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1. 发明申请

WO2007022241A3 NOVEL HIGH AFFINITY QUINOLINE-BASED KINASE LIGANDS 审中-公开
标题翻译：新型高亲和力喹啉类激酶配体
公开(公告)号：WO2007022241A3
公开(公告)日：2007-09-27
申请号：PCT/US2006031945
申请日：2006-08-16
申请人： SCHERING CORP , DENG YONGQI , CURRAN PATRICK J , SHIPPS GERALD W JR , ZHAO LIANYUN , SIDDIQUI M ARSHAD , POPOVICI-MULLER JANETA , DUCA JOSE S , HRUZA ALAN W , FISCHMANN THIERRY O , MADISON VINCENT S , ZHANG RUMIN , MCNEMAR CHARLES WAYNE , MAYHOOD TODD W , WINDSOR WILLIAM T , LEES EMMA M , PARRY DAVID A
发明人： DENG YONGQI , CURRAN PATRICK J , SHIPPS GERALD W JR , ZHAO LIANYUN , SIDDIQUI M ARSHAD , POPOVICI-MULLER JANETA , DUCA JOSE S , HRUZA ALAN W , FISCHMANN THIERRY O , MADISON VINCENT S , ZHANG RUMIN , MCNEMAR CHARLES WAYNE , MAYHOOD TODD W , WINDSOR WILLIAM T , LEES EMMA M , PARRY DAVID A
IPC分类号： C07D409/04 , C07D215/42 , C07D215/48 , C07D215/50 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/10
CPC分类号： C07D409/04 , C07D215/42 , C07D215/48 , C07D215/50 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/10
摘要： Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.
摘要翻译：描述了细胞周期蛋白依赖性激酶2的基于喹啉的抑制剂，包含该抑制剂的组合物，以及使用该抑制剂和抑制剂组合物的方法。包含它们的抑制剂和组合物可用于治疗疾病或疾病症状。本发明还提供了制备CDK-2抑制剂化合物的方法，抑制CDK-2的方法以及治疗疾病或疾病症状的方法。

2. 发明申请

WO2009038701A3 FORMULATION CONTAINING CYCLIN-DEPENDENT KINASE INHIBITING COMPOUND AND METHOD OF TREATING TUMORS USING THE SAME 审中-公开
标题翻译：含有CYCLIN依赖性激酶抑制化合物的制剂及使用该方法治疗肿瘤的方法
公开(公告)号：WO2009038701A3
公开(公告)日：2009-09-11
申请号：PCT/US2008010778
申请日：2008-09-16
申请人： SCHERING CORP , ANTOCHSHUK VALENTYN , BANNERJI RAJAT , DABBARA ANITA , KIRSCHMEIER PAUL , PARRY DAVID A , SHAMEEM MOHAMMED , STATKEVICH PAUL , YAO SIU-LONG
发明人： ANTOCHSHUK VALENTYN , BANNERJI RAJAT , DABBARA ANITA , KIRSCHMEIER PAUL , PARRY DAVID A , SHAMEEM MOHAMMED , STATKEVICH PAUL , YAO SIU-LONG
IPC分类号： A61K9/08 , A61K31/519 , A61K47/12 , A61P35/00
CPC分类号： A61K31/519
摘要： This application discloses a novel formulation containing a 3-amino-4-sub stituted pyrazole derivative which has cyclin-dependent kinase inhibiting properties, and a method of treating tumors using the novel formulation.
摘要翻译：本申请公开了含有具有细胞周期蛋白依赖性激酶抑制性质的3-氨基-4-取代的吡唑衍生物的新型制剂，以及使用该新制剂治疗肿瘤的方法。

