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1. 发明申请

WO2008124134A3 HIGH-PRESSURE REFOLDING OF PROTEINS IN THE PRESENCE OF BINDING PARTNERS 审中-公开
标题翻译：结合合作伙伴的蛋白质高压重组
公开(公告)号：WO2008124134A3
公开(公告)日：2009-03-19
申请号：PCT/US2008004517
申请日：2008-04-07
申请人： BAROFOLD INC , SEEFELDT MATTHEW B , HESTERBERG LYNDAL K , RANDOLPH THEODORE W , CARPENTER JOHN F
发明人： SEEFELDT MATTHEW B , HESTERBERG LYNDAL K , RANDOLPH THEODORE W , CARPENTER JOHN F
IPC分类号： C07K1/113
CPC分类号： C07K1/1136
摘要： Methods for producing biologically active protein from aggregated and/or denatured proteins which comprise subjecting the protein to high hydrostatic pressure in the presence of a ligand or specific binding agent are disclosed. The ligand can be a macromolecule, such as another protein, a nucleic acid, or other macromolecules, or the ligand can be a small organic molecule.
摘要翻译：公开了从凝集和/或变性蛋白质生产生物活性蛋白质的方法，其包括在配体或特异性结合剂存在下使蛋白质达到高静水压力。配体可以是大分子，例如另一种蛋白质，核酸或其他大分子，或者配体可以是小的有机分子。

2. 发明申请

WO2003087339A3 SPRAY FREEZE DRY OF COMPOSITIONS FOR PULMONARY ADMINISTRATION 审中-公开
公开(公告)号：WO2003087339A3
公开(公告)日：2003-10-23
申请号：PCT/US2003/011447
申请日：2003-04-10
申请人： MEDIMMUNE VACCINES, INC. , THE REGENTS OF THE UNIVERSITY OF COLORADO , TRUONG-LE, Vu , PHAM, Binh, V. , CARPENTER, John, F. , SEID, Robert , RANDOLPH, Theodore
发明人： TRUONG-LE, Vu , PHAM, Binh, V. , CARPENTER, John, F. , SEID, Robert , RANDOLPH, Theodore
IPC分类号： A61K39/00 , F26B7/00
摘要： This invention provides methods and compositions to preserve bioactive materials, such as viruses, bacteria, cells, or liposomes, in freeze dried particles suitable for pulmonary administration. Methods provide spray freeze drying of formulations to form stable freeze dried particles.

3. 发明申请

WO2002062827A3 IMPROVED PROTEIN DISAGGREGATION AND REFOLDING USING HIGH PRESSURE 审中-公开
公开(公告)号：WO2002062827A3
公开(公告)日：2002-08-15
申请号：PCT/US2001/045728
申请日：2001-10-31
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , RANDOLPH, Theodore, W. , CARPENTER, John, F. , ST. JOHN, Richard, J. , WEBB, Jonathan, N.
发明人： RANDOLPH, Theodore, W. , CARPENTER, John, F. , ST. JOHN, Richard, J. , WEBB, Jonathan, N.
IPC分类号： C07K1/113
摘要： The present invention discloses improved methods of disaggregating protein aggregates, and refolding denatured proteins, using high pressure. In particular, the present invention provides for the use of agitation, high temperature, "stepped" depressurization, dialysis and dilution under pressure to increase the speed and extent of aggregate dissolution and protein refolding.

4. 发明申请

WO9947543A2 SUSTAINED-RELEASE COMPOSITION INCLUDING AMORPHOUS POLYMER 审中-公开
标题翻译：持续释放组合物，包括非晶聚合物
公开(公告)号：WO9947543A2
公开(公告)日：1999-09-23
申请号：PCT/US9906198
申请日：1999-03-18
申请人： UNIV TECHNOLOGY CORP , RANDOLPH THEODORE W , MANNING MARK C , FALK RICHARD F
发明人： RANDOLPH THEODORE W , MANNING MARK C , FALK RICHARD F
IPC分类号： A61K9/16 , A61K9/22 , C07K
CPC分类号： A61K9/1617 , A61K9/0024 , A61K9/145 , A61K9/1694 , A61K47/541 , A61K47/554
摘要： Provided is a sustained release composition for sustained release of a pharmaceutical substance. The composition includes a biocompatible polymer that is highly amorphous and a pharmaceutical substance in a hydrophobic ion complex with an amphiphilic material. Also provided a compressed antisolvent method for manufacturing the composition, various product forms incorporating the composition and various uses for the composition.
摘要翻译：提供用于药物物质的持续释放的持续释放组合物。该组合物包括高度无定形的生物相容性聚合物和与两亲性物质在疏水性离子络合物中的药物。还提供了用于制造组合物的压缩抗溶剂方法，包含组合物的各种产品形式和用于组合物的各种用途。

