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1. 发明申请

WO2013022279A2 N1-CYCLIC AMINE-N5-SUBSTITUTED BIGUANIDE DERIVATIVES, METHODS OF PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： N1-环状胺-N5-取代的双胍衍生物，其制备方法和包含该化合物的药物组合物
公开(公告)号：WO2013022279A2
公开(公告)日：2013-02-14
申请号：PCT/KR2012006327
申请日：2012-08-08
申请人： HANALL BIOPHARMA CO LTD , KIM SUNG WUK , MIN CHANG HEE , PARK SE HWAN , KIM DUCK , LEE JI SUN , KIM YONG EUN , OH JU HOON
发明人： KIM SUNG WUK , MIN CHANG HEE , PARK SE HWAN , KIM DUCK , LEE JI SUN , KIM YONG EUN , OH JU HOON
IPC分类号： C07C279/26 , A61K31/155 , A61P35/00 , C07C277/02
CPC分类号： C07D295/215 , C07D205/04 , C07D213/40 , C07D307/52 , C07D333/20
摘要： A N1-cyclic amine-N5-substituted biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient are provided. The biguanide derivatives have an effect of inhibiting cancer cell proliferation and also exhibit anticancer activity including inhibition of cancer metastasis and cancer recurrence, because they are effective in activating AMPK, which is associated with the control of energy metabolism, even when administered in a small dose compared with conventional drugs. Also, the biguanide derivatives are highly effective at lowering blood glucose and lipid concentration by AMPK activation, thus they may be effectively used to treat diabetes mellitus, obesity, hyperlipemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome and metabolic syndrome.
摘要翻译：提供了式1的N1-环胺-N5-取代的双胍衍生物或其药学上可接受的盐，其制备方法以及包含该双胍衍生物或其药学上可接受的盐作为活性成分的药物组合物。双胍衍生物具有抑制癌细胞增殖的效果，并且即使以小剂量给药也具有与能量代谢的控制相关的活化AMPK的活化作用，因此具有抑制癌转移和癌复发的抗癌活性与传统药物相比。此外，双胍衍生物在通过AMPK活化降低血糖和脂质浓度方面非常有效，因此它们可以有效地用于治疗糖尿病，肥胖症，高脂血症，高胆固醇血症，脂肪肝，冠状动脉疾病，骨质疏松症，多囊卵巢综合征和代谢综合征。

2. 发明申请

WO2013022278A2 N1-CYCLIC AMINE-N5-SUBSTITUTED PHENYL BIGUANIDE DERIVATIVES, METHODS OF PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： N1循环胺-N5取代苯基双胍衍生物，其制备方法和包含其的药物组合物
公开(公告)号：WO2013022278A2
公开(公告)日：2013-02-14
申请号：PCT/KR2012/006326
申请日：2012-08-08
申请人： HANALL BIOPHARMA CO., LTD. , KIM, Sung Wuk , MIN, Chang Hee , PARK, Se Hwan , KIM, Duck , LEE, Ji Sun , KIM, Yong Eun , OH, Ju Hoon
发明人： KIM, Sung Wuk , MIN, Chang Hee , PARK, Se Hwan , KIM, Duck , LEE, Ji Sun , KIM, Yong Eun , OH, Ju Hoon
IPC分类号： C07C279/26 , C07C277/02 , A61K31/155 , A61P35/00
CPC分类号： C07D211/14 , C07D205/04 , C07D207/04 , C07D207/06 , C07D211/06 , C07D223/04 , C07D257/04 , C07D295/14 , C07D295/215
摘要： An N1-cyclic amine-N5-substituted phenyl biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient are provided. The biguanide derivatives have an effect of inhibiting cancer cell proliferation and also exhibit anticancer activity including inhibition of cancer metastasis and cancer recurrence, because they are effective in activating AMPK, which is associated with the control of energy metabolism, even when administered in a small dose compared with conventional drugs. Also, the biguanide derivatives are highly effective at lowering blood glucose and lipid concentration by AMPK activation, thus they may be effectively used to treat diabetes mellitus, obesity, hyperlipemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome and metabolic syndrome.
摘要翻译：提供式1的N 1 - 环胺-N 5 - 取代的苯基双胍衍生物或其药学上可接受的盐，其制备方法和包含双胍衍生物或其药学上可接受的盐作为活性成分的药物组合物。双胍衍生物具有抑制癌细胞增殖的作用，并且还表现出抗肿瘤活性，包括抑制癌症转移和癌症复发，因为即使以小剂量施用也能有效地激活与能量代谢控制有关的AMPK 与常规药物相比。此外，双胍衍生物通过AMPK活化降低血糖和脂质浓度高度有效，因此可有效用于治疗糖尿病，肥胖，高脂血症，高胆固醇血症，脂肪肝，冠状动脉疾病，骨质疏松症，多囊卵巢综合征和代谢综合征。

