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1. 发明申请

WO2012151196A1 DRUG DELIVERY COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：药物输送组合物和使用方法
公开(公告)号：WO2012151196A1
公开(公告)日：2012-11-08
申请号：PCT/US2012/035975
申请日：2012-05-01
申请人： ORTHOCON, INC. , KNAACK, David , GANDHI, Ankur , KATZ, Jordan , WIRTZ, Marci , KRONENTHAL, Richard, L.
发明人： KNAACK, David , GANDHI, Ankur , KATZ, Jordan , WIRTZ, Marci , KRONENTHAL, Richard, L.
IPC分类号： A61K9/14
CPC分类号： A61K47/34 , A61K9/146 , A61K31/167
摘要： The invention provides moldable drug delivery carriers made up of a suspension of a solid phase and an organic liquid phase for the sustained release of a therapeutic agent. The invention also provides multiphase drug delivery systems made up of a granular hydrophobic solid phase, an organic liquid phase and a hydrogel, for sustained drug delivery at varying rates over the life of the composition.
摘要翻译：本发明提供了由固相和有机液相的悬浮液构成的可成形药物递送载体，用于持续释放治疗剂。本发明还提供由粒状疏水性固相，有机液相和水凝胶组成的多相药物递送系统，用于在组合物的整个寿命期内以不同的速率持续给药。

2. 发明申请

WO2013067154A1 COMPOSITIONS AND METHODS FOR HEMOSTASIS 审中-公开
标题翻译：组合物和方法用于HEMOSTASIS
公开(公告)号：WO2013067154A1
公开(公告)日：2013-05-10
申请号：PCT/US2012/063022
申请日：2012-11-01
申请人： ORTHOCON, INC.
发明人： KNAACK, David , PACIFICO, John , WIRTZ, Marci , KRONENTHAL, Richard, L. , DO, Frank , DARR, Aniq
IPC分类号： A61K31/70 , A61K33/14 , A61K33/06 , A61P19/00
CPC分类号： A61L24/00 , A61L24/001 , A61L24/0089 , A61L24/02 , A61L24/046 , A61L24/08 , A61L27/446 , A61L27/50 , A61L27/56 , A61L2400/04
摘要： The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for use in tamponade hemostasis of bone or cartilage.
摘要翻译：本发明涉及具有蜡或蜡状基质的水溶性和完全可吸收和/或生理可降解的止血组合物，其有效用于骨或软骨的止血止血。

3. 发明申请

WO2012170700A3 APPLICATOR WITH CONFORMABLE TIP 审中-公开
公开(公告)号：WO2012170700A3
公开(公告)日：2012-12-13
申请号：PCT/US2012/041372
申请日：2012-06-07
申请人： ORTHOCON, INC. , KAPEC, Jeffrey , TANAKA, Kazuna , NAOI, Yukiko , WIRTZ, Marci
发明人： KAPEC, Jeffrey , TANAKA, Kazuna , NAOI, Yukiko , WIRTZ, Marci
IPC分类号： A61M35/00 , A61B17/56 , A61M37/00 , A61B19/00
摘要： Described herein are applicators for delivery of a viscous material to a bone surface and methods of use. The applicator includes an elongate handle portion and a tip coupled to a distal location of the handle portion and formed of an elastomeric material configured to conform to the bone surface. The tip includes a bend a distance away from the distal location, a contact surface distal to the bend and including one or more surface features configured to adhere to theviscous material, and a front end having a conic curvature. The bend is between about 20 degrees to about 40 degrees from a longitudinal axis of the tip.

