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1. 发明申请

WO2010121141A1 COMPOSITIONS AND METHODS TO TREAT ACUTE MYELOGENOUS LEUKEMIA 审中-公开
标题翻译：组合物和治疗急性髓性白血病的方法
公开(公告)号：WO2010121141A1
公开(公告)日：2010-10-21
申请号：PCT/US2010/031407
申请日：2010-04-16
申请人： BIOGEN IDEC MA INC. , MCLACHLAN, Karen
发明人： MCLACHLAN, Karen
IPC分类号： A61K39/395
CPC分类号： C07K16/2842 , C07K2317/24 , C07K2317/76
摘要： Compositions and methods for treating or preventing a hematologic malignancy, such as AML, using an antι-alpha4 antibody in combination with chemotherapy agents in a therapeutically effective amount The method includes administering to the patient a therapeutically effective amount of a composition containing an antagonist of an interaction between an integnn with an alpha4 subunit (VLA-4) and a ligand for this integnn (VCAM-1)
摘要翻译：治疗或预防血液恶性肿瘤的组合物和方法，例如使用抗α-α4抗体与化疗剂联合治疗有效量的AML。该方法包括向患者施用治疗有效量的含有拮抗剂与α4亚基（VLA-4）的整合与该内含子（VCAM-1）的配体之间的相互作用

2. 发明申请

WO2004066933A3 COMPOSITIONS AND METHODS FOR TREATING CANCER USING IGSF9 AND LIV-1 审中-公开
标题翻译：使用IGSF9和LIV-1治疗癌症的组合物和方法
公开(公告)号：WO2004066933A3
公开(公告)日：2006-03-02
申请号：PCT/US2004002044
申请日：2004-01-27
申请人： BIOGEN IDEC INC , MCLACHLAN KAREN , GLASER SCOTT , PEACH ROBERT J , ROWE TONY
发明人： MCLACHLAN KAREN , GLASER SCOTT , PEACH ROBERT J , ROWE TONY
IPC分类号： A61K20060101 , A61K6/00 , A61K39/00 , A61K39/395 , A61K48/00 , A61K51/00 , A61K51/10 , A61P35/00 , C07H21/00 , C07K14/47 , C07K14/705 , C07K16/28 , C07K16/30 , C07K16/46 , C12N15/12 , C12Q1/68 , G01N33/574 , C07K16/00
CPC分类号： C07K14/70503 , A61K51/1027 , A61K51/1045 , C07K14/47 , C07K16/2803 , C07K16/30 , C07K2319/30
摘要： Human IGSF9 and LIV-1 polypeptides and DNA (RNA) encoding such polypeptides are disclosed. The disclosed polypeptides and/or polynucleotide are particularly useful generating antibodies, both modified and native, which bind IGSF9 or LIV-1. Also disclosed are pharmaceutical compositions and vaccines comprising the antibodies, polypeptides and polynucleotides of the invention. Also disclosed are methods for utilizing such polypeptides for identifying ligands, antagonists and agonists to said polypeptides. Finally, methods comprising the above-mentioned compositions are disclosed for the treatment, diagnosis, and/or prognosis of neoplastic disorders.
摘要翻译：公开了人IGSF9和LIV-1多肽和编码这种多肽的DNA（RNA）。公开的多肽和/或多核苷酸是特别有用的，其产生结合IGSF9或LIV-1的经修饰和天然的抗体。还公开了包含本发明的抗体，多肽和多核苷酸的药物组合物和疫苗。还公开了利用这些多肽鉴定所述多肽的配体，拮抗剂和激动剂的方法。最后，公开了包含上述组合物的方法用于肿瘤性疾病的治疗，诊断和/或预后。

3. 发明申请

WO2004046342A3 NOVEL GENE TARGETS AND LIGANDS THAT BIND THERETO FOR TREATMENT AND DIAGNOSIS OF CARCINOMAS 审中-公开
标题翻译：新的基因靶点和配体结合治疗和诊断CARCINOMAS
公开(公告)号：WO2004046342A3
公开(公告)日：2004-08-05
申请号：PCT/US0337206
申请日：2003-11-20
申请人： BIOGEN IDEC INC , MCLACHLAN KAREN , GATELY DENNIS P
发明人： MCLACHLAN KAREN , GATELY DENNIS P
IPC分类号： C12Q1/68 , C07K14/435
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： Isolated nucleic acids and proteins that are overexpressed in human cancers, and antibodies that specifically bind the proteins, which are useful diagnostic and therapeutic targets.
摘要翻译：在人类癌症中过表达的分离的核酸和蛋白质以及特异性结合蛋白质的抗体，这些蛋白质是有用的诊断和治疗靶标。

