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1. 发明申请

WO2012159040A3 FLUID MANAGEMENT AND PATIENT MONITORING SYSTEM 审中-公开
公开(公告)号：WO2012159040A3
公开(公告)日：2012-11-22
申请号：PCT/US2012/038598
申请日：2012-05-18
申请人： PEPEX BIOMEDICAL INC. , SAY, James, L.
发明人： SAY, James, L.
IPC分类号： A61B5/145 , A61B5/157
摘要： A lactate sensor arrangement includes a catheter for withdrawing a test fluid sample, a sensor module for measuring an analyte such as lactate in the sample, and a pumping mechanism. A single uninterrupted flow path extends between the pumping mechanism and the catheter and within the flow path resides a sensor module containing a test chamber. The sensor arrangement also includes a control unit or controller that interfaces with a pumping mechanism driver. The sensor arrangement also includes a source of sensor calibration and anticoagulant solution, such as a reservoir, which has a silicone rubber fill septum, a non-woven Teflon air vent, and a check valve sub-assembly.

2. 发明申请

WO2012159040A2 FLUID MANAGEMENT AND PATIENT MONITORING SYSTEM 审中-公开
标题翻译：流体管理与患者监测系统
公开(公告)号：WO2012159040A2
公开(公告)日：2012-11-22
申请号：PCT/US2012038598
申请日：2012-05-18
申请人： PEPEX BIOMEDICAL INC , SAY JAMES L
发明人： SAY JAMES L
CPC分类号： A61B5/14546 , A61B5/14532 , A61B5/1473 , A61B5/1495 , A61B5/6866
摘要： A lactate sensor arrangement includes a catheter for withdrawing a test fluid sample, a sensor module for measuring an analyte such as lactate in the sample, and a pumping mechanism. A single uninterrupted flow path extends between the pumping mechanism and the catheter and within the flow path resides a sensor module containing a test chamber. The sensor arrangement also includes a control unit or controller that interfaces with a pumping mechanism driver. The sensor arrangement also includes a source of sensor calibration and anticoagulant solution, such as a reservoir, which has a silicone rubber fill septum, a non-woven Teflon air vent, and a check valve sub-assembly.
摘要翻译：乳酸盐传感器装置包括用于取出测试流体样品的导管，用于测量样品中诸如乳酸盐的分析物的传感器模块和泵送机构。单个不间断的流动路径在泵送机构和导管之间延伸，并且在流动路径内是包含测试室的传感器模块。传感器装置还包括与泵送机构驱动器接口的控制单元或控制器。传感器装置还包括传感器校准源和抗凝血剂溶液，例如储存器，其具有硅橡胶填充隔膜，非织造特氟隆通风口和止回阀子组件。

3. 发明申请

WO2015187959A1 ELECTROCHEMICAL SENSORS AND METHODS FOR MAKING ELECTROCHEMICAL SENSORS USING ADVANCED PRINTING TECHNOLOGY 审中-公开
标题翻译：电化学传感器及使用高级印刷技术制造电化学传感器的方法
公开(公告)号：WO2015187959A1
公开(公告)日：2015-12-10
申请号：PCT/US2015/034210
申请日：2015-06-04
申请人： PEPEX BIOMEDICAL, INC.
发明人： SVOBODA, Vojtech , SAY, James, L. , POHL, Steve, L.
IPC分类号： G01N27/26 , G01N27/30 , A61B5/1473 , A61B5/15 , B41J2/04 , B41J3/407
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , A61B5/150022 , A61B5/150213 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B2562/12 , B41M3/006 , G01N27/3271
摘要： A sensor can be manufactured by printing a working electrode onto a substrate using aerosol jet printing. Sensing chemistry (e.g., enzyme-based ink that including detection chemistry) also can be printed onto the working electrode using aerosol jet printing. A reference electrode also can be printed on the substrate at a position spaced along the substrate from the working electrode. In certain examples, the substrate can be positioned within a lumen of a skin piercing member of a sensor module.
摘要翻译：可以通过使用气溶胶喷射印刷将工作电极印刷到基板上来制造传感器。感测化学（例如，包括检测化学的酶基油墨）也可以使用气溶胶喷射印刷印刷到工作电极上。参考电极也可以在与工作电极沿衬底间隔开的位置上印刷在衬底上。在某些实例中，基底可以位于传感器模块的皮肤刺穿构件的内腔中。

