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1. 发明申请

WO1995027505A1 CELLULAR IMMUNE RESPONSE-SPECIFIC ANTIGENS AND USES THEREFOR 审中-公开
标题翻译：细胞免疫反应特异性抗原及其用途
公开(公告)号：WO1995027505A1
公开(公告)日：1995-10-19
申请号：PCT/US1995004540
申请日：1995-04-12
申请人： BIOMIRA, INC. , LONGENECKER, B., Michael , DING, Lei , REDDISH, Mark, A. , KOGANTY, Raghupathi, Rao
发明人： BIOMIRA, INC.
IPC分类号： A61K39/00
CPC分类号： C07K14/70539 , A61K39/00 , C07K14/4727 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/476
摘要： A CMI-specific immunogenic composition, comprising: (a) a non-naturally occurring conjugate of a primary epitope which is substantially the same as a T cell epitope of a cancer-, microbial-, parasitic-, or virally infected cell-associated antigen, and of an immunomodulatory peptide, or (b) a mixture of (1) primary antigen bearing a primary epitope which is substantially the same as a T-cell epitope of a cancer-, microbial-, parasitic-, or virally infected cell-associated antigen, (2) an immunomodulatory peptide, where the conjugate of (a) and the immunomodulatory peptide of (b) have a molecular weight of less than 5,000 daltons, where said immunomodulatory peptide of (a) or (b) comprises an allopeptide moiety of at least five amino acids whose amino acid sequence corresponds essentially to that of a polymorphic region of an MHC-encoded polymorphic Class I or Class II antigen. The composition modulates a stronger cellular immune response than the humoral immune response and is useful for treatment of tumors.
摘要翻译：一种CMI特异性免疫原性组合物，其包含：（a）主要表位的非天然存在的缀合物，其与癌症，微生物，寄生虫或病毒感染的细胞相关抗原的T细胞表位基本相同，和免疫调节肽，或（b）（1）具有与癌，微生物，寄生虫或病毒感染细胞的T细胞表位基本上相同的主要表位的一级抗原的混合物，（2）免疫调节肽，其中（a）和（b）的免疫调节肽的缀合物具有小于5,000道尔顿的分子量，其中（a）或（b）的所述免疫调节肽包含异肽至少5个氨基酸的部分，其氨基酸序列基本上与MHC编码的多态性I类或II类抗原的多态性区域相符。该组合物调节比体液免疫应答更强的细胞免疫应答，并且可用于治疗肿瘤。

2. 发明申请

WO2006068663A2 VACCINE COMPOSITIONS AND METHODS OF TREATING CORONAVIRUS INFECTION 审中-公开
标题翻译：疫苗组合物和治疗肠毒素感染的方法
公开(公告)号：WO2006068663A2
公开(公告)日：2006-06-29
申请号：PCT/US2005/023598
申请日：2005-06-30
申请人： ID BIOMEDICAL CORPORATION OF QUEBEC , BURT, David, S. , REDDISH, Mark, A. , HU, Mary, ChaoHong , LOWELL, George, H. , JONES, David, Hugh
发明人： BURT, David, S. , REDDISH, Mark, A. , HU, Mary, ChaoHong , LOWELL, George, H. , JONES, David, Hugh
CPC分类号： A61K39/215 , A61K39/12 , A61K2039/543 , A61K2039/55511 , A61K2039/55516 , A61K2039/55572 , A61K2039/57 , C07K14/005 , C12N2770/20022 , C12N2770/20034
摘要： The present disclosure relates to compositions and methods for treating or preventing coronavirus infections. For example, compositions are provided that comprise a coronavirus S protein or N protein, fragment, or variant thereof, capable of eliciting a protective humoral and/or cell-mediated immune response, which compositions are useful for treating or preventing infection by coronavirus, such as the causative agent of SARS. Also, coronavirus S protein and N protein immunogen compositions are provided that include an adjuvant, such as Proteosome or Protollin, which may be used for treating or preventing infection caused by a coronavirus, such as a SARS coronavirus.
摘要翻译：本公开涉及用于治疗或预防冠状病毒感染的组合物和方法。例如，提供了包含能够引发保护性体液和/或细胞介导的免疫应答的冠状病毒S蛋白或N蛋白，片段或变体的组合物，该组合物可用于治疗或预防冠状病毒感染，例如作为SARS的病因。此外，提供冠状病毒S蛋白和N蛋白免疫原组合物，其包括佐剂，例如Proteosome或Protollin，其可用于治疗或预防冠状病毒如SARS冠状病毒引起的感染。

