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1. 发明申请

WO1996000288A2 CLASS BI AND CI SCAVENGER RECEPTORS 审中-公开
标题翻译：类BI和CI SCAVENGER受体
公开(公告)号：WO1996000288A2
公开(公告)日：1996-01-04
申请号：PCT/US1995007721
申请日：1995-06-19
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , KRIEGER, Monty , ACTON, Susan, L. , PEARSON, Alan, M. , RIGOTTI, Attilio
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
IPC分类号： C12N15/12
CPC分类号： C07K14/705 , A61K38/00
摘要： Two distinct scavenger receptor type proteins having high affinity for modified lipoproteins and other ligands have been isolated, characterized and cloned. HaSR-BI, an AcLDL and LDL binding scavenger receptor, which is distinct from the type I and type II macrophage scavenger receptors, has been isolated and characterized and DNA encoding the receptor cloned from a variant of Chinese Hamster Ovary Cells, designated Var-261. dSR-CI, a non-mammalian AcLDL binding scavenger receptor having high ligand affinity and broad specificity, was isolated from Drosophila melanogaster. The isolated receptors are useful in screening for drugs that inhibit uptake of cholesterol in endothelial or adipose cells or macrophages, respectively. They are also useful as probes for the isolation of other lipoprotein receptors and in research the roles of these receptors.
摘要翻译：已经分离，表征和克隆了对修饰的脂蛋白和其他配体具有高亲和力的两种不同的清道夫受体型蛋白质。已经分离和鉴定了与I型和II型巨噬细胞清道夫受体不同的AcLDL和LDL结合清道夫受体的HaSR-BI，并且编码从中国仓鼠卵巢细胞变体克隆的受体的DNA，命名为Var-261 。从黑腹果蝇中分离出具有高配体亲和性和广泛特异性的非哺乳动物AcLDL结合清道夫受体的dSR-CI。分离的受体可用于筛选分别抑制内皮或脂肪细胞或巨噬细胞中胆固醇摄取的药物。它们也可用作分离其他脂蛋白受体的探针和研究这些受体的作用。

2. 发明申请

WO9600288A3 CLASS BI AND CI SCAVENGER RECEPTORS 审中-公开
标题翻译： CLASS BI和CI清除剂受体
公开(公告)号：WO9600288A3
公开(公告)日：1996-04-04
申请号：PCT/US9507721
申请日：1995-06-19
申请人： MASSACHUSETTS INST TECHNOLOGY , KRIEGER MONTY , ACTON SUSAN L , PEARSON ALAN M , RIGOTTI ATTILIO
发明人： KRIEGER MONTY , ACTON SUSAN L , PEARSON ALAN M , RIGOTTI ATTILIO
IPC分类号： G01N33/53 , A61K38/00 , A61P3/02 , A61P9/10 , C07K14/705 , C07K16/28 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , C12R1/91 , G01N33/566 , A61K38/17
CPC分类号： C07K14/705 , A61K38/00
摘要： Two distinct scavenger receptor type proteins having high affinity for modified lipoproteins and other ligands have been isolated, characterized and cloned. HaSR-BI, an AcLDL and LDL binding scavenger receptor, which is distinct from the type I and type II macrophage scavenger receptors, has been isolated and characterized and DNA encoding the receptor cloned from a variant of Chinese Hamster Ovary Cells, designated Var-261. dSR-CI, a non-mammalian AcLDL binding scavenger receptor having high ligand affinity and broad specificity, was isolated from Drosophila melanogaster. The isolated receptors are useful in screening for drugs that inhibit uptake of cholesterol in endothelial or adipose cells or macrophages, respectively. They are also useful as probes for the isolation of other lipoprotein receptors and in research the roles of these receptors.
摘要翻译：已经分离出两种截然不同的对修饰脂蛋白和其他配体具有高亲和力的清道夫受体型蛋白质，并对其进行了鉴定和克隆。 HaSR-BI是一种与I型和II型巨噬细胞清道夫受体不同的AcLDL和LDL结合清除剂受体，已经被分离并表征，并且编码从中国仓鼠卵巢细胞的变体克隆的编码该受体的DNA，命名为Var-261 。从果蝇中分离出具有高配体亲和力和广泛特异性的非哺乳动物AcLDL结合清除受体dSR-CI。分离的受体可用于筛选分别抑制内皮或脂肪细胞或巨噬细胞中胆固醇摄取的药物。它们也可用作探针来分离其他脂蛋白受体并研究这些受体的作用。

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