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1. 发明申请

WO2011133685A3 NANOPARTICLE TARGETING TO ISCHEMIA FOR IMAGING AND THERAPY 审中-公开
标题翻译：针对成像和治疗的ISCHEMIA的纳米技术
公开(公告)号：WO2011133685A3
公开(公告)日：2012-05-03
申请号：PCT/US2011033272
申请日：2011-04-20
申请人： HARVARD COLLEGE , KIM JAEYUN , CAO LAN , MOONEY DAVID J
发明人： KIM JAEYUN , CAO LAN , MOONEY DAVID J
IPC分类号： A61K38/19 , A61K9/16 , A61K38/18 , A61K39/395 , A61K49/18 , A61P7/00 , A61P7/06
CPC分类号： A61K49/005 , A61K38/1866 , A61K47/6923 , A61K49/0002 , A61K49/0032 , A61K49/0065 , A61K49/0093 , A61K2300/00
摘要： The invention provides compositions and methods that provide a solution to the difficulties in diagnosing ischemia, e.g., identifying specific affected anatomical areas, and treating ischemic tissue so as to minimize damage and promote healing of damaged tissue in a subject such as a human or other animal.
摘要翻译：本发明提供组合物和方法，其提供诊断缺血的困难的解决方案，例如鉴定特定的受影响的解剖区域，以及治疗缺血组织，以便最小化受试者（例如人或其他动物）中受损组织的损伤和促进愈合。。

2. 发明申请

WO2011133685A2 NANOPARTICLE TARGETING TO ISCHEMIA FOR IMAGING AND THERAPY 审中-公开
标题翻译：针对成像和治疗的ISCHEMIA的纳米技术
公开(公告)号：WO2011133685A2
公开(公告)日：2011-10-27
申请号：PCT/US2011/033272
申请日：2011-04-20
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , KIM, Jaeyun , CAO, Lan , MOONEY, David, J.
发明人： KIM, Jaeyun , CAO, Lan , MOONEY, David, J.
IPC分类号： A61K38/19 , A61K38/18 , A61K39/395 , A61K9/16 , A61K49/18 , A61P7/06 , A61P7/00
CPC分类号： A61K49/005 , A61K38/1866 , A61K47/6923 , A61K49/0002 , A61K49/0032 , A61K49/0065 , A61K49/0093 , A61K2300/00
摘要： The invention provides compositions and methods that provide a solution to the difficulties in diagnosing ischemia, e.g., identifying specific affected anatomical areas, and treating ischemic tissue so as to minimize damage and promote healing of damaged tissue in a subject such as a human or other animal.
摘要翻译：本发明提供组合物和方法，其提供诊断缺血的困难的解决方案，例如鉴定特定的受影响的解剖区域，以及治疗缺血组织，以便最小化受试者（例如人或其他动物）中受损组织的损伤和促进愈合。。

3. 发明申请

WO2006015354A2 ELECTROSURGICAL SYSTEMS AND METHODS 审中-公开
标题翻译：电磁系统和方法
公开(公告)号：WO2006015354A2
公开(公告)日：2006-02-09
申请号：PCT/US2005/027375
申请日：2005-07-29
申请人： WASHINGTON UNIVERSITY IN ST. LOUIS , LANDMAN, Jaime , SACHDEV, Manu, M. , HUESEN, Lauren , KIM, Jaeyun
发明人： LANDMAN, Jaime , SACHDEV, Manu, M. , HUESEN, Lauren , KIM, Jaeyun
IPC分类号： A61B18/18
CPC分类号： A61B18/148 , A61B18/1477 , A61B2018/0016 , A61B2018/1425 , A61B2018/143 , A61B2018/1467
摘要： An electrosurgical device includes a plurality of electrodes for forming a plurality of bipolar circuits usable for affecting a patient's tissue during a surgical operation. At least one of said electrodes is operable as an active electrode in one of said bipolar circuits and as a return electrode in another one of said bipolar circuits.
摘要翻译：电外科装置包括多个电极，用于在手术过程中形成可用于影响患者组织的多个双极电路。所述电极中的至少一个可在所述双极电路之一中作为有源电极工作，并且作为另一个所述双极性电路中的返回电极。

