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1. 发明申请

WO03059256A2 GENES OVEREXPRESSES BY OVARIAN CANCER AND THEIR USE IN DEVELOPING NOVEL THERAPEUTICS ESPECIALLY ANTIBODIES 审中-公开
标题翻译：由OVARIAN癌症引起的超表现及其在开发新型治疗药物中的应用特别抗体
公开(公告)号：WO03059256A2
公开(公告)日：2003-07-24
申请号：PCT/US0240861
申请日：2002-12-23
申请人： IDEC PHARMA CORP , MCLACHLAN KAREN , REFF MITCHELL , DANIELS MARK
发明人： MCLACHLAN KAREN , REFF MITCHELL , DANIELS MARK
IPC分类号： C12Q1/68 , A61K
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： Nucleic acid sequences encoding genes that are overexpressed by human ovarian cancers are provided. These genes and the corresponding antigens are useful diagnostic and therapeutic targets. The invention provides cancer therapies that target these antigens, especially using monoclonal antibodies that target the Anat-2 antigen.
摘要翻译：提供编码人卵巢癌过表达基因的核酸序列。这些基因和相应的抗原是有用的诊断和治疗靶点。本发明提供靶向这些抗原的癌症疗法，特别是使用靶向Anat-2抗原的单克隆抗体。

2. 发明申请

WO2003048306A3 POLYCISTRONIC EXPRESSION OF ANTIBODIES 审中-公开
公开(公告)号：WO2003048306A3
公开(公告)日：2003-06-12
申请号：PCT/US2002/036856
申请日：2002-11-18
申请人： IDEC PHARMACEUTICALS CORPORATION , REFF, Mitchell , BARNETT, Richard
发明人： REFF, Mitchell , BARNETT, Richard
IPC分类号： C12N15/63
摘要： Described herein is a novel expression system for producing multiple gene products of interest from a single polycistronic construct. In particular, the expression system contains a polycistronic vector capable of expressing functional antibodies in eukaryotic host cells, which vector contains at least the following elements operably linked in the 5' to 3' orientation: a promoter operable in a eukaryotic cell; a DNA sequence encoding at least the variable region of an antibody light chain; an internal ribosome entry site (IRES); and at least one DNA sequence encoding an antibody heavy chain. Also disclosed are mammalian cells containing the polycistronic expression vector, and a method of producing functional antibodies in mammalian cells transfected with the polycistronic expression vector.

3. 发明申请

WO2008121876A2 NON-FUCOSYLATED ANTIBODIES 审中-公开
标题翻译：非结合抗体
公开(公告)号：WO2008121876A2
公开(公告)日：2008-10-09
申请号：PCT/US2008/058750
申请日：2008-03-28
申请人： BIOGEN IDEC INC. , REFF, Mitchell , HARIHARAN, Kandasamy , MACLAREN, Ann
发明人： REFF, Mitchell , HARIHARAN, Kandasamy , MACLAREN, Ann
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
CPC分类号： C07K16/2851 , A61K39/3955 , A61K45/06 , C07K16/2827 , C07K16/2887 , C07K2317/24 , C07K2317/41 , C07K2317/72 , C07K2317/732
摘要： The present invention provides non-fucosylated therapeutic antibodies. More particularly, the invention provides non-fucosylated anti-CD20, anti-CD23 and anti-CD80 antibodies, which show enhanced antibody effector functions. Also provided are cells expressing the non-fucosylated antibodies and therapeutic methods using the non-fucosylated antibodies.
摘要翻译：本发明提供非岩藻糖化治疗性抗体。更具体地，本发明提供非岩藻糖基化抗CD20，抗CD23和抗CD80抗体，其显示增强的抗体效应子功能。还提供了表达非岩藻糖基化抗体的细胞和使用非岩藻糖基化抗体的治疗方法。

4. 发明申请

WO2005000899A3 MODIFIED BINDING MOLECULES COMPRISING CONNECTING PEPTIDES 审中-公开
标题翻译：包含连接肽的修饰的结合分子
公开(公告)号：WO2005000899A3
公开(公告)日：2005-08-11
申请号：PCT/US2004020945
申请日：2004-06-28
申请人： BIOGEN IDEC INC , GLASER SCOTT , REFF MITCHELL , YANG TZUNG-HORNG , WU XIUFENG , CHINN PAUL
发明人： GLASER SCOTT , REFF MITCHELL , YANG TZUNG-HORNG , WU XIUFENG , CHINN PAUL
IPC分类号： A61K39/00 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/30 , C12N15/62
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/2851 , C07K16/30 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/622 , C07K2317/624 , C07K2319/00
摘要： The instant invention describes methods of separating or preferentially synthesizing dimers which are linked via at least one interchain disulfide linkage from dimers which are not linked via at least one interchain disulfide linkage from a mixture comprising the two types of polypeptide dimers. These forms can be separated from each other using hydrophobic interaction chromatography. In addition, the invention pertains to connecting peptides that result in the preferential biosynthesis of dimers that are linked via at least one interchain disulfide linkage or that are not linked via at least one interchain disulfide linkage. The invention also pertains to compositions in which a majority of the dimers are linked via at least one interchain disulfide linkage or are not linked via at least one interchain disulfide linkage. The invention still further pertains to novel binding molecules, e.g., comprising; connecting peptides of the invention.
摘要翻译：本发明描述了分离或优先合成二聚体的方法，二聚体通过至少一个链间二硫键连接，二聚体不通过至少一个链间二硫键与包含两种类型的多肽二聚体的混合物连接。这些形式可以使用疏水相互作用色谱法彼此分离。此外，本发明涉及连接导致通过至少一个链间二硫键连接或不通过至少一个链间二硫键连接的二聚体的优先生物合成的肽。本发明还涉及其中大多数二聚体通过至少一个链间二硫键连接或不通过至少一个链间二硫键连接的组合物。本发明还涉及新颖的结合分子，例如包含：连接本发明的肽。