4. 发明申请

WO2014089058A1 SENSOR MODULE AND METHOD OF USING A SENSOR MODULE 审中-公开
标题翻译：传感器模块和使用传感器模块的方法
公开(公告)号：WO2014089058A1
公开(公告)日：2014-06-12
申请号：PCT/US2013/072846
申请日：2013-12-03
申请人： PEPEX BIOMEDICAL, INC.
发明人： SAY, James, L.
IPC分类号： A61B5/151 , A61B5/157
CPC分类号： A61B5/150396 , A61B5/14532 , A61B5/14865 , A61B5/150022 , A61B5/150213 , A61B5/150389 , A61B5/150755 , A61B5/15105 , A61B5/15142 , A61B5/157 , A61B5/6848 , A61B2560/0468 , A61B2562/0209
摘要： A sensor module is disclosed herein. The sensor module includes a skin piercing member carried by the carrier. The skin piercing member has a skin piercing end positioned opposite from a base end. The skin piercing member defines a lumen that extends along the central longitudinal axis from the skin piercing end toward the base end and the lumen having a lumen axis. The sensor module also includes a blood sample analysis zone located entirely within the lumen of the skin piercing member and a capillary flow stop for stopping capillary flow at a predetermined location within the lumen of the skin piercing member. The sensor module includes an elongated working electrode positioned within the lumen. The working electrode has a length that extends along the lumen axis where at least a section of the working electrode is positioned within the analysis zone. The working electrode includes sensing chemistry.
摘要翻译：本文公开了传感器模块。传感器模块包括由载体承载的皮肤刺穿构件。皮肤刺穿构件具有与基端相对定位的皮肤刺穿端。皮肤刺穿构件限定了沿着中心纵向轴线从皮肤刺穿端朝向基端延伸的内腔，并且具有管腔轴线的管腔。传感器模块还包括完全位于皮肤刺穿构件的内腔内的血液样本分析区域和用于在皮肤穿孔构件的内腔内的预定位置处阻止毛细管流动的毛细管流动停止件。传感器模块包括位于内腔内的细长工作电极。工作电极具有沿管腔轴线延伸的长度，其中工作电极的至少一部分位于分析区内。工作电极包括感测化学。

5. 发明申请

WO2012094502A2 SENSOR ARRAY MOUNTED ON FLEXIBLE CARRIER 审中-公开
标题翻译：传感器阵列安装在灵活的载体上
公开(公告)号：WO2012094502A2
公开(公告)日：2012-07-12
申请号：PCT/US2012/020342
申请日：2012-01-05
申请人： PEPEX BIOMEDICAL, INC. , SAY, James, L.
发明人： SAY, James, L.
IPC分类号： G01N35/08 , G01N27/30 , G01N33/48
CPC分类号： G01N27/403 , G01N27/30 , G01N27/3272
摘要： A sensor apparatus is disclosed herein. The sensor apparatus includes a flexible carrier that is elongated along a length of the carrier. The sensor apparatus also includes a plurality of analysis zones carried by the carrier. The analysis zones are spaced-apart from one another along the length of the carrier. The sensor apparatus further includes first and second spaced-apart electrodes carried by the flexible carrier. The first and second electrodes have lengths that extend along the length of the carrier. At least one of the first and second electrodes includes analyte sensing chemistry. The first and second electrodes extending across and contact the plurality of analysis zones.
摘要翻译：这里公开了一种传感器装置。传感器装置包括沿着载体的长度伸长的柔性载体。传感器装置还包括由载体携带的多个分析区域。分析区域沿着载体的长度彼此间隔开。传感器装置还包括由柔性载体承载的第一和第二间隔开的电极。第一和第二电极具有沿着载体的长度延伸的长度。第一和第二电极中的至少一个包括分析物感测化学物质。第一和第二电极延伸并接触多个分析区。

