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1. 发明申请

WO2005124423A1 AUTOFOCUS MECHANISM FOR SPECTROSCOPIC SYSTEM 审中-公开
标题翻译：用于光谱系统的自动机械机构
公开(公告)号：WO2005124423A1
公开(公告)日：2005-12-29
申请号：PCT/IB2005/051848
申请日：2005-06-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , VAN BEEK, Michael Cornelis , LUCASSEN, Gerald , VAN DER VOORT, Marjolein , RENSEN, Wouter Harry Jacinth , DE VRIES, Durk Jolmer
发明人： VAN BEEK, Michael Cornelis , LUCASSEN, Gerald , VAN DER VOORT, Marjolein , RENSEN, Wouter Harry Jacinth , DE VRIES, Durk Jolmer
IPC分类号： G02B21/24
CPC分类号： G02B21/247 , G01J3/02 , G01J3/0237 , G01J3/44 , G01N21/645 , G01N21/65 , G01N2021/6463 , G01N2021/653 , G01N2021/655
摘要： The present invention provides an autofocus mechanism for a spectroscopic system (400) that is adapted to determine a property of a volume of interest. The volume of interest has an optical property that varies with time. The invention provides measurement means that are adapted to measure the fluctuations of the optical property of the volume of interest for determining the position (428) of the volume of interest. The spectroscopic system being further adapted to focus an excitation beam (418) into the determined volume of interest and for collecting return radiation (420) emanating from the volume of interest for spectroscopic analysis. Preferably, inelastically scattered radiation of an excitation beam (428) is separated from elastically scattered radiation for spectroscopic analysis. The elastically scattered radiation of the excitation beam is in turn exploited in order to measure the fluctuations of the optical property of the volume of interest. Making use of a control loop allows for maximization of the amplitude and/or intensity of the fluctuation inherently specifying the position of a volume of interest e.g. the center of a capillary vessel (450).
摘要翻译：本发明提供一种用于分光系统（400）的自动对焦机构，其适于确定感兴趣体积的性质。感兴趣的体积随着时间而变化。本发明提供了测量装置，其适于测量感兴趣体积的光学性质的波动，以确定感兴趣体积的位置（428）。光谱系统还适于将激发光束（418）聚焦到所确定的感兴趣体积中并且用于收集从用于光谱分析的感兴趣体积发出的返回辐射（420）。优选地，激发光束（428）的非弹性散射辐射与用于光谱分析的弹性散射辐射分离。激发光束的弹性散射辐射又被利用来测量感兴趣体积的光学特性的波动。利用控制回路允许最大化固有地指定感兴趣体积的位置的波动的幅度和/或强度，毛细血管的中心（450）。

2. 发明申请

WO2005107579A1 MEASUREMENT HEAD FOR NON-INVASIVE BLOOD ANALYSIS 审中-公开
标题翻译：非侵入性血液分析的测量头
公开(公告)号：WO2005107579A1
公开(公告)日：2005-11-17
申请号：PCT/IB2005/051430
申请日：2005-05-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VOORT, Marjolein , BAKKER, Bernadus, Leonardus, Gerardus , LUCASSEN, Gerald , COMPEN, Hendrikus, Antonius, Cornelus, Maria , VAN BEEK, Michael, Cornelis , RENSEN, Wouter, Harry, Jacinth
发明人： VOORT, Marjolein , BAKKER, Bernadus, Leonardus, Gerardus , LUCASSEN, Gerald , COMPEN, Hendrikus, Antonius, Cornelus, Maria , VAN BEEK, Michael, Cornelis , RENSEN, Wouter, Harry, Jacinth
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0062 , A61B5/68 , A61B5/6843
摘要： The present invention provides an efficient approach of attaching and fixing a measurement head for a spectroscopic system to a variety of different parts of the skin of a patient. The measurement head preferably features a compact design providing a flexible handling and offering a huge variety of application areas taking into account the plurality of properties of various portions of the skin. Furthermore, the measurement head features a robust and uncomplicated optical design not requiring a lateral shifting of the optical axis of the objective. Such transverse relative movements between the objective and a capillary vessel in the skin are preferably performed by mechanically shifting the skin with respect to the objective of the measurement head. Moreover, the measurement head is adapted to host one or more pressure sensors measuring the contact pressure between the measurement head and the skin. This pressure information can further be exploited in order to calibrate the spectroscopic analysis means, to regulate the contact pressure within predefined margins specifying an optimum range of contact pressure for spectroscopic examination of capillary vessels.
摘要翻译：本发明提供了将用于分光系统的测量头附接和固定到患者皮肤的各种不同部分的有效方法。测量头优选地具有紧凑的设计，提供灵活的处理，并且考虑到皮肤的各个部分的多个性质，提供了各种各样的应用领域。此外，测量头具有坚固且不复杂的光学设计，不需要物镜的光轴的横向偏移。物体和皮肤中的毛细血管之间的这种横向相对移动优选通过相对于测量头的目标机械地移动皮肤来执行。此外，测量头适于承载测量测量头与皮肤之间的接触压力的一个或多个压力传感器。可以进一步利用该压力信息来校准光谱分析装置，以调节预定余量内的接触压力，从而规定用于毛细血管的光谱检查的最佳接触压力范围。

