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1. 发明申请

WO2012108648A2 METHOD OF PREPARING IRON OXIDE NANOPARTICLES COATED WITH HYDROPHILIC MATERIAL, AND MAGNETIC RESONANCE IMAGING CONTRAST AGENT USING THE SAME 审中-公开
标题翻译：用氢化物质涂覆氧化镍纳米粒子的方法和使用其的磁共振成像对比剂
公开(公告)号：WO2012108648A2
公开(公告)日：2012-08-16
申请号：PCT/KR2012/000845
申请日：2012-02-06
申请人： HANWHA CHEMICAL CORPORATION , HYEON, Taeghwan , PIAO, Yuanzhe , PARK, Yong Il
发明人： HYEON, Taeghwan , PIAO, Yuanzhe , PARK, Yong Il
IPC分类号： A61K49/18 , A61K49/04 , A61K9/28 , A61K9/16 , A61K47/30
CPC分类号： A61K49/1824 , A61K49/186 , A61K49/1863 , B82Y30/00 , C01G49/02 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/51 , C01P2004/64 , C01P2006/42 , C09C1/24 , C09C3/08
摘要： The present invention relates to a method of preparing biocompatible iron oxide nanoparticles by coating iron oxide nanoparticles having improved magnetism via annealing treatment using salt particles with a hydrophilic material and to a magnetic resonance imaging (MRI) contrast agent including the iron oxide nanoparticles prepared thereby. Among hydrophilic materials, carboxymethyl dextran (CM-dextran) is the most efficient in terms of stabilizing the annealed iron oxide nanoparticles and exhibiting contrast effects.
摘要翻译：本发明涉及一种制备生物相容性氧化铁纳米粒子的方法，该方法是通过使用具有亲水性材料的盐颗粒进行退火处理和通过包含由其制备的氧化铁纳米粒子的磁共振成像（MRI）造影剂来涂覆具有改善的磁性的氧化铁纳米颗粒。在亲水性材料中，羧甲基葡聚糖（CM-葡聚糖）在稳定退火的氧化铁纳米颗粒方面是最有效的，并且具有对比效果。

2. 发明申请

WO2013012268A2 VOLUME PRODUCTION METHOD FOR UNIFORMLY SIZED SILICA NANOPARTICLES 审中-公开
公开(公告)号：WO2013012268A2
公开(公告)日：2013-01-24
申请号：PCT/KR2012005770
申请日：2012-07-19
申请人： SNU R&DB FOUNDATION , HYEON TAEGHWAN , PIAO YUANZHE , QUAN BO
发明人： HYEON TAEGHWAN , PIAO YUANZHE , QUAN BO
IPC分类号： C01B33/18 , B82B3/00 , B82Y40/00 , C01B33/12
CPC分类号： C01B33/18 , B82Y30/00 , B82Y40/00 , C01P2004/52 , C01P2004/64
摘要： The present invention relates to a volume production method for uniformly sized silica nanoparticles using a basic buffer solution. More specifically, the present invention relates to a production method for uniformly sized silica nanoparticles comprising the steps of: (i) adding a solution, obtained by dissolving a silica precursor in an organic solvent, to a basic buffer solution and heating same; and (ii) isolating the silica nanoparticles generated in step (i).

