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1. 发明申请

WO2010086382A1 TARGET FOR TREATMENT OF ACUTE HEART FAILURE 审中-公开
标题翻译：治疗急性心脏衰竭的目标
公开(公告)号：WO2010086382A1
公开(公告)日：2010-08-05
申请号：PCT/EP2010/051019
申请日：2010-01-28
申请人： PRONOTA N.V. , KAS, Koen
发明人： KAS, Koen
IPC分类号： A61K38/44 , C12N9/02 , G01N33/50 , C12Q1/02 , C12Q1/26 , A61P9/10
CPC分类号： C12N9/0051 , A61K38/00 , C12Y108/03002 , G01N33/6893 , G01N2800/325
摘要： The application discloses Quiescin Q6 as a new target for treating acute heart failure; methods for screening agents that can modulate the level and/or activity of said target and methods for treating acute heart failure based on modulating the level and/or activity of said target; and kits and devices for performing said methods.
摘要翻译：该申请公开了Quiescin Q6作为治疗急性心力衰竭的新靶点; 可以调节所述靶标的水平和/或活性的筛选剂的方法和基于调节所述靶标的水平和/或活性来治疗急性心力衰竭的方法; 以及用于执行所述方法的套件和设备。

2. 发明申请

WO2009050275A1 A PROTEASE-SENSITIVE SITE IN APOLIPOPROTEIN A1, THERAPEUTIC AND DIAGNOSTIC IMPLICATIONS 审中-公开
标题翻译： APOLIPOPROTEIN A1中的蛋白敏感位点，治疗和诊断意义
公开(公告)号：WO2009050275A1
公开(公告)日：2009-04-23
申请号：PCT/EP2008/064054
申请日：2008-10-17
申请人： PRONOTA N.V. , EYCKERMAN, Sven , KAS, Koen , LABEUR, Christine
发明人： EYCKERMAN, Sven , KAS, Koen , LABEUR, Christine
IPC分类号： C07K14/775 , A61K38/17 , G01N33/50 , G01N33/92
CPC分类号： C07K14/775 , A61K38/00
摘要： The invention relates to the identification of a naturally occurring internal proteolytic cleavage site in the ApoA1 protein, which leads to inactivation of the mature protein. Specific modification of this cleavage site leads to a stabilised ApoA1 protein, which is beneficial for the reverse cholesterol transport. The invention therefore encompasses pharmaceutical compositions comprising a recombinant stabilised variant ApoA1 protein or rHDL particles comprising such a protein, for use in the treatment of patients having reduced HDL or hampered reverse cholesterol transport.
摘要翻译：本发明涉及鉴定ApoA1蛋白质中天然存在的内部蛋白水解切割位点，导致成熟蛋白质失活。该切割位点的特异性修饰导致稳定的ApoA1蛋白，其有利于反向胆固醇转运。因此，本发明包括包含重组稳定变体ApoA1蛋白或包含这种蛋白质的rHDL颗粒的药物组合物，用于治疗具有降低的HDL或阻碍的反向胆固醇转运的患者。

3. 发明申请

WO2011048168A1 BIOMARKER FOR DIAGNOSIS, PREDICTION AND/OR PROGNOSIS OF ACUTE HEART FAILURE AND USES THEREOF 审中-公开
标题翻译：用于诊断，预测和/或预防急性心脏衰竭的生物标记物及其用途
公开(公告)号：WO2011048168A1
公开(公告)日：2011-04-28
申请号：PCT/EP2010/065841
申请日：2010-10-21
申请人： Pronota N.V. , KAS, Koen
发明人： KAS, Koen
IPC分类号： G01N33/68
CPC分类号： G01N33/6872 , G01N33/574 , G01N33/68 , G01N2333/70503 , G01N2333/70596 , G01N2800/12 , G01N2800/325 , G01N2800/52
摘要： The application discloses MCAM as a new biomarker for acute heart failure; methods for predicting, diagnosing, prognosticating and/or monitoring acute heart failure based on measuring said biomarker; and kits and devices for measuring said biomarker and/or performing said methods.
摘要翻译：该申请公开了MCAM作为急性心力衰竭的新生物标志物; 基于测量所述生物标志物来预测，诊断，预后和/或监测急性心力衰竭的方法; 以及用于测量所述生物标志物和/或执行所述方法的试剂盒和装置。

