendable polymer tissue fixation device suitable to be implanted into a living body, consisting of a highly porous body, made from a polymer, the porous body having a plurality of pores, such that the device is capable of being smoothly bent, wherein the bending collapses a portion of the pores to form a radius curve, and the polymer fixation device is rigid enough to protect a tissue from shifting. Preferably, the polymer fixation device may be capable of being gradually resorbed by said living body. In one embodiment, the polymer fixation device consists of a plurality of layers distinguishable by various characteristics, such as structural or chemical properties. In another embodiment, the polymer fixation device may feature additional materials which serve to reinforce or otherwise alter the structure or physical characteristics of the device, or alternatively the additional materials serve to deliver therapies to the living being.
摘要翻译：一种可弯曲聚合物组织固定装置，适合于植入由聚合物制成的高度多孔体的活体中，所述多孔体具有多个孔，使得该装置能够平滑弯曲，其中弯曲塌陷一部分孔以形成半径曲线，并且聚合物固定装置足够刚性以保护组织免于移动。优选地，聚合物固定装置可能能够被所述活体逐渐吸收。在一个实施方案中，聚合物固定装置由可由各种特性区分的多个层组成，例如结构或化学性质。在另一个实施方案中，聚合物固定装置可以具有用于加强或以其它方式改变装置的结构或物理特性的附加材料，或者替代地，附加材料用于将疗法递送至生物体。

2. 发明申请

WO2005082431A1 GEL SUITABLE FOR IMPLANTATION AND DELIVERY SYSTEM 审中-公开
标题翻译：凝胶适用于植入和输送系统
公开(公告)号：WO2005082431A1
公开(公告)日：2005-09-09
申请号：PCT/US2005/005621
申请日：2005-02-23
申请人： KENSEY NASH CORPORATION , RINGEISEN, Timothy A. , WATTENGEL, William Christian , BRADICA, Gino
发明人： RINGEISEN, Timothy A. , WATTENGEL, William Christian , BRADICA, Gino
IPC分类号： A61L27/24
CPC分类号： A61L27/56 , A61L27/20 , A61L27/24 , A61L27/52 , C08L5/08
摘要： The invention concerns a dried form of a porous polymer gel material which may be rehydrated and placed under pressure or compression to induce solvation, thereby forming a high concentration gel, in the form of an injectable viscous putty or dough, which may be implanted in the body.
摘要翻译：本发明涉及多孔聚合物凝胶材料的干燥形式，其可以被再水化并置于压力或压缩下以引发溶剂化，从而形成可注射粘性油灰或面团形式的高浓度凝胶，其可以植入身体。

3. 发明申请

WO2003039615A3 POROUS POLYMERIC PROSTHESES AND METHODS FOR MAKING SAME 审中-公开
公开(公告)号：WO2003039615A3
公开(公告)日：2003-05-15
申请号：PCT/US2002/035848
申请日：2002-11-07
申请人： KENSEY NASH CORPORATION , RINGEISEN, Timothy, A.
发明人： RINGEISEN, Timothy, A.
IPC分类号： A61L27/56
摘要： Porous polymers having a plurality of openings or chambers that are highly convoluted, with each chamber being defined by multiple, thin, flat partitions are produced by a new gel enhanced phase separation techinque. In a preferred embodiment, a second solven t is added to a ploymer solution, the second solvent causing the solution to gel. The gel can then be shaped as needed. Subsequent solvent extraction leaves the porous polymeric body of defined shape. The porous polymers have utility as medical protheses, t he porosity permitting ingrowth of neighboring tissue. The present technique also enhances shape-making capability, for example, of bifurcated vascular grafts, which feature a common entrance re gion but two or more exit regions.