3. 发明申请

WO2011083999A2 BIGUANIDE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ACTIVE INGREDIENT 审中-公开
标题翻译： BIGUANIDE衍生物，其制备方法和含有作为活性成分的药物组合物
公开(公告)号：WO2011083999A2
公开(公告)日：2011-07-14
申请号：PCT/KR2011000098
申请日：2011-01-06
申请人： HANALL BIOPHARMA CO LTD , KIM SUNG WUK , JUN SUNG SOO , MIN CHANG HEE , PARK SE HWAN , KIM YONG EUN , KIM DUCK , LEE JI SUN , OH JU HOON
发明人： KIM SUNG WUK , JUN SUNG SOO , MIN CHANG HEE , PARK SE HWAN , KIM YONG EUN , KIM DUCK , LEE JI SUN , OH JU HOON
IPC分类号： C07C279/26 , A61K31/155 , A61P3/10 , A61P35/00 , C07C277/00
CPC分类号： A61K31/155 , A61K31/341 , A61K31/4406 , A61K31/472 , C07C277/04 , C07C279/04 , C07C279/06 , C07C279/08 , C07C279/16 , C07C279/18 , C07C279/26 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D213/38 , C07D307/52 , C07D317/58 , C07D333/20
摘要： The present invention provides a biguanide derivative or pharmaceutically acceptable salt thereof represented by Formula 1 with N4-N5-substitutions, a preparation method thereof and a pharmaceutical composition containing the biguanide derivative as an active ingredient. Compared with conventional drugs, even a small amount of the biguanide derivative of the present invention exhibits excellent effects of AMPKa activation and inhibition of cancer cell proliferation, which makes it useful for the treatment of diabetes, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer and the like.
摘要翻译：本发明提供由式1表示的具有N4-N5取代基的双胍衍生物或其药学上可接受的盐，其制备方法和含有双胍衍生物作为活性成分的药物组合物。与常规药物相比，即使少量本发明的双胍衍生物也表现出AMPKa活化和癌细胞增殖抑制作用的优异性，因此可用于治疗糖尿病，肥胖症，高脂血症，高胆固醇血症，脂肪肝，冠心病动脉疾病，骨质疏松症，多囊卵巢综合征，代谢综合征，癌症等。

4. 发明申请

WO2012169730A3 METHOD AND APPARATUS FOR PROVIDING CHARACTER INPUT INTERFACE 审中-公开
公开(公告)号：WO2012169730A3
公开(公告)日：2012-12-13
申请号：PCT/KR2012/003332
申请日：2012-04-30
申请人： SAMSUNG ELECTRONICS CO., LTD. , PARK, Sung Wook , PARK, Se Hwan , KIM, Ji Hoon , LEE, Ji Hoon
发明人： PARK, Sung Wook , PARK, Se Hwan , KIM, Ji Hoon , LEE, Ji Hoon
IPC分类号： G06F3/02 , G06F3/048 , G06F3/14 , G06F3/041
摘要： A method and an apparatus for providing a character input interface are provided. The method for providing a character input interface in a terminal having a touchscreen, includes simultaneously displaying a first keyboard on a first region and a second keyboard including second keyboard language selection keys on a second region by the touchscreen in a character inputting mode; and changing a language of the second keyboard to a language corresponding to a second touched keyboard language selection key touched while maintaining a language of the first keyboard when input touching the second keyboard language key is received.