5. 发明申请

WO2012158978A1 THERMOSTABLE VACCINE COMPOSITIONS AND METHODS OF PREPARING SAME 审中-公开
标题翻译：可热灭活疫苗组合物及其制备方法
公开(公告)号：WO2012158978A1
公开(公告)日：2012-11-22
申请号：PCT/US2012/038457
申请日：2012-05-17
申请人： SOLIGENIX, INC. , THE REGENTS OF THE UNIVERSITY OF COLORADO , HASSETT, Kimberly , NANDI, Pradyot , BREY, Robert , CARPENTER, John , RANDOLPH, Theodore
发明人： HASSETT, Kimberly , NANDI, Pradyot , BREY, Robert , CARPENTER, John , RANDOLPH, Theodore
IPC分类号： A61K39/00 , A61K39/38
CPC分类号： A61K39/00 , A61K9/0019 , A61K9/19 , A61K47/183 , A61K47/26 , A61K2039/55505 , A61K2039/55572 , Y02A50/464
摘要： The disclosure provides compositions relating to thermostable vaccines and methods of preparing same. Specifically, the disclosure provides for methods of preparing thermostable vaccines based on a recombinant ricin neurotoxin protein and uses of co-adjuvants to develop a composition capable of eliciting an immune response in a subject.
摘要翻译：本公开提供了与热稳定性疫苗有关的组合物及其制备方法。具体地，本公开提供了基于重组蓖麻毒蛋白神经毒素蛋白质制备耐热性疫苗的方法和辅助佐剂的用途来开发能够在受试者中引发免疫应答的组合物。

6. 发明申请

WO2009035617A1 HIGH-PRESSURE REFOLDING OF MONOCLONAL ANTIBODY AGGREGATES 审中-公开
标题翻译：单克隆抗体聚合物的高压重建
公开(公告)号：WO2009035617A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/010595
申请日：2008-09-10
申请人： BAROFOLD, INC. , SEEFELDT, Matthew, B. , RANDOLPH, Theodore, W. , NELSON, Robert , HESTERBERG, Lyndal, K.
发明人： SEEFELDT, Matthew, B. , RANDOLPH, Theodore, W. , NELSON, Robert , HESTERBERG, Lyndal, K.
IPC分类号： C07K1/113 , C07K16/00
CPC分类号： C07K16/2827 , C07K1/113 , C07K1/1136 , C07K14/70521 , C07K2319/30 , C07K2319/33
摘要： Methods for refolding antibodies, particularly monoclonal antibodies, from aggregated and/or denatured preparations by subjecting the antibody preparation to high hydrostatic pressure are provided. Refolded preparations of antibodies produced by the methods described herein are also provided.
摘要翻译：提供了通过使抗体制剂进行高静水压力从聚合和/或变性制剂中重新折叠抗体，特别是单克隆抗体的方法。还提供了通过本文所述方法产生的抗体的重折叠制剂。

7. 发明申请

WO2008118691A3 METHOD OF PREPARING AN IMMUNOLOGICALLY-ACTIVE ADJUVANT-BOUND DRIED VACCINE COMPOSITION 审中-公开
标题翻译：制备免疫活性佐剂结合疫苗组合物的方法
公开(公告)号：WO2008118691A3
公开(公告)日：2008-12-18
申请号：PCT/US2008057355
申请日：2008-03-18
申请人： UNIV COLORADO , RANDOLPH THEODORE W , CLAUSI AMBER , CARPENTER JOHN F , SCHWARTZ DANIEL K
发明人： RANDOLPH THEODORE W , CLAUSI AMBER , CARPENTER JOHN F , SCHWARTZ DANIEL K
IPC分类号： A61K39/00 , A01N63/00 , A61K39/02 , A61K39/38 , A61K45/00 , A61K49/00 , C07K2/00 , C07K14/00
CPC分类号： A61K47/48015 , A61K9/19 , A61K39/08 , A61K2039/55505 , A61K2039/55511 , A61K2039/60 , A61K2039/622
摘要： The disclosure provides a method of preparing an immunologically-active adjuvant-bound freeze dried vaccine composition. A specific embodiment provides a stable vaccine composition comprising an aluminum-salt adjuvant, a recombinant Clostridium botulinum neurotoxin protein and a glass-forming agent. These vaccine compositions are useful in the treatment of humans and other animals at risk of infection from Clostridium botulinum neurotoxin.
摘要翻译：本公开提供了制备免疫活性佐剂结合的冻干疫苗组合物的方法。具体的实施方案提供了稳定的疫苗组合物，其包含铝盐佐剂，重组肉毒杆菌神经毒素蛋白质和玻璃形成剂。这些疫苗组合物可用于治疗有肉毒梭状芽孢杆菌神经毒素感染风险的人和其他动物。