3. 发明申请

WO2008063558A2 COMBINATION THERAPY FOR PROLIFERATIVE DISORDERS 审中-公开
标题翻译：加重疾病的组合治疗
公开(公告)号：WO2008063558A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/024064
申请日：2007-11-15
申请人： SCHERING CORPORATION , PARRY, David, A. , TARICANI, Lorena
发明人： PARRY, David, A. , TARICANI, Lorena
CPC分类号： A61K45/06
摘要： The present invention provides compositions and methods of treating proliferative disorders using combination therapy with a first agent that specifically inhibits DNA polymerase alpha and a second agent that inhibits protein kinases, such as Chk1.
摘要翻译：本发明提供使用特异性抑制DNA聚合酶α的第一药剂和抑制蛋白激酶例如Chk1的第二药物的联合治疗来治疗增殖性疾病的组合物和方法。

4. 发明申请

WO2007044441A2 METHODS FOR INHIBITING PROTEIN KINASES 审中-公开
标题翻译：抑制蛋白激酶的方法
公开(公告)号：WO2007044441A2
公开(公告)日：2007-04-19
申请号：PCT/US2006038917
申请日：2006-10-04
申请人： SCHERING CORP , GUZI TIMOTHY J , PARUCH KAMIL , DWYER MICHAEL P , PARRY DAVID A
发明人： GUZI TIMOTHY J , PARUCH KAMIL , DWYER MICHAEL P , PARRY DAVID A
CPC分类号： A61K31/519 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pirn kinases, and tyrosine kinase using pyrazolo[1 ,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.
摘要翻译：本发明提供使用吡唑并[1,5-a]嘧啶化合物抑制选自AKT，检查点激酶，极光激酶，皮激酶和酪氨酸激酶的蛋白激酶的方法，以及治疗，预防，抑制或使用这种化合物改善与蛋白激酶相关的一种或多种疾病。

5. 发明申请

WO2007056468A1 METHODS FOR INHIBITING PROTEIN KINASES 审中-公开
标题翻译：抑制蛋白激酶的方法
公开(公告)号：WO2007056468A1
公开(公告)日：2007-05-18
申请号：PCT/US2006/043512
申请日：2006-11-08
申请人： SCHERING CORPORATION , GUZI, Timothy J. , PARUCH, Kamil , DWYER, Michael P. , PARRY, David, A. , ZHAO, Lianyun , CURRAN, Patrick, J. , BELANGER, David, B. , HAMANN, Blake , REDDY, Panduranga, Adulla, P. , SIDDIQUI, M. Arshad , TADIKONDA, Praveen, K.
发明人： GUZI, Timothy J. , PARUCH, Kamil , DWYER, Michael P. , PARRY, David, A. , ZHAO, Lianyun , CURRAN, Patrick, J. , BELANGER, David, B. , HAMANN, Blake , REDDY, Panduranga, Adulla, P. , SIDDIQUI, M. Arshad , TADIKONDA, Praveen, K.
IPC分类号： A61K31/4985 , A61P35/00
CPC分类号： A61K31/4985 , A61K31/498
摘要： The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim-1 kinase, and tyrosine kinase using imidazo[1,2-a]pyrazine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.
摘要翻译：本发明提供使用咪唑并[1,2-a]吡嗪化合物抑制选自AKT，检查点激酶，极光激酶，Pim-1激酶和酪氨酸激酶的蛋白激酶的方法，以及治疗，预防，抑制，或使用这些化合物改善与蛋白激酶相关的一种或多种疾病。

6. 发明申请

WO2007044441A3 USE OF PYRAZOLO [1 , 5 -A] PYRIMIDINE DERIVATIVES FOR INHIBITING PROTEIN KINASES METHODS FOR INHIBITING PROTEIN KINASES 审中-公开
公开(公告)号：WO2007044441A3
公开(公告)日：2007-04-19
申请号：PCT/US2006/038917
申请日：2006-10-04
申请人： SCHERING CORPORATION , GUZI, Timothy, J. , PARUCH, Kamil , DWYER, Michael, P. , PARRY, David, A.
发明人： GUZI, Timothy, J. , PARUCH, Kamil , DWYER, Michael, P. , PARRY, David, A.
IPC分类号： A61K31/519 , A61P25/00 , A61P19/00 , A61P35/00 , A61P9/00 , C07D487/04
摘要： The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pirn kinases, and tyrosine kinase using pyrazolo[1 ,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.

