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1. 发明申请

WO2009116089A3 NOVEL INTERMEDIATES AND METHOD FOR SYNTHESIS OF 4'-[(1,4'-DIMETHYL-2'-PROPYL-[2,6'- BI-1HBENZIMIDAZOL]-L-YL)METHYL]-1,1-BIPHENYL]-2-CARBOXYLIC ACID. 审中-公开
标题翻译：合成4' - [（1,4'-二甲基-2'-丙基 - [2,6'-二氢苯并咪唑] -L-YL）甲基] -1,1-联苯] -2的新型中间体和方法 -羧酸。
公开(公告)号：WO2009116089A3
公开(公告)日：2010-11-25
申请号：PCT/IN2009000176
申请日：2009-03-13
申请人： IPCA LAB LTD , KUMAR ASHOK , DIKE SUNEEL YESHWANT , MATHUR PRAMIKUMAR , PATEL YOGESH MOHANBHAI
发明人： KUMAR ASHOK , DIKE SUNEEL YESHWANT , MATHUR PRAMIKUMAR , PATEL YOGESH MOHANBHAI
IPC分类号： C07D235/08 , C07D235/20
CPC分类号： C07D235/08
摘要： Disclosed herein is a method for synthesis of 4'-[(1,4'-dimethyl-2'-propyl-[2,6'-bi- 1H]benzimidazol]-l-yl)methyl]-[1,1-biphenyl]-2-carboxylic acid or its derivatives, and novel intermediate compounds useful in the synthesis.
摘要翻译：本文公开了一种合成4' - [（1,4'-二甲基-2'-丙基 - [2,6'-二] 1H]苯并咪唑] -1-基）甲基] - [ 联苯] -2-羧酸或其衍生物，以及可用于合成的新型中间体化合物。

2. 发明申请

WO2007016174A3 RADIATION-SHIELDING ASSEMBLIES AND METHODS 审中-公开
标题翻译：辐射防护组件及方法
公开(公告)号：WO2007016174A3
公开(公告)日：2007-05-03
申请号：PCT/US2006029059
申请日：2006-07-26
申请人： MALLINCKRODT INC , WAGNER GARY S , HAYNES ELAINE E , PATEL YOGESH P
发明人： WAGNER GARY S , HAYNES ELAINE E , PATEL YOGESH P
IPC分类号： G21F5/015
CPC分类号： G21F5/015 , G21Y2002/208 , G21Y2002/304 , G21Y2002/501 , G21Y2004/30 , G21Y2004/303 , G21Y2004/304
摘要： The invention relates to the handling of radioactive material. For instance, a radiation shield of the invention may include a body having a cavity therein for receiving radioactive material. An opening to the cavity may be defined in the body. A base may be releasably attachable to the body (generally toward the opening) to at least partially enclose the radioactive material in the cavity. In the case that the radiation shield includes a plurality of interchangeable bases, one of the bases may have at least one of a shorter length and a lighter weight than another of the bases. The base(s) may be designed to enclose more than one size and/or shape of container in the cavity. The base(s) may include a hand grip to facilitate manual gripping of the radiation shield. The base(s) may include a guard to reduce exposure to radiation from manual handling of the radiation shield.
摘要翻译：本发明涉及放射性物质的处理。例如，本发明的辐射屏蔽可以包括其中具有用于接收放射性材料的空腔的主体。可以在体内限定到空腔的开口。基部可以可释放地附接到主体（通常朝向开口）以至少部分地将放射性材料包围在空腔中。在辐射屏蔽包括多个可互换基座的情况下，其中一个基座可以具有比另一个基座更短的长度和更轻的重量中的至少一个。底座可以设计成在腔体中包围多于一个尺寸和/或形状的容器。基座可以包括手柄以便于手动抓握辐射屏蔽。底座可以包括防护装置，以减少手动处理辐射屏蔽物对辐射的暴露。

