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1. 发明申请

WO1995032672A1 DISPOSABLE ROTARY SUCTION AMNIOTOME AND FETAL SCALP ELECTRODE INTRODUCER 审中-公开
标题翻译：可拆卸的旋转吸收和电极电极引导器
公开(公告)号：WO1995032672A1
公开(公告)日：1995-12-07
申请号：PCT/US1995002530
申请日：1995-03-07
申请人： REES, Paul, M.
IPC分类号： A61B17/42
CPC分类号： A61B5/4362 , A61B5/0448 , A61B17/4208
摘要： The invention discloses a method and apparatus for rupturing the amniotic membrane of a mother during labor. The device (2) comprises a tubular member (4) having a first end (6) that has a collar (32) and cutting members (38-42). The tubular member (4) also includes a piston (16) and rod member (18) for creating a negative pressure force. After rupturing the amniotic membrane (130), a standard fetal scalp electrode (110) can be inserted within the tubular member (4) and the fetal heart rate may be monitored. The method generally comprises inserting into the vagina of the mother the tubular member (4), contacting the amniotic membrane (130) with the first end (6) of an instrument used to perform two procedures with the tubular member (4), creating a negative pressure in the tubular member (4) by use of the piston (16) and rod member (18), which in turn causes the membrane (130) to contact the cutting members (38-42) so that the membrane (130) is ruptured, and the amniotic fluid (132) can be analyzed. Next, after removal of the piston (16) and the rod member (18), the fetal scalp electrode (110) can be inserted within the tubular member (4), which serves as a guide for the placement of the fetal scalp electrode (110), and the fetal heart rate monitored.
摘要翻译：本发明公开了一种在劳动期间破裂母亲的羊膜的方法和装置。装置（2）包括管状构件（4），其具有具有轴环（32）和切割构件（38-42）的第一端（6）。管状构件（4）还包括用于产生负压力的活塞（16）和杆构件（18）。在破裂羊膜（130）之后，可以在管状部件（4）内插入标准胎头部电极（110），并且可以监测胎儿心率。该方法通常包括将管状构件（4）插入到母体的阴道中，使羊膜与用于与管状构件（4）执行两个步骤的器械的第一端（6）接触，从而产生通过使用活塞（16）和杆构件（18）在管状构件（4）中的负压，这又导致膜（130）接触切割构件（38-42），使得膜（130）破裂，羊水（132）可以分析。接下来，在去除活塞（16）和杆构件（18）之后，胎头部电极（110）可插入管状构件（4）内，该管状构件（4）用作用于放置胎儿头皮电极 110），并监测胎儿心率。

2. 发明申请

WO1994011491A1 PROCESS FOR THE SEPARATION OF SOLID MATERIALS FROM MICROORGANISMS 审中-公开
标题翻译：微生物分离固体材料的方法
公开(公告)号：WO1994011491A1
公开(公告)日：1994-05-26
申请号：PCT/GB1993002329
申请日：1993-11-12
申请人： ZENECA LIMITED , CUMMING, Robert, Henry , REES, Paul , WATSON, Julie, Sandra
发明人： ZENECA LIMITED
IPC分类号： C12N01/06
CPC分类号： C12N1/06 , C12P7/625 , Y10S435/829 , Y10S435/872
摘要： Solid materials are separated from microorganisms by a process which comprises growing them at a fermentation temperature, conditioning them by cooling them without freezing and then heating to above the fermentation temperature without permitting substantial recovery from the conditioning stage.
摘要翻译：固体材料通过包括在发酵温度下生长它们的方法与微生物分离，通过将其冷却而不冷冻，然后加热至高于发酵温度进行调理，而不允许从调理阶段显着回收。

3. 发明申请

WO2015168026A3 METHOD FOR LABEL-FREE IMAGE CYTOMETRY 审中-公开
标题翻译：无标记图像细胞计数的方法
公开(公告)号：WO2015168026A3
公开(公告)日：2016-03-17
申请号：PCT/US2015027809
申请日：2015-04-27
申请人： BROAD INST INC , HENNIG HOLGER , REES PAUL , BLASI THOMAS , CARPENTER VAN DYK ANNE
发明人： HENNIG HOLGER , REES PAUL , BLASI THOMAS , CARPENTER VAN DYK ANNE
IPC分类号： G06K9/00
CPC分类号： G01N15/1475 , G01N2015/1006 , G01N2015/1488 , G01N2015/149 , G01N2015/1493 , G01N2015/1497 , G06K9/00147
摘要： A computer-implemented method for the label-free classification of cells using image cytometry is provided. In some exemplary embodiments of the computer implemented method, the classification is the classification of the cells, such as individual cells, into a phase of the cell cycle or by cell type. A user computing device receives as an input one or more images of a cell obtained from a image cytometer. The user computing device extracts features form the one or more images, such as brightfield and/or darkfield images. The user computing device classifies the cell in the one or more images based on the extracted features using a cell classifier. The user computing device then outputs the class label of the cell, as defined by the classifier.
摘要翻译：提供了一种用计算机实现的使用图像细胞计数分类细胞标记的方法。在计算机实现的方法的一些示例性实施例中，分类是细胞（例如单个细胞）分类成细胞周期的阶段或细胞类型。用户计算装置接收从图像细胞仪获得的细胞的一个或多个图像作为输入。用户计算设备从一个或多个图像提取特征，例如明场和/或暗场图像。用户计算设备使用小区分类器基于所提取的特征来对一个或多个图像中的小区进行分类。然后，用户计算设备输出由分类器定义的单元的类标签。

