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1. 发明申请

WO2009067536A3 FORMULATION FOR DECREASING TOBACCO, ALCOHOL, DRUG OR FOOD CONSUMPTION 审中-公开
标题翻译：减少烟草，酒类，药物或食品消费的配方
公开(公告)号：WO2009067536A3
公开(公告)日：2009-07-30
申请号：PCT/US2008084064
申请日：2008-11-19
申请人： XVASIVE INC , ORONSKY BRYAN T , ORONSKY NEIL C , ORONSKY ARNOLD L
发明人： ORONSKY BRYAN T , ORONSKY NEIL C , ORONSKY ARNOLD L
IPC分类号： A61K9/28 , A61K9/00 , A61K47/02 , A61K47/10
CPC分类号： A61K47/34 , A24B15/16 , A61K9/0056 , A61K9/08 , A61K47/02 , A61K47/32 , A61K47/36
摘要： Formulations have been developed which assist individuals having an addiction such as smoking to reduce or quit engaging in the addictive behavior. Representative behaviors include smoking, excessive alcohol or food ingestion, drug addiction, and ingestion of caffeine or junk food providing quick 'highs'. The formulations assist the smoker to become dissatisfied with smoking, until he or she willingly gives up the habit or at least cuts down on the number of cigarettes smoked per day as an initial step towards quitting in the future. The formulations can also be used in conjunction with other known formulations, such as nicotine gum or patch. The formulations contain hydrophilic polymers, for example, polyethylene glycol (PEG) alone or in combination or polyvinyl pyrrolidone (PVP) (also known as povidone or polyvidone alone or in combination.), sweeteners and/or flavorings, viscosity modifiers/binders, and pH or buffering agents.
摘要翻译：已经开发了帮助患有吸烟等成瘾的个体减少或戒除上瘾行为的制剂。代表性的行为包括吸烟，过量酒精或摄入食物，吸毒成瘾，以及摄取咖啡因或垃圾食品，提供快速的“高”。这些配方有助于吸烟者对吸烟不满意，直到他或她愿意放弃习惯，或者至少减少每天吸烟的香烟数量，作为今后戒烟的最初步骤。制剂也可以与其它已知的制剂结合使用，例如尼古丁胶或贴剂。制剂含有亲水性聚合物，例如单独或组合使用的聚乙二醇（PEG）或聚乙烯吡咯烷酮（PVP）（也称为聚维酮或聚维酮，单独或组合使用），甜味剂和/或调味剂，粘度调节剂/粘合剂和 pH或缓冲剂。

2. 发明申请

WO2001091798A3 TUMOR ACTIVATED PRODRUG COMPOUNDS 审中-公开
公开(公告)号：WO2001091798A3
公开(公告)日：2001-12-06
申请号：PCT/EP2001/006106
申请日：2001-05-29
申请人： UNIVERSITE CATHOLIQUE DE LOUVAIN , TROUET, André , DUBOIS, Vincent , ORONSKY, Arnold
发明人： TROUET, André , DUBOIS, Vincent , ORONSKY, Arnold
IPC分类号： A61K47/48
摘要： The invention is directed to novel prodrug compounds, compositions comprising the prodrug compounds, methods of making the prodrug compounds and methods of using the prodrug compounds. The prodrug compounds comprise a biologically active entity linked to a masking moiety via a linking moiety. The prodrug compoundsare selectively activated at or near target cells and display lower toxicity and possibly a longer in vivo or serum half-life than the corresponding naked biologically active entity.

3. 发明申请

WO2009067535A1 TOPICAL COMPOSITION FOR TREATING PAIN 审中-公开
标题翻译：用于治疗疼痛的主题组合物
公开(公告)号：WO2009067535A1
公开(公告)日：2009-05-28
申请号：PCT/US2008/084062
申请日：2008-11-19
申请人： XVASIVE, INC. , ORONSKY, Bryan, T. , ORONSKY, Neil, C. , ORONSKY, Arnold, L.
发明人： ORONSKY, Bryan, T. , ORONSKY, Neil, C. , ORONSKY, Arnold, L.
IPC分类号： A61K31/77 , A61K47/10 , A61K9/06 , A61P25/00
CPC分类号： A61K9/0014 , A61K31/75 , A61K31/765 , A61K31/77 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/38
摘要： Topical compositions having as the active ingredient a hydrophilic material, such as a polyalkylene oxide homopolymer or copolymer, and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of a cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The composition may contain a penetration enhancer, most preferably one with membrane disruptive properties. In one embodiment, the compositions are incorporated onto or into disposables such as hemorrhoid wipes, gauze, sponge, bandages, and wraps; mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands, for ease of application. The composition is applied topically to a site at or adjacent to a painful region. The composition is reapplied as necessary. Pain relief is typically obtained within minutes and lasts for periods of variable duration ranging from minutes to several hours and even, in some cases, days. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness.
摘要翻译：已经开发了具有亲水性材料如聚环氧烷均聚物或共聚物作为活性成分的局部组合物和使用方法，用于改善或预防疼痛或疼痛后遗症。组合物可以是霜剂，凝胶剂，洗剂，喷雾剂，泡沫剂，糊剂，贴剂，悬浮液或分散体的形式。在优选的实施方案中，制剂是凝胶。组合物可以含有渗透促进剂，最优选的是具有膜破坏性的组分。在一个实施方案中，将组合物掺入或放入一次性物品中，例如痔疮巾，纱布，海绵，绷带和包裹物; 口罩，牙盘; 针或导管; 成人尿布; 手套，袜子或腕带，以方便使用。将组合物局部施用于疼痛区域处或邻近疼痛区域的部位。必要时重新施加组合物。疼痛缓解通常在几分钟内获得，持续时间可变持续时间从几分钟到几小时，甚至在某些情况下也是几天。该组合物可有效治疗急性和慢性的内脏，躯体和神经性疼痛，以及肌肉疼痛和僵硬以及关节疼痛和僵硬。

