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1. 发明申请

WO2009132244A1 METHODS FOR PREPARING IMMUNOGENIC COMPOSITIONS 审中-公开
标题翻译：制备免疫组化的方法
公开(公告)号：WO2009132244A1
公开(公告)日：2009-10-29
申请号：PCT/US2009/041619
申请日：2009-04-24
申请人： ID BIOMEDICAL CORPORATION OF QUEBEC , SMITHKLINE BEECHAM CORPORATION , BROUGHTON, Ricahrd, L. , MALLETT, Corey , NAMDARAN, Frahad , TOROSSIAN, Krikor , ZIMMERMAN, Joseph
发明人： BROUGHTON, Ricahrd, L. , MALLETT, Corey , NAMDARAN, Frahad , TOROSSIAN, Krikor , ZIMMERMAN, Joseph
IPC分类号： C07K1/36 , C12Q1/00
CPC分类号： A61K39/39 , A61K39/095 , A61K39/102 , A61K39/12 , A61K39/145 , A61K39/35 , A61K2039/5252 , A61K2039/543 , A61K2039/55516 , A61K2039/55594 , A61K2039/70 , C12N2760/16134 , C12N2760/16234 , C12N2760/18534 , Y02A50/403 , Y02A50/478
摘要： The present invention relates methods of preparing a composition comprising the steps of: releasing from at least one cell a composition comprising at least one outer membrane protein from said at least one cell comprising contacting said at least one said cell with at least one agent capable of solubilizing at least one lipid and optionally an osmalalic agent, forming a mixture comprising said at least one outer membrane protein, at least one endogenous liposaccharide and cell debris; adding an agent capable of separating said cell debris from said at least one outer membrane protein; separating said separated cell debris from said mixture; removing at least one agent capable of solubilizing at least one lipid and said optional osmolalic agent from said at least one outer membrane protein wherein said at least one outer membrane protein remains soluble. Also, included within this invention are compositions comprising at least one outer membrane protein and an endogenous liposacharide wherein said endogenous liposaccharide is in the range of about 0.03 grams to about 0.99 grams endogenous liposaccharide to 1.0 gram of at least one outer membrane protein weight.
摘要翻译：本发明涉及制备组合物的方法，其包括以下步骤：从至少一个细胞释放包含至少一种来自所述至少一种细胞的外膜蛋白的组合物，包括使所述至少一种所述细胞与至少一种能够溶解至少一种脂质和任选的奥斯卡里奇剂，形成包含所述至少一种外膜蛋白，至少一种内源性脂蛋白和细胞碎片的混合物; 添加能够将所述细胞碎片与所述至少一种外膜蛋白分离的药剂; 将所述分离的细胞碎片与所述混合物分离; 从所述至少一种外膜蛋白中除去至少一种能够溶解至少一种脂质和所述任选的渗透压剂的试剂，其中所述至少一种外膜蛋白保持可溶。本发明中还包括包含至少一种外膜蛋白和内源性脂肪法的组合物，其中所述内源性脂糖在约0.03克至约0.99克内源性脂糖至1.0克至少一种外膜蛋白重量的范围内。

2. 发明申请

WO2009079796A1 RECOMBINANT RSV ANTIGENS 审中-公开
标题翻译：重组RSV抗原
公开(公告)号：WO2009079796A1
公开(公告)日：2009-07-02
申请号：PCT/CA2008/002277
申请日：2008-12-23
申请人： ID BIOMEDICAL CORPORATION OF QUEBEC , GlaxoSmithKline Biologicals s.a. , BAUDOUX, Jean-Pierre , BLAIS, Normand , RHEAULT, Patrick , RUELLE, Jean-Louis
发明人： BAUDOUX, Jean-Pierre , BLAIS, Normand , RHEAULT, Patrick , RUELLE, Jean-Louis
IPC分类号： C07K19/00 , A61K39/00 , A61K39/155 , A61K39/295 , A61K9/107 , A61K9/127 , A61P31/14 , A61P37/04 , C07K14/135 , C12N15/45 , C12N15/62
CPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61K2039/55505 , A61K2039/55572 , A61K2039/55577 , C07K16/1027 , C07K2317/21 , C07K2317/76 , C07K2319/73 , C12N2760/18522 , C12N2760/18534 , Y02A50/466
摘要： This disclosure provides recombinant respiratory syncytial virus (RSV) antigens and methods for making and using them, including immunogenic compositions ( e.g ., vaccines) for the treatment and/or prevention of RSV infection.
摘要翻译：本公开提供重组呼吸道合胞病毒（RSV）抗原及其制备和使用它们的方法，包括用于治疗和/或预防RSV感染的免疫原性组合物（例如疫苗）。

