专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005056020B1 NF-KB OLIGONUCLEOTIDE DECOY MOLECULES 审中-公开
标题翻译： NF-KB寡核苷酸分解
公开(公告)号：WO2005056020B1
公开(公告)日：2005-09-22
申请号：PCT/US2004040673
申请日：2004-12-02
申请人： CORGENTECH INC , MCEVOY LESLIE M , PARHAM CHRISTI , ZHANG JIE
发明人： MCEVOY LESLIE M , PARHAM CHRISTI , ZHANG JIE
IPC分类号： A61K48/00 , C07H21/04 , C12N15/113 , C12N15/115 , A61K31/70
CPC分类号： C12N15/115 , C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/345 , C12N2310/53
摘要： The present invention concerns double-stranded NF-KB decoy oligodeoxynucleotide (NF-KB dsODN) molecules that contain a core sequence capable of specific binding to an NF-KB transcription factor. In a particular aspect, the invention concerns NF-KB decoy molecules that preferentially bind p50/p65 and/or cRel/p50 heterodimers over p50/p50 homodimers. In another aspect, the invention concerns NF-KB decoy molecules with improved binding affinity to p65.
摘要翻译：本发明涉及含有能够与NF-κB转录因子特异性结合的核心序列的双链NF-κB诱饵寡脱氧核苷酸（NF-κBdsODN）分子。在一个特定方面，本发明涉及在p50 / p50同源二聚体上优先结合p50 / p65和/或cRel / p50异二聚体的NF-κB诱饵分子。另一方面，本发明涉及对p65具有改善的结合亲和力的NF-κB诱饵分子。

2. 发明申请

WO2005035547A3 E2F OLIGONUCLEOTIDE DECOY MOLECULES 审中-公开
标题翻译： E2F寡核苷酸decOY分子
公开(公告)号：WO2005035547A3
公开(公告)日：2005-07-21
申请号：PCT/US2004033272
申请日：2004-10-06
申请人： CORGENTECH INC , PARHAM CHRISTI , MCEVOY LESLIE , ZHANG JIE , RAO XIAOPING
发明人： PARHAM CHRISTI , MCEVOY LESLIE , ZHANG JIE , RAO XIAOPING
IPC分类号： A61K38/00 , C12N15/113 , C12Q1/68 , C12N15/11 , A61K31/713
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/111 , C12N2310/13
摘要： The invention concerns E2F oligonucleotide decoy molecules with improved properties. In particular, the invention concerns a double-stranded E2F decoy oligodeoxynucleotide (dsODN) molecule comprising a core sequence that is capable of specific binding to an E2F transcription factor, flanked by 5' and 3' sequences, wherein (i) the core sequence consists of about 5 to 12 base pairs; (ii) the molecule comprises an about 12 to 28 base-pair long double stranded region composed of two fully complementary strands; and (iii) the E217 dsODN binds to said E217 transcription factor with a binding affinity that is at least about 5-fold of the binding affinity of a reference decoy molecule shown in Figure 1 (SEQ ID NOS: 1 and 2), as determined by a competitive gel mobility shift binding assay performed on nuclear extract from THP-1 cells.
摘要翻译：本发明涉及具有改进性质的E2F寡核苷酸诱饵分子。特别地，本发明涉及双链E2F诱饵寡脱氧核苷酸（dsODN）分子，其包含能够与侧翼为5'和3'序列的E2F转录因子特异性结合的核心序列，其中（i）核心序列组成约5至12个碱基对; （ii）分子包含由两个完全互补的链组成的约12至28个碱基对长双链区域; 和（iii）E217 dsODN以如图1所示的参考诱饵分子（SEQ ID NO：1和2）的结合亲和力的至少约5倍的结合亲和力结合所述E217转录因子，如已确定的通过对来自THP-1细胞的核提取物进行的竞争性凝胶迁移转移结合测定。