5. 发明申请

WO2009104854A2 PORTABLE MEDICAL TREATMENT APPARATUS FOR SEBACEOUS GLANDS DISEASE USING A HEAT SOURCE UNITED WITH A LIGHT IRRADIATION 审中-公开
标题翻译：使用光源照射的热源可以使用特殊的药物治疗设备
公开(公告)号：WO2009104854A2
公开(公告)日：2009-08-27
申请号：PCT/KR2008/006100
申请日：2008-10-16
申请人： HA, Dong Hoon , PARK, Se Hwan
发明人： HA, Dong Hoon , PARK, Se Hwan
IPC分类号： A61B18/04
CPC分类号： A61F7/007 , A61B2017/00115 , A61B2017/00132 , A61F2007/0078 , A61F2007/0096 , A61N5/0616 , A61N2005/0644 , A61N2005/0652 , A61N2005/0659 , A61N2005/0662
摘要： A portable medical device for treating sebaceous glands diseases using a heat source combined with light irradiation. The device includes a housing capable of being gripped by a hand, a heating element disposed inside the housing and generating heat, a light source circuit having a light source emitting a wavelength of 400nm to 900nm, a temperature sensor detecting whether the internal temperature of the housing is between a lower limit T 1 and a upper limit T 2 and transferring the value to a control unit, a heating element control circuit unit for automatically re-heating the heating element when the temperature detected by the temperature sensor is less than T 1 , and for automatically interrupting power supply to the heating element when the temperature is higher than T 2 , a control unit for controlling operation of internal circuits; and a rechargeable power supply for supplying electric power to the internal circuits.
摘要翻译：一种用于使用与光照射结合的热源治疗皮脂腺疾病的便携式医疗装置。该装置包括能够被手抓住的壳体，设置在壳体内部并产生热量的加热元件，具有发射波长为400nm至900nm的光源的光源电路，检测壳体在下限T1和上限T2之间，并将该值传送到控制单元，当由温度传感器检测到的温度小于T1时，加热元件控制电路单元用于自动重新加热加热元件，并且对于当温度高于T2时，自动中断加热元件的电源;控制单元，用于控制内部电路的工作; 以及用于向内部电路供电的可再充电电源。

6. 发明申请

WO2013022280A2 N1-CYCLIC AMINE-N2-SUBSTITUTED BIGUANIDE DERIVATIVES, METHODS OF PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： N1-环状胺-N2-取代的双胍衍生物，其制备方法和包含该化合物的药物组合物
公开(公告)号：WO2013022280A2
公开(公告)日：2013-02-14
申请号：PCT/KR2012/006328
申请日：2012-08-08
申请人： HANALL BIOPHARMA CO., LTD. , KIM, Sung Wuk , MIN, Chang Hee , PARK, Se Hwan , KIM, Duck , LEE, Ji Sun , KIM, Yong Eun , OH, Ju Hoon
发明人： KIM, Sung Wuk , MIN, Chang Hee , PARK, Se Hwan , KIM, Duck , LEE, Ji Sun , KIM, Yong Eun , OH, Ju Hoon
IPC分类号： C07C279/26 , C07C277/02 , A61K31/155 , A61P35/00
CPC分类号： C07D307/52 , C07D295/215 , C07D333/20
摘要： An N1-cyclic amine-N2-substituted biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient are provided. The biguanide derivatives have an effect of inhibiting cancer cell proliferation and also exhibit anticancer activity including inhibition of cancer metastasis and cancer recurrence, because they are effective in activating AMPK, which is associated with the control of energy metabolism, even when administered in a small dose compared with conventional drugs. Also, the biguanide derivatives are highly effective at lowering blood glucose and lipid concentration by AMPK activation, thus they may be effectively used to treat diabetes mellitus, obesity, hyperlipemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome and metabolic syndrome.
摘要翻译：式1的N1-环胺-N 2 - 取代的双胍衍生物或其药学上可接受的盐，其制备方法以及包含该双胍衍生物或其药学上可接受的盐的药物组合物作为有效成分。双胍衍生物具有抑制癌细胞增殖的效果，并且即使以小剂量给药也具有与能量代谢的控制相关的活化AMPK的活化作用，因此具有抑制癌转移和癌复发的抗癌活性与传统药物相比。此外，双胍衍生物在通过AMPK活化降低血糖和脂质浓度方面非常有效，因此它们可以有效地用于治疗糖尿病，肥胖症，高脂血症，高胆固醇血症，脂肪肝，冠状动脉疾病，骨质疏松症，多囊卵巢综合征和代谢综合征。

