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1. 发明申请

WO2004051414A3 WAVE GUIDE WITH ISOLATED COUPLING INTERFACE 审中-公开
公开(公告)号：WO2004051414A3
公开(公告)日：2004-06-17
申请号：PCT/US2003/037872
申请日：2003-11-24
申请人： EDC BIOSYSTEMS, INC. , REICHEL, Charles, A. , FORBUSH, Michael, J. , JHUTTY, Tarlochan, S. , NASILEVICH, Marina , VAN TUYL, Michael, R. , SINCLAIR, James, E. , CHOW, Humphrey, W.
发明人： REICHEL, Charles, A. , FORBUSH, Michael, J. , JHUTTY, Tarlochan, S. , NASILEVICH, Marina , VAN TUYL, Michael, R. , SINCLAIR, James, E. , CHOW, Humphrey, W.
IPC分类号： A61M35/00
摘要： Disclosed is an apparatus (1) for high-throughput non-contact liquid transfer. The apparatus (1) may be implemented for high-throughput biological, chemical and biochemical, synthesis and/or screening.

2. 发明申请

WO2003074166A3 APPARATUS AND METHOD FOR COMPOSING HIGH DENSITY MATERIALS ONTO TARGET SUBSTRATES BY A RAPID SEQUENCE 审中-公开
公开(公告)号：WO2003074166A3
公开(公告)日：2003-09-12
申请号：PCT/US2003/006063
申请日：2003-02-26
申请人： EDC BIOSYSTEMS, INC. , WILLIAMS, Roger, O. , REICHEL, Charles, A.
发明人： WILLIAMS, Roger, O. , REICHEL, Charles, A.
IPC分类号： B01J19/00
摘要： A system for composing high-density arrays of biological and chemical materials onto target substrates by a rapid sequence. A system includes a thin liquid transfer plate having a fill side, a dispense side and a plurality of channels extending therethrough. The channels of the liquid transfer plate may be loaded with chemical and or biological materials. Once loaded, the materials are ejected from the liquid transfer plate onto a plurality of target substrates. The system further includes various arm assemblies to manipulate and position the liquid transfer plate and the target plates. Additional liquid transfer plates may be loaded and dispensed onto the plurality of target substrates. Methods for composing a high-density array are also provided.

3. 发明申请

WO03074166A2 APPARATUS AND METHOD FOR COMPOSING HIGH DENSITY MATERIALS ONTO TARGET SUBSTRATES BY A RAPID SEQUENCE 审中-公开
标题翻译：通过快速序列将高密度材料组合到目标基底上的装置和方法
公开(公告)号：WO03074166A2
公开(公告)日：2003-09-12
申请号：PCT/US0306063
申请日：2003-02-26
申请人： EDC BIOSYSTEMS INC , WILLIAMS ROGER O , REICHEL CHARLES A
发明人： WILLIAMS ROGER O , REICHEL CHARLES A
IPC分类号： B01J19/00 , B01L3/00 , B01L3/02 , C40B60/14 , G01N35/02 , G01N35/10
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00317 , B01J2219/0036 , B01J2219/00364 , B01J2219/00418 , B01J2219/00691 , B01J2219/00695 , B01J2219/0072 , B01L3/5025 , B01L3/5088 , B01L2200/04 , B01L2200/0605 , B01L2300/0819 , B01L2400/0487 , C40B60/14 , G01N35/028 , G01N2035/1037 , Y10T436/2575
摘要： A system for composing high-density arrays of biological and chemical materials onto target substrates by a rapid sequence. A system includes a thin liquid transfer plate having a fill side, a dispense side and a plurality of channels extending therethrough. The channels of the liquid transfer plate may be loaded with chemical and or biological materials. Once loaded, the materials are ejected from the liquid transfer plate onto a plurality of target substrates. The system further includes various arm assemblies to manipulate and position the liquid transfer plate and the target plates. Additional liquid transfer plates may be loaded and dispensed onto the plurality of target substrates. Methods for composing a high-density array are also provided.
摘要翻译：一种用于通过快速顺序将生物和化学材料的高密度阵列组合到靶基质上的系统。一种系统包括具有填充侧，分配侧和延伸穿过其中的多个通道的薄液体转移板。液体转移板的通道可以装载化学和/或生物材料。一旦装载，材料从液体转移板喷射到多个目标基底上。该系统还包括用于操纵和定位液体转移板和靶板的各种臂组件。附加的液体转移板可以装载并分配到多个目标基底上。还提供了组合高密度阵列的方法。