3. 发明申请

WO2007016174A2 RADIATION-SHIELDING ASSEMBLIES AND METHODS 审中-公开
标题翻译：辐射屏蔽组件和方法
公开(公告)号：WO2007016174A2
公开(公告)日：2007-02-08
申请号：PCT/US2006/029059
申请日：2006-07-26
申请人： MALLINCKRODT INC. , WAGNER, Gary, S. , HAYNES, Elaine, E. , PATEL, Yogesh, P.
发明人： WAGNER, Gary, S. , HAYNES, Elaine, E. , PATEL, Yogesh, P.
IPC分类号： G21F5/015
CPC分类号： G21F5/015 , G21Y2002/208 , G21Y2002/304 , G21Y2002/501 , G21Y2004/30 , G21Y2004/303 , G21Y2004/304
摘要： The invention relates to the handling of radioactive material. For instance, a radiation shield of the invention may include a body having a cavity therein for receiving radioactive material. An opening to the cavity may be defined in the body. A base may be releasably attachable to the body (generally toward the opening) to at least partially enclose the radioactive material in the cavity. In the case that the radiation shield includes a plurality of interchangeable bases, one of the bases may have at least one of a shorter length and a lighter weight than another of the bases. The base(s) may be designed to enclose more than one size and/or shape of container in the cavity. The base(s) may include a hand grip to facilitate manual gripping of the radiation shield. The base(s) may include a guard to reduce exposure to radiation from manual handling of the radiation shield.
摘要翻译：本发明涉及放射性物质的处理。例如，本发明的辐射防护罩可以包括其中具有用于接收放射性材料的空腔的主体。身体的开口可以限定在身体中。基座可以可拆卸地连接到主体（通常朝向开口）以将放射性材料至少部分地包围在腔中。在辐射护罩包括多个可互换基座的情况下，基座中的一个可以具有比另一个基座更短的长度和更轻的重量中的至少一个。底座可以被设计成在容腔中封装多于一种尺寸和/或形状的容器。基座可以包括手柄以便于手动夹紧辐射护罩。基座可以包括一个防护装置，以减少手动操作辐射防护罩对辐射的暴露。

4. 发明申请

WO2019049164A1 METHOD OF USING SOAPNUTS EXTRACT AS ORGANIC FERTILIZER 审中-公开
公开(公告)号：WO2019049164A1
公开(公告)日：2019-03-14
申请号：PCT/IN2018/050057
申请日：2018-02-03
申请人： PATEL, Yogesh Ganpatbhai
发明人： PATEL, Yogesh Ganpatbhai
IPC分类号： A01N63/00
摘要： The present invented system consist with following steps to extract use of the non organic fertilizer. (a) collect the soapnuts seed; (b) soak the soapnuts seed into water for the one full day; (c) filter the water and remove the soapnuts seeds; (d) use the filter water as liquid fertilizer; The said liquid fertilizer is spry on the plants which creates layer on the leaves of the pants and that layer prevents the crop from any bacterial effect. Moreover it drops the cone shapes crystal particles on the leaves so, when the due to humidity in the environment, when this cone shapes crystal partial come in contact with this humidity then the water remains in the humidity is entered into the leaves from such cone shape crystal particle to the leaves.

5. 发明申请

WO2011082264A1 METHODS FOR ATTACHING THERMOPLASTIC PROFILE TO ROOFING MEMBRANE AND DUAL WELDING DEVICE 审中-公开
标题翻译：用于连接热塑型材以覆盖膜和双焊接装置的方法
公开(公告)号：WO2011082264A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/062425
申请日：2010-12-29
申请人： BUILDING MATERIALS INVESTMENT CORPORATION , YANG, Li-Ying , RAILKAR, Sudhir , PATEL, Yogesh
发明人： YANG, Li-Ying , RAILKAR, Sudhir , PATEL, Yogesh
IPC分类号： E04D5/14
CPC分类号： B29C66/524 , B29C65/103 , B29C65/12 , B29C65/125 , B29C65/76 , B29C66/1122 , B29C66/474 , B29C66/71 , B29C66/7315 , B29C66/73921 , B29C66/8223 , B29C66/836 , B29C66/8362 , B29C66/84121 , B29C66/8432 , B29C66/861 , B29C66/8652 , B29C66/86521 , B29L2031/003 , B29L2031/108 , E04D5/12 , E04D15/04 , Y10T156/10 , Y10T156/17 , B29K2023/00 , B29K2027/06 , B29K2069/00 , B29K2067/003 , B29K2077/00 , B29K2025/06 , B29K2055/02
摘要： Embodiments disclosed herein provide an application of a thermoplastic heat-welding rod for welding thermoplastic standing seam profiles to thermoplastic roofing membrane, and providing secure attachment without roof penetration and profile/membrane separation In addition, embodiments disclosed herein provide a welding attachment or apparatus for heat-welding thermoplastic materials In one embodiment, an apparatus for welding a thermoplastic profile strip to a thermoplastic membrane may comprise a first nozzle configured to direct hot air along a portion of a first longitudinal edge of a horizontal base of a thermoplastic profile strip placed on a thermoplastic membrane Also, such an apparatus may comprise a second nozzle configured to direct hot air along a portion of a second, opposing longitudinal edge of the thermoplastic profile strip Furthermore, the apparatus may also comprise a tubular splitter configured to simultaneously supply hot air to the nozzles
摘要翻译：本文公开的实施例提供了一种用于将热塑性塑料立式接缝型材焊接到热塑性屋顶隔膜上的热塑性热焊条的应用，并且提供了无屋顶穿透和型材/膜分离的安全连接。此外，本文公开的实施例提供了用于加热的焊接附件或设备焊接热塑性材料在一个实施例中，用于将热塑性型材条焊接到热塑性膜的设备可以包括第一喷嘴，其被配置为沿着位于一个热塑性塑料薄膜上的热塑性塑料型材带的水平底座的第一纵向边缘的一部分引导热空气热塑性膜此外，这种装置可以包括构造成沿着热塑性型材带的第二相对的纵向边缘的一部分引导热空气的第二喷嘴。此外，该装置还可以包括管状分离器，其被配置为同时向喷嘴