8. 发明申请

WO2008039761A2 STABILIZED ANTIBODY FORMULATIONS AND USES THEREOF 审中-公开
标题翻译：稳定的抗体制剂及其用途
公开(公告)号：WO2008039761A2
公开(公告)日：2008-04-03
申请号：PCT/US2007079403
申请日：2007-09-25
申请人： MEDIMMUNE INC , CARPENTER JOHN , SATHISH HASIGE , RANDOLPH THEODORE , SALINAS BRANDEN , ALLAN CHRISTIAN , BISHOP STEVEN
发明人： CARPENTER JOHN , SATHISH HASIGE , RANDOLPH THEODORE , SALINAS BRANDEN , ALLAN CHRISTIAN , BISHOP STEVEN
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K9/0019 , A61K39/39591 , A61K2039/505 , C07K16/00 , C07K2317/56 , C07K2317/565
摘要： The present invention provides methods of optimizing certain stable liquid formulations of antibodies that immunospecifically bind to antigens of interest. Such formulations are suitable for parenteral administration to a subject, and exhibit increased stability, low to undetectable levels of aggregation, low to undetectable levels of antibody fragmentation/degradation, and very little to no loss of the biological activities of the antibodies, even during long periods of storage. The methods of the invention provide formulations that offer multiple advantages over formulations produced by non-optimized methods, including less stringent or more readily available transportation and storage conditions, less frequent dosing, and/or smaller dosage amounts in the therapeutic, prophylactic and diagnostic uses of such formulations. The invention further provides methods of identifying antibodies exhibiting certain phase behaviors such that the antibodies can be formulated by the methods of the invention. Also provided are prophylactic, therapeutic, and diagnostic uses of such antibody formulations.
摘要翻译：本发明提供了优化免疫特异性结合目标抗原的抗体的某些稳定液体制剂的方法。这样的制剂适合于肠胃外施用于受试者，并且表现出增加的稳定性，低至不可检测的聚集水平，低至不可检测水平的抗体片段化/降解以及即使在长期储存期。本发明的方法提供了制剂，其提供了多种优于由非优化方法产生的制剂的优点，包括在治疗，预防和诊断用途中较不严格或更容易获得的运输和储存条件，较少频率的剂量和/或较小剂量的这种制剂。本发明进一步提供鉴定表现出某些相行为的抗体的方法，使得抗体可以通过本发明的方法配制。还提供了这些抗体制剂的预防，治疗和诊断用途。

9. 发明申请

WO2008033556A3 HIGH PRESSURE TREATMENT OF PROTEINS FOR REDUCED IMMUNOGENICITY 审中-公开
公开(公告)号：WO2008033556A3
公开(公告)日：2008-03-20
申请号：PCT/US2007/020128
申请日：2007-09-17
申请人： BAROFOLD, INC. , RANDOLPH, Theodore, W. , CARPENTER, John, F. , ST. JOHN, Richard , HESTERBERG, Lyndal, K. , SEEFELDT, Matthew, B.
发明人： RANDOLPH, Theodore, W. , CARPENTER, John, F. , ST. JOHN, Richard , HESTERBERG, Lyndal, K. , SEEFELDT, Matthew, B.
IPC分类号： C07K1/113 , A61K38/27 , A61K38/21 , A61K38/17
摘要： Protein compositions obtained by high pressure treatment and with reduced immunogenicity are disclosed, as well as methods for producing such compositions.

10. 发明申请

WO2009055427A3 METHODS FOR EVALUATING THE AGGREGATION OF A PROTEIN IN A SUSPENSION INCLUDING ORGANOPOLYSILOXANE AND MEDICAL ARTICLES COATED WITH ORGANOPOLYSILOXANE CONTAINING A PROTEIN SOLUTION 审中-公开
公开(公告)号：WO2009055427A3
公开(公告)日：2009-04-30
申请号：PCT/US2008/080721
申请日：2008-10-22
申请人： BECTON, DICKINSON AND COMPANY , THE REGENTS OF THE UNIVERSITY OF COLORADO , TROTTER, Joseph, T. , HAMEL, Jean-Bernard , CARPENTER, John, Frank , RANDOLPH, Theodore , GABRIELSON, John, Paul
发明人： TROTTER, Joseph, T. , HAMEL, Jean-Bernard , CARPENTER, John, Frank , RANDOLPH, Theodore , GABRIELSON, John, Paul
IPC分类号： G01N33/58 , G01N33/68 , A61M3/00
摘要： This invention relates to methods for evaluating or inhibiting the aggregation of a protein in an aqueous suspension including organopolysiloxane and medical articles coated with organopolysiloxane containing a protein solution including sugar and a non-ionic surfactant.

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