4. 发明申请

WO2010086384A1 TARGET FOR TREATMENT OF ACUTE HEART FAILURE 审中-公开
标题翻译：治疗急性心力衰竭的目标
公开(公告)号：WO2010086384A1
公开(公告)日：2010-08-05
申请号：PCT/EP2010/051022
申请日：2010-01-28
申请人： PRONOTA N.V. , KAS, Koen
发明人： KAS, Koen
IPC分类号： A61K38/44 , C12N9/02 , C12Q1/02 , C12Q1/26 , G01N33/50 , C12N15/113 , C12N15/115 , A61P9/10
CPC分类号： C12N9/0051 , A61K38/00 , C12N15/1137 , C12N2310/14 , C12Y108/03002 , G01N33/6893 , G01N2333/90212 , G01N2500/04 , G01N2800/325
摘要： The application discloses Quiescin Q6 as a new target for treating acute heart failure; methods for screening agents that can modulate the level and/or activity of said target and methods for treating acute heart failure based on modulating the level and/or activity of said target; and kits and devices for performing said methods.
摘要翻译：该申请公开了Quiescin Q6作为治疗急性心力衰竭的新靶标; 基于调节所述靶标的水平和/或活性，筛选能够调节所述靶标的水平和/或活性的试剂的方法和治疗急性心力衰竭的方法; 以及执行所述方法的试剂盒和设备。

5. 发明申请

WO2009141359A1 NEW BIOMARKER FOR DIAGNOSIS, PREDICTION AND/OR PROGNOSIS OF SEPSIS AND USES THEREOF 审中-公开
标题翻译：用于诊断，预测和/或预防接种的新生物标记及其用途
公开(公告)号：WO2009141359A1
公开(公告)日：2009-11-26
申请号：PCT/EP2009/056094
申请日：2009-05-19
申请人： PRONOTA N.V. , KAS, Koen , VANPOUCKE, Griet
发明人： KAS, Koen , VANPOUCKE, Griet
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2800/26 , G01N2800/56
摘要： The present invention provides kits and methods for the diagnosis, prognosis and prediction of sepsis in a subject using the expression level of the TREML-1 biomarker as an indication of the condition of the patient, alone or in combination with further sepsis markers.
摘要翻译：本发明提供用于使用TREML-1生物标志物的表达水平单独或与进一步的败血症标记物组合的患者状况的指示来诊断，预测和预测受试者中败血症的试剂盒和方法。

6. 发明申请

WO2009138466A3 NOVEL POLYPEPTIDES RELATED TO B-TYPE NATRIURETIC PEPTIDES AND METHODS OF THEIR IDENTIFICATION AND USE 审中-公开
公开(公告)号：WO2009138466A3
公开(公告)日：2009-11-19
申请号：PCT/EP2009/055851
申请日：2009-05-14
申请人： PRONOTA N.V. , KAS, Koen , TUYTTEN, Robin , DE CREMER, Koen , VANPOUCKE, Griet
发明人： KAS, Koen , TUYTTEN, Robin , DE CREMER, Koen , VANPOUCKE, Griet
IPC分类号： C07K14/575 , C07K14/58 , G01N33/74
摘要： The invention provides novel fragments of proBNP and NTproBNP, particularly useful in prognosing or diagnosing acute heart failure, chronic heart failure or sepsis.

7. 发明申请

WO2013023994A1 NEW BIOMARKER FOR THE CLASSIFICATION OF OVARIAN TUMOURS 审中-公开
标题翻译：用于OVARIAN肿瘤分类的新生物标记
公开(公告)号：WO2013023994A1
公开(公告)日：2013-02-21
申请号：PCT/EP2012/065610
申请日：2012-08-09
申请人： PRONOTA N.V. , MOERMAN, Piet
发明人： MOERMAN, Piet
IPC分类号： G01N33/574
CPC分类号： G01N33/57449 , G01N2333/4725 , G01N2333/8139 , G01N2800/50 , G01N2800/52
摘要： The application discloses Cystatin-C or fragments thereof as a new biomarker for classifying an ovarian tumour in a subject; methods for classification of an ovarian tumour in a subject based on measuring said biomarker; and kits and devices for measuring said biomarker and/or performing said methods.
摘要翻译：该申请公开了半胱氨酸蛋白酶抑制剂C或其片段作为用于分类受试者卵巢肿瘤的新生物标志物; 基于测量所述生物标志物在受试者中分类卵巢肿瘤的方法; 以及用于测量所述生物标志物和/或执行所述方法的试剂盒和装置。