3. 发明申请

WO2003065973A3 MULTIVALENT STREPTOCOCCAL VACCINE COMPOSITIONS AND METHODS FOR USE 审中-公开
公开(公告)号：WO2003065973A3
公开(公告)日：2003-08-14
申请号：PCT/US2002/034769
申请日：2002-10-28
申请人： ID BIOMEDICAL CORPORATION OF WASHINGTON , UNIVERSITY OF TENNESSEE RESEARCH CORPORATION , REDDISH, Mark, A. , HU, Mary, Chaohong , WALLS, Michael, A. , DALE, James, B.
发明人： REDDISH, Mark, A. , HU, Mary, Chaohong , WALLS, Michael, A. , DALE, James, B.
IPC分类号： A61K39/00
摘要： Compositions and methods for making and using therapeutic formulations of multivalent hybrid polypeptides comprising immunogenic peptides of M proteins from various different serotypes of group A streptococci and antibodies thereto are provided. Also provided are nucleic acids encoding such hybrid polypeptides. The hybrid polypeptide formulations may be used, for example, in methods for treating or preventing a microbial infection and eliciting a protective immune response having broadly protective opsonic antibodies in the absence of tissue cross-reactive antibodies.

4. 发明申请

WO2003065973A2 MULTIVALENT STREPTOCOCCAL VACCINE COMPOSITIONS AND METHODS FOR USE 审中-公开
标题翻译：多发性支气管炎组合物及其使用方法
公开(公告)号：WO2003065973A2
公开(公告)日：2003-08-14
申请号：PCT/US2002/034769
申请日：2002-10-28
申请人： ID BIOMEDICAL CORPORATION OF WASHINGTON , UNIVERSITY OF TENNESSEE RESEARCH CORPORATION , REDDISH, Mark, A. , HU, Mary, Chaohong , WALLS, Michael, A. , DALE, James, B.
发明人： REDDISH, Mark, A. , HU, Mary, Chaohong , WALLS, Michael, A. , DALE, James, B.
IPC分类号： A61K
CPC分类号： C12N15/70 , A61K39/00 , A61K2039/505 , C07K14/315 , C07K2319/00 , Y10S530/806 , Y10S530/825
摘要： Compositions and methods for making and using therapeutic formulations of multivalent hybrid polypeptides comprising immunogenic peptides of M proteins from various different serotypes of group A streptococci and antibodies thereto are provided. Also provided are nucleic acids encoding such hybrid polypeptides. The hybrid polypeptide formulations may be used, for example, in methods for treating or preventing a microbial infection and eliciting a protective immune response having broadly protective opsonic antibodies in the absence of tissue cross-reactive antibodies.
摘要翻译：制备和使用多价杂交多肽的治疗制剂的组合物和方法，其包含来自各种不同血清型A组链球菌及其抗体的M蛋白的免疫原性肽。还提供了编码这种杂合多肽的核酸。杂交多肽制剂可用于例如在不存在组织交叉反应性抗体的情况下用于治疗或预防微生物感染和引发具有广泛保护性opsonic抗体的保护性免疫应答的方法。