4. 发明申请

WO03059256A2 GENES OVEREXPRESSES BY OVARIAN CANCER AND THEIR USE IN DEVELOPING NOVEL THERAPEUTICS ESPECIALLY ANTIBODIES 审中-公开
标题翻译：由OVARIAN癌症引起的超表现及其在开发新型治疗药物中的应用特别抗体
公开(公告)号：WO03059256A2
公开(公告)日：2003-07-24
申请号：PCT/US0240861
申请日：2002-12-23
申请人： IDEC PHARMA CORP , MCLACHLAN KAREN , REFF MITCHELL , DANIELS MARK
发明人： MCLACHLAN KAREN , REFF MITCHELL , DANIELS MARK
IPC分类号： C12Q1/68 , A61K
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： Nucleic acid sequences encoding genes that are overexpressed by human ovarian cancers are provided. These genes and the corresponding antigens are useful diagnostic and therapeutic targets. The invention provides cancer therapies that target these antigens, especially using monoclonal antibodies that target the Anat-2 antigen.
摘要翻译：提供编码人卵巢癌过表达基因的核酸序列。这些基因和相应的抗原是有用的诊断和治疗靶点。本发明提供靶向这些抗原的癌症疗法，特别是使用靶向Anat-2抗原的单克隆抗体。

5. 发明申请

WO2011130603A2 ANTI-VLA-4 ANTIBODIES 审中-公开
标题翻译：抗VLA-4抗体
公开(公告)号：WO2011130603A2
公开(公告)日：2011-10-20
申请号：PCT/US2011/032641
申请日：2011-04-15
申请人： BIOGEN IDEC MA INC. , LUGOVSKOY, Alexey, A. , TAYLOR, Frederick, R. , MCLACHLAN, Karen
发明人： LUGOVSKOY, Alexey, A. , TAYLOR, Frederick, R. , MCLACHLAN, Karen
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
CPC分类号： A61K39/39558 , A61K45/06 , C07K16/2839 , C07K16/2842 , C07K16/3061 , C07K2317/24 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： This invention relates to alpha-4 binding antibodies, and fragments thereof.
摘要翻译：本发明涉及α-4结合抗体及其片段。

6. 发明申请

WO2006047357A3 HUMAN LY6-BIG MOLECULES AND METHODS OF USE 审中-公开
标题翻译：人LY6-大分子和使用方法
公开(公告)号：WO2006047357A3
公开(公告)日：2006-12-28
申请号：PCT/US2005038076
申请日：2005-10-24
申请人： BIOGEN IDEC INC , CHU PETER , DANIELS MARK , PEACH ROBERT , MCLACHLAN KAREN , JUNG JAEHO , GLASER SCOTT
发明人： CHU PETER , DANIELS MARK , PEACH ROBERT , MCLACHLAN KAREN , JUNG JAEHO , GLASER SCOTT
IPC分类号： C07H21/04 , A61K38/00 , C07K1/00 , C12N1/20 , C12P21/06
CPC分类号： C07K16/28 , C07K14/705
摘要： The present invention is directed to human Ly6-BIG molecules and their use in diagnostic, prognostic, and treatment methods for colon, lung and other cancers, in preventing the reoccurrence of such cancers, and in diagnostic, prognostic, and treatment methods for autoimmune disorders and AIDS.
摘要翻译：本发明涉及人Ly6-BIG分子及其在结肠癌，肺癌和其他癌症的诊断，预后和治疗方法中的用途，用于预防这种癌症的复发，以及用于自身免疫疾病的诊断，预后和治疗方法和艾滋病。

7. 发明申请

WO2005108415A8 MEMBRANE ASSOCIATED MOLECULES 审中-公开
标题翻译：膜相关分子
公开(公告)号：WO2005108415A8
公开(公告)日：2006-05-18
申请号：PCT/US2005015207
申请日：2005-05-02
申请人： BIOGEN IDEC INC , BECHTEL PAMELA , DANIELS MARK , MCLACHLAN KAREN , ZHAI YUFENG , COLSON BENJAMIN L , O'BRIEN NICOLE W
发明人： BECHTEL PAMELA , DANIELS MARK , MCLACHLAN KAREN , ZHAI YUFENG , COLSON BENJAMIN L , O'BRIEN NICOLE W
IPC分类号： C07H21/04 , C07K14/47
CPC分类号： C07H21/04 , C07K14/47
摘要： The present invention is directed to novel methods of treating, indentifying or diagnosing a hyperproliferative disorder in a patient in need thereof. The methods of the invention include administering to a patient a composition comprising a binding molecule which binds to a cell surface expressed glycoprotein expressed predominantly in tumor or tumor-associated cells. In particular, the therapeutic and diagnostic methods of the present invention include the use of a binding molecule, for example an antibody or immunospecific fragment thereof, which specifically binds to a membrane associated molecule, variant polypeptide or fragment thereof. The present invention is based, at least in part, on the discovery of membrane associated proteins, i.e., nucleic acid molecules which encode membrane proteins and the use of these molecules to generate custom arrays to screen for markers associated with various diseases and disorders, e.g., cancer, e.g., lung, colon, pancreatic and ovarian cancer and autoimmune diseases or disorders. The invention further relates to various methods, reagents and kits for diagnosing, staging, prognosing, monitoring and treating hyperproliferative diseases or disorders such as cancer, e.g., lung, colon, pancreatic and ovarian cancer and autoimmune diseases or disorders.
摘要翻译：本发明涉及在有需要的患者中治疗，鉴别或诊断过度增殖性疾病的新方法。本发明的方法包括向患者施用包含与主要在肿瘤或肿瘤相关细胞中表达的表达糖蛋白结合的结合分子的组合物。特别地，本发明的治疗和诊断方法包括使用特异性结合膜相关分子，变体多肽或其片段的结合分子，例如抗体或其免疫特异性片段。本发明至少部分地基于膜相关蛋白的发现，即编码膜蛋白的核酸分子，以及这些分子用于产生定制阵列以筛选与各种疾病和病症相关的标记的用途，例如，癌症，例如肺，结肠，胰腺和卵巢癌以及自身免疫性疾病或病症。本发明还涉及用于诊断，分期，预后，监测和治疗过度增殖性疾病或病症如癌症，例如肺癌，结肠癌，胰腺癌和卵巢癌以及自身免疫疾病或病症的各种方法，试剂和试剂盒。