3. 发明申请

WO2010149745A1 RECOMBINANT RSV ANTIGENS 审中-公开
标题翻译：重组RSV抗原
公开(公告)号：WO2010149745A1
公开(公告)日：2010-12-29
申请号：PCT/EP2010/059008
申请日：2010-06-24
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , ID BIOMEDICAL CORPORATION OF QUEBEC , BAUDOUX, Guy Jean Marie Fernand Pierre , BLAIS, Normand , CYR, Sonya L , RHEAULT, Patrick , RUELLE, Jean Louis
发明人： BAUDOUX, Guy Jean Marie Fernand Pierre , BLAIS, Normand , CYR, Sonya L , RHEAULT, Patrick , RUELLE, Jean Louis
IPC分类号： A61K39/155 , C07K14/135
CPC分类号： A61K39/155 , A61K39/12 , A61K2039/55505 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , C07K14/005 , C07K2319/70 , C07K2319/73 , C12N2760/18522 , C12N2760/18534
摘要： This disclosure provides recombinant respiratory syncytial virus (RSV) antigens and methods for making and using them, including immunogenic compositions (e.g., vaccines) for the treatment and/or prevention of RSV infection.
摘要翻译：本公开提供重组呼吸道合胞病毒（RSV）抗原及其制备和使用它们的方法，包括用于治疗和/或预防RSV感染的免疫原性组合物（例如疫苗）。

4. 发明申请

WO2008039494A1 DEVICE AND METHODS OF INACTIVATING INFLUENZA VIRUS AND ADVENTITIOUS AGENTS WITH ULTRAVIOLET LIGHT 审中-公开
标题翻译：灭活流行性感冒病毒和先天性紫癜药物的装置和方法
公开(公告)号：WO2008039494A1
公开(公告)日：2008-04-03
申请号：PCT/US2007/020776
申请日：2007-09-26
申请人： ID BIOMEDICAL CORPORATION OF QUEBEC , LE GROUP ENICO, INC. , DUTIL, Frederic , OLIVEIRA, George , PELLETIER, Nadine , POULIN, Micheline , TSCHUMAKOW, Alexander, George
发明人： DUTIL, Frederic , OLIVEIRA, George , PELLETIER, Nadine , POULIN, Micheline , TSCHUMAKOW, Alexander, George
IPC分类号： A61L2/00 , A61L2/10
CPC分类号： A61L2/0011
摘要： A device (100) for irradiating a fluid is disclosed. The device (100) includes an elongated tube (106) having a fluid injection port (106a) and a fluid discharge port (106b), wherein the elongated tube (106) is rotatable about a longitudinal axis (107). The longitudinal axis (107) extends at an angle oblique to the horizontal. A source of radiation (116) extends within the elongated tube (106) along the longitudinal axis (107). A sleeve (146) extends within the elongated tube (106) and surrounds a length of the source of radiation (116), thereby defining an airflow path between the source of radiation (116) and the sleeve (146). An air flow source (164) is in fluid communication with the airflow path proximate to the fluid injection port (106a). An air flow discharge (180) is in fluid communication with the airflow path proximate to the fluid discharge port (106b). The fluid injection port (106a) and the fluid discharge port (106b) are in communication with the space between the tube (106) and the sleeve ( 146). A method of inactivating a virus and an inactivated virus manufactured according to the method are also disclosed.
摘要翻译：公开了一种用于照射流体的装置（100）。装置（100）包括具有流体注入口（106a）和流体排出口（106b）的细长管（106），其中细长管（106）能够围绕纵向轴线（107）旋转。纵轴（107）以与水平方向倾斜的角度延伸。辐射源（116）沿着纵向轴线（107）在细长管（106）内延伸。套管146在细长管106内延伸并且围绕辐射源116的一段长度，由此在辐射源116和套筒146之间形成气流路径。气流源（164）与靠近流体喷射口（106a）的气流路流体连通。气流排出口（180）与靠近流体排出口（106b）的气流通道流体连通。流体注入口（106a）和流体排出口（106b）与管（106）和套筒（146）之间的空间连通。还公开了灭活根据该方法制造的病毒和灭活病毒的方法。