5. 发明申请

WO2006068663A3 VACCINE COMPOSITIONS FOR TREATING CORONAVIRUS INFECTION 审中-公开
标题翻译：用于治疗蛔虫感染的疫苗组合物
公开(公告)号：WO2006068663A3
公开(公告)日：2006-11-16
申请号：PCT/US2005023598
申请日：2005-06-30
申请人： ID BIOMEDICAL CORP QUEBEC , BURT DAVID S , REDDISH MARK A , HU MARY CHAOHONG , LOWELL GEORGE H , JONES DAVID HUGH
发明人： BURT DAVID S , REDDISH MARK A , HU MARY CHAOHONG , LOWELL GEORGE H , JONES DAVID HUGH
IPC分类号： A61K39/215 , C07K14/165
CPC分类号： A61K39/215 , A61K39/12 , A61K2039/543 , A61K2039/55511 , A61K2039/55516 , A61K2039/55572 , A61K2039/57 , C07K14/005 , C12N2770/20022 , C12N2770/20034
摘要： The present disclosure relates to compositions and methods for treating or preventing coronavirus infections. For example, compositions are provided that comprise a coronavirus S protein or N protein, fragment, or variant thereof, capable of eliciting a protective humoral and/or cell-mediated immune response, which compositions are useful for treating or preventing infection by coronavirus, such as the causative agent of SARS. Also, coronavirus S protein and N protein immunogen compositions are provided that include an adjuvant, such as Proteosome or Protollin, which may be used for treating or preventing infection caused by a coronavirus, such as a SARS coronavirus.
摘要翻译：本公开涉及用于治疗或预防冠状病毒感染的组合物和方法。例如，提供了包含能够引发保护性体液和/或细胞介导的免疫应答的冠状病毒S蛋白或N蛋白，片段或变体的组合物，该组合物可用于治疗或预防冠状病毒感染，例如作为SARS的病因。此外，提供冠状病毒S蛋白和N蛋白免疫原组合物，其包括佐剂，例如Proteosome或Protollin，其可用于治疗或预防冠状病毒如SARS冠状病毒引起的感染。

6. 发明申请

WO03065973A8 MULTIVALENT STREPTOCOCCAL VACCINE COMPOSITIONS AND METHODS FOR USE 审中-公开
标题翻译：多价链球菌疫苗组合物及使用方法
公开(公告)号：WO03065973A8
公开(公告)日：2003-09-12
申请号：PCT/US0234769
申请日：2002-10-28
申请人： ID BIOMEDICAL CORP OF WASHINGT , UNIV TENNESSEE RES CORP , REDDISH MARK A , HU MARY CHAOHONG , WALLS MICHAEL A , DALE JAMES B
发明人： REDDISH MARK A , HU MARY CHAOHONG , WALLS MICHAEL A , DALE JAMES B
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/395 , A61P31/04 , A61P37/02 , C07K14/185 , C07K14/315 , C07K16/12 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/70 , C12P21/02 , A61K
CPC分类号： C12N15/70 , A61K39/00 , A61K2039/505 , C07K14/315 , C07K2319/00 , Y10S530/806 , Y10S530/825
摘要： Compositions and methods for making and using therapeutic formulations of multivalent hybrid polypeptides comprising immunogenic peptides of M proteins from various different serotypes of group A streptococci and antibodies thereto are provided. Also provided are nucleic acids encoding such hybrid polypeptides. The hybrid polypeptide formulations may be used, for example, in methods for treating or preventing a microbial infection and eliciting a protective immune response having broadly protective opsonic antibodies in the absence of tissue cross-reactive antibodies.
摘要翻译：提供了制备和使用多价杂合多肽治疗制剂的组合物和方法，所述多价杂合多肽治疗制剂包含来自A群链球菌各种不同血清型的M蛋白的免疫原性肽及其抗体。还提供了编码这种杂合多肽的核酸。例如，杂交多肽制剂可用于治疗或预防微生物感染和在缺乏组织交叉反应性抗体的情况下引发具有广泛保护性调理性抗体的保护性免疫应答的方法。

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