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1. 发明申请

WO2015112619A1 METHODS AND SYSTEMS FOR DETECTING GENETIC MUTATIONS 审中-公开
标题翻译：用于检测遗传突变的方法和系统
公开(公告)号：WO2015112619A1
公开(公告)日：2015-07-30
申请号：PCT/US2015/012273
申请日：2015-01-21
申请人： PLATT, Adam
发明人： PLATT, Adam
IPC分类号： C12Q1/68 , G06F19/22
CPC分类号： C12Q1/6827 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G06F19/18 , G06F19/22
摘要： Methods for detecting a genetic mutation in target nucleotide sequences by sorting the target nucleotide sequences into bins, aligning the target nucleotide sequences in each bin with reference nucleotide sequences, and quantifying the number of target nucleotide sequences that align with reference sequences. Systems and kits for detecting a genetic mutation in target nucleotide sequences.
摘要翻译：用于通过将靶核苷酸序列分选成箱体来检测靶核苷酸序列中的遗传突变的方法，使每个箱中的靶核苷酸序列与参考核苷酸序列匹配，并定量与参考序列一致的靶核苷酸序列的数目。用于检测靶核苷酸序列遗传突变的系统和试剂盒。

2. 发明申请

WO2009053936A1 VALVE, COMPRISING SNAP-FITTING HANDLE FOR REGULATING FLUID 审中-公开
标题翻译：阀，包括用于调节流体的快速锁定手柄
公开(公告)号：WO2009053936A1
公开(公告)日：2009-04-30
申请号：PCT/IB2008/054397
申请日：2008-10-24
申请人： UPONOR INNOVATION AB , CLASEN, Keith , PLATT, Adam
发明人： CLASEN, Keith , PLATT, Adam
IPC分类号： F16K3/08 , F16K35/06
CPC分类号： F16K3/085 , Y10T137/86743
摘要： A valve comprises a housing and at least three ceramic discs in the housing such that at least two fixed ceramic discs are provided and at least one rotatable ceramic disc is provided between the fixed ceramic discs. The ceramic discs comprise through holes such that when the holes are aligned, the valve is open, and turning the rotatable ceramic disc turns the holes to be misaligned in successive ceramic discs, which prevents water flow through the valve. The valve further comprises a handle for rotating a rotatable ceramic disc and the handle comprises a stem extending through the housing, and a curved part, the curved part curving at least partly around the housing along the circumference of the housing.
摘要翻译：阀包括壳体和壳体中的至少三个陶瓷盘，使得设置至少两个固定陶瓷盘，并且在固定陶瓷盘之间提供至少一个可旋转陶瓷盘。陶瓷盘包括通孔，使得当孔对准时，阀打开，并且转动可旋转的陶瓷盘将孔转动成在连续的陶瓷盘中不对准，这防止水流过阀。阀还包括用于旋转可旋转陶瓷盘的手柄，并且手柄包括延伸穿过壳体的杆和弯曲部分，弯曲部分沿着壳体的圆周至少部分地围绕壳体弯曲。

3. 发明申请

WO2015112619A9 METHODS AND SYSTEMS FOR DETECTING GENETIC MUTATIONS 审中-公开
标题翻译：用于检测遗传突变的方法和系统
公开(公告)号：WO2015112619A9
公开(公告)日：2016-03-17
申请号：PCT/US2015012273
申请日：2015-01-21
申请人： PLATT ADAM
发明人： PLATT ADAM
IPC分类号： C12Q1/68 , G06F19/22
CPC分类号： C12Q1/6827 , C12Q1/6883 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G06F19/18 , G06F19/22
摘要： Methods for detecting a genetic mutation in target nucleotide sequences by sorting the target nucleotide sequences into bins, aligning the target nucleotide sequences in each bin with reference nucleotide sequences, and quantifying the number of target nucleotide sequences that align with reference sequences. Systems and kits for detecting a genetic mutation in target nucleotide sequences.
摘要翻译：用于通过将靶核苷酸序列分选成箱体来检测靶核苷酸序列中的遗传突变的方法，使每个箱中的靶核苷酸序列与参考核苷酸序列匹配，并定量与参考序列一致的靶核苷酸序列的数目。用于检测靶核苷酸序列遗传突变的系统和试剂盒。

4. 发明申请

WO2012093254A1 LIPOCALIN 2 AS A BIOMARKER FOR IL-17 INHIBITOR THERAPY EFFICACY 审中-公开
标题翻译： LIPOCALIN 2作为IL-17抑制剂治疗效果的生物标志物
公开(公告)号：WO2012093254A1
公开(公告)日：2012-07-12
申请号：PCT/GB2012/000014
申请日：2012-01-09
申请人： UCB PHARMA S.A. , PLATT, Adam, Samuel , RAPECKI, Stephen, Edward , FORTUNATO, Mara , RUNDLE, Jon Leigh , SMITH, Paul Alfred , WATT, Gillian Sairfull
发明人： PLATT, Adam, Samuel , RAPECKI, Stephen, Edward , FORTUNATO, Mara , RUNDLE, Jon Leigh , SMITH, Paul Alfred , WATT, Gillian Sairfull
IPC分类号： G01N33/564 , G01N33/68
CPC分类号： G01N33/6869 , G01N33/564 , G01N33/6893 , G01N2333/54 , G01N2800/52
摘要： The present invention provides the use of lipocalin 2 (LCN2) as a biomarker for IL-17 mediated diseases and for monitoring the response of a patient to anti-IL-17 therapy.
摘要翻译：本发明提供脂质运载蛋白2（LCN2）作为IL-17介导的疾病的生物标志物并用于监测患者对抗IL-17治疗的反应的用途。

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