8. 发明申请

WO2004066933A2 COMPOSITIONS AND METHODS FOR TREATING CANCER USING IGSF9 AND LIV-1 审中-公开
标题翻译：使用IGSF9和LIV-1治疗癌症的组合物和方法
公开(公告)号：WO2004066933A2
公开(公告)日：2004-08-12
申请号：PCT/US2004/002044
申请日：2004-01-27
申请人： MCLACHLAN, Karen , GLASER, Scott , PEACH, Robert, J. , ROWE, Tony
发明人： MCLACHLAN, Karen , GLASER, Scott , PEACH, Robert, J. , ROWE, Tony
IPC分类号： A61K
CPC分类号： C07K14/70503 , A61K51/1027 , A61K51/1045 , C07K14/47 , C07K16/2803 , C07K16/30 , C07K2319/30
摘要： Human IGSF9 and LIV-1 polypeptides and DNA (RNA) encoding such polypeptides are disclosed. The disclosed polypeptides and/or polynucleotide are particularly useful generating antibodies, both modified and native, which bind IGSF9 or LIV-1. Also disclosed are pharmaceutical compositions and vaccines comprising the antibodies, polypeptides and polynucleotides of the invention. Also disclosed are methods for utilizing such polypeptides for identifying ligands, antagonists and agonists to said polypeptides. Finally, methods comprising the above-mentioned compositions are disclosed for the treatment, diagnosis, and/or prognosis of neoplastic disorders.
摘要翻译：公开了人IGSF9和LIV-1多肽和编码这种多肽的DNA（RNA）。公开的多肽和/或多核苷酸是特别有用的，其产生结合IGSF9或LIV-1的经修饰和天然的抗体。还公开了包含本发明的抗体，多肽和多核苷酸的药物组合物和疫苗。还公开了利用这些多肽鉴定所述多肽的配体，拮抗剂和激动剂的方法。最后，公开了包含上述组合物的方法用于肿瘤性疾病的治疗，诊断和/或预后。

9. 发明申请

WO2004046342A2 NOVEL GENE TARGETS AND LIGANDS THAT BIND THERETO FOR TREATMENT AND DIAGNOSIS OF CARCINOMAS 审中-公开
标题翻译：新的基因组目标和与其相关的配体用于治疗和诊断癌症
公开(公告)号：WO2004046342A2
公开(公告)日：2004-06-03
申请号：PCT/US2003/037206
申请日：2003-11-20
申请人： BIOGEN IDEC INC. , MCLACHLAN, Karen , GATELY, Dennis, P.
发明人： MCLACHLAN, Karen , GATELY, Dennis, P.
IPC分类号： C12N
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： Isolated nucleic acids and proteins that are overexpressed in human cancers, and antibodies that specifically bind the proteins, which are useful diagnostic and therapeutic targets.
摘要翻译：在人类癌症中过表达的分离的核酸和蛋白质，以及特异性结合蛋白质的抗体，这是有用的诊断和治疗靶点。

10. 发明申请

WO2003104429A3 GENES OVEREXPRESSED BY OVARIAN CANCER AND THEIR USE IN DEVELOPING NOVEL THERAPEUTICS 审中-公开
公开(公告)号：WO2003104429A3
公开(公告)日：2003-12-18
申请号：PCT/US2003/018253
申请日：2003-06-10
申请人： IDEC PHARMACEUTICALS CORPORATION , HARIHARAN, Kandasamy , DANIELS, Mark , MCLACHLAN, Karen
发明人： HARIHARAN, Kandasamy , DANIELS, Mark , MCLACHLAN, Karen
IPC分类号： A01N61/00
摘要： Nucleic acid sequences encoding genes that are overexpressed by human ovarian cancers are provided. These genes and the corresponding antigens are useful diagnostic and therapeutic targets. The invention provides cancer therapies that target these antigens, especially using monoclonal antibodies that target the Anat-2 antigen.

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