4. 发明申请

WO2012167230A1 IN SITU ANTIGEN-GENERATING CANCER VACCINE 审中-公开
标题翻译：在原发抗癌疫苗中
公开(公告)号：WO2012167230A1
公开(公告)日：2012-12-06
申请号：PCT/US2012/040687
申请日：2012-06-04
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , KIM, Jaeyun , MOONEY, David, J. , LI, Weiwei, Aileen , ARANY, Praveen , GADISH, Or
发明人： KIM, Jaeyun , MOONEY, David, J. , LI, Weiwei, Aileen , ARANY, Praveen , GADISH, Or
IPC分类号： A61K39/00 , A61K41/00 , B82Y5/00 , A61P35/00
CPC分类号： A61K39/0011 , A61K38/193 , A61K41/0052 , A61K45/06 , A61K2039/5152 , A61K2039/5154 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/55511 , A61K2039/55561 , A61K2039/57 , A61K2039/572 , A61K2039/70 , B82Y5/00
摘要： The invention provides compositions and methods for utilizing scaffolds in cancer vaccines.
摘要翻译：本发明提供了在癌症疫苗中利用支架的组合物和方法。

5. 发明申请

WO2008069561A1 METAL OXIDE HOLLOW NANOCAPSULE AND A METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：金属氧化物中空纳米颗粒及其制备方法
公开(公告)号：WO2008069561A1
公开(公告)日：2008-06-12
申请号：PCT/KR2007/006269
申请日：2007-12-05
申请人： SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION , HYEON, Taeghwan , PIAO, Yuanzhe , KIM, Jaeyun
发明人： HYEON, Taeghwan , PIAO, Yuanzhe , KIM, Jaeyun
IPC分类号： C01F1/00 , C01G1/02 , B82B3/00 , A61K9/51 , B82B1/00
CPC分类号： C01G49/04 , A61K9/5115 , A61K9/5192 , B82Y30/00 , C01B13/18 , C01F5/06 , C01F7/441 , C01G49/06 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/34 , C01P2004/62 , C01P2004/64 , C01P2004/90 , C01P2006/12 , C01P2006/17
摘要： The present invention relates to a metal oxide hollow nanocapsule which is able to disperse well in aqueous systems and a method for preparing thereof. The method for preparing the iron oxide hollow nanocapsules according to the present invention is characterized by dispersing metal oxyhydroxide in an aqueous solution and coating said metal oxyhydroxide with silica coating layer and administering heat treatment to form a metal oxide layer around the internal hollow space of the silica coating layer and removing said silica to obtain the metal oxide hollow nanocapsule. The iron oxide hollow nanoparticles prepared by the method of the present invention do not only have superior dispers ability in aqueous solutions and uniform size distribution, and said iron oxide hollow nanocapsule can also carry physiologically active materials within the hollow space of said nanocapsule. In addition, the iron oxide hollow nanocapsules of the present invention have a large surface area of at least 100 m2/g and narrow mesopore size distribution which allows physiologically active material carrying capability which brings great expectations for a wide range of industrial uses such as drug delivery vehicles for biomedical applications, gas sensors, lithium ion batteries, etc.
摘要翻译：本发明涉及能够在水性体系中良好分散的金属氧化物中空纳米胶囊及其制备方法。根据本发明的制备氧化铁中空纳米胶囊的方法的特征在于将金属氢氧化物分散在水溶液中并用二氧化硅涂层涂覆所述金属羟基氧化物，并施加热处理以在内部中空空间周围形成金属氧化物层二氧化硅涂层并除去二氧化硅，得到金属氧化物空心纳米胶囊。通过本发明的方法制备的氧化铁中空纳米颗粒不仅在水溶液中具有优异的分散能力和均匀的粒度分布，并且所述氧化铁中空纳米胶囊还可以在所述纳米胶囊的中空空间内承载生理活性材料。此外，本发明的氧化铁中空纳米胶囊具有至少100m 2 / g的大的表面积和窄的中孔尺寸分布，其允许生理活性物质携带能力，这对于广泛的工业用途如药物具有极大的期望用于生物医学应用的输送车辆，气体传感器，锂离子电池等