7. 发明申请

WO2009061781A1 NOVEL MODULATORS OF CELL CYCLE CHECKPOINTS AND THEIR USE IN COMBINATION WITH CHECKPOINT KINASE INHIBITORS 审中-公开
标题翻译：细胞周期检测点的新型调节因子及其与检测点激酶抑制剂的组合使用
公开(公告)号：WO2009061781A1
公开(公告)日：2009-05-14
申请号：PCT/US2008/082429
申请日：2008-11-05
申请人： SCHERING CORPORATION , GUZI, Timothy, J. , PARRY, David, A. , LABROLI, Marc, A. , DWYER, Michael, P. , PARUCH, Kamil , ROSNER, Kristen, E. , SHEN, Ruichao , POPOVICI-MULLER, Janeta
发明人： GUZI, Timothy, J. , PARRY, David, A. , LABROLI, Marc, A. , DWYER, Michael, P. , PARUCH, Kamil , ROSNER, Kristen, E. , SHEN, Ruichao , POPOVICI-MULLER, Janeta
IPC分类号： C07H19/073 , C07H19/067 , A61K31/7068 , A61P35/00
CPC分类号： C07H19/067 , C07H19/073
摘要： In its many embodiments, the present invention provides a novel class of pyrimidine analogs of formula (V) as targeted mechanism-based modulators of cell cycle checkpoints. Cancers and/or malignancies can be treated by administration of a cell cycle checkpoint modulator of the invention. Also discussed are suitable combinations of the cell cycle checkpoint modulator with a checkpoint kinase inhibitor to produce synergistic apoptosis in cancer cells. The invention includes methods of treating cancers by administering the combination of the cell cycle checkpoint modulator and the checkpoint kinase inhibitor, pharmaceutical compositions comprising the activator as well as the combination and pharmaceutical kits.
摘要翻译：在其许多实施方案中，本发明提供了一类新颖的式（V）嘧啶类似物作为细胞周期检查点的靶向基于机制的调节剂。可以通过施用本发明的细胞周期检查点调节剂来治疗癌症和/或恶性肿瘤。还讨论了细胞周期检查点调节剂与检查点激酶抑制剂的合适组合，以在癌细胞中产生协同凋亡。本发明包括通过施用细胞周期检查点调节剂和检查点激酶抑制剂的组合，包含活化剂的药物组合物以及组合药物试剂盒来治疗癌症的方法。

8. 发明申请

WO2008063558A3 COMBINATION OF AN INHIBITOR OF DNA POLYMERASE-ALPHA AND AN INHIBITOR OF A CHECKPOINT KINASE FOR PROLIFERATIVE DISORDERS 审中-公开
标题翻译： DNA聚合酶ALPHA的抑制剂和用于增殖性疾病的检查点激酶的抑制剂的组合
公开(公告)号：WO2008063558A3
公开(公告)日：2009-01-22
申请号：PCT/US2007024064
申请日：2007-11-15
申请人： SCHERING CORP , PARRY DAVID A , TARICANI LORENA
发明人： PARRY DAVID A , TARICANI LORENA
IPC分类号： A61P35/00 , A61K45/06
CPC分类号： A61K45/06
摘要： The present invention provides compositions and methods of treating proliferative disorders using combination therapy with a first agent that specifically inhibits DNA polymerase alpha and a second agent that inhibits protein kinases, such as Chk1.
摘要翻译：本发明提供使用特异性抑制DNA聚合酶α的第一药剂和抑制蛋白激酶例如Chk1的第二药物的联合治疗来治疗增殖性疾病的组合物和方法。