3. 发明申请

WO2005064314A1 OPTICAL ANALYSIS SYSTEM, BLOOD ANALYSIS SYSTEM AND METHOD OF DETERMINING AN AMPLITUDE OF A PRINCIPAL COMPONENT 审中-公开
标题翻译：光学分析系统，血液分析系统和确定主成分振幅的方法
公开(公告)号：WO2005064314A1
公开(公告)日：2005-07-14
申请号：PCT/IB2004/052786
申请日：2004-12-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , VAN BEEK, Michael, Cornelis , BAKKER, Bernardus, Leonardus, Gerardus , RENSEN, Wouter, Harry, Jacinth , SCHUURMANS, Frank, Jeroen, Pieter
发明人： VAN BEEK, Michael, Cornelis , BAKKER, Bernardus, Leonardus, Gerardus , RENSEN, Wouter, Harry, Jacinth , SCHUURMANS, Frank, Jeroen, Pieter
IPC分类号： G01N21/31
CPC分类号： G01N21/31 , G01J3/28 , G01N21/274 , G01N21/64 , G01N21/6445 , G01N21/65 , G01N2021/3196 , G01N2021/6417 , G01N2021/655
摘要： The optical analysis system (20) is arranged to determine an amplitude of a principal component of an optical signal. The optical analysis system (20) comprises a multivariate optical element (5, 6) for weighing the optical signal by a spectral weighing function and a detector (7, 8) for detecting the weighed optical signal. The optical signal comprises the principal component and a further component which was not accounted for when designing the spectral weighing function. Therefore, the detected weighed optical signal comprises a part relating to the amplitude of the principal component and a further part relating to a further amplitude of the further component. The optical analysis system (20) further comprises a modulator element (13) for modulating the detected weighed optical signal. The difference between the modulated detected weighed optical signal and the detected weighed optical signal relates to the amplitude of the principal component and thus allows for determining the amplitude of the principal component in an accurate way. The blood analysis system (40) comprises such an optical analysis system (20). The method of determining an amplitude of an principal component makes use of the optical analysis system (20).
摘要翻译：光学分析系统（20）被布置成确定光信号的主分量的幅度。光学分析系统（20）包括用于通过光谱称重功能称量光信号的多元光学元件（5,6）和用于检测加权光信号的检测器（7,8）。光信号包括主分量和另外的分量，这在设计光谱称重功能时不被考虑。因此，检测到的加权光信号包括与主分量的振幅有关的部分，以及与另一分量的另一幅度相关的另一部分。光学分析系统（20）还包括用于调制检测到的称重光信号的调制器元件（13）。调制检测到的称重光信号与检测到的称重光信号之间的差异与主分量的振幅有关，因此允许以准确的方式确定主分量的振幅。血液分析系统（40）包括这样的光学分析系统（20）。确定主成分的振幅的方法利用光学分析系统（20）。