4. 发明申请

WO2004051414A2 WAVE GUIDE WITH ISOLATED COUPLING INTERFACE 审中-公开
标题翻译：带有隔离耦合接口的波导
公开(公告)号：WO2004051414A2
公开(公告)日：2004-06-17
申请号：PCT/US0337872
申请日：2003-11-24
申请人： EDC BIOSYSTEMS INC , REICHEL CHARLES A , FORBUSH MICHAEL J , JHUTTY TARLOCHAN S , NASILEVICH MARINA , VAN TUYL MICHAEL R , SINCLAIR JAMES E , CHOW HUMPHREY W
发明人： REICHEL CHARLES A , FORBUSH MICHAEL J , JHUTTY TARLOCHAN S , NASILEVICH MARINA , VAN TUYL MICHAEL R , SINCLAIR JAMES E , CHOW HUMPHREY W
IPC分类号： A61M35/00 , G06F20060101 , G06F
CPC分类号： A61M35/00 , G06F1/00
摘要： Disclosed is an apparatus for high-throughput non-contact liquid transfer. The high-throughput non-contact liquid transfer apparatus may be implemented for high-throughput biological, chemical and biochemical, synthesis and/or screening. In one variation, the apparatus comprise of an acoustic emitter, one or more X/Y linear stage with associated handling device, one or more storage queue, and an image detection system. The apparatus may be controlled by a centralized system controller with associated electronic and/or software. The apparatus may further be integrated within a frame with environment and safety enclosure. The system controller may control positioning of source vessel and target device relative to an acoustic emitter device. The system controller may also track the location of all the source well plates and target well plates, thus providing for user-defined association of any well on any source well plate with any well on any target well plate for liquid transfer.
摘要翻译：公开了一种用于高通量非接触液体转移的装置。高通量非接触式液体输送装置可以用于高通量生物，化学和生化，合成和/或筛选。在一个变型中，该装置包括声发射器，一个或多个具有相关处理装置的X / Y线性平台，一个或多个存储队列和图像检测系统。该装置可以由具有相关联的电子和/或软件的集中式系统控制器来控制。该装置还可以与环境和安全壳体集成在框架内。系统控制器可以控制源容器和目标装置相对于声发射器装置的定位。系统控制器还可以跟踪所有源阱板和目标阱板的位置，从而在任何源阱板上的任何阱与用于液体转移的任何目标阱板上的任何井提供用户定义的关联。

