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1. 发明申请

WO2008021974A1 PRODUCTION OF HIGH TRYPTOPHAN MAIZE BY CHLOROPLAST TARGETED EXPRESSION OF ANTHRANILATE SYNTHASE 审中-公开
标题翻译：通过氯化钠合成酶的氯化物指示表达生产高三聚磷酸
公开(公告)号：WO2008021974A1
公开(公告)日：2008-02-21
申请号：PCT/US2007/075614
申请日：2007-08-09
申请人： MONSANTO TECHNOLOGY LLC , MANJUNATH, Siva , NAVARRO, Santiago, Xavier , RAPP, William, D. , SHI, Xiaohong , VARAGONA, Marguerite, J. , WINSON, Jennifer, L. , YE, Guangning
发明人： MANJUNATH, Siva , NAVARRO, Santiago, Xavier , RAPP, William, D. , SHI, Xiaohong , VARAGONA, Marguerite, J. , WINSON, Jennifer, L. , YE, Guangning
IPC分类号： C12N15/82 , C12N9/88 , C07K14/195 , A01H5/00
CPC分类号： C12N9/88 , C12N15/8214 , C12N15/8254
摘要： Novel expression vectors and constructs encoding a chloroplast transit peptide (CTP) operably linked to a monomeric anthranilate synthase are provided. Additionally, novel polynucleotide sequences encoding monomeric anthranilate synthases are provided. Also provided are methods for increasing the levels of free tryptophan in transgenic plants containing the expression vectors and constructs.
摘要翻译：提供了编码与单体邻氨基苯甲酸合酶可操作地连接的叶绿体转运肽（CTP）的新型表达载体和构建体。另外，提供了编码单体邻氨基苯甲酸合酶的新型多核苷酸序列。还提供了增加含有表达载体和构建体的转基因植物中游离色氨酸水平的方法。

2. 发明申请

WO2004101744A3 PLANTS WITH INCREASED LEVELS OF ONE OR MORE AMINO ACIDS 审中-公开
标题翻译：具有增加一种或多种氨基酸水平的植物
公开(公告)号：WO2004101744A3
公开(公告)日：2006-03-30
申请号：PCT/US2004014120
申请日：2004-05-06
申请人： RENESSEN LLC , WEAVER LISA M , MITSKY TIMOTHY A , RAPP WILLIAM D , GRUYS KENNETH J , LIANG JIHONG , VADUVA GABRIELA
发明人： WEAVER LISA M , MITSKY TIMOTHY A , RAPP WILLIAM D , GRUYS KENNETH J , LIANG JIHONG , VADUVA GABRIELA
IPC分类号： C12N9/88 , C12N15/82 , C12N15/00 , A01H1/00
CPC分类号： C12N9/88 , C12N15/8251
摘要： The present invention provides DNA constructs comprising exogenous polynucleotides encoding a threonine deaminase and/or AHAS. Transgenic plants transformed with the constructs, as well as seed and progeny dervied from these plants, are also provided. The transgenic plants have an increased level of one or more amino acids as compared to a non-transgenic plant of the same species.
摘要翻译：本发明提供包含编码苏氨酸脱氨酶和/或AHAS的外源多核苷酸的DNA构建体。还提供了用这些植物转化的转基因植物，以及从这些植物衍生的种子和后代。与相同物种的非转基因植物相比，转基因植物具有增加的一种或多种氨基酸水平。

3. 发明申请

WO2004101744A2 PLANTS WITH INCREASED LEVELS OF ONE OR MORE AMINO ACIDS 审中-公开
标题翻译：具有增加一种或多种氨基酸水平的植物
公开(公告)号：WO2004101744A2
公开(公告)日：2004-11-25
申请号：PCT/US2004/014120
申请日：2004-05-06
申请人： MONSANTO TECHNOLOGY, LLC , WEAVER, Lisa, M. , MITSKY, Timothy, A. , RAPP, William, D. , GRUYS, Kenneth, J. , LIANG, Jihong
发明人： WEAVER, Lisa, M. , MITSKY, Timothy, A. , RAPP, William, D. , GRUYS, Kenneth, J. , LIANG, Jihong
IPC分类号： C12N
CPC分类号： C12N9/88 , C12N15/8251
摘要： The present invention provides DNA constructs comprising exogenous polynucleotides encoding a threonine deaminase and/or AHAS. Transgenic plants transformed with the constructs, as well as seed and progeny dervied from these plants, are also provided. The transgenic plants have an increased level of one or more amino acids as compared to a non-transgenic plant of the same species.
摘要翻译：本发明提供了包含编码苏氨酸脱氨酶和/或AHAS的外源多核苷酸的DNA构建体。还提供了用这些植物转化的转基因植物，以及从这些植物衍生的种子和后代。与相同物种的非转基因植物相比，转基因植物具有增加的一种或多种氨基酸水平。