4. 发明申请

WO03039615A2 POROUS POLYMERIC PROSTHESES AND METHODS FOR MAKING SAME 审中-公开
标题翻译：多孔聚合物的制备方法和制备方法
公开(公告)号：WO03039615A2
公开(公告)日：2003-05-15
申请号：PCT/US0235848
申请日：2002-11-07
申请人： KENSEY NASH CORP , RINGEISEN TIMOTHY A
发明人： RINGEISEN TIMOTHY A
IPC分类号： A61L27/00 , A61F2/00 , A61F2/04 , A61F2/06 , A61K9/14 , A61L27/14 , A61L27/56 , B29C65/00 , B29D22/00 , B29D23/00 , B32B1/08 , B65D1/00 , C08F2/00 , C08F283/04 , C08J3/00 , C08J9/00 , C08J9/28 , C08J11/00 , C08K3/00 , C08L1/00 , C08L101/16 , F16L1/00
CPC分类号： C08J9/28 , A61L27/18 , A61L27/48 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/114 , A61L2300/236 , A61L2300/252 , A61L2300/406 , A61L2300/42 , A61L2300/43 , A61L2300/64 , A61L2300/802 , C08J2201/054 , Y10T428/1386 , Y10T428/139 , C08L75/04
摘要： Porous polymers having a plurality of openings or chambers that are highly convoluted, with each chamber being defined by multiple, thin, flat partitions are produced by a new gel enhanced phase separation techinque. In a preferred embodiment, a second solven t is added to a ploymer solution, the second solvent causing the solution to gel. The gel can then be shaped as needed. Subsequent solvent extraction leaves the porous polymeric body of defined shape. The porous polymers have utility as medical protheses, t he porosity permitting ingrowth of neighboring tissue. The present technique also enhances shape-making capability, for example, of bifurcated vascular grafts, which feature a common entrance re gion but two or more exit regions.
摘要翻译：多孔聚合物具有高度卷曲的多个开口或室，每个室由多个薄的扁平隔板限定，通过新的凝胶增强相分离技术产生。在优选的实施方案中，将第二溶剂t加入到聚合溶液中，第二溶剂引起溶液凝胶化。然后可以根据需要成型凝胶。随后的溶剂萃取离开具有限定形状的多孔聚合体。多孔聚合物具有作为医疗保护的效用，孔隙度允许相邻组织的向内生长。本技术还增强了形状制造能力，例如分叉血管移植物，其具有普通的入口，但具有两个或更多个出口区域。

5. 发明申请

WO2006083471A3 CORING DEVICE FOR PRESERVING LIVING TISSUE 审中-公开
标题翻译：用于保存生命组织的核心装置
公开(公告)号：WO2006083471A3
公开(公告)日：2006-11-02
申请号：PCT/US2006000222
申请日：2006-01-04
申请人： KENSEY NASH CORP , BRADICA GINO , RINGEISEN TIMOTHY A
发明人： BRADICA GINO , RINGEISEN TIMOTHY A
IPC分类号： A61B17/32 , A61B17/16
CPC分类号： A61B17/32053 , A61B17/1635 , A61B17/32002 , A61B2017/00464 , A61B2017/00858
摘要： Improved coring devices suitable for articular cartilage and bone, wherein the cutting device is capable of slicing through a tough protective tangential zone, delicately separating the shock absorbing columns of cells in the radial zone of the cartilage, and finally cutting into the hard underlying bone in a manner that preserves the viability of osteochondral cells. The coring device features an annulus having a flat annular cutting edge interrupted by at least one serration having neutral cutting angles. A method for concurrently removing cartilaginous and bony tissue using an improved coring device that preserves the viability of osteochondral cells.
摘要翻译：改进的适用于关节软骨和骨骼的取芯装置，其中切割装置能够切割通过坚韧的保护切向区域，在软骨的径向区域中精细地分离细胞的减震柱，并最终切入保持骨软骨细胞活力的方式。取芯装置具有环形件，该环形件具有由至少一个具有中性切割角的锯齿中断的扁平环形切割边缘。一种使用改进的取芯装置同时去除软骨和骨组织的方法，所述改进的取芯装置保存骨软骨细胞的存活力。

6. 发明申请

WO2005056071A1 COMPRESSED HIGH DENSITY FIBROUS POLYMERS SUITABLE FOR IMPLANT 审中-公开
标题翻译：压缩高密度纤维聚合物适用于植入
公开(公告)号：WO2005056071A1
公开(公告)日：2005-06-23
申请号：PCT/US2004/040645
申请日：2004-12-03
申请人： KENSEY NASH CORPORATION , RINGEISEN, Timothy A. , WATTENGEL, William Christian
发明人： RINGEISEN, Timothy A. , WATTENGEL, William Christian
IPC分类号： A61L27/24
CPC分类号： A61L31/141 , A61L27/502 , A61L31/10
摘要： An embodiment of the present invention may be made by the following steps: providing a mixture comprising a plurality of fibers, a lubricant, and a suspension fluid, with the suspension fluid filling a void space between the fibers and subjecting the mixture to at least one compressive force. The compressive force causes the migration and alignment of the fibers; and may remove substantially all of the suspension fluid from the mixture. The mixture may further comprise a biologically active agent, or a reinforcing agent.
摘要翻译：本发明的一个实施方案可以通过以下步骤制备：提供包含多种纤维，润滑剂和悬浮液的混合物，其中悬浮液填充纤维之间的空隙，并使混合物经受至少一种压缩力。压缩力导致纤维的迁移和排列; 并且可以从混合物中基本上去除所有悬浮液。该混合物可进一步包含生物活性剂或增强剂。