6. 发明申请

WO2010041269A1 PROCESS FOR PREPARATION OF MYCOPHENOLIC ACID, ITS SALT AND ESTER DERIVATIVES 审中-公开
标题翻译：麦芽酚酸，盐及其衍生物的制备方法
公开(公告)号：WO2010041269A1
公开(公告)日：2010-04-15
申请号：PCT/IN2009/000493
申请日：2009-09-09
申请人： IPCA LABORATORIES LIMITED , KUMAR, Ashok , SINGH, Dharmendra , LUTHARA, Umesh , PATEL, Yogesh, Mohandhai
发明人： KUMAR, Ashok , SINGH, Dharmendra , LUTHARA, Umesh , PATEL, Yogesh, Mohandhai
IPC分类号： C12P17/04 , C07D307/88 , B01D11/00
CPC分类号： C07D307/88 , C12P17/04
摘要： The present invention discloses an isolation and purification process for mycophenolic acid obtained from the fermentation process. Invention further discloses preparation of sodium salt of mycophenolic acid and mycophenolate mofetil from mycophenolic acid.
摘要翻译：本发明公开了从发酵过程获得的霉酚酸的分离纯化方法。本发明还公开了霉酚酸的霉酚酸和霉酚酸酯的钠盐的制备。

7. 发明申请

WO2010018593A3 GASTRIC ACID RESISTANT BENZIMIDAZOLE MULTIPLE UNIT TABLET COMPOSITION 审中-公开
公开(公告)号：WO2010018593A3
公开(公告)日：2010-02-18
申请号：PCT/IN2009/000379
申请日：2009-07-03
申请人： TORRENT PHARMACEUTICALS LTD. , JOHNSON, Pratheep , PATEL, Yogesh , SHETH, Rakesh
发明人： JOHNSON, Pratheep , PATEL, Yogesh , SHETH, Rakesh
IPC分类号： A61K9/20 , A61K9/50 , A61K31/4184
摘要： The present invention relates to a stable, gastric acid resistant multiple unit tableted dosage form of benzimidazole compound comprising of a cushioning agent such as polyethylene glycol and at least one pharmaceutically acceptable excipient. The invention also relates to the process involved therein.

8. 发明申请

WO0166723A3 HETERO-OLIGOMERIC G PROTEIN-COUPLED RECEPTORS AS DRUG TARGET 审中-公开
标题翻译：异氟醚G蛋白偶联受体作为药物目标
公开(公告)号：WO0166723A3
公开(公告)日：2004-02-26
申请号：PCT/CA0100318
申请日：2001-03-12
申请人： UNIV MCGILL , PATEL YOGESH C , ROCHEVILLE MAGALIE
发明人： PATEL YOGESH C , ROCHEVILLE MAGALIE
IPC分类号： C07K14/705 , C07K14/72 , C12N15/12 , C12N5/10 , G01N33/68
CPC分类号： C07K14/723 , C07K14/70571
摘要： The present invention provides hetero-oligomers of G protein-coupled receptors (GPCRs) as novel drug targets, cells expressing endogenous hetero-oligomers of GPCRs, and cells transfected with GPCRs that express GPCRs capable of forming hetero-oligomers of GPCRs. These cells are useful for evaluating the activity of known and putative receptor ligands including but not limited to drugs, hormones, neurotransmitters, cytokines and related agonists and antagonists.
摘要翻译：本发明提供作为新药物靶点的G蛋白偶联受体（GPCR）的杂寡聚物，表达GPCR的内源性杂寡聚物的细胞，以及表达能够形成GPCR的异寡聚体的GPCR的GPCR转染的细胞。这些细胞可用于评估已知和推定的受体配体的活性，包括但不限于药物，激素，神经递质，细胞因子和相关的激动剂和拮抗剂。