7. 发明申请

WO2012169730A2 METHOD AND APPARATUS FOR PROVIDING CHARACTER INPUT INTERFACE 审中-公开
标题翻译：用于提供字符输入接口的方法和装置
公开(公告)号：WO2012169730A2
公开(公告)日：2012-12-13
申请号：PCT/KR2012003332
申请日：2012-04-30
申请人： SAMSUNG ELECTRONICS CO LTD , PARK SUNG WOOK , PARK SE HWAN , KIM JI HOON , LEE JI HOON
发明人： PARK SUNG WOOK , PARK SE HWAN , KIM JI HOON , LEE JI HOON
IPC分类号： G06F3/02 , G06F3/041 , G06F3/048 , G06F3/14
CPC分类号： G06F3/04886 , G06F3/018 , G06F3/0238 , G06F3/04847 , G06F3/04883
摘要： A method and an apparatus for providing a character input interface are provided. The method for providing a character input interface in a terminal having a touchscreen, includes simultaneously displaying a first keyboard on a first region and a second keyboard including second keyboard language selection keys on a second region by the touchscreen in a character inputting mode; and changing a language of the second keyboard to a language corresponding to a second touched keyboard language selection key touched while maintaining a language of the first keyboard when input touching the second keyboard language key is received.
摘要翻译：提供了一种用于提供字符输入接口的方法和装置。用于在具有触摸屏的终端中提供字符输入接口的方法包括：以字符输入模式，通过触摸屏同时显示第一区域上的第一键盘和包括第二区域上的第二键盘语言选择键的第二键盘; 以及当接收到接触到所述第二键盘语言密钥的输入时，将所述第二键盘的语言改变为对应于所触摸的第二触摸键盘语言选择键的语言，同时保持所述第一键盘的语言。

8. 发明申请

WO2013022278A3 N1-CYCLIC AMINE-N5-SUBSTITUTED PHENYL BIGUANIDE DERIVATIVES, METHODS OF PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： N1-环状胺-N5-取代的苯基双胍衍生物，其制备方法和包含该化合物的药物组合物
公开(公告)号：WO2013022278A3
公开(公告)日：2013-04-25
申请号：PCT/KR2012006326
申请日：2012-08-08
申请人： HANALL BIOPHARMA CO LTD , KIM SUNG WUK , MIN CHANG HEE , PARK SE HWAN , KIM DUCK , LEE JI SUN , KIM YONG EUN , OH JU HOON
发明人： KIM SUNG WUK , MIN CHANG HEE , PARK SE HWAN , KIM DUCK , LEE JI SUN , KIM YONG EUN , OH JU HOON
IPC分类号： C07C279/26 , A61K31/155 , A61P35/00 , C07C277/02
CPC分类号： C07D211/14 , C07D205/04 , C07D207/04 , C07D207/06 , C07D211/06 , C07D223/04 , C07D257/04 , C07D295/14 , C07D295/215
摘要： An N1-cyclic amine-N5-substituted phenyl biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient are provided. The biguanide derivatives have an effect of inhibiting cancer cell proliferation and also exhibit anticancer activity including inhibition of cancer metastasis and cancer recurrence, because they are effective in activating AMPK, which is associated with the control of energy metabolism, even when administered in a small dose compared with conventional drugs. Also, the biguanide derivatives are highly effective at lowering blood glucose and lipid concentration by AMPK activation, thus they may be effectively used to treat diabetes mellitus, obesity, hyperlipemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome and metabolic syndrome.
摘要翻译：提供了式1的N1-环胺-N 5 - 取代苯基双胍衍生物或其药学上可接受的盐，其制备方法以及包含该双胍衍生物或其药学上可接受的盐作为活性成分的药物组合物。双胍衍生物具有抑制癌细胞增殖的效果，并且即使以小剂量给药也具有与能量代谢的控制相关的活化AMPK的活化作用，因此具有抑制癌转移和癌复发的抗癌活性与传统药物相比。此外，双胍衍生物在通过AMPK活化降低血糖和脂质浓度方面非常有效，因此它们可以有效地用于治疗糖尿病，肥胖症，高脂血症，高胆固醇血症，脂肪肝，冠状动脉疾病，骨质疏松症，多囊卵巢综合征和代谢综合征。