4. 发明申请

WO2003025153A2 ENHANCED PROTEINS AND METHODS FOR THEIR USE 审中-公开
标题翻译：增强蛋白质及其使用方法
公开(公告)号：WO2003025153A2
公开(公告)日：2003-03-27
申请号：PCT/US2002/030373
申请日：2002-09-17
申请人： MONSANTO TECHNOLOGY, LLC , RAPP, William, D. , PENG, Jiexin , NADIG, Gautham , VENKATESH, Tyamagondlu
发明人： RAPP, William, D. , PENG, Jiexin , NADIG, Gautham , VENKATESH, Tyamagondlu
IPC分类号： C12N
CPC分类号： C12N15/8254 , C07K14/415 , C12N15/8251 , C12N15/8253
摘要： The present invention generally relates to the field of plant genetics and protein biochemistry. More specifically, the present invention relates to modified proteins having an increased number of essential amino acids. The invention provides proteins modified to have an increased number of essential amino acids, nucleic acid sequences encoding the enhanced proteins, and methods of designing, producting, and using the same. The invention also includes compositions, transformed host cells, transgenic plants and seeds containing the enhanced proteins, and methods for preparing and using the same.
摘要翻译：本发明一般涉及植物遗传学和蛋白质生物化学领域。更具体地说，本发明涉及具有增加必需氨基酸数量的修饰蛋白质。本发明提供了经修饰以增加必需氨基酸数量的蛋白质，编码增强蛋白质的核酸序列，以及设计，生产和使用该蛋白质的方法。本发明还包括组合物，转化的宿主细胞，转基因植物和含有增强蛋白质的种子，以及制备和使用该蛋白质的方法。

5. 发明申请

WO2003025153A3 ENHANCED PROTEINS AND METHODS FOR THEIR USE 审中-公开
公开(公告)号：WO2003025153A3
公开(公告)日：2003-03-27
申请号：PCT/US2002/030373
申请日：2002-09-17
申请人： MONSANTO TECHNOLOGY, LLC , RAPP, William, D. , PENG, Jiexin , NADIG, Gautham , VENKATESH, Tyamagondlu
发明人： RAPP, William, D. , PENG, Jiexin , NADIG, Gautham , VENKATESH, Tyamagondlu
IPC分类号： A61K35/78
摘要： The present invention generally relates to the field of plant genetics and protein biochemistry. More specifically, the present invention relates to modified proteins having an increased number of essential amino acids. The invention provides proteins modified to have an increased number of essential amino acids, nucleic acid sequences encoding the enhanced proteins, and methods of designing, producting, and using the same. The invention also includes compositions, transformed host cells, transgenic plants and seeds containing the enhanced proteins, and methods for preparing and using the same.

6. 发明申请

WO2010002876A3 COMPOSITIONS AND METHODS FOR ENHANCED AMINO ACID LEVELS IN PLANTS 审中-公开
标题翻译：增强植物氨基酸水平的组合物和方法
公开(公告)号：WO2010002876A3
公开(公告)日：2010-03-11
申请号：PCT/US2009049233
申请日：2009-06-30
申请人： MONSANTO TECHNOLOGY LLC , CROWLEY JAMES H , GOLDMAN BARRY S , HUANG JINTAI , QI QUNGANG , RAPP WILLIAM D
发明人： CROWLEY JAMES H , GOLDMAN BARRY S , HUANG JINTAI , QI QUNGANG , RAPP WILLIAM D
IPC分类号： C12N15/54 , C12N15/82
CPC分类号： C12N9/1217 , C12N15/8251 , C12N15/8254
摘要： Threonine is an essential amino acid for humans and in the animal feed industry where its levels in feed rations can significantly impact the cost of production of important meat sources, such as swine and poultry. Threonine as well as essential amino acids lysine and methionine are all synthesized via the aspartate family pathway. Aspartate kinase (AK) is the first enzyme in the pathway, and catalyzes the ATP-dependent phosphorylation of aspartate to form ß-aspartyl phosphate. AK constitutes the main regulatory step controlling the metabolic flux through the pathway, and is subject to end product inhibition by Lys and/or Thr. The current invention provides a method to produce a transgenic high free threonine soybean via the overexpression of feedback-resistant AK enzymes in developing soybean plants and seeds. These modifications provide a method to enhance both plant nitrogen metabolism and crop growth performance.
摘要翻译：苏氨酸是人体必需的氨基酸，在动物饲料行业中，它的饲料日粮水平可以显着影响猪和家禽等重要肉类的生产成本。苏氨酸以及必需氨基酸赖氨酸和甲硫氨酸都是通过天冬氨酸家族途径合成的。天冬氨酸激酶（AK）是该途径中的第一种酶，并且催化天冬氨酸的ATP依赖性磷酸化以形成β-天冬氨酰磷酸。 AK构成控制通过途径的代谢通量的主要调节步骤，并且受到Lys和/或Thr的最终产物抑制。本发明提供了一种通过在发育中的大豆植物和种子中过量表达反馈抗性AK酶来生产转基因高游离苏氨酸大豆的方法。这些修改提供了一种提高植物氮代谢和作物生长性能的方法。

