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1. 发明申请

WO2020051646A1 ARTIFICIAL PERIOSTEUM 审中-公开
公开(公告)号：WO2020051646A1
公开(公告)日：2020-03-19
申请号：PCT/AU2019/050984
申请日：2019-09-13
申请人： ORTHOCELL LIMITED
发明人： ZHENG, Ming-Hao
IPC分类号： A61K9/70 , A61L27/00
摘要： The invention relates to an artificial periosteum comprising a functionalized collagen-containing membrane and a drug-carrier mixture, wherein the drug-carrier mixture comprises at least one therapeutic agent and a calcium-containing carrier mixture. The invention also relates to use of the artificial periosteum for repairing bone.

2. 发明申请

WO2020051647A1 NANOPARTICLE-COATED COLLAGEN IMPLANT 审中-公开
公开(公告)号：WO2020051647A1
公开(公告)日：2020-03-19
申请号：PCT/AU2019/050985
申请日：2019-09-13
申请人： ORTHOCELL LIMITED
发明人： ZHENG, Ming-Hao
IPC分类号： A61L27/44 , B01J19/10 , A61F2/00
摘要： The invention relates to a method of producing an implantable collagen-containing medical device comprising the step of coating said collagen-containing medical device with metal microparticles and/or metal nanoparticles, wherein said step of coating said collagen-containing medical device is by sonication such that the collagen-containing medical device has anti-bacterial and anti-inflammatory properties on implantation compared to the medical device not coated with metal microparticles and/or metal nanoparticles.

3. 发明申请

WO2018223183A1 A MEDICAL PROCEDURE KIT AND A RELATED METHOD 审中-公开
公开(公告)号：WO2018223183A1
公开(公告)日：2018-12-13
申请号：PCT/AU2018/050558
申请日：2018-06-05
申请人： ORTHOCELL LIMITED
发明人： ANDERSON, Paul , ZHENG, Ming Hao
IPC分类号： A61B10/02
摘要： The present disclosure provides a medical procedure kit for ameliorating tissue damage in a patient, the kit comprising a container enclosing a receptacle, an extractor for extracting biological material including autologous cells from the patient, a strainer for straining autologous cells from the biological material and an implantable support having a surface onto which the autologous cells can adhere, the implantable support configured to be received by the receptacle. Also disclosed are related methods of manufacturing a medical material and using the medical procedure kit.

4. 发明申请

WO2016054686A1 COLLAGEN CONSTRUCT AND METHOD FOR PRODUCING THE COLLAGEN CONSTRUCT 审中-公开
标题翻译：胶原结构和生产胶原结构的方法
公开(公告)号：WO2016054686A1
公开(公告)日：2016-04-14
申请号：PCT/AU2015/000611
申请日：2015-10-12
申请人： ORTHOCELL LIMITED
发明人： ZHENG, Ming Hao
IPC分类号： A61L27/24 , A61F2/08
CPC分类号： A61F2/08 , A61F2/0095 , A61F2240/001 , A61L27/24 , A61L2430/10
摘要： There is disclosed a collagen construct comprising a plurality of elongate strips, wherein each strip contains a plurality of collagen fibres that are substantially aligned along the length of the respective strips, and the strips are braided or woven together to produce a collagen construct in the form of a rope that can be used for replacing tendons or ligaments, such as cruciate ligaments. Also disclosed is a method for making or producing the collagen construct from a collagen membrane having a plurality of collagen fibres being substantially aligned parallel to each other in a common direction. The membrane is cut along cut lines that are orientated substantially parallel to that common direction, thereby to separate elongate strips from the membrane. The strips are then braided or woven together to form the collagen construct.
摘要翻译：公开了一种包含多个细长条带的胶原构建体，其中每个条带包含沿着相应条的长度基本对准的多个胶原纤维，并且条被编织或编织在一起以产生形式的胶原构建体可用于替换腱或韧带的绳索，例如十字韧带。还公开了一种由具有多个胶原纤维的胶原膜制造或制造胶原构建体的方法，所述胶原纤维在共同的方向上基本上彼此平行排列。沿着切割线切割膜，所述切割线基本上平行于该共同方向取向，从而将细长条与膜分离。然后将条编织或编织在一起以形成胶原构建体。

5. 发明申请

WO2022226590A1 EPINEURIUM REPAIR DEVICE AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2022226590A1
公开(公告)日：2022-11-03
申请号：PCT/AU2022/050386
申请日：2022-04-27
申请人： ORTHOCELL LIMITED
发明人： ZHENG, Minghao , ANDERSON, Paul
IPC分类号： A61B17/00 , A61B17/11 , A61B50/30 , A61L27/24
摘要： The subject invention relates generally to the repair of severed or damaged nerve and/or epineurium in a patient in need of such treatment. In particular, the present invention provides devices and methods of repairing severed or damaged nerve and/or epineurium. In some embodiments, a device is provided for the in vivo repair of severed or damaged nerve and/or epineurium comprising: a pliable collagen membrane comprising a first surface and a second surface, said first surface having a plurality of protruding collagen bundles and said second surface comprising a plurality of apertures, said apertures and said collagen bundles arranged to form a self-engaging attachment when said first surface and said second surface are placed together.

6. 发明申请

WO2016054687A1 SUTURELESS REPAIR OF SOFT TISSUE 审中-公开
标题翻译：软组织的无法修复
公开(公告)号：WO2016054687A1
公开(公告)日：2016-04-14
申请号：PCT/AU2015/000612
申请日：2015-10-12
申请人： ORTHOCELL LIMITED
发明人： ZHENG, Ming, Hao
IPC分类号： A61L15/32 , A61L27/58 , A61F2/08
CPC分类号： A61F2/08 , A61B17/00491 , A61B17/11 , A61B17/1128 , A61B17/1146 , A61B2017/00508 , A61B2017/0065 , A61B2017/00659 , A61B2017/1107 , A61B2017/1132 , A61F2/0036 , A61L27/24 , A61L27/50 , A61L2430/10 , A61L2430/34
摘要： The present invention relates to a sutureless method of repairing soft tissue defects in soft tissue including ligaments such as anterior cruciate ligaments (ACLs). Jn particular, the present invention relates a sutureless method of repairing soft tissue defect comprising: (i) providing a collagen-containing patch adapted to enclose at least a portion of said soft tissue defect; (ii) contacting said soft tissue defect and/or collagen-containing patch with a sensitizer; (Hi) enclosing said soft tissue defect in said collagen-containing patch to produce a bioactivc chamber; and (iv) adhering said collagen-containing patch to said soft tissue defect without sutures.
摘要翻译：本发明涉及一种修复软组织软组织缺损的无缝合方法，包括诸如前十字韧带（ACL）的韧带。具体地说，本发明涉及一种修复软组织缺损的无缝线方法，包括：（i）提供适于包围所述软组织缺损的至少一部分的含胶原的贴剂; （ii）使所述软组织缺损和/或含胶原的贴片与敏化剂接触; （Hi），在所述含胶原蛋白的贴片中包围所述软组织缺损以产生生物活化室; 和（iv）在没有缝合的情况下将所述含胶原蛋白的贴片粘附到所述软组织缺损。

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