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1. 发明申请

WO2012068637A1 COMPOSITIONS AND METHODS 审中-公开
标题翻译：组合物和方法
公开(公告)号：WO2012068637A1
公开(公告)日：2012-05-31
申请号：PCT/AU2011/001534
申请日：2011-11-25
申请人： THE MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH , DRUMMER, Heidi , MCCAFFREY, Kathleen , POUMBOURIOS, Pantelis
发明人： DRUMMER, Heidi , MCCAFFREY, Kathleen , POUMBOURIOS, Pantelis
IPC分类号： A61K39/29 , A61P31/14 , C07K14/18 , C07K16/10 , G01N33/576
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/55577 , A61K2039/70 , C07K14/005 , C12N2770/24222 , C12N2770/24234 , C12N2770/24271 , G01N33/5767 , G01N2333/186 , G01N2400/02 , G01N2469/20 , G01N2800/52
摘要： The present invention provides a composition comprising hepatitis C virus (HCV) Envelope 2 (E2) glycoprotein, wherein the HCV E2 is substantially monomer depleted HCV E2. Also provide are methods of inducing an HCV immune response.
摘要翻译：本发明提供包含丙型肝炎病毒（HCV）包膜2（E2）糖蛋白的组合物，其中HCV E2基本上是单体耗尽的HCV E2。还提供诱导HCV免疫应答的方法。

2. 发明申请

WO2012016290A1 MODIFIED HEPATITIS C VIRUS PROTEINS 审中-公开
标题翻译：改良型HEPATITIS C病毒蛋白
公开(公告)号：WO2012016290A1
公开(公告)日：2012-02-09
申请号：PCT/AU2011/000991
申请日：2011-08-04
申请人： THE MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH LTD , DRUMMER, Heidi , POUMBOURIOS, Pantelis , MCCAFFREY, Kathleen
发明人： DRUMMER, Heidi , MCCAFFREY, Kathleen
IPC分类号： A61K39/29 , C12N7/00 , C07K14/02 , C12Q1/70
CPC分类号： C07K14/1833 , A61K39/00 , A61K39/12 , C07K14/005 , C07K16/109 , C07K2317/76 , C12N7/00 , C12N2770/24222 , C12N2770/24261 , C12N2770/24262 , G01N33/56983
摘要： A composition comprising a hepatitis C virus (HCV) Envelope 2 (E2) polypeptide including a receptor binding variant, wherein the polypeptide is modified to comprise: (i) a cysteine mutated or disrupted at 2, 3, or 4 cysteines selected from C452, C486, C569, and C597; and wherein the polypeptide forms substantially fewer multimers by intermolecular disulfide bonding relative to the HCV E2 polypeptide without cysteine modification, and substantially retains CD81 binding; and various uses thereof. A method of producing a composition comprising at least 40%, or at least 45%, or at least 50%, or at least 55%, or at least 60%, or at least 65%, or at least 70% monomelic HCV E2 polypeptide, the method comprising expressing a polypeptide in a host cell and isolating the expressed product, wherein the polypeptide is an HCV E2 polypeptide including a receptor binding variant, and wherein the polypeptide is modified to comprise: (i) a cysteine mutated or disrupted at 2, 3, or 4 cysteines selected from C452, C486, C569, and C597.
摘要翻译：一种组合物，其包含包含受体结合变体的丙型肝炎病毒（HCV）包膜2（E2）多肽，其中所述多肽被修饰为包含：（i）在2,3或4个半胱氨酸突变或破坏的半胱氨酸，所述半胱氨酸选自C452， C486，C569和C597; 并且其中所述多肽通过分子间二硫键相对于没有半胱氨酸修饰的HCV E2多肽而形成基本上更少的多聚体，并且基本上保留CD81结合; 及其各种用途。一种制备包含至少40％，或至少45％，或至少50％，或至少55％，或至少60％，或至少65％，或至少70％单体HCV E2的组合物的方法所述方法包括在宿主细胞中表达多肽并分离所述表达的产物，其中所述多肽是包含受体结合变体的HCV E2多肽，并且其中所述多肽被修饰为包含：（i）在所述多肽中突变或破坏的半胱氨酸 2,3或4个选自C452，C486，C569和C597的半胱氨酸。

3. 发明申请

WO2008022401A1 RECOMBINANT HCV E2 GLYCOPROTEIN 审中-公开
标题翻译：重组HCV E2 GLYCOPROTEIN
公开(公告)号：WO2008022401A1
公开(公告)日：2008-02-28
申请号：PCT/AU2007/001221
申请日：2007-08-24
申请人： THE MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH LIMITED , MC CAFFREY, Kathleen , DRUMMER, Heidi , POUMBOURIOS, Pantelis
发明人： MC CAFFREY, Kathleen , DRUMMER, Heidi , POUMBOURIOS, Pantelis
IPC分类号： C07K14/18 , A61K39/29 , C07K1/36 , A61K35/76 , A61K39/42 , C07K16/08 , A61K38/02 , A61P31/14 , C12P21/08
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/505 , A61K2039/545 , A61K2039/55577 , C07K16/109 , C07K2317/34 , C07K2317/76 , C07K2319/00 , C12N2770/24222 , C12N2770/24234
摘要： The invention provides modified hepatitis C virus (HCV) E2 glycoproteins comprising the HCV-E2 receptor-binding domain (RBD) including the HVR1, HVR2 and igVR variable regions wherein in at least one of said variable regions at least a part of the variable region is replaced with a flexible linker sequence. The invention also provides vaccine compositions comprising the modified glycoproteins as well as methods of use thereof.
摘要翻译：本发明提供了包含HVR1，HVR2和igVR可变区的HCV-E2受体结合结构域（RBD）的修饰型丙型肝炎病毒（HCV）E2糖蛋白，其中在至少一个所述可变区中至少一部分可变区被柔性接头序列替代。本发明还提供包含修饰的糖蛋白的疫苗组合物及其使用方法。

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