5. 发明申请

WO2005042017A1 COMPOSITIONS AND METHODS FOR ACTIVATING INNATE AND ALLERGIC IMMUNITY 审中-公开
标题翻译：用于激活浸润和过敏免疫的组合物和方法
公开(公告)号：WO2005042017A1
公开(公告)日：2005-05-12
申请号：PCT/US2004/035041
申请日：2004-10-22
申请人： ID BIOMEDICAL CORPORATION OF QUEBEC , LOWELL, George, H. , BURT, David, S. , JONES, David, Hugh , ZIMMERMANN, Joseph, J. , RIOUX, Clement
发明人： LOWELL, George, H. , BURT, David, S. , JONES, David, Hugh , ZIMMERMANN, Joseph, J. , RIOUX, Clement
IPC分类号： A61K39/39
CPC分类号： A61K39/095 , A61K35/74 , A61K39/00 , A61K39/0011 , A61K39/145 , A61K39/165 , A61K39/39 , A61K2039/55544 , A61K2039/55572 , A61K2039/57 , A61K2039/6037 , C07K14/005 , C07K14/22 , C12N2710/24143 , Y02A50/394
摘要： Methods for making and using therapeutic formulations of Proteosome-based immunoactive compositions are provided. The immunogenic compositions, which include Proteosomes and liposaccharides, may be used to elicit or enhance a nonspecific innate immune response to, for example, treat or prevent infectious disease. In addition, after activating the innate immune system, immunogenic compositions further containing an antigen may be used to elicit a specific adaptive immune response. Furthermore, provided are compositions capable of altering hyperreactive responses or inflammatory immune responses, such as allergic reactions. Such compositions may be used as a prophylactic, or in various clinical settings to treat or prevent infectious disease (such as parasite, fungal, bacterial or viral infections), or to alter inappropriate inflammatory immune responses (such as allergic reactions or asthma).
摘要翻译：提供了制备和使用基于蛋白质组的免疫组合物的治疗制剂的方法。包括蛋白质体和脂糖的免疫原性组合物可用于引发或增强非特异性先天免疫应答，例如治疗或预防感染性疾病。此外，在激活先天免疫系统之后，可以使用进一步含有抗原的免疫原性组合来引发特异性的适应性免疫应答。此外，提供能够改变高反应性反应或炎性免疫应答（例如过敏反应）的组合物。或者在各种临床环境中用于治疗或预防感染性疾病（例如寄生虫，真菌，细菌或病毒感染）或改变不适当的炎症免疫应答（如过敏反应或哮喘）的组合物。