6. 发明申请

WO2012162151A2 MANUFACTURING ELECTROCHEMICAL SENSOR MODULES 审中-公开
标题翻译：制造电化学传感器模块
公开(公告)号：WO2012162151A2
公开(公告)日：2012-11-29
申请号：PCT/US2012/038601
申请日：2012-05-18
申请人： PEPEX BIOMEDICAL, INC. , SAY, James, L.
发明人： SAY, James, L.
IPC分类号： G01N27/26 , G01N27/416
CPC分类号： H05K3/00 , B81C1/00317 , B81C1/00333 , B81C1/00888 , G01N27/3272 , H01L21/306 , H01L21/6836 , H01L21/78 , H01L24/82 , Y10T29/49155
摘要： Certain processes for manufacturing an electrochemical sensor module include etching a Silicon wafer to form precursor sensor bodies, disposing sensor fibers along rows of the precursor sensor bodies, securing a rigid layer over the sensor fibers, dividing the wafer, rigid layer, and sensor fibers into individual precursor sensor bodies, and joining each precursor sensor body to a component body to form sensor modules.
摘要翻译：用于制造电化学传感器模块的某些方法包括蚀刻硅晶片以形成前体传感器主体，沿着前体传感器主体的行布置传感器光纤，将刚性层固定在传感器光纤上，将晶片，刚性层和传感器光纤分成单独的前体传感器体，并将每个前体传感器主体连接到组件主体以形成传感器模块。

7. 发明申请

WO2012094502A3 SENSOR ARRAY MOUNTED ON FLEXIBLE CARRIER 审中-公开
标题翻译：传感器阵列安装在灵活的载体上
公开(公告)号：WO2012094502A3
公开(公告)日：2012-11-01
申请号：PCT/US2012020342
申请日：2012-01-05
申请人： PEPEX BIOMEDICAL INC , SAY JAMES L
发明人： SAY JAMES L
IPC分类号： G01N35/08 , G01N27/30 , G01N33/48
CPC分类号： G01N27/403 , G01N27/30 , G01N27/3272
摘要： A sensor apparatus is disclosed herein. The sensor apparatus includes a flexible carrier that is elongated along a length of the carrier. The sensor apparatus also includes a plurality of analysis zones carried by the carrier. The analysis zones are spaced-apart from one another along the length of the carrier. The sensor apparatus further includes first and second spaced-apart electrodes carried by the flexible carrier. The first and second electrodes have lengths that extend along the length of the carrier. At least one of the first and second electrodes includes analyte sensing chemistry. The first and second electrodes extending across and contact the plurality of analysis zones.
摘要翻译：本文公开了传感器装置。传感器装置包括沿着载体长度伸长的柔性载体。传感器装置还包括由载体承载的多个分析区域。分析区沿着载体的长度彼此间隔开。传感器装置还包括由柔性载体承载的第一和第二隔开的电极。第一和第二电极具有沿着载体的长度延伸的长度。第一和第二电极中的至少一个包括分析物感测化学。第一和第二电极延伸并接触多个分析区。

8. 发明申请

WO2012106060A2 SENSOR MODULE WITH ENHANCED CAPILLARY FLOW 审中-公开
标题翻译：具有增强毛细管流量的传感器模块
公开(公告)号：WO2012106060A2
公开(公告)日：2012-08-09
申请号：PCT/US2012/020339
申请日：2012-01-05
申请人： PEPEX BIOMEDICAL, INC. , SAY, James, L. , POHL, Steve
发明人： SAY, James, L. , POHL, Steve
IPC分类号： G01N27/00 , G01N27/26
CPC分类号： A61B5/157 , A61B5/1411 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/150022 , A61B5/150282 , A61B5/150412 , A61B5/150419 , A61B5/150572 , A61B5/15105 , A61B5/15113 , A61B5/15126 , A61B5/1513 , A61B5/15142 , A61B5/15146
摘要： A sensor module is disclosed herein. The sensor module includes a main housing defining an analysis zone within the housing. The sensor module also includes a skin piercing member mounted within the main housing. The skin piercing member is movable relative to the main housing between a retracted position and an extended position. The main housing of the sensor module defines a fluid sample flow passage that extends from a sampling end of the main housing to the analysis zone. The fluid sample flow passage includes a funnel structure through which the skin piecing member extends when in the extended position. The fluid sample flow passage also includes capillary flow enhancing slots that extend outwardly from opposite sides of the funnel structure.
摘要翻译：本文公开了传感器模块。传感器模块包括限定壳体内的分析区的主壳体。传感器模块还包括安装在主壳体内的皮肤刺穿构件。皮肤穿刺构件可在缩回位置和延伸位置之间相对于主壳体移动。传感器模块的主壳体限定了从主壳体的采样端延伸到分析区域的流体样品流动通道。流体样品流动通道包括漏斗结构，当处于伸出位置时，皮肤接头构件通过该漏斗结构延伸。流体样品流动通道还包括从漏斗结构的相对侧向外延伸的毛细管流动增强槽。