4. 发明申请

WO2005037094A1 A METHOD OF DETERMINING A PROPERTY OF A FLUID AND SPECTROSCOPIC SYSTEM 审中-公开
标题翻译：一种确定流体和光谱系统性质的方法
公开(公告)号：WO2005037094A1
公开(公告)日：2005-04-28
申请号：PCT/IB2004/052110
申请日：2004-10-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , RENSEN, Wouter, Harry, Jacinth , VAN BEEK, Michael, Cornelis , VAN DER VOORT, Marjolein , BAKKER, Bernardus, Leonardus, Gerardus , LUCASSEN, Gerhardus, Wilhelmus , TUKKER, Teunis, Willem
发明人： RENSEN, Wouter, Harry, Jacinth , VAN BEEK, Michael, Cornelis , VAN DER VOORT, Marjolein , BAKKER, Bernardus, Leonardus, Gerardus , LUCASSEN, Gerhardus, Wilhelmus , TUKKER, Teunis, Willem
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0068 , A61B5/489
摘要： The present invention enables to determine the property of a fluid, such as for the purposes of in vivo blood analysis. First the position of a volume of interest through which the fluid flows is determined by means of an optical detection step by making use of an objective. Preferably the optical detection step is an imaging step. Next the objective is moved to bring the focal point of the objective to the volume of interest. In this position an optical spectroscopic step is performed. This has the advantage that the measurement beam for performing the optical spectroscopy travels along the optical axis for optimum efficiency.
摘要翻译：本发明能够确定流体的性质，例如用于体内血液分析的目的。首先，通过利用目标通过光学检测步骤来确定流体流过的感兴趣体积的位置。优选地，光学检测步骤是成像步骤。接下来，将目标转移到目标的焦点。在该位置，进行光学分光步骤。这具有以下优点：用于执行光学光谱的测量光束沿着光轴行进以获得最佳效率。

5. 发明申请

WO2012069637A1 DEVICE AND METHOD FOR DETERMINING A DISEASE ACTIVITY 审中-公开
标题翻译：用于确定疾病活动的装置和方法
公开(公告)号：WO2012069637A1
公开(公告)日：2012-05-31
申请号：PCT/EP2011/071043
申请日：2011-11-25
申请人： AKESO MEDICAL IMAGING B.V. , RENSEN, Wouter Harry Jacinth , DE BOKX, Pieter Klaas
发明人： RENSEN, Wouter Harry Jacinth , DE BOKX, Pieter Klaas
IPC分类号： A61B5/00
CPC分类号： A61B5/0082 , A61B5/0075 , A61B5/022 , A61B5/0261 , A61B5/4528 , A61B5/4842 , A61B5/6825 , A61B5/6829
摘要： For determining a disease activity as a single value by means of optical measurements in order to facilitate an analysis of a current disease status and a future course of disease, thus assisting a doctor's diagnosis or decision on a therapy, a system and a method are provided, wherein a blood perfusion is varied in an area of interest; the area of interest is irradiated with light of at least two wavelengths; an intensity of light reflected and/or transmitted by the area of interest is detected; features are derived from detected intensity curves of at least two predetermined wavelengths under at least two different perfusion conditions; and the disease activity is determined using these features.
摘要翻译：为了通过光学测量将疾病活动确定为单一值，以便于分析当前疾病状况和未来疾病进程，从而帮助医生对治疗的诊断或决定，提供系统和方法，其中在感兴趣区域中改变血液灌注; 用至少两个波长的光照射感兴趣的区域; 检测由感兴趣区域反射和/或传输的光的强度; 特征从至少两个不同灌注条件下的至少两个预定波长的检测强度曲线导出; 并且使用这些特征确定疾病活动。

6. 发明申请

WO2005104932A1 PROBE HEAD FOR SPECTROSCOPIC ANALYSIS OF A FLUID 审中-公开
标题翻译：用于流体光谱分析的探头
公开(公告)号：WO2005104932A1
公开(公告)日：2005-11-10
申请号：PCT/IB2005/050564
申请日：2005-02-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , LUCASSEN, Gerhardus Wilhelmus , RENSEN, Wouter Harry Jacinth , VAN BEEK, Michael Cornelis , VAN DER VOORT, Marjolein , BAKKER, Bernardus Leonardus Gerardus
发明人： LUCASSEN, Gerhardus Wilhelmus , RENSEN, Wouter Harry Jacinth , VAN BEEK, Michael Cornelis , VAN DER VOORT, Marjolein , BAKKER, Bernardus Leonardus Gerardus
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/489 , A61B2562/0242
摘要： The present invention provides a spectroscopic system for determining a property of a fluid flowing through a volume of interest underneath the surface of the skin of a patient. The spectroscopic system comprises a probe head that has at least an objective for directing an excitation beam into the volume of interest and for collecting return radiation. The spectroscopic system has further a base station having at least a spectroscopic analysis unit and a power supply. The system makes use of a beam combination unit, a filter unit and a focusing unit for combining and separating a variety of different optical signals and for precisely positioning the optical signals inside the volume of interest. The beam combination unit, the filter unit and the focusing unit can be variably implemented inside the probe head or inside the base station depending on a specific applications of the spectroscopic system, thereby allowing for a flexible and compact design of the probe head.
摘要翻译：本发明提供了一种用于确定流过患者皮肤表面下方的感兴趣体积的流体的性质的光谱系统。分光系统包括探头，该探头至少具有将激发光束引导到感兴趣体积中并用于收集返回辐射的目的。光谱系统还具有至少具有光谱分析单元和电源的基站。该系统利用光束组合单元，滤光器单元和聚焦单元，用于组合和分离各种不同的光信号，并将光信号精确地定位在感兴趣的体积内。根据分光系统的具体应用，光束组合单元，滤光器单元和聚焦单元可以可变地实现在探头内部或基站内部，从而允许探头的灵活且紧凑的设计。