5. 发明申请

WO2008121876A3 NON-FUCOSYLATED ANTIBODIES 审中-公开
标题翻译：非结合抗体
公开(公告)号：WO2008121876A3
公开(公告)日：2009-01-22
申请号：PCT/US2008058750
申请日：2008-03-28
申请人： BIOGEN IDEC INC , REFF MITCHELL , HARIHARAN KANDASAMY , MACLAREN ANN
发明人： REFF MITCHELL , HARIHARAN KANDASAMY , MACLAREN ANN
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
CPC分类号： C07K16/2851 , A61K39/3955 , A61K45/06 , C07K16/2827 , C07K16/2887 , C07K2317/24 , C07K2317/41 , C07K2317/72 , C07K2317/732
摘要： Provision of non-fucosylated therapeutic antibodies. More particularly non-fucosylated anti-CD20, anti-CD23 and anti-CD80 antibodies, which show enhanced antibody effector functions. Also provided are cells expressing the non-fucosylated antibodies and therapeutic methods using the non-fucosylated antibodies.
摘要翻译：提供非岩藻糖化治疗性抗体。更具体地，非岩藻糖化的抗CD20，抗CD23和抗CD80抗体，其显示增强的抗体效应子功能。还提供了表达非岩藻糖基化抗体的细胞和使用非岩藻糖基化抗体的治疗方法。

6. 发明申请

WO2004111194A3 METHOD TO INCREASE PROTEIN PRODUCTION IN CULTURE 审中-公开
标题翻译：增加文化中蛋白质生产的方法
公开(公告)号：WO2004111194A3
公开(公告)日：2005-03-24
申请号：PCT/US2004018185
申请日：2004-06-10
申请人： BIOGEN IDEC INC , AILOR ERIC N , REFF MITCHELL E
发明人： AILOR ERIC N , REFF MITCHELL E
IPC分类号： A61K9/70 , B32B27/12 , C07K14/47 , C07K16/28 , C12N20060101 , C12N5/00 , C12N15/00 , C12N15/63 , C12P21/02 , C12P21/06 , C12Q1/68 , G01N33/567
CPC分类号： C12P21/02 , C07K14/4705 , C07K16/2875 , C07K2317/24 , Y10T442/2525
摘要： A new recombinant protein production methodology has been discovered for expression of genes of interest. This should be useful for low or poorly expressing genes and in cellular production of high levels of proteins when such high levels may be detrimental or stressful to cells. Isolated polynucleotides encoding a spliced form XBP-l, ATF6, and eIF2alpha S51A are disclosed. Expression vectors comprising these polynucleotides are useful in increasing the specific cellular productivity in a cell expressing a polypeptide of interest by augmenting the unfolded protein response in a cell. Finally, methods to increase specific cellular productivity in mammalian cells using the above mentioned polynucleotides are also disclosed.
摘要翻译：已经发现新的重组蛋白质生产方法用于表达感兴趣的基因。这对于低表达或表达差的基因以及在高水平蛋白质的细胞产生中可能是有用的，当这种高水平可能是有害的或对细胞的压力。公开了编码剪接形式XBP-1，ATF6和eIF2αS51A的分离的多核苷酸。包含这些多核苷酸的表达载体可用于通过增加细胞中未折叠的蛋白质应答来增加表达目标多肽的细胞中的特异性细胞生产力。最后，还公开了使用上述多核苷酸增加哺乳动物细胞中特异性细胞生产力的方法。

7. 发明申请

WO2003059256A3 GENES OVEREXPRESSES BY OVARIAN CANCER AND THEIR USE IN DEVELOPING NOVEL THERAPEUTICS ESPECIALLY ANTIBODIES 审中-公开
公开(公告)号：WO2003059256A3
公开(公告)日：2003-07-24
申请号：PCT/US2002/040861
申请日：2002-12-23
申请人： IDEC PHARMACEUTICALS CORPORATION , MCLACHLAN, Karen , REFF, Mitchell , DANIELS, Mark
发明人： MCLACHLAN, Karen , REFF, Mitchell , DANIELS, Mark
IPC分类号： C07H21/04
摘要： Nucleic acid sequences encoding genes that are overexpressed by human ovarian cancers are provided. These genes and the corresponding antigens are useful diagnostic and therapeutic targets. The invention provides cancer therapies that target these antigens, especially using monoclonal antibodies that target the Anat-2 antigen.