3. 发明申请

WO2011025276A3 PREPARATION METHOD OF METAL OXIDE-CARBON NANOCOMPOSITE 审中-公开
标题翻译：金属氧化物 - 碳纳米复合材料的制备方法
公开(公告)号：WO2011025276A3
公开(公告)日：2011-08-04
申请号：PCT/KR2010005725
申请日：2010-08-26
申请人： SNU R&DB FOUNDATION , HYEON TAEGHWAN , PIAO YUANZHE , SUNG YUNG-EUN , KIM HYUN SIK
发明人： HYEON TAEGHWAN , PIAO YUANZHE , SUNG YUNG-EUN , KIM HYUN SIK
IPC分类号： B82B3/00
CPC分类号： H01M4/131 , H01M4/366 , H01M4/525
摘要： Disclosed is a preparation method of a metal oxide-carbon nanocomposite, wherein a mixture comprising nanoparticles comprising metal oxyhydroxides or metal oxides and a carbon precursor is treated at pressure lower than an atmospheric pressure to form an organic coating layer encompassing the nanoparticles. The nanoparticles encompassed by the organic coating layer are heat treated to form metal oxide nanoparticles encompassed by a carbon substrate. The metal oxide-carbon nanocomposite is applied to an electrode material of a secondary battery, thereby improving charge/discharge performance and capacity.
摘要翻译：公开了一种金属氧化物 - 碳纳米复合材料的制备方法，其中包含含有金属羟基氧化物或金属氧化物的纳米颗粒和碳前体的混合物在低于大气压的压力下处理以形成包围纳米颗粒的有机涂层。将由有机涂层包围的纳米粒子热处理以形成由碳基材包围的金属氧化物纳米粒子。将金属氧化物 - 碳纳米复合材料应用于二次电池的电极材料，由此改善充电/放电性能和容量。

4. 发明申请

WO2013012268A3 VOLUME PRODUCTION METHOD FOR UNIFORMLY SIZED SILICA NANOPARTICLES 审中-公开
标题翻译：用于均匀二氧化硅纳米粒子的体积生产方法
公开(公告)号：WO2013012268A3
公开(公告)日：2013-05-10
申请号：PCT/KR2012005770
申请日：2012-07-19
申请人： SNU R&DB FOUNDATION , HYEON TAEGHWAN , PIAO YUANZHE , QUAN BO
发明人： HYEON TAEGHWAN , PIAO YUANZHE , QUAN BO
IPC分类号： C01B33/18 , B82B3/00 , B82Y40/00 , C01B33/12
CPC分类号： C01B33/18 , B82Y30/00 , B82Y40/00 , C01P2004/52 , C01P2004/64
摘要： The present invention relates to a volume production method for uniformly sized silica nanoparticles using a basic buffer solution. More specifically, the present invention relates to a production method for uniformly sized silica nanoparticles comprising the steps of: (i) adding a solution, obtained by dissolving a silica precursor in an organic solvent, to a basic buffer solution and heating same; and (ii) isolating the silica nanoparticles generated in step (i).
摘要翻译：本发明涉及使用碱性缓冲溶液的均匀二氧化硅纳米粒子的体积生产方法。更具体地说，本发明涉及均匀尺寸的二氧化硅纳米粒子的制造方法，包括以下步骤：（i）将通过将二氧化硅前体溶解在有机溶剂中得到的溶液加入到碱性缓冲溶液中并加热; 和（ii）分离步骤（i）中生成的二氧化硅纳米颗粒。

5. 发明申请

WO2012108648A3 METHOD OF PREPARING IRON OXIDE NANOPARTICLES COATED WITH HYDROPHILIC MATERIAL, AND MAGNETIC RESONANCE IMAGING CONTRAST AGENT USING THE SAME 审中-公开
标题翻译：制备包含亲水材料的氧化铁纳米颗粒的方法以及使用该方法的磁共振成像造影剂
公开(公告)号：WO2012108648A3
公开(公告)日：2012-11-01
申请号：PCT/KR2012000845
申请日：2012-02-06
申请人： HANWHA CHEMICAL CORP , HYEON TAEGHWAN , PIAO YUANZHE , PARK YONG IL
发明人： HYEON TAEGHWAN , PIAO YUANZHE , PARK YONG IL
IPC分类号： A61K49/18 , A61K9/16 , A61K9/28 , A61K47/30 , A61K49/04
CPC分类号： A61K49/1824 , A61K49/186 , A61K49/1863 , B82Y30/00 , C01G49/02 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/51 , C01P2004/64 , C01P2006/42 , C09C1/24 , C09C3/08
摘要： The present invention relates to a method of preparing biocompatible iron oxide nanoparticles by coating iron oxide nanoparticles having improved magnetism via annealing treatment using salt particles with a hydrophilic material and to a magnetic resonance imaging (MRI) contrast agent including the iron oxide nanoparticles prepared thereby. Among hydrophilic materials, carboxymethyl dextran (CM-dextran) is the most efficient in terms of stabilizing the annealed iron oxide nanoparticles and exhibiting contrast effects.
摘要翻译：本发明涉及一种制备生物相容性氧化铁纳米颗粒的方法，该方法通过使用具有亲水性材料的盐颗粒进行退火处理来涂覆具有改善的磁性的氧化铁纳米颗粒，并且涉及包括由其制备的氧化铁纳米颗粒的磁共振成像（MRI）造影剂。在亲水性材料中，羧甲基葡聚糖（CM-葡聚糖）在稳定退火的氧化铁纳米颗粒方面是最有效的并且表现出对比效果。

