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1. 发明申请

WO2012011877A2 APPARATUS AND METHOD FOR MULTIPLE REACTIONS IN SMALL VOLUMES 审中-公开
标题翻译：小容量多重反应的装置和方法
公开(公告)号：WO2012011877A2
公开(公告)日：2012-01-26
申请号：PCT/SG2011/000263
申请日：2011-07-25
申请人： CURIOX BIOSYSTEMS PTE LTD , KIM, Namyong , CHEONG, Siah Chong , LYE, Melvin, Han Wen , PHONG, Mark, Siew, Peng , LI, Li , SEAH, Teow, Soon
发明人： KIM, Namyong , CHEONG, Siah Chong , LYE, Melvin, Han Wen , PHONG, Mark, Siew, Peng , LI, Li , SEAH, Teow, Soon
IPC分类号： B01L3/00 , C12M1/00
CPC分类号： B01L3/5085 , B01L3/50853 , B01L3/50855 , B01L2200/0689 , B01L2300/0618 , B01L2300/0829 , C12M23/12 , C12M23/34
摘要： In some embodiments, the invention relates to a removable grid insertable into an apparatus comprising a plate comprising a number of elements having a first surface energy arranged in an array with an overlay having a second surface energy and a wall circumferential to the plate, said grid comprising dividers enclosing a number of through-holes, said through-holes spaced in the grid to allow alignment of the through- holes of the grid over the elements in the plate when said grid is inserted into the apparatus, wherein said dividers of the grid inserted into the apparatus form sides of wells bottomed by the plate and at least one element on said plate. In other embodiments, the invention also relates to an apparatus comprising: a plate comprising a number of elements, said elements each having an identical diameter and having a first surface energy, said elements arranged in an array in an overlay having a second surface energy, and a wall circumferential to the plate, wherein said overlay is a height over the elements of between about 5% and 100% of the diameter of the elements. In yet addition embodiments, the invention relates to methods for using the apparatuses described herein to perform multiple reactions in small volumes.
摘要翻译：在一些实施例中，本发明涉及一种可插入到装置中的可拆卸格栅，包括：板，该板包括多个元件，该元件具有排列成阵列的第一表面能，其中覆盖层具有第二表面能和围绕该板的壁，包括分隔件，其包围多个通孔，所述通孔在网格中间隔开，以便当所述格栅插入设备中时允许栅格的通孔对齐在板上的元件上，其中网格的分隔器插入到设备的形式的侧面，底板的底部和所述板上的至少一个元件。在其它实施例中，本发明还涉及一种装置，包括：板，其包括多个元件，所述元件各自具有相同的直径并具有第一表面能，所述元件排列成具有第二表面能的覆盖层，以及围绕所述板的壁的壁，其中所述覆盖层是所述元件之间的高度在所述元件的直径的约5％至100％之间。在另外的实施方案中，本发明涉及使用本文所述装置以小体积进行多重反应的方法。

2. 发明申请

WO2012011877A3 APPARATUS AND METHOD FOR MULTIPLE REACTIONS IN SMALL VOLUMES 审中-公开
标题翻译：用于小体积中的多次反应的装置和方法
公开(公告)号：WO2012011877A3
公开(公告)日：2012-04-26
申请号：PCT/SG2011000263
申请日：2011-07-25
申请人： CURIOX BIOSYSTEMS PTE LTD , KIM NAMYONG , CHEONG SIAH CHONG , LYE MELVIN HAN WEN , PHONG MARK SIEW PENG , LI LI , SEAH TEOW SOON
发明人： KIM NAMYONG , CHEONG SIAH CHONG , LYE MELVIN HAN WEN , PHONG MARK SIEW PENG , LI LI , SEAH TEOW SOON
IPC分类号： B01L3/00 , C12M1/00
CPC分类号： B01L3/5085 , B01L3/50853 , B01L3/50855 , B01L2200/0689 , B01L2300/0618 , B01L2300/0829 , C12M23/12 , C12M23/34
摘要： In some embodiments, the invention relates to a removable grid insertable into an apparatus comprising a plate comprising a number of elements having a first surface energy arranged in an array with an overlay having a second surface energy and a wall circumferential to the plate, said grid comprising dividers enclosing a number of through-holes, said through-holes spaced in the grid to allow alignment of the through- holes of the grid over the elements in the plate when said grid is inserted into the apparatus, wherein said dividers of the grid inserted into the apparatus form sides of wells bottomed by the plate and at least one element on said plate. In other embodiments, the invention also relates to an apparatus comprising: a plate comprising a number of elements, said elements each having an identical diameter and having a first surface energy, said elements arranged in an array in an overlay having a second surface energy, and a wall circumferential to the plate, wherein said overlay is a height over the elements of between about 5% and 100% of the diameter of the elements. In yet addition embodiments, the invention relates to methods for using the apparatuses described herein to perform multiple reactions in small volumes.
摘要翻译：在一些实施例中，本发明涉及一种可插入到设备中的可移除栅格，所述设备包括板，所述板包括具有第一表面能的多个元件，所述第一表面能布置成具有第二表面能和板周向的壁的覆盖层，所述栅格包括分隔器，所述分隔器包围多个通孔，所述通孔在所述格栅中间隔开以允许当所述格栅插入所述设备时所述格栅的所述通孔在所述板中的所述元件上对齐，其中所述格栅的所述分隔器从所述板的底部和所述板上的至少一个元件形成插入到所述设备中的侧壁。在其它实施例中，本发明还涉及一种设备，其包括：包括多个元件的板，所述元件各自具有相同的直径并且具有第一表面能，所述元件以具有第二表面能的覆盖物排列成阵列，以及围绕所述板的壁，其中所述覆盖层的高度在所述元件之上的高度在所述元件的直径的约5％和100％之间。在另外的实施方案中，本发明涉及使用本文所述的装置以小体积进行多重反应的方法。

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