6. 发明申请

WO2006015354A3 ELECTROSURGICAL SYSTEMS AND METHODS 审中-公开
标题翻译：电外科系统和方法
公开(公告)号：WO2006015354A3
公开(公告)日：2006-03-16
申请号：PCT/US2005027375
申请日：2005-07-29
申请人： UNIV ST LOUIS , LANDMAN JAIME , SACHDEV MANU M , HUESEN LAUREN , KIM JAEYUN
发明人： LANDMAN JAIME , SACHDEV MANU M , HUESEN LAUREN , KIM JAEYUN
IPC分类号： A61B18/18
CPC分类号： A61B18/148 , A61B18/1477 , A61B2018/0016 , A61B2018/1425 , A61B2018/143 , A61B2018/1467
摘要： An electrosurgical device includes a plurality of electrodes for forming a plurality of bipolar circuits usable for affecting a patient's tissue during a surgical operation. At least one of said electrodes is operable as an active electrode in one of said bipolar circuits and as a return electrode in another one of said bipolar circuits.
摘要翻译：电外科手术装置包括多个电极，用于形成可用于在手术操作期间影响患者组织的多个双极电路。所述电极中的至少一个可用作所述双极电路中的一个中的有源电极并且作为另一个所述双极电路中的返回电极。

7. 发明申请

WO2012148684A1 CELL-FRIENDLY INVERSE OPAL HYDROGELS FOR CELL ENCAPSULATION, DRUG AND PROTEIN DELIVERY, AND FUNCTIONAL NANOPARTICLE ENCAPSULATION 审中-公开
标题翻译：细胞免疫反应用于细胞浸润，药物和蛋白质递送和功能纳米颗粒的水解
公开(公告)号：WO2012148684A1
公开(公告)日：2012-11-01
申请号：PCT/US2012/033208
申请日：2012-04-12
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , MOONEY, David, J. , KIM, Jaeyun , BENCHERIF, Sidi , LI, Weiwei, Aileen
发明人： MOONEY, David, J. , KIM, Jaeyun , BENCHERIF, Sidi , LI, Weiwei, Aileen
IPC分类号： A61L27/14 , A61L27/52 , A61L27/56 , C12N5/00 , B82Y5/00 , A61K9/51
CPC分类号： C12N5/0012 , A61L27/38 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/624 , A61L2400/08 , B82Y5/00 , C12N2533/74
摘要： The invention provides polymer scaffolds for cell-based tissue engineering.
摘要翻译：本发明提供用于基于细胞的组织工程的聚合物支架。

8. 发明申请

WO2011133685A9 NANOPARTICLE TARGETING TO ISCHEMIA FOR IMAGING AND THERAPY 审中-公开
标题翻译：纳米颗粒靶向缺血影像学及治疗
公开(公告)号：WO2011133685A9
公开(公告)日：2012-06-28
申请号：PCT/US2011033272
申请日：2011-04-20
申请人： HARVARD COLLEGE , KIM JAEYUN , CAO LAN , MOONEY DAVID J
发明人： KIM JAEYUN , CAO LAN , MOONEY DAVID J
IPC分类号： A61K38/19 , A61K9/16 , A61K38/18 , A61K39/395 , A61K49/18 , A61P7/00 , A61P7/06
CPC分类号： A61K49/005 , A61K38/1866 , A61K47/6923 , A61K49/0002 , A61K49/0032 , A61K49/0065 , A61K49/0093 , A61K2300/00
摘要： The invention provides compositions and methods that provide a solution to the difficulties in diagnosing ischemia, e.g., identifying specific affected anatomical areas, and treating ischemic tissue so as to minimize damage and promote healing of damaged tissue in a subject such as a human or other animal.
摘要翻译：本发明提供了组合物和方法，其提供了诊断局部缺血（例如，识别特定受影响的解剖区域）和治疗局部缺血组织以便使损伤最小化并促进受试者如人或其他动物中受损组织的愈合。

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