8. 发明申请

WO2012004371A3 QUIESCIN Q6 AS BIOMARKER FOR HYPERTENSIVE DISORDERS OF PREGNANCY 审中-公开
公开(公告)号：WO2012004371A3
公开(公告)日：2012-01-12
申请号：PCT/EP2011/061565
申请日：2011-07-08
申请人： PRONOTA N.V. , KAS, Koen
发明人： KAS, Koen
IPC分类号： G01N33/68
摘要： The application discloses a new tool for predicting, diagnosing and prognosing hypertensive disorders of pregnancy and particularly preeclampsia; methods for the diagnosis, prediction, prognosis and/or monitoring said disorders; and kits and devices for measuring said biomarker and/or performing said methods.

9. 发明申请

WO2011048173A1 MCAM AS A BIOMARKER FOR FLUID HOMEOSTASIS 审中-公开
标题翻译： MCAM作为流体动力学的生物标记
公开(公告)号：WO2011048173A1
公开(公告)日：2011-04-28
申请号：PCT/EP2010/065852
申请日：2010-10-21
申请人： PRONOTA N.V. , KAS, Koen
发明人： KAS, Koen
IPC分类号： G01N33/68
CPC分类号： G01N33/6872 , G01N33/574 , G01N33/68 , G01N2333/70503 , G01N2333/70596 , G01N2800/12 , G01N2800/325 , G01N2800/52
摘要： The application discloses MCAM as a new biomarker for fluid homeostatic imbalance; methods for predicting, diagnosing, prognosticating and/or monitoring fluid homeostatic imbalance based on measuring said biomarker; and kits and devices for measuring said biomarker and/or performing said methods.
摘要翻译：该应用公开了MCAM作为流体稳态失衡的新生物标志物; 基于测量所述生物标志物预测，诊断，预测和/或监测流体稳态不平衡的方法; 以及用于测量所述生物标志物和/或执行所述方法的试剂盒和装置。

10. 发明申请

WO2009062948A1 BIOMARKERS AND METHODS FOR DIAGNOSING, PREDICTING AND/OR PROGNOSING SEPSIS AND USES THEREOF 审中-公开
标题翻译：用于诊断，预测和/或预防接触的生物标记物和方法及其用途
公开(公告)号：WO2009062948A1
公开(公告)日：2009-05-22
申请号：PCT/EP2008/065364
申请日：2008-11-12
申请人： PRONOTA N.V. , KAS, Koen , VANPOUCKE, Griet , DEGROEVE, Sven , HUIJBEN, Kathleen
发明人： KAS, Koen , VANPOUCKE, Griet , DEGROEVE, Sven , HUIJBEN, Kathleen
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C07K17/02 , G01N2800/26 , G01N2800/50 , G01N2800/52
摘要： The present invention provides kits and methods for the diagnosis, prognosis and prediction of sepsis in a subject or for the differentiation between sepsis and SIRS in a subject, the method comprising(a) measuring the level of pro-hepcidin (pro-HEPC) in a biological sample taken from said subject, (b) measuring the level of at least one further biomarker selected from the group consisting of soluble TNF-receptor 2 (sTNFR2), Pentraxin-3 (PTX-3), Macrophage Colony-Stimulating Factor (MCSF), pro-Brain Natriuretic Protein (pro-BNP), one or more members of the Histone protein family, Procalcitonin (PCT) and c-Reactive Protein (CRP) in a biological sample from said subject, (c) using said measurements obtained in steps (a) and (b) to create a profile for said biomarkers and (d) comparing said profile with a reference biomarker profile obtained form a patient having SIRS or from a healthy subject.
摘要翻译：本发明提供了用于诊断，预后和预测受试者中败血症或受试者中脓毒症和SIRS之间分化的试剂盒和方法，所述方法包括（a）测量前体铁调素（pro-hepcidin）从所述对象获取的生物样品，（b）测量至少一种选自下组的生物标志物的水平：可溶性TNF-受体2（sTNFR2），Pentraxin-3（PTX-3），巨噬细胞集落刺激因子 MCSF），前脑利钠蛋白（pro-BNP），组蛋白家族中的一个或多个成员，来自所述受试者的生物样品中的降钙素原（PCT）和C-反应蛋白（CRP），（c）在步骤（a）和（b）中获得以产生用于所述生物标志物的分布图，和（d）将所述分布与从具有SIRS或健康受试者的患者获得的参考生物标志物概况进行比较。

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