4. 发明申请

WO2015168026A2 METHOD FOR LABEL-FREE IMAGE CYTOMETRY 审中-公开
标题翻译：无标记图像细胞计数的方法
公开(公告)号：WO2015168026A2
公开(公告)日：2015-11-05
申请号：PCT/US2015/027809
申请日：2015-04-27
申请人： THE BROAD INSTITUTE, INC. , HENNIG, Holger , REES, Paul , BLASI, Thomas , CARPENTER VAN DYK, Anne
发明人： HENNIG, Holger , REES, Paul , BLASI, Thomas , CARPENTER VAN DYK, Anne
IPC分类号： G06F19/00
CPC分类号： G01N15/1475 , G01N2015/1006 , G01N2015/1488 , G01N2015/149 , G01N2015/1493 , G01N2015/1497 , G06K9/00147
摘要： A computer-implemented method for the label-free classification of cells using image cytometry is provided. In some exemplary embodiments of the computer implemented method, the classification is the classification of the cells, such as individual cells, into a phase of the cell cycle or by cell type. A user computing device receives as an input one or more images of a cell obtained from a image cytometer. The user computing device extracts features form the one or more images, such as brightfield and/or darkfield images. The user computing device classifies the cell in the one or more images based on the extracted features using a cell classifier. The user computing device then outputs the class label of the cell, as defined by the classifier.
摘要翻译：提供了一种用计算机实现的使用图像细胞计数分类细胞标记的方法。在计算机实现的方法的一些示例性实施例中，分类是细胞（例如单个细胞）分类成细胞周期的阶段或细胞类型。用户计算装置接收从图像细胞仪获得的细胞的一个或多个图像作为输入。用户计算设备从一个或多个图像提取特征，例如明场和/或暗场图像。用户计算设备使用小区分类器基于所提取的特征来对一个或多个图像中的小区进行分类。然后，用户计算设备输出由分类器定义的单元的类标签。

5. 发明申请

WO2009071915A1 MATERIAL ANALYSIS DEVICE BASED ON EDGE-EMITTER SEMICONDUCTOR LASER CHRYSTAL, AND ASSICIATED ANALYSIS TOOL 审中-公开
标题翻译：基于边缘发光半导体激光晶体的材料分析装置和相关分析工具
公开(公告)号：WO2009071915A1
公开(公告)日：2009-06-11
申请号：PCT/GB2008/004033
申请日：2008-12-05
申请人： UNIVERSITY COLLEGE CARDIFF CONSULTANTS LTD , SUMMERS, Huw , REES, Paul
发明人： SUMMERS, Huw , REES, Paul
IPC分类号： C12M1/34 , G01N21/77 , G01N33/487 , H01S5/026 , H01S5/06 , H01S5/40 , G01N15/14
CPC分类号： G01N21/05 , G01N15/1436 , G01N2021/0346 , G01N2021/7789 , H01S5/0028 , H01S5/4031
摘要： An edge-emitter semiconductor laser crystal having a receptacle for sample material which can influence the crystal's laser operation. There may be separate zones of laser action within the crystal, creating respective sensing zones in the receptacle. Detection may be achieved by providing photo-diode regions within the crystal, for example.
摘要翻译：一种边缘发射半导体激光晶体，具有可影响晶体激光器操作的样品材料容器。在晶体内部可能存在单独的激光作用区域，从而在容器中产生相应的感测区域。例如，可以通过在晶体内提供光电二极管区域来实现检测。

6. 发明申请

WO2010112913A1 FLUORESCENCE LIFETIME IMAGING 审中-公开
标题翻译：荧光生物成像
公开(公告)号：WO2010112913A1
公开(公告)日：2010-10-07
申请号：PCT/GB2010/050539
申请日：2010-03-30
申请人： UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED , SUMMERS, Huw , ERRINGTON, Rachel , REES, Paul
发明人： SUMMERS, Huw , ERRINGTON, Rachel , REES, Paul
IPC分类号： G01N21/64
CPC分类号： G01N21/6408 , G01N21/6458
摘要： A method of measuring fluorescence from a location, the method comprising applying to the location a first fluorescence excitation signal having a first duty cycle, accumulating as a first result fluorescence that emanates from the location in response to the first excitation signal, applying to the location a second fluorescence excitation signal having a second duty cycle, accumulating as a second result fluorescence that emanates from the location in response to the second excitation signal, and comparing the first and second results to provide a comparison result for the location. The invention also relates to apparatus for performing the method.
摘要翻译：一种测量来自位置的荧光的方法，所述方法包括将具有第一占空比的第一荧光激发信号应用于所述位置，作为响应于所述第一激发信号而从所述位置发出的第一结果荧光，应用于所述位置具有第二占空比的第二荧光激发信号，作为响应于所述第二激发信号而从所述位置发出的第二结果荧光积累，以及比较所述第一和第二结果以提供所述位置的比较结果。本发明还涉及用于执行该方法的装置。

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