9. 发明申请

WO1998008100A1 AGONIST-DEPENDENT INTERNALIZATION OF HUMAN SOMATOSTATIN RECEPTORS TYPES 1-5 审中-公开
标题翻译：人类SOMATOSTATIN受体的激素依赖性内分泌类型1-5
公开(公告)号：WO1998008100A1
公开(公告)日：1998-02-26
申请号：PCT/CA1997000592
申请日：1997-08-20
申请人： PATEL, CELL & RECEPTOR TECHNOLOGIES INC. , PATEL, Yogesh, C. , HUKOVIC, Nedim , PANETTA, Rosemarie , KUMAR, Ujendra
发明人： PATEL, CELL & RECEPTOR TECHNOLOGIES INC.
IPC分类号： G01N33/74
CPC分类号： A61K51/08 , G01N33/574 , G01N33/57415 , G01N33/6893 , G01N2333/726
摘要： The present invention relates to the uses of human somatostatin receptors types 1-5 in the diagnosis and/or treatment of diseases and more particularly to tumor cells, e.g. breast cancer and in cases of Alzheimer's. The present invention relates to (i) recombinant host cells (CHO-Kl cells) individually expressing the 5 hSSTR subtypes; (ii) the use of these cells as tools for testing the ability of synthetic SST agonists or antagonists to induce receptor internalization or upregulation; (iii) the use of the internalization property of hSSTR subtypes to target tumors for selective targeted destruction. For instance, subtypes such as hSSTR3 and 5 which are extensively internalized could be targeted with selective alpha or beta -emitting SST radioligands for radiotherapy of, for example, breast cancers which display a rich concentration of these receptors; (iv) the use of the ability of hSSTR1 (in particular) and hSSTR2 and 4 (to a lesser extent) to be upregulated at the cell surface upon prolonged treatment with agonist as a test for increasing the sensitivity of receptor scans for detection and diagnosis of tumors and inflammatory conditions; (v) the use of the differential ability of the hSSTR subtypes to be upregulated or internalized as a means for producing enhanced images in receptor scans by subtraction analysis to recruit, for example, SSTR1 selective to the membrane whilst internalizing others such as hSSTR3, hSSTR4, and hSSTR5.
摘要翻译：本发明涉及1-5型人生长抑素受体在诊断和/或治疗疾病中的用途，更具体地涉及肿瘤细胞，例如，乳腺癌和阿尔茨海默病。本发明涉及（i）分别表达5个hSSTR亚型的重组宿主细胞（CHO-K1细胞）; （ii）使用这些细胞作为测试合成SST激动剂或拮抗剂诱导受体内化或上调的能力的工具; （iii）使用hSSTR亚型的内在特性来靶向肿瘤以进行选择性靶向破坏。例如，广泛内化的hSSTR3和5型亚型可以用选择性α或β发射的SST放射性配体靶向用于放射治疗，例如显示这些受体浓度较高的乳腺癌; （iv）长时间用激动剂治疗时，使用hSSTR1（特别是）和hSSTR2和4（在较小程度上）的能力在细胞表面上调节作为增加受体扫描检测和诊断灵敏度的试验的肿瘤和炎症病症; （v）使用hSSTR亚型的差异能力作为在受体扫描中通过减法分析产生增强图像的手段进行上调或内化，以招募例如对膜选择性的SSTR1，同时内化其他如hSSTR3，hSSTR4 ，和hSSTR5。

10. 发明申请

WO2022173825A1 SYSTEMS AND METHODS FOR HARDWARE DEVICE FINGERPRINTING 审中-公开
公开(公告)号：WO2022173825A1
公开(公告)日：2022-08-18
申请号：PCT/US2022/015814
申请日：2022-02-09
申请人： PATEL, Yogesh Kumar Jitendra , CALLSIGN, INC.
发明人： PATEL, Yogesh Kumar Jitendra
IPC分类号： G06F21/44 , G06F21/60 , G06F21/71 , G06N20/00
摘要： Disclosed are systems and methods for uniquely identifying a hardware device. In one aspect, a method may comprise (a) obtaining a first partial key and encrypted parameters from a database and a second partial key from a remote server; (b) decrypting the encrypted parameters using the first partial key and the second partial key, to thereby generate decrypted parameters; (c) obtaining attributes of a hardware device, wherein the attributes comprise a state of a CPU or GPU of the hardware device; (d) processing, on the hardware device, the attributes with a first ML algorithm to generate a digital fingerprint of the hardware device, wherein the first ML algorithm comprises the decrypted parameters; and (e) processing, on the remote server, at least the digital fingerprint of the hardware device and the attributes with a second ML algorithm configured to determine whether the hardware device has been previously identified.

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