5. 发明申请

WO03039760A2 APPARATUS AND METHOD FOR CONTROLLING THE FREE SURFACE OF LIQUID IN A WELL PLATE 审中-公开
标题翻译：用于控制井壁中的液体的自由表面的装置和方法
公开(公告)号：WO03039760A2
公开(公告)日：2003-05-15
申请号：PCT/US0235619
申请日：2002-11-05
申请人： EDC BIOSYSTEMS INC , WILLIAMS ROGER O , CHOW HUMPHREY , REICHEL CHARLES A , SINCLAIR JAMES E , FORBUSH MICHAEL J , VAN TUYL MICHAEL
发明人： WILLIAMS ROGER O , CHOW HUMPHREY , REICHEL CHARLES A , SINCLAIR JAMES E , FORBUSH MICHAEL J , VAN TUYL MICHAEL
IPC分类号： B01L3/00 , B41J2/14 , G01N35/10 , B05C
CPC分类号： B01L3/50853 , B01L3/5085 , B01L2200/0642 , B01L2200/14 , B01L2300/047 , B01L2300/0838 , B01L2400/0406 , B41J2/14008 , G01N2035/1041
摘要： Devices useful in liquid transfer applications and in particular, devices for controlling the free surface of a source liquid in acoustic liquid ejection systems are disclosed. The devices advantageously maintain a source liquid to be transferred at a constant height and reduce disturbances formed in the liquid due to droplet ejection. In one variation, a well plate includes a plurality of wells each having a capillary. Source liquid in a well moves up the capillary due to capillary action and arrives at a certain height. The height arrived at remains constant despite the source liquid depleting from the well during the ejection process. The capillary can be separately joined or integral with the well plate, In another variation, an insert includes a capillary tube and at least one support attached thereto. In another variation, a device includes a plurality of capillary tubes joined together by a frame or other substrate. The device is positioned atop a well plate such that the capillary tubes align with and extend into the wells. In yet another variation, an insert includes a tubular member having a liquid restricting inlet. The restricting inlet is sufficiently small such that liquid forms a meniscus at the inlet. Methods for controlling the free surface of a source liquid in a source fluid container are also disclosed.
摘要翻译：公开了可用于液体转移应用的装置，特别是用于控制声学液体喷射系统中源液体的自由表面的装置。这些装置有利地将待传输的源液体保持在恒定的高度并且减少由于液滴喷射而在液体中形成的干扰。在一个变型中，孔板包括多个具有毛细管的孔。井中的源液体由于毛细作用而向上移动毛细管并达到一定的高度。尽管在喷射过程中源的液体从井中耗尽，达到的高度保持恒定。毛细管可以单独地与孔板连接或成一体。在另一个实施例中，插入件包括毛细管和附接到其上的至少一个支撑件。在另一个实施例中，一种装置包括通过框架或其它基底连接在一起的多个毛细管。该装置位于孔板顶部，使得毛细管与孔对准并延伸到孔中。在又一个变型中，插入件包括具有液体限制入口的管状构件。限制入口足够小，使得液体在入口处形成弯液面。还公开了用于控制源流体容器中源液体的游离表面的方法。

6. 发明申请

WO2003039760A3 APPARATUS AND METHOD FOR CONTROLLING THE FREE SURFACE OF LIQUID IN A WELL PLATE 审中-公开
公开(公告)号：WO2003039760A3
公开(公告)日：2003-05-15
申请号：PCT/US2002/035619
申请日：2002-11-05
申请人： EDC BIOSYSTEMS INC. , WILLIAMS, Roger, O. , CHOW, Humphrey , REICHEL, Charles, A. , SINCLAIR, James, E. , FORBUSH, Michael, J. , VAN TUYL, Michael
发明人： WILLIAMS, Roger, O. , CHOW, Humphrey , REICHEL, Charles, A. , SINCLAIR, James, E. , FORBUSH, Michael, J. , VAN TUYL, Michael
IPC分类号： B41J2/135
摘要： Devices useful in liquid transfer applications and in particular, devices for controlling the free surface (150) of a source liquid in acoustic liquid ejection systems are disclosed. The devices advantageously maintain a source liquid (40) to be transferred at a constant height and reduce disturbances formed in the liquid (40) due to droplet ejection. In one variation, a well plate (100) includes a plurality of wells (102) each having a capillary (104). Source liquid (40) in a well (206) moves up the capillary (104) due to capillary action and arrives at a certain height. The height arrived at remains constant despite the source liquid (40) depleting from the well (206) during the ejection process. The capillary (104) can be separately joined or integral with the well plate (100). In another variation, an insert (400) includes a capillary tube (204) and at least one support (402) attached thereto. In another variation, a device includes a plurality of capillary tubes (404) joined together by a frame (210) or other substrate. The device is positioned atop a well plate (300) such that the capillary tubes (404) align with and extend into the wells (310). In yet another variation, an insert (800) includes a tubular member (805) having a liquid restricting inlet (810). The restricting inlet (810) is sufficiently small such that liquid forms a meniscus at the inlet (810). Methods for controlling the free surface of a source liquid in a source fluid container are also disclosed.

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