7. 发明申请

WO2006083471A2 CORING DEVICE FOR PRESERVING LIVING TISSUE 审中-公开
标题翻译：用于保存生活组织的牙齿装置
公开(公告)号：WO2006083471A2
公开(公告)日：2006-08-10
申请号：PCT/US2006/000222
申请日：2006-01-04
申请人： KENSEY NASH CORPORATION , BRADICA, Gino , RINGEISEN, Timothy A.
发明人： BRADICA, Gino , RINGEISEN, Timothy A.
IPC分类号： A61B17/32 , A61B17/16
CPC分类号： A61B17/32053 , A61B17/1635 , A61B17/32002 , A61B2017/00464 , A61B2017/00858
摘要： Improved coring devices suitable for articular cartilage and bone, wherein the cutting device is capable of slicing through a tough protective tangential zone, delicately separating the shock absorbing columns of cells in the radial zone of the cartilage, and finally cutting into the hard underlying bone in a manner that preserves the viability of osteochondral cells. The coring device features an annulus having a flat annular cutting edge interrupted by at least one serration having neutral cutting angles. A method for concurrently removing cartilaginous and bony tissue using an improved coring device that preserves the viability of osteochondral cells.
摘要翻译：改进的适用于关节软骨和骨骼的取芯装置，其中切割装置能够穿过坚韧的保护性切向区域，精细地分离软骨的径向区域中的细胞的减震柱，并最终切割成硬的下面的骨骼一种保持骨软骨细胞活力的方法。取芯装置具有环形，其具有由至少一个具有中间切割角度的锯齿状物中断的平坦环形切割刃。使用改进的取芯装置同时去除软骨和骨组织的方法，其保持骨软骨细胞的活力。

8. 发明申请

WO2005107829A3 COMPRESSED POROUS MATERIALS SUITABLE FOR IMPLANT 审中-公开
标题翻译：压缩多孔材料适合植入
公开(公告)号：WO2005107829A3
公开(公告)日：2006-03-09
申请号：PCT/US2005014878
申请日：2005-04-29
申请人： KENSEY NASH CORP , DEMEO JOSEPH , MCDADE ROBERT L , RINGEISEN TIMOTHY A , HEARN PATRICK E , TURNER AMANDA
发明人： DEMEO JOSEPH , MCDADE ROBERT L , RINGEISEN TIMOTHY A , HEARN PATRICK E , TURNER AMANDA
IPC分类号： A61F2/02 , A61F2/28 , A61F2/44 , A61L27/00 , A61L27/56
CPC分类号： A61B17/0642 , A61B17/7059 , A61B17/846 , A61B17/866 , A61F2/3094 , A61F2002/2817 , A61F2002/30014 , A61F2002/30032 , A61F2002/30036 , A61F2002/30062 , A61F2002/30235 , A61F2002/30563 , A61F2002/30578 , A61F2002/30677 , A61F2002/30904 , A61F2002/3092 , A61F2002/30971 , A61F2310/00293 , A61F2310/0097 , A61L27/56
摘要： A high strength porous polymeric material manufactured by a compression and/or sintering process is disclosed. The material results in a network of interconnected collapsed pores, which forces thin overlapping walls and passages to be created. The network provides permeable access for fluid migration throughout the material. The strength and/or permeability are advantageous for medical devices and implants.
摘要翻译：公开了通过压缩和/或烧结工艺制造的高强度多孔聚合材料。该材料导致相互连接的塌陷孔的网络，这迫使薄的重叠壁和通道产生。网络为整个材料的流体迁移提供可渗透性。强度和/或渗透性对于医疗装置和植入物是有利的。