4. 发明申请

WO2013036525A2 ABSORBABLE MULTI-PUTTY BONE CEMENTS AND HEMOSTATIC COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：可吸收的多皮肤骨质和化学成分及其使用方法
公开(公告)号：WO2013036525A2
公开(公告)日：2013-03-14
申请号：PCT/US2012053778
申请日：2012-09-05
申请人： ORTHOCON INC , BEZWADA RAO , DARR ANIQ , KRONENTHAL RICHARD L , PACIFICO JOHN
发明人： BEZWADA RAO , DARR ANIQ , KRONENTHAL RICHARD L , PACIFICO JOHN
IPC分类号： A61L24/04
CPC分类号： A61L24/046 , A61L24/0036 , A61L24/0042 , A61L24/0073 , A61L27/18 , A61L27/44 , A61L27/58 , A61L2400/04 , A61L2430/02 , C08L75/04
摘要： The present invention relates to absorbable polyurethane compositions suitable for use in bone repair or reconstruction. The present invention relates to the field of polyurethane-based cements, and putties for use in bone hemostasis, repair and reconstruction. The putty compositions may comprise a mixture of two or more individual putties formed through mixing of one or more reactive components and one or more additive (filler) components. Also disclosed herein are methods of using the putty compositions in medical applications to repair gaps or fractures, or to aid in tissue growth or adhesion.
摘要翻译：本发明涉及适用于骨修复或重建的可吸收聚氨酯组合物。本发明涉及聚氨酯类粘固剂领域，以及用于骨止血，修复和重建的油灰。油灰组合物可以包含通过混合一种或多种反应性组分和一种或多种添加剂（填料）组分形成的两种或多种单独油灰的混合物。本文还公开了在医疗应用中使用油灰组合物来修复间隙或骨折或帮助组织生长或粘附的方法。

5. 发明申请

WO2013036525A3 ABSORBABLE MULTI-PUTTY BONE CEMENTS AND HEMOSTATIC COMPOSITIONS AND METHODS OF USE 审中-公开
公开(公告)号：WO2013036525A3
公开(公告)日：2013-03-14
申请号：PCT/US2012/053778
申请日：2012-09-05
申请人： ORTHOCON, INC. , BEZWADA, Rao , DARR, Aniq , KRONENTHAL, Richard, L. , PACIFICO, John
发明人： BEZWADA, Rao , DARR, Aniq , KRONENTHAL, Richard, L. , PACIFICO, John
IPC分类号： A61L24/04 , A61L24/00 , A61L27/14
摘要： The present invention relates to absorbable polyurethane compositions suitable for use in bone repair or reconstruction. The present invention relates to the field of polyurethane-based cements, and putties for use in bone hemostasis, repair and reconstruction. The putty compositions may comprise a mixture of two or more individual putties formed through mixing of one or more reactive components and one or more additive (filler) components. Also disclosed herein are methods of using the putty compositions in medical applications to repair gaps or fractures, or to aid in tissue growth or adhesion.

6. 发明申请

WO2007014210A2 COMPOSITIONS AND METHODS FOR THE REDUCTION OF POST-OPERATIVE PAIN 审中-公开
标题翻译：减少手术后疼痛的组合物和方法
公开(公告)号：WO2007014210A2
公开(公告)日：2007-02-01
申请号：PCT/US2006/028823
申请日：2006-07-25
申请人： ORTHOCON, INC. , KRONENTHAL, Richard, L.
发明人： KRONENTHAL, Richard, L.
IPC分类号： A61K9/20 , A61K31/19
CPC分类号： A61K9/0024 , A61K31/19
摘要： At least three component, body-implantable, absorbable, biocompatible, putty, and non-putty pain-relieving compositions for use in surgery comprising in intimate admixture: an analgesic having local pain-relieving activity for internal relief of pain, a finely powdered bulking material, preferably less than 50 microns, e.g. the metal salts of fatty acid, hydroxyapatite, DBM, polyglycolide, polylactide, polycaprolactones, absorbable glasses, gelatin, collagens, mono, and polysaccharides starches. An organic liquid capable of solubilizing, dispensing or suspending the analgesic, such as esters of monohydric alcohols with aliphatic monocarboxylic acids; C 2 -C 18 monohydric alcohols with polycarboxylic acids; C 8 -C 30 monohydric alcohols; tocopherol and esters thereof with mono or polycarboxylic acids; free carboxylic acids such as oleic, capric, and lauric; dialkyl ethers and ketones; polyhydroxy compounds and esters and ethers thereof; random or block copolymers of ethylene oxide and propylene oxide.
摘要翻译：用于外科手术的至少三种组分，可植入人体，可吸收，生物相容性，油灰和非油腻性疼痛的组合物，其包括在紧密混合物中：对局部疼痛具有局部止痛活性的止痛剂缓解疼痛，细粉状填充材料，优选小于50微米，脂肪酸金属盐，羟基磷灰石，DBM，聚乙醇酸交酯，聚丙交酯，聚己内酯，可吸收玻璃，明胶，胶原，单糖和多糖淀粉。能溶解，分散或悬浮止痛剂的有机液体，如一元醇与脂族一元羧酸的酯; C12-C18一元醇与多元羧酸的反应; C8-C30一元醇; 生育酚及其与单羧酸或多羧酸的酯; 游离羧酸如油酸，癸酸和月桂酸; 二烷基醚和酮; 多羟基化合物及其酯和醚; 环氧乙烷和环氧丙烷的无规或嵌段共聚物。