3. 发明申请

WO2005052157A1 IL-23 AND ITS RECEPTOR; RELATED REAGENTS AND METHODS 审中-公开
标题翻译： IL-23及其受体; 相关试剂和方法
公开(公告)号：WO2005052157A1
公开(公告)日：2005-06-09
申请号：PCT/US2004/038886
申请日：2004-11-18
申请人： SCHERING CORPORATION , CHIRICA, Madaline , KASTELEIN, Robert, A. , MOORE, Kevin, W. , PARHAM, Christi, L.
发明人： CHIRICA, Madaline , KASTELEIN, Robert, A. , MOORE, Kevin, W. , PARHAM, Christi, L.
IPC分类号： C12N15/12
CPC分类号： A61K38/20 , A61K31/7088 , A61K38/1793 , A61K48/00 , C07K14/54 , C07K14/715 , C07K14/7155 , C07K16/244 , C07K16/2866 , C07K2319/00 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12Q1/6876 , G01N33/6869 , G01N33/6893
摘要： Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
摘要翻译：编码哺乳动物，例如灵长类动物，受体，纯化受体蛋白及其片段的核酸。还提供了抗体，包括多克隆和单克隆抗体。描述了用于诊断和治疗用途的组合物的方法。

4. 发明申请

WO2005035547A2 E2F OLIGONUCLEOTIDE DECOY MOLECULES 审中-公开
标题翻译： E2F寡核苷酸诱饵分子
公开(公告)号：WO2005035547A2
公开(公告)日：2005-04-21
申请号：PCT/US2004/033272
申请日：2004-10-06
申请人： CORGENTECH, INC. , PARHAM, Christi , MCEVOY, Leslie , ZHANG, Jie , RAO, Xiaoping
发明人： PARHAM, Christi , MCEVOY, Leslie , ZHANG, Jie , RAO, Xiaoping
IPC分类号： C07H21/00
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/111 , C12N2310/13
摘要： The invention concerns E2F oligonucleotide decoy molecules with improved properties. In particular, the invention concerns a double-stranded E2F decoy oligodeoxynucleotide (dsODN) molecule comprising a core sequence that is capable of specific binding to an E2F transcription factor, flanked by 5' and 3' sequences, wherein (i) the core sequence consists of about 5 to 12 base pairs; (ii) the molecule comprises an about 12 to 28 base-pair long double stranded region composed of two fully complementary strands; and (iii) the E217 dsODN binds to said E217 transcription factor with a binding affinity that is at least about 5-fold of the binding affinity of a reference decoy molecule shown in Figure 1 (SEQ ID NOS: 1 and 2), as determined by a competitive gel mobility shift binding assay performed on nuclear extract from THP-1 cells.
摘要翻译：本发明涉及具有改进性质的E2F寡核苷酸诱饵分子。具体地，本发明涉及包含能够特异性结合E2F转录因子的核心序列，侧接5'和3'序列的双链E2F诱骗寡脱氧核苷酸（dsODN）分子，其中（i）核心序列由约5至12个碱基对; （ii）该分子包含约12至28个碱基对长的双重和害羞; 由两条完全互补的链组成的双链区; 和（iii）E217 dsODN结合所述E217转录因子的结合亲和力为图1所示参考诱杀因子分子（SEQ ID NO：1和2）的结合亲和力的至少约5倍，如所测定的通过对来自THP-1细胞的核提取物进行竞争性凝胶迁移率变化结合测定。