7. 发明申请

WO2005107578A1 PROTECTION MECHANISM FOR SPECTROSCOPIC ANALYSIS OF BIOLOGICAL TISSUE 审中-公开
标题翻译：生物组织光谱分析保护机制
公开(公告)号：WO2005107578A1
公开(公告)日：2005-11-17
申请号：PCT/IB2005/051266
申请日：2005-04-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , VAN BEEK, Michael Cornelis , RENSEN, Wouter Harry Jacinth , VAN DER VOORT, Marjolein
发明人： VAN BEEK, Michael Cornelis , RENSEN, Wouter Harry Jacinth , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0531 , A61B2090/065
摘要： The present invention provides a protection mechanism for a spectroscopic analysis system being adapted to determine a property of a biological structure in a volume of interest of a patient. The spectroscopic system preferably makes use of high power radiation, and provides a protection mechanism for preventing an accidental exposure of light sensitive tissue of a body. The invention provides a variety of approaches to detect whether a measurement head of the spectroscopic system is in a measurement position. The measurement position of the measurement head can effectively be determined by making use of e.g. a pressure sensor, a sensor measuring the electric resistance of the skin of the patient, or even by optical means analyzing the intensity or the spatial structure of a monitoring beam providing a visual image of the volume of interest.
摘要翻译：本发明提供了一种用于光谱分析系统的保护机制，其适于确定患者感兴趣体积的生物结构的性质。光谱系统优选利用高功率辐射，并且提供用于防止身体的感光组织的意外暴露的保护机构。本发明提供了多种方法来检测分光系统的测量头是否处于测量位置。测量头的测量位置可以有效地通过使用例如测量头来确定。压力传感器，测量患者皮肤电阻的传感器，或者甚至通过分析提供感兴趣体积的视觉图像的监测光束的强度或空间结构的光学装置来测量。

8. 发明申请

WO2005103778A1 OPTICAL FIBER FOR SPECTROSCOPIC ANALYSIS SYSTEM 审中-公开
标题翻译：光纤光谱分析系统
公开(公告)号：WO2005103778A1
公开(公告)日：2005-11-03
申请号：PCT/IB2005/051204
申请日：2005-04-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , RENSEN, Wouter Harry Jacinth
发明人： RENSEN, Wouter Harry Jacinth
IPC分类号： G02B6/22
CPC分类号： G01J3/02
摘要： The present invention provides an optical fiber for connecting a probe head and a base station of a spectroscopic analysis system for analyzing the molecular composition of a volume of interest. The optical fiber comprises a core for transmission of excitation radiation from the base station to the probe head and a first cladding for transmission of multi-mode return radiation from the probe head to a spectroscopic analysis unit of the base station. Preferably, the first cladding is surrounded by a second cladding and therefore provides a multi-mode wave guide by itself. Appropriately designing the dimensions of the core, the first cladding and the second cladding provides an optimal collection and coupling efficiency of the optical fiber. Coating of the distal end facet of the optical fiber with multi-layer optical filters allows an effective separation of elastically and inelastically scattered radiation which is of advantage for the spectroscopic analysis.
摘要翻译：本发明提供了用于连接用于分析感兴趣体积的分子组成的光谱分析系统的探针头和基站的光纤。光纤包括用于从基站传输到探头的激发辐射的核心和用于将多模返回辐射从探头传输到基站的光谱分析单元的第一包层。优选地，第一包层被第二包层包围，因此本身提供多模式波导。适当地设计芯的尺寸，第一包层和第二包层提供了光纤的最佳收集和耦合效率。使用多层光学滤光器对光纤的远端面进行涂覆，可有效地分离弹性和非弹性散射的辐射，这对于光谱分析是有利的。