7. 发明申请

WO2012170700A2 APPLICATOR WITH CONFORMABLE TIP 审中-公开
标题翻译：具有一致性提示的申请人
公开(公告)号：WO2012170700A2
公开(公告)日：2012-12-13
申请号：PCT/US2012041372
申请日：2012-06-07
申请人： ORTHOCON INC , KAPEC JEFFREY , TANAKA KAZUNA , NAOI YUKIKO , WIRTZ MARCI
发明人： KAPEC JEFFREY , TANAKA KAZUNA , NAOI YUKIKO , WIRTZ MARCI
IPC分类号： A61M35/00 , A61B17/56 , A61B19/00 , A61M37/00
CPC分类号： A61B17/8811 , A61B17/8825 , A61B17/8836 , A61M37/00
摘要： Described herein are applicators for delivery of a viscous material to a bone surface and methods of use. The applicator includes an elongate handle portion and a tip coupled to a distal location of the handle portion and formed of an elastomeric material configured to conform to the bone surface. The tip includes a bend a distance away from the distal location, a contact surface distal to the bend and including one or more surface features configured to adhere to theviscous material, and a front end having a conic curvature. The bend is between about 20 degrees to about 40 degrees from a longitudinal axis of the tip.
摘要翻译：这里描述了用于将粘性材料输送到骨表面的施用器和使用方法。施用器包括细长手柄部分和联接到手柄部分的远侧位置并由构造成符合骨表面的弹性体材料形成的尖端。所述尖端包括远离所述远侧位置的距离的弯曲部，远离所述弯曲部的接触表面，并且包括配置成粘附到所述粘性材料的一个或多个表面特征以及具有锥形曲率的前端。该弯曲部与尖端的纵向轴线成约20度至约40度。

8. 发明申请

WO2007014210A3 COMPOSITIONS AND METHODS FOR THE REDUCTION OF POST-OPERATIVE PAIN 审中-公开
标题翻译：用于减少术后疼痛的组合物和方法
公开(公告)号：WO2007014210A3
公开(公告)日：2007-10-18
申请号：PCT/US2006028823
申请日：2006-07-25
申请人： ORTHOCON INC , KRONENTHAL RICHARD L
发明人： KRONENTHAL RICHARD L
IPC分类号： A61K9/22 , A61F13/00 , A61M31/00
CPC分类号： A61K9/0024 , A61K31/19
摘要： At least three component, body-implantable, absorbable, biocompatible, putty, and non-putty pain-relieving compositions for use in surgery comprising in intimate admixture: an analgesic having local pain-relieving activity for internal relief of pain, a finely powdered bulking material, preferably less than 50 microns, e.g. the metal salts of fatty acid, hydroxyapatite, DBM, polyglycolide, polylactide, polycaprolactones, absorbable glasses, gelatin, collagens, mono, and polysaccharides starches. An organic liquid capable of solubilizing, dispensing or suspending the analgesic, such as esters of monohydric alcohols with aliphatic monocarboxylic acids; C 2 -C 18 monohydric alcohols with polycarboxylic acids; C 8 -C 30 monohydric alcohols; tocopherol and esters thereof with mono or polycarboxylic acids; free carboxylic acids such as oleic, capric, and lauric; dialkyl ethers and ketones; polyhydroxy compounds and esters and ethers thereof; random or block copolymers of ethylene oxide and propylene oxide.
摘要翻译：用于手术的至少三种组分，可植入体，可吸收，生物相容性，油灰和非油灰的止痛组合物，其包括紧密混合物：镇痛剂具有局部止痛活性，用于内部缓解疼痛，细粉状膨胀材料，优选小于50微米，例如脂肪酸，羟基磷灰石，DBM，聚乙交酯，聚丙交酯，聚己内酯，可吸收玻璃，明胶，胶原，单糖和多糖淀粉的金属盐。能够溶解，分配或悬浮止痛剂的有机液体，例如一元醇与脂族一元羧酸的酯; C 2 -C 18一元醇与多元羧酸; C 8 -C 30一元醇; 生育酚及其酯与单羧酸或多元羧酸; 游离羧酸如油酸，癸酸和月桂酸; 二烷基醚和酮; 多羟基化合物及其酯和醚; 环氧乙烷和环氧丙烷的无规或嵌段共聚物。

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