8. 发明申请

WO2004111194A2 METHOD TO INCREASE PROTEIN PRODUCTION IN CULTURE 审中-公开
标题翻译：增加文化中蛋白质生产的方法
公开(公告)号：WO2004111194A2
公开(公告)日：2004-12-23
申请号：PCT/US2004/018185
申请日：2004-06-10
申请人： AILOR, Eric, N. , REFF, Mitchell, E.
发明人： AILOR, Eric, N. , REFF, Mitchell, E.
IPC分类号： C12N
CPC分类号： C12P21/02 , C07K14/4705 , C07K16/2875 , C07K2317/24 , Y10T442/2525
摘要： A new recombinant protein production methodology has been discovered for expression of genes of interest. This should be useful for low or poorly expressing genes and in cellular production of high levels of proteins when such high levels may be detrimental or stressful to cells. Isolated polynucleotides encoding a spliced form XBP-l, ATF6, and eIF2α S51A are disclosed. Expression vectors comprising these polynucleotides are useful in increasing the specific cellular productivity in a cell expressing a polypeptide of interest by augmenting the unfolded protein response in a cell. Finally, methods to increase specific cellular productivity in mammalian cells using the above mentioned polynucleotides are also disclosed.
摘要翻译：已经发现新的重组蛋白质生产方法用于表达感兴趣的基因。这对于低表达或表达差的基因以及在高水平蛋白质的细胞产生中可能是有用的，当这种高水平可能是有害的或对细胞的压力。公开了编码剪接形式XBP-1，ATF6和eIF2αS51A的分离的多核苷酸。包含这些多核苷酸的表达载体可用于通过增加细胞中未折叠的蛋白质应答来增加表达目标多肽的细胞中的特异性细胞生产力。最后，还公开了使用上述多核苷酸增加哺乳动物细胞中特异性细胞生产力的方法。

9. 发明申请

WO03006607A9 INHIBITION OF APOPTOSIS PROCESS AND IMPROVEMENT OF CELL PERFORMANCE 审中-公开
标题翻译：抑制过程和细胞表现的改善
公开(公告)号：WO03006607A9
公开(公告)日：2003-04-10
申请号：PCT/US0221606
申请日：2002-07-10
申请人： IDEC PHARMA CORP , REFF MITCHELL , BETENBAUGH MICHAEL J , FIGUEROA BRUNO JR , AILOR ERIC , HARDWICK MARIE
发明人： REFF MITCHELL , BETENBAUGH MICHAEL J , FIGUEROA BRUNO JR , AILOR ERIC , HARDWICK MARIE
IPC分类号： C12N15/09 , A61K35/12 , A61K39/00 , A61K48/00 , A61P43/00 , C07K14/47 , C07K14/72 , C07K16/28 , C12N5/08 , C12N5/10 , C12N15/67 , C12N15/85 , C12P21/02 , C12N
CPC分类号： C07K14/4747 , A61K39/00 , A61K48/005 , C07K14/721 , C07K16/2875 , C07K2319/00 , C12N15/67 , C12N15/85 , C12N2800/108 , C12N2830/002 , C12N2830/15 , C12N2840/20 , C12N2840/44
摘要： The present invention relates to preventing or delaying programmed cell death by expressing one or more anti-apoptotic polypeptides in a cell such that programmed cell death in the cell is prevented or delayed. The present invention also relates to increasing production of a cell-related product by expressing one or more anti-apoptotic polypeptides in a cell such that production of the cell-related product by the cell is increased. Recombinant cells useful for producing cell-related product or cellular therapy are also provided.
摘要翻译：本发明涉及通过在细胞中表达一种或多种抗细胞凋亡多肽来防止或延缓程序性细胞死亡，使得细胞中的程序性细胞死亡被阻止或延迟。本发明还涉及通过在细胞中表达一种或多种抗细胞凋亡多肽来增加细胞相关产品的生产，从而增加细胞产生细胞相关产物。还提供了可用于产生细胞相关产物或细胞治疗的重组细胞。

10. 发明申请

WO2002079255A1 RECOMBINANT ANTIBODIES COEXPRESSED WITH GnTIII 审中-公开
标题翻译：与GnTIII共同表达的重组抗体
公开(公告)号：WO2002079255A1
公开(公告)日：2002-10-10
申请号：PCT/US2002/010164
申请日：2002-04-02
申请人： IDEC PHARMACEUTICALS CORPORATION , REFF, Mitchell, E. , DAVIES, Julian
发明人： REFF, Mitchell, E. , DAVIES, Julian
IPC分类号： C07K16/00
CPC分类号： C12N9/1051 , A61K2039/505 , C07K16/00 , C07K16/2896 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C12P21/005 , Y02A50/466
摘要： Methods, compositions and kits comprising antibodies for the treatment of neoplastic, autoimmune or other disorders are provided.
摘要翻译：提供了包含用于治疗肿瘤，自身免疫或其他疾病的抗体的方法，组合物和试剂盒。

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