6. 发明申请

WO2010149743A2 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：WO2010149743A2
公开(公告)日：2010-12-29
申请号：PCT/EP2010/059006
申请日：2010-06-24
申请人： ID BIOMEDICAL CORPORATION OF QUEBEC , GLAXOSMITHKLINE BIOLOGICALS S.A. , BLAIS, Normand , RHEAULT, Patrick , VAN-SCHERPENZEEL-THIM, Virginie , VASSILEV, Ventzislav
发明人： BLAIS, Normand , RHEAULT, Patrick , VAN-SCHERPENZEEL-THIM, Virginie , VASSILEV, Ventzislav
IPC分类号： A61K39/155
CPC分类号： A61K39/155 , A61K39/12 , A61K39/17 , A61K2039/555 , A61K2039/55566 , A61K2039/70 , C07K14/005 , C07K2319/00 , C07K2319/73 , C12N2760/18322 , C12N2760/18334 , C12N2760/18522 , C12N2760/18534 , C12N2760/18622 , C12N2760/18634
摘要： The present disclosure provides immunogenic compositions that include at least two paramyxovirus F protein antigens selected from human metapnuemovirus (hMPV), paarainfluenza virus (PIV) and respiratory syncytial virus (RSV). The antigens of the disclosed compositions are recombinant F protein polypeptides, which have been modified to stabilize the trimeric prefusion conformation. Nucleic acids encoding the antigens, as well as methods for their production and use are also provided.
摘要翻译：本公开提供包含至少两种选自人metapnuovovirus（hMPV），paarainfluenza virus（PIV）和呼吸道合胞病毒（RSV））的副粘病毒F蛋白抗原的免疫原性组合物。所公开组合物的抗原是重组F蛋白多肽，其已被修饰以稳定三聚体预制构象。还提供了编码抗原的核酸，以及其生产和使用的方法。

7. 发明申请

WO2010006447A1 CHIMERIC RESPIRATORY SYNCYTIAL VIRUS POLYPEPTIDE ANTIGENS 审中-公开
标题翻译： CHIMERIC呼吸道同源性病毒多肽抗原
公开(公告)号：WO2010006447A1
公开(公告)日：2010-01-21
申请号：PCT/CA2009/001021
申请日：2009-07-17
申请人： ID BIOMEDICAL CORPORATION OF QUEBEC , BLAIS, Normand , RHEAULT, Patrick
发明人： BLAIS, Normand , RHEAULT, Patrick
IPC分类号： C07K19/00 , A61K39/155 , A61K39/385 , A61P31/14 , A61P37/04 , C07K14/135 , C12N15/44 , C12N15/62
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2760/18522 , Y02A50/466
摘要： Chimeric respiratory syncytial virus (RSV) polypeptide antigens are provided. The disclosed polypeptides include a first amino acid sequence comprising an F2 domain uncleavably joined to an Fl domain of a Respiratory Syncytial Virus (RSV) Fusion (F) protein polypeptide; and a second amino acid sequence comprising a portion of an RSV Attachment (G) protein polypeptide comprising an immunologically dominant epitope.. The disclosure also provides nucleic acids that encode, and pharmaceutical compositions that contain, the chimeric RSV polypeptides, as well as methods for their production and use.
摘要翻译：提供嵌合呼吸道合胞病毒（RSV）多肽抗原。所公开的多肽包括第一氨基酸序列，其包含不可分裂地连接到呼吸道合胞病毒（RSV）融合（F）蛋白多肽的Fl结构域的F2结构域; 以及包含包含免疫优势表位的RSV附着（G）蛋白多肽的一部分的第二氨基酸序列。本公开还提供编码和含有嵌合RSV多肽的药物组合物的核酸，以及包含嵌合RSV多肽的方法他们的生产和使用。