6. 发明申请

WO2008069561A1 METAL OXIDE HOLLOW NANOCAPSULE AND A METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：金属氧化物中空纳米颗粒及其制备方法
公开(公告)号：WO2008069561A1
公开(公告)日：2008-06-12
申请号：PCT/KR2007/006269
申请日：2007-12-05
申请人： SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION , HYEON, Taeghwan , PIAO, Yuanzhe , KIM, Jaeyun
发明人： HYEON, Taeghwan , PIAO, Yuanzhe , KIM, Jaeyun
IPC分类号： C01F1/00 , C01G1/02 , B82B3/00 , A61K9/51 , B82B1/00
CPC分类号： C01G49/04 , A61K9/5115 , A61K9/5192 , B82Y30/00 , C01B13/18 , C01F5/06 , C01F7/441 , C01G49/06 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/34 , C01P2004/62 , C01P2004/64 , C01P2004/90 , C01P2006/12 , C01P2006/17
摘要： The present invention relates to a metal oxide hollow nanocapsule which is able to disperse well in aqueous systems and a method for preparing thereof. The method for preparing the iron oxide hollow nanocapsules according to the present invention is characterized by dispersing metal oxyhydroxide in an aqueous solution and coating said metal oxyhydroxide with silica coating layer and administering heat treatment to form a metal oxide layer around the internal hollow space of the silica coating layer and removing said silica to obtain the metal oxide hollow nanocapsule. The iron oxide hollow nanoparticles prepared by the method of the present invention do not only have superior dispers ability in aqueous solutions and uniform size distribution, and said iron oxide hollow nanocapsule can also carry physiologically active materials within the hollow space of said nanocapsule. In addition, the iron oxide hollow nanocapsules of the present invention have a large surface area of at least 100 m2/g and narrow mesopore size distribution which allows physiologically active material carrying capability which brings great expectations for a wide range of industrial uses such as drug delivery vehicles for biomedical applications, gas sensors, lithium ion batteries, etc.
摘要翻译：本发明涉及能够在水性体系中良好分散的金属氧化物中空纳米胶囊及其制备方法。根据本发明的制备氧化铁中空纳米胶囊的方法的特征在于将金属氢氧化物分散在水溶液中并用二氧化硅涂层涂覆所述金属羟基氧化物，并施加热处理以在内部中空空间周围形成金属氧化物层二氧化硅涂层并除去二氧化硅，得到金属氧化物空心纳米胶囊。通过本发明的方法制备的氧化铁中空纳米颗粒不仅在水溶液中具有优异的分散能力和均匀的粒度分布，并且所述氧化铁中空纳米胶囊还可以在所述纳米胶囊的中空空间内承载生理活性材料。此外，本发明的氧化铁中空纳米胶囊具有至少100m 2 / g的大的表面积和窄的中孔尺寸分布，其允许生理活性物质携带能力，这对于广泛的工业用途如药物具有极大的期望用于生物医学应用的输送车辆，气体传感器，锂离子电池等

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