9. 发明申请

WO2005107829A2 COMPRESSED POROUS MATERIALS SUITABLE FOR IMPLANT 审中-公开
标题翻译：压缩多孔材料适合植入
公开(公告)号：WO2005107829A2
公开(公告)日：2005-11-17
申请号：PCT/US2005/014878
申请日：2005-04-29
申请人： KENSEY NASH CORPORATION , DEMEO, Joseph , MCDADE, Robert, L. , RINGEISEN, Timothy, A. , HEARN, Patrick, E. , TURNER, Amanda
发明人： DEMEO, Joseph , MCDADE, Robert, L. , RINGEISEN, Timothy, A. , HEARN, Patrick, E. , TURNER, Amanda
IPC分类号： A61L27/00
CPC分类号： A61B17/0642 , A61B17/7059 , A61B17/846 , A61B17/866 , A61F2/3094 , A61F2002/2817 , A61F2002/30014 , A61F2002/30032 , A61F2002/30036 , A61F2002/30062 , A61F2002/30235 , A61F2002/30563 , A61F2002/30578 , A61F2002/30677 , A61F2002/30904 , A61F2002/3092 , A61F2002/30971 , A61F2310/00293 , A61F2310/0097 , A61L27/56
摘要： A high strength porous polymeric material manufactured by a compression and/or sintering process is disclosed. The material results in a network of interconnected collapsed pores, which forces thin overlapping walls and passages to be created. The network provides permeable access for fluid migration throughout the material. The strength and/or permeability are advantageous for medical devices and implants.
摘要翻译：公开了通过压缩和/或烧结工艺制造的高强度多孔聚合材料。这种材料导致相互连接的塌陷孔隙的网络，这促使要产生薄的重叠壁和通道。网络为整个材料的流体迁移提供可渗透性。强度和/或渗透性对于医疗装置和植入物是有利的。

10. 发明申请

WO2011002511A1 MULTI-PHASIC IMPLANT DEVICE FOR THE REPAIR OR REPLACEMENT OF CARTILAGE TISSUE 审中-公开
标题翻译：用于修复或更换卡质组织的多相植入装置
公开(公告)号：WO2011002511A1
公开(公告)日：2011-01-06
申请号：PCT/US2010/001878
申请日：2010-06-30
申请人： KENSEY NASH CORPORATION , CASTIGLIONE-DODD, Emme, M. , BRADICA, Gino , EBRAHIMI, Ali , RINGEISEN, Timothy, A. , WATTENGEL, William, Christian , MCDADE, Robert, L.
发明人： CASTIGLIONE-DODD, Emme, M. , BRADICA, Gino , EBRAHIMI, Ali , RINGEISEN, Timothy, A. , WATTENGEL, William, Christian , MCDADE, Robert, L.
IPC分类号： A61F2/28 , A61F2/30 , A61F2/00
CPC分类号： A61F2/28 , A61F2/30756 , A61F2002/30014 , A61F2002/30028 , A61F2002/30031 , A61F2002/30052 , A61F2002/30088 , A61F2002/30332 , A61F2002/3092 , A61F2002/30971 , A61F2002/4495 , A61F2210/008 , A61F2220/0033 , A61F2250/0018 , A61F2250/0043 , A61F2250/0051 , A61F2250/0056 , A61F2310/00365 , A61L27/24 , A61L27/48 , A61L27/50 , A61L27/52 , A61L27/56 , A61L2430/06
摘要： Tissue implants prepared for the repair of tissues, especially avascular tissues such as cartilage. One embodiment presents an electric potential capable of receiving and accumulating desirable factors or molecules from surrounding fluid when exposed to dynamic loading. In another embodiment the implant promotes tissue conduction by retarding, restricting and controlling cellular invasion through use of gradients until competent tissue forms. Further embodiments of the tissue implants may be formed into a multi-phasic device that provides deep tissue mechanical stimulus by conduction of mechanical and fluid forces experienced at the surface of the implant.
摘要翻译：组织植入物准备用于修复组织，特别是无血管组织如软骨。一个实施例呈现出当暴露于动态载荷时能够从周围流体接收和积聚期望因子或分子的电势。在另一个实施方案中，所述植入物通过使用梯度来延缓，限制和控制细胞侵袭直到感染组织形成来促进组织传导。组织植入物的其它实施方案可以形成为通过在植入物表面经历的机械和流体力的传导而提供深层组织机械刺激的多相装置。

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