8. 发明申请

WO2006004749A2 COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS 审中-公开
标题翻译：用于治疗神经疾病的组合物和方法
公开(公告)号：WO2006004749A2
公开(公告)日：2006-01-12
申请号：PCT/US2005/022922
申请日：2005-06-27
申请人： ID BIOMEDICAL CORPORATION OF QUEBEC , BRIGHAM AND WOMEN'S HOSPITAL , FRENKEL, Dan , MARON, Ruth , BURT, David , WEINER, Howard, L.
发明人： FRENKEL, Dan , MARON, Ruth , BURT, David , WEINER, Howard, L.
IPC分类号： A61K39/02
CPC分类号： A61K31/739 , A61K38/02 , A61K38/164 , A61K39/0008 , A61K39/02 , A61K39/095 , A61K39/39 , A61K2039/55594 , A61K2300/00
摘要： Compositions useful for treating neurological disorders including neurodegenerative disorders associated with deleterious protein aggregation, aberrant protein folding, such as brain amylogenic diseases, and/or neurodegenerative autoimmune disorders are described. Methods of using said compositions also are described. In particular, methods to treat a neurodegenerative disorder such as Alzheimer's disease and a neurodegenerative autoimmune disorder such as Multiple Sclerosis are contemplated utilizing proteosomes and/or Glatiramer Acetate, wherein the GA is in a submicron emulsion or a nanoemulsion.
摘要翻译：描述了可用于治疗神经系统疾病的组合物，包括与有害的蛋白质聚集，异常蛋白质折叠（例如脑淀粉样变性疾病）和/或神经变性自身免疫性疾病相关的神经变性疾病。还描述了使用所述组合物的方法。特别地，考虑使用蛋白质体和/或醋酸格拉美拉姆治疗神经变性疾病如阿尔茨海默氏病和神经变性自身免疫性疾病如多发性硬化症的方法，其中GA在亚微米乳剂或纳米乳剂中。

9. 发明申请

WO2005007189A1 SUBUNIT VACCINE AGAINST RESPIRATORY SYNCYTIAL VIRUS INFECTION 审中-公开
标题翻译：亚种疫苗对抗呼吸道感染病毒感染
公开(公告)号：WO2005007189A1
公开(公告)日：2005-01-27
申请号：PCT/CA2004/001007
申请日：2004-07-14
申请人： ID BIOMEDICAL CORPORATION OF QUEBEC , ANDERSON, Robert , HUANG, Yan , BURT, David, S.
发明人： ANDERSON, Robert , HUANG, Yan , BURT, David, S.
IPC分类号： A61K39/155
CPC分类号： A61K39/155 , A61K39/12 , A61K2039/543 , A61K2039/55505 , A61K2039/55555 , A61K2039/55572 , A61K2039/55588 , A61K2039/55594 , C07K14/005 , C12N2760/18522 , C12N2760/18534
摘要： The present invention relates generally to methods of treating or preventing RSV infections, and more specifically, to compositions, and the use thereof, comprising one or more RSV G protein immunogen or fragment thereof capable of eliciting protective immunity without eliciting an immunopathological response or eliciting a reduced immunopathological response.
摘要翻译：本发明一般涉及治疗或预防RSV感染的方法，更具体地涉及组合物及其用途，其包含一种或多种能够引发免疫病理学应答或引发免疫病理学应答的RSV免疫原或其片段，减少免疫病理反应。

10. 发明申请

WO2008144924A1 IMMUNOGENIC COMPOSITIONS COMPRISING AN AGENT CAPABLE OF MODULATING A CD 1D-MODULATED PATHWAY AND METHODS OF USE 审中-公开
标题翻译：包含调制CD一维调制路径的试剂的免疫组合物及其使用方法
公开(公告)号：WO2008144924A1
公开(公告)日：2008-12-04
申请号：PCT/CA2008/001040
申请日：2008-05-30
申请人： ID Biomedical Corporation of Quebec , CYR, Sonia, L.
发明人： CYR, Sonia, L.
IPC分类号： A61K39/112 , A61K39/095 , A61K39/21 , A61K39/35 , A61P31/00 , A61P33/10 , A61P37/04
CPC分类号： A61K39/39 , A61K2039/55572
摘要： Immunogenic compositions are provided comprising at least one agent capable of modulating a CD Id-modulated pathway either directly or indirectly through a Toll Like Receptor when said immunogenic composition is administered to a mammal. Methods are also provided for inducing an immune response in a mammal comprising administering to said mammal an immunogenic composition comprising at least one agent capable of modulating a CD Id-modulated cell pathway.
摘要翻译：当向哺乳动物施用所述免疫原性组合物时，提供免疫原性组合物，其包含至少一种能够通过Toll样受体直接或间接调节CD1d调节的途径的试剂。还提供了用于在哺乳动物中诱导免疫应答的方法，包括向所述哺乳动物施用包含至少一种能够调节CD1d调节细胞途径的试剂的免疫原性组合物。

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