9. 发明申请

WO2012043970A2 RAPIDLY-HEATABLE HEATING UNIT STRUCTURE FOR A DEVICE FOR TREATING SEBACEOUS GLAND DISEASE 审中-公开
标题翻译：用于治疗海绵状病的装置的快速加热单元结构
公开(公告)号：WO2012043970A2
公开(公告)日：2012-04-05
申请号：PCT/KR2011004674
申请日：2011-06-28
申请人： PARK SE HWAN
发明人： PARK SE HWAN
IPC分类号： A61B18/04 , A61F7/00 , A61N1/00
CPC分类号： A61F7/007 , A61F2007/0095
摘要： The present invention relates to a rapidly-heatable heating unit structure for a device for treating sebaceous gland disease, in which a printed circuit board (PCB, 5) for a heating material part having a heating material (4) disposed therein is mounted at an upper portion of a PCB (6) vertically to the PCB (6) and parallel to a skin-contacting surface of a skin-contacting housing (2). Since the heating material (4) and a temperature sensor (3) are mounted on an upper surface of the PCB (5) for the heating material part, the volume of the space between the skin-contacting housing (2) and the heating material (4) is minimized, and the heat of the heating material (4) is transmitted to the skin-contacting housing (2) within a short period of time for convenient and quick use.
摘要翻译：本发明涉及一种用于治疗皮脂腺疾病的装置的可快速加热的加热单元结构，其中用于加热材料部件的印刷电路板（PCB，5）安装在其中设置有加热材料（4）的印刷电路板垂直于PCB（6）且平行于皮肤接触外壳（2）的皮肤接触表面的PCB（6）的上部。由于加热材料（4）和温度传感器（3）安装在用于加热材料部件的PCB（5）的上表面上，所以皮肤接触壳体（2）与加热材料（4）被最小化，并且加热材料（4）的热量在短时间内被传递到皮肤接触外壳（2）以方便和快速使用。

10. 发明申请

WO2013022280A3 N1-CYCLIC AMINE-N2-SUBSTITUTED BIGUANIDE DERIVATIVES, METHODS OF PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： N1循环胺-N 2取代的双胍衍生物，其制备方法和包含其的药物组合物
公开(公告)号：WO2013022280A3
公开(公告)日：2013-04-25
申请号：PCT/KR2012006328
申请日：2012-08-08
申请人： HANALL BIOPHARMA CO LTD , KIM SUNG WUK , MIN CHANG HEE , PARK SE HWAN , KIM DUCK , LEE JI SUN , KIM YONG EUN , OH JU HOON
发明人： KIM SUNG WUK , MIN CHANG HEE , PARK SE HWAN , KIM DUCK , LEE JI SUN , KIM YONG EUN , OH JU HOON
IPC分类号： C07C279/26 , A61K31/155 , A61P35/00 , C07C277/02
CPC分类号： C07D307/52 , C07D295/215 , C07D333/20
摘要： An N1-cyclic amine-N2-substituted biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient are provided. The biguanide derivatives have an effect of inhibiting cancer cell proliferation and also exhibit anticancer activity including inhibition of cancer metastasis and cancer recurrence, because they are effective in activating AMPK, which is associated with the control of energy metabolism, even when administered in a small dose compared with conventional drugs. Also, the biguanide derivatives are highly effective at lowering blood glucose and lipid concentration by AMPK activation, thus they may be effectively used to treat diabetes mellitus, obesity, hyperlipemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome and metabolic syndrome.
摘要翻译：提供式1的N 1 - 环胺-N 2取代双胍衍生物或其药学上可接受的盐，其制备方法和包含双胍衍生物或其药学上可接受的盐作为活性成分的药物组合物。双胍衍生物具有抑制癌细胞增殖的作用，并且还表现出抗肿瘤活性，包括抑制癌症转移和癌症复发，因为即使以小剂量施用也能有效地激活与能量代谢控制有关的AMPK 与常规药物相比。此外，双胍衍生物通过AMPK活化降低血糖和脂质浓度高度有效，因此可有效用于治疗糖尿病，肥胖，高脂血症，高胆固醇血症，脂肪肝，冠状动脉疾病，骨质疏松症，多囊卵巢综合征和代谢综合征。

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