5. 发明申请

WO2005056020A8 NF-KB OLIGONUCLEOTIDE DECOY MOLECULES 审中-公开
标题翻译： NF-KB寡核苷酸分解
公开(公告)号：WO2005056020A8
公开(公告)日：2006-08-31
申请号：PCT/US2004040673
申请日：2004-12-02
申请人： CORGENTECH INC , MCEVOY LESLIE M , PARHAM CHRISTI , ZHANG JIE , EHRHARDT ROLF
发明人： MCEVOY LESLIE M , PARHAM CHRISTI , ZHANG JIE , EHRHARDT ROLF
IPC分类号： A61K48/00 , C07H21/04 , C12N15/113 , C12N15/115
CPC分类号： C12N15/115 , C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/345 , C12N2310/53
摘要： The present invention concerns double-stranded NF- K B decoy oligodeoxynucleotide (NF- K B dsODN) molecules that contain a core sequence capable of specific binding to an NF- K B transcription factor. In a particular aspect, the invention concerns NF- K B decoy molecules that preferentially bind p50/p65 and/or cRel/p50 heterodimers over p50/p50 homodimers. In another aspect, the invention concerns NF- K B decoy molecules with improved binding affinity to p65.
摘要翻译：本发明涉及含有能够特异性结合NF-SUB的核心序列的双链NF-κB诱饵寡聚脱氧核苷酸（NF-κBdsODN） > K B转录因子。在一个特定方面，本发明涉及优于p50 / p50同源二聚体优先结合p50 / p65和/或cRel / p50异源二聚体的NF-κB诱饵分子。另一方面，本发明涉及具有改善的对p65的结合亲和力的NF-K B诱饵分子。

6. 发明申请

WO2005056020A3 NF-KB OLIGONUCLEOTIDE DECOY MOLECULES 审中-公开
标题翻译： NF-κB寡核苷酸decoy分子
公开(公告)号：WO2005056020A3
公开(公告)日：2005-08-04
申请号：PCT/US2004040673
申请日：2004-12-02
申请人： CORGENTECH INC , MCEVOY LESLIE M , PARHAM CHRISTI , ZHANG JIE
发明人： MCEVOY LESLIE M , PARHAM CHRISTI , ZHANG JIE
IPC分类号： A61K48/00 , C07H21/04 , C12N15/113 , C12N15/115 , A61K31/70
CPC分类号： C12N15/115 , C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/345 , C12N2310/53
摘要： The present invention concerns double-stranded NF-KB decoy oligodeoxynucleotide (NF-KB dsODN) molecules that contain a core sequence capable of specific binding to an NF-KB transcription factor. In a particular aspect, the invention concerns NF-KB decoy molecules that preferentially bind p50/p65 and/or cRel/p50 heterodimers over p50/p50 homodimers. In another aspect, the invention concerns NF-KB decoy molecules with improved binding affinity to p65.
摘要翻译：本发明涉及含有能够与NF-κB转录因子特异性结合的核心序列的双链NF-κB诱饵寡脱氧核苷酸（NF-KB dsODN）分子。在一个特定的方面，本发明涉及相对于p50 / p50同型二聚体优先结合p50 / p65和/或cRel / p50异二聚体的NF-κB诱饵分子。另一方面，本发明涉及对p65具有改善的结合亲和力的NF-κB诱饵分子。

7. 发明申请

WO2005056020A2 NF-KB OLIGONUCLEOTIDE DECOY MOLECULES 审中-公开
标题翻译： NF-κB寡核苷酸decoy分子
公开(公告)号：WO2005056020A2
公开(公告)日：2005-06-23
申请号：PCT/US2004/040673
申请日：2004-12-02
申请人： CORGENTECH, INC. , MCEVOY, Leslie, M. , PARHAM, Christi , ZHANG, Jie
发明人： MCEVOY, Leslie, M. , PARHAM, Christi , ZHANG, Jie
IPC分类号： A61K31/70
CPC分类号： C12N15/115 , C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/345 , C12N2310/53
摘要： The present invention concerns double-stranded NF- K B decoy oligodeoxynucleotide (NF- K B dsODN) molecules that contain a core sequence capable of specific binding to an NF- K B transcription factor. In a particular aspect, the invention concerns NF- K B decoy molecules that preferentially bind p50/p65 and/or cRel/p50 heterodimers over p50/p50 homodimers. In another aspect, the invention concerns NF- K B decoy molecules with improved binding affinity to p65.
摘要翻译：本发明涉及包含核心序列的双链NF-κB诱饵寡脱氧核苷酸（NF-κBdsODN）分子，其核心序列能够与NF-κB转录因子特异性结合。在一个特定的方面，本发明涉及相对于p50 / p50同型二聚体优先结合p50 / p65和/或cRel / p50异二聚体的NF-κB诱饵分子。另一方面，本发明涉及对p65具有改善的结合亲和力的NF-κB诱饵分子。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式