9. 发明申请

WO2011158159A1 SYSTEM FOR MONITORING THE POSITION OF A TUBE'S DISTAL END RELATIVE TO A BLOOD VESSEL 审中-公开
标题翻译：用于监测管道与血液管的距离相对位置的系统
公开(公告)号：WO2011158159A1
公开(公告)日：2011-12-22
申请号：PCT/IB2011/052539
申请日：2011-06-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , RENSEN, Judith, Margreet , RENSEN, Wouter, Harry, Jacinth
发明人： RENSEN, Judith, Margreet , RENSEN, Wouter, Harry, Jacinth
IPC分类号： A61M5/168 , A61B5/06
CPC分类号： G01B11/14 , A61B5/065 , A61B5/15003 , A61B5/150396 , A61B5/150511 , A61B5/150748 , A61B5/153 , A61M5/16836 , A61M2205/3306 , A61M2205/3313
摘要： The invention relates to a system (101) for monitoring a position of a distal end (102) of a tube (104) with respect to a blood vessel (106) of a mamma. The system comprises a source (110) for generating an outgoing beam (112) of electromagnetic radiation having a predefined electromagnetic spectrum. The system furthermore comprises a guideway (114) for guiding the outgoing beam to the distal end, and for guiding an incoming beam (116) of electromagnetic radiation reflected by surroundings (118) of the distal end in response to said outgoing beam to a measurement arrangement (120) which is arranged for measuring a parameter (122) associated with an electromagnetic spectrum of the incoming beam. The system furthermore comprises a comparator arrangement (124) for comparing said parameter with a reference parameter (126) associated with a reference electromagnetic spectrum representing a predefined location of the distal end inside the mammal.
摘要翻译：本发明涉及一种用于监测管（104）的远端（102）相对于母体的血管（106）的位置的系统（101）。该系统包括用于产生具有预定电磁光谱的电磁辐射的输出光束（112）的源（110）。该系统还包括用于将出射光束引导到远端的导轨（114），并且用于响应于所述输出光束来引导远端周围环境（118）反射的电磁辐射（116）进行测量布置（120），其布置成用于测量与入射光束的电磁光谱相关联的参数（122）。该系统还包括比较器装置（124），用于将所述参数与参考参数（126）进行比较，参考参数（126）与表示哺乳动物内的远端的预定位置的参考电磁谱相关联。

10. 发明申请

WO2006000939A1 ABERRATION CORRECTION FOR SPECTROSCOPIC ANALYSIS 审中-公开
标题翻译：光谱分析的校正校正
公开(公告)号：WO2006000939A1
公开(公告)日：2006-01-05
申请号：PCT/IB2005/051944
申请日：2005-06-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , VAN BEEK, Michael Cornelis , RENSEN, Wouter Harry Jacinth , LUCASSEN, Gerald , VAN DER VOORT, Marjolein , BAKKER, Bernardus Leonardus Gerardus
发明人： VAN BEEK, Michael Cornelis , RENSEN, Wouter Harry Jacinth , LUCASSEN, Gerald , VAN DER VOORT, Marjolein , BAKKER, Bernardus Leonardus Gerardus
IPC分类号： G02B21/00
CPC分类号： G02B27/0025 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/28
摘要： The present invention provides a spectroscopic system (100) for determining of a property of a biological structure in a volume of interest (120) of a person. The spectroscopic system (100) comprises a low cost objective lens (118) for directing an excitation beam into a volume of interest (120) and for collecting return radiation (124) from the volume of interest (120). After detection of the return radiation (124), i.e. the spectroscopic signals, a correction unit (106) performs the compensation of the aberrations of the spectroscopic signals introduced by the low cost objective lens (118). Since the aberrations of the objective lens (118) strongly depend on the lateral distance (122) of the volume of interest (120) from the optical axis (116) of the objective lens (118), the correction unit (106) makes effective use of a correction table (110) providing an assignment between correction values and various lateral positions (122) of the volume of interest (120).
摘要翻译：本发明提供一种用于确定人的感兴趣体积（120）中的生物结构的性质的光谱系统（100）。分光系统（100）包括用于将激发光束引导到感兴趣体积（120）中并用于从感兴趣体积（120）收集返回辐射（124）的低成本物镜（118）。在检测到返回辐射（124）即分光信号之后，校正单元（106）执行由低成本物镜（118）引入的分光信号的像差的补偿。由于物镜（118）的像差强烈地取决于物镜（118）的光轴（116）的感兴趣体积（120）的横向距离（122），所以校正单元（106）有效使用校正表（110）提供校正值与感兴趣体积（120）的各种侧向位置（122）之间的分配。

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