9. 发明申请

WO2004070673A1 HAZARD DETECTION 审中-公开
标题翻译：危害检测
公开(公告)号：WO2004070673A1
公开(公告)日：2004-08-19
申请号：PCT/GB2004/000321
申请日：2004-02-02
申请人： KIDDE IP HOLDINGS LIMITED , HARVEY, Ann, M. , PARRY, David, A.
发明人： HARVEY, Ann, M. , PARRY, David, A.
IPC分类号： G08B17/10
CPC分类号： G08B29/26 , G08B17/10
摘要： In order to allow a smoke detector unit (1) to be utilised in, for example, a domestic kitchen environment, appliances (11, 21) whose operation is commonly associated with the generation of non-hazardous smoke or aerosols are connected to a conventional mains supply socket (7, 19) via a current monitoring unit (3, 15). The current monitoring units include a radio transceiver (13, 23) which transmits the operational status of the appliances (11, 21) to a corresponding transceiver (25) of the smoke detector unit 1. If the signals transmitted by the current monitoring units indicate that the appliances (11) and (21) are off, the smoke detector unit (1) generates a warning signal when the smoke density exceeds a lower threshold. If one of the appliances (11) and (21) is detected to be on, the smoke detector unit generates a warning signal only when a second, higher threshold of smoke density is exceeded. Optionally, when the higher smoke density threshold is exceeded, the smoke detector unit transmits the signal to the current monitoring unit to power off the appliances. The invention is also applicable to the detection of other characteristics of ambient fluid, such as temperature or the presence of a particular gas or vapour.
摘要翻译：为了允许在例如家庭厨房环境中使用烟雾探测器单元（1），其操作通常与产生非危险烟雾或气溶胶相关联的电器（11,21）连接到常规电源插座（7,19）通过电流监视单元（3,15）进行。目前的监控单元包括将设备（11,21）的操作状态发送到烟雾探测器单元1的对应收发器（25）的无线电收发器（13,23）。如果由当前监控单元发送的信号指示（11）和（21）关闭时，烟雾浓度超过下限阈值时烟检测器单元（1）产生警告信号。如果检测到设备（11）和（21）中的一个处于打开状态，则烟雾探测器单元仅在超过第二较高的烟雾密度阈值时产生警告信号。可选地，当超过较高烟雾浓度阈值时，烟雾检测器单元将信号发送到当前监测单元以关闭设备。本发明还适用于检测环境流体的其它特性，例如温度或特定气体或蒸气的存在。

10. 发明申请

WO2009038701A2 FORMULATION CONTAINING CYCLIN-DEPENDENT KINASE INHIBITING COMPOUND AND METHOD OF TREATING TUMORS USING THE SAME 审中-公开
标题翻译：含有周期蛋白依赖性激酶抑制化合物的制剂和使用该制剂治疗肿瘤的方法
公开(公告)号：WO2009038701A2
公开(公告)日：2009-03-26
申请号：PCT/US2008/010778
申请日：2008-09-16
申请人： SCHERING CORPORATION , ANTOCHSHUK, Valentyn , BANNERJI, Rajat , DABBARA, Anita , KIRSCHMEIER, Paul , PARRY, David, A. , SHAMEEM, Mohammed , STATKEVICH, Paul , YAO, Siu-Long
发明人： ANTOCHSHUK, Valentyn , BANNERJI, Rajat , DABBARA, Anita , KIRSCHMEIER, Paul , PARRY, David, A. , SHAMEEM, Mohammed , STATKEVICH, Paul , YAO, Siu-Long
IPC分类号： A61K9/08 , A61K31/519 , A61P35/00 , A61K47/12
CPC分类号： A61K31/519
摘要： This application discloses a novel formulation containing a 3-amino-4-sub stituted pyrazole derivative which has cyclin-dependent kinase inhibiting properties, and a method of treating tumors using the novel formulation.
摘要翻译：该申请公开了含有具有细胞周期蛋白依赖性激酶抑制特性的3-氨基-4-取代的吡唑衍生物的新制剂以及使用该新制剂治疗肿瘤的方法。

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