9. 发明申请

WO2012162151A3 MANUFACTURING ELECTROCHEMICAL SENSOR MODULES 审中-公开
标题翻译：制造电化学传感器模块
公开(公告)号：WO2012162151A3
公开(公告)日：2013-02-14
申请号：PCT/US2012038601
申请日：2012-05-18
申请人： PEPEX BIOMEDICAL INC , SAY JAMES L
发明人： SAY JAMES L
IPC分类号： G01N27/26 , G01N27/416
CPC分类号： H05K3/00 , B81C1/00317 , B81C1/00333 , B81C1/00888 , G01N27/3272 , H01L21/306 , H01L21/6836 , H01L21/78 , H01L24/82 , Y10T29/49155
摘要： Certain processes for manufacturing an electrochemical sensor module include etching a Silicon wafer to form precursor sensor bodies, disposing sensor fibers along rows of the precursor sensor bodies, securing a rigid layer over the sensor fibers, dividing the wafer, rigid layer, and sensor fibers into individual precursor sensor bodies, and joining each precursor sensor body to a component body to form sensor modules.
摘要翻译：用于制造电化学传感器模块的某些方法包括蚀刻硅晶片以形成前体传感器主体，沿着前体传感器主体的行布置传感器光纤，将刚性层固定在传感器光纤上，将晶片，刚性层和传感器光纤分成单独的前体传感器体，并将每个前体传感器主体连接到组件主体以形成传感器模块。

10. 发明申请

WO2012106060A3 SENSOR MODULE WITH ENHANCED CAPILLARY FLOW 审中-公开
标题翻译：具有增强毛细管流量的传感器模块
公开(公告)号：WO2012106060A3
公开(公告)日：2012-11-01
申请号：PCT/US2012020339
申请日：2012-01-05
申请人： PEPEX BIOMEDICAL INC , SAY JAMES L , POHL STEVE
发明人： SAY JAMES L , POHL STEVE
IPC分类号： G01N27/00 , G01N27/26
CPC分类号： A61B5/157 , A61B5/1411 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/150022 , A61B5/150282 , A61B5/150412 , A61B5/150419 , A61B5/150572 , A61B5/15105 , A61B5/15113 , A61B5/15126 , A61B5/1513 , A61B5/15142 , A61B5/15146
摘要： A sensor module is disclosed herein. The sensor module includes a main housing defining an analysis zone within the housing. The sensor module also includes a skin piercing member mounted within the main housing. The skin piercing member is movable relative to the main housing between a retracted position and an extended position. The main housing of the sensor module defines a fluid sample flow passage that extends from a sampling end of the main housing to the analysis zone. The fluid sample flow passage includes a funnel structure through which the skin piecing member extends when in the extended position. The fluid sample flow passage also includes capillary flow enhancing slots that extend outwardly from opposite sides of the funnel structure.
摘要翻译：这里公开了一种传感器模块。传感器模块包括在壳体内限定分析区域的主壳体。传感器模块还包括安装在主壳体内的皮肤刺穿构件。皮肤穿刺构件可相对于主壳体在缩回位置和延伸位置之间移动。传感器模块的主壳体限定从主壳体的采样端延伸到分析区域的流体样本流动通道。流体样本流动通道包括漏斗结构，当处于伸展位置时，皮肤接头构件通过该漏斗结构延伸。流体样本流动通道还包括从漏斗结构的相对侧向外延伸的毛细流动增强槽。

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