7. 发明申请

WO2010002876A2 COMPOSITIONS AND METHODS FOR ENHANCED AMINO ACID LEVELS IN PLANTS 审中-公开
标题翻译：植物中增强氨基酸水平的组成和方法
公开(公告)号：WO2010002876A2
公开(公告)日：2010-01-07
申请号：PCT/US2009/049233
申请日：2009-06-30
申请人： MONSANTO TECHNOLOGY LLC , CROWLEY, James, H. , GOLDMAN, Barry, S. , HUANG, Jintai , QI, Qungang , RAPP, William, D.
发明人： CROWLEY, James, H. , GOLDMAN, Barry, S. , HUANG, Jintai , QI, Qungang , RAPP, William, D.
IPC分类号： C12N15/54 , C12N15/82
CPC分类号： C12N9/1217 , C12N15/8251 , C12N15/8254
摘要： Threonine is an essential amino acid for humans and in the animal feed industry where its levels in feed rations can significantly impact the cost of production of important meat sources, such as swine and poultry. Threonine as well as essential amino acids lysine and methionine are all synthesized via the aspartate family pathway. Aspartate kinase (AK) is the first enzyme in the pathway, and catalyzes the ATP-dependent phosphorylation of aspartate to form β-aspartyl phosphate. AK constitutes the main regulatory step controlling the metabolic flux through the pathway, and is subject to end product inhibition by Lys and/or Thr. The current invention provides a method to produce a transgenic high free threonine soybean via the overexpression of feedback-resistant AK enzymes in developing soybean plants and seeds. These modifications provide a method to enhance both plant nitrogen metabolism and crop growth performance.
摘要翻译：苏氨酸是人类和动物饲料工业中必不可少的氨基酸，其饲料配给水平可以显着影响重要肉源的生产成本，如猪和家禽。苏氨酸以及必需氨基酸赖氨酸和甲硫氨酸均通过天冬氨酸家族途径合成。天冬氨酸激酶（AK）是途径中的第一个酶，并催化天冬氨酸的ATP依赖性磷酸化形成β-天冬氨酰磷酸酯。 AK构成控制通过该途径的代谢通量的主要调控步骤，并且受到Lys和/或Thr的最终产物抑制。本发明提供了一种通过在开发大豆植物和种子中反馈抗性AK酶的过表达产生转基因高游离苏氨酸大豆的方法。这些修饰提供了增强植物氮代谢和作物生长性能的方法。

8. 发明申请

WO2002090497A3 TRANSGENIC HIGH TRYPTOPHAN PLANTS 审中-公开
公开(公告)号：WO2002090497A3
公开(公告)日：2002-11-14
申请号：PCT/US2002/014207
申请日：2002-05-03
申请人： RENESSEN LLC , MONSANTO COMPANY , WEAVER, Lisa, M. , LIANG, Jihong , CHEN, Ridong , JEONG, Soon, Seog , MITSKY, Timothy , SLATER, Steven , RAPP, William
发明人： WEAVER, Lisa, M. , LIANG, Jihong , CHEN, Ridong , JEONG, Soon, Seog , MITSKY, Timothy , SLATER, Steven , RAPP, William
IPC分类号： A01H5/00
摘要： The present invention provides a method for conferring tolerance to an amino acid analog of tryptophan to a plant and/or altering the tryptophan content of a plant by introducing and expressing an isolated DNA segment encoding an anthranilate synthase in the cells of the plant. Transgenic plants transformed with an isolated DNA segment encoding an anthranilate synthase, as well as human or animal food, seeds and progeny derived from these plants, are also provided.

9. 发明申请

WO2002090497A2 TRANSGENIC HIGH TRYPTOPHAN PLANTS 审中-公开
标题翻译：转基因高铁植物
公开(公告)号：WO2002090497A2
公开(公告)日：2002-11-14
申请号：PCT/US2002/014207
申请日：2002-05-03
申请人： RENESSEN LLC , MONSANTO COMPANY , WEAVER, Lisa, M. , LIANG, Jihong , CHEN, Ridong , JEONG, Soon, Seog , MITSKY, Timothy , SLATER, Steven , RAPP, William
发明人： WEAVER, Lisa, M. , LIANG, Jihong , CHEN, Ridong , JEONG, Soon, Seog , MITSKY, Timothy , SLATER, Steven , RAPP, William
IPC分类号： C12N
CPC分类号： C12N15/8254 , C12N9/88
摘要： The present invention provides a method for conferring tolerance to an amino acid analog of tryptophan to a plant and/or altering the tryptophan content of a plant by introducing and expressing an isolated DNA segment encoding an anthranilate synthase in the cells of the plant. Transgenic plants transformed with an isolated DNA segment encoding an anthranilate synthase, as well as human or animal food, seeds and progeny derived from these plants, are also provided.
摘要翻译：本发明提供了通过在植物细胞中引入和表达编码邻氨基苯甲酸合酶的分离的DNA区段来赋予植物对色氨酸的氨基酸类似物的耐受性和/或改变植物的色氨酸含量的方法。还提供了用分离的DNA片段转化的转基因植物，其编码邻氨基苯甲酸合酶，以及人或动物食物，来自这些植物的种子和后代。

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