4. 发明申请

WO0191798A2 TUMOR ACTIVATED PRODRUG COMPOUNDS AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：肿瘤激活的PRODRUG化合物及其制备和使用方法
公开(公告)号：WO0191798A2
公开(公告)日：2001-12-06
申请号：PCT/EP0106106
申请日：2001-05-29
申请人： UNIV LOUVAIN , TROUET ANDRE , DUBOIS VINCENT , ORONSKY ARNOLD
发明人： TROUET ANDRE , DUBOIS VINCENT , ORONSKY ARNOLD
IPC分类号： A61K47/48 , A61P31/18
CPC分类号： A61K47/65
摘要： The invention is directed to novel prodrug compounds, compositions comprising the prodrug compounds, methods of making the prodrug compounds and methods of using the prodrug compounds. The prodrug compounds comprise a biologically active entity linked to a masking moiety via a linking moiety. The prodrug compounds are selectively activated at or near target cells and display lower toxicity and possibly a longer in vivo or serum half-life than the corresponding naked biologically active entity.
摘要翻译：本发明涉及新型前药化合物，包含前药化合物的组合物，制备前药化合物的方法和使用前药化合物的方法。前药化合物包含通过连接部分连接至掩蔽部分的生物活性实体。前体药物化合物在靶细胞处或靶附近被选择性活化，并且显示比相应的裸生物活性实体更低的毒性和可能更长的体内或血清半衰期。

5. 发明申请

WO2009105564A3 ACUPUNCTURE AND ACUPRESSURE THERAPIES 审中-公开
标题翻译：治疗和预防治疗
公开(公告)号：WO2009105564A3
公开(公告)日：2009-11-12
申请号：PCT/US2009034550
申请日：2009-02-19
申请人： XVASIVE INC , ORONSKY BRYAN T , ORONSKY NEIL C , ORONSKY ARNOLD L
发明人： ORONSKY BRYAN T , ORONSKY NEIL C , ORONSKY ARNOLD L
IPC分类号： A61H39/08 , A61M5/28 , A61M5/315 , A61M5/32 , A61M31/00 , A61M35/00 , A61M37/00
CPC分类号： A61H39/086 , A61H23/0245 , A61H39/002 , A61H39/007 , A61H39/083 , A61H2039/005 , A61H2201/0207 , A61H2201/105 , A61M5/28 , A61M5/329 , A61M37/0015 , A61M37/0092 , A61M2005/3201 , A61M2037/0023 , A61M2037/0046
摘要： Described here are devices, methods, and kits for acupuncture or acupressure therapy. The devices may include a tissue-piercing member and a reservoir containing an agent. The devices and agents may be packaged as kits useful for relieving pain and/or treating various medical conditions. One example device comprises an acupuncture needle (204) which may be solid or have one or more lumens with a coating. The needle may be connected to a syringe pump which may be programmable. Other devices tha t may be used to deliver the agent alone or in combination with a tissue-piercing member include an implantable reservoir, an external reservoir, or a patch.
摘要翻译：这里描述的是用于针灸或指压治疗的装置，方法和试剂盒。装置可以包括组织刺穿构件和包含试剂的储存器。装置和试剂可以包装成用于缓解疼痛和/或治疗各种医疗状况的试剂盒。一个示例性装置包括针刺针（204），其可以是实心的或具有一个或多个具有涂层的腔。针可以连接到可编程的注射泵。可以使用其它装置单独递送或与组织刺穿构件组合，包括可植入储存器，外部储存器或贴片。

6. 发明申请

WO2009105564A2 ACUPUNCTURE AND ACUPRESSURE THERAPIES 审中-公开
标题翻译：治疗和预防治疗
公开(公告)号：WO2009105564A2
公开(公告)日：2009-08-27
申请号：PCT/US2009/034550
申请日：2009-02-19
申请人： XVASIVE, INC. , ORONSKY, Bryan, T. , ORONSKY, Neil, C. , ORONSKY, Arnold, L.
发明人： ORONSKY, Bryan, T. , ORONSKY, Neil, C. , ORONSKY, Arnold, L.
IPC分类号： A61H39/08 , A61M5/28 , A61M5/315 , A61M5/32 , A61M31/00 , A61M35/00 , A61M37/00
CPC分类号： A61H39/086 , A61H23/0245 , A61H39/002 , A61H39/007 , A61H39/083 , A61H2039/005 , A61H2201/0207 , A61H2201/105 , A61M5/28 , A61M5/329 , A61M37/0015 , A61M37/0092 , A61M2005/3201 , A61M2037/0023 , A61M2037/0046
摘要： Described here are devices, methods, and kits for acupuncture or acupressure therapy. The devices may include a tissue-piercing member and a reservoir containing an agent. The devices and agents may be packaged as kits useful for relieving pain and/or treating various medical conditions. The devices, methods, and kits may enable less skilled practitioners to administer acupuncture or acupressure therapy, and may extend the duration of pain relief or other symptom relief.
摘要翻译：这里描述的是用于针灸或指压治疗的装置，方法和试剂盒。装置可以包括组织刺穿构件和包含试剂的储存器。装置和试剂可以包装成用于缓解疼痛和/或治疗各种医疗状况的试剂盒。装置，方法和试剂盒可以使较不熟练的从业者执行针灸或指压治疗，并且可以延长疼痛缓解或其它症状缓解的持续时间。

7. 发明申请

WO2009067536A2 FORMULATION FOR DECREASING TOBACCO, ALCOHOL, DRUG OR FOOD CONSUMPTION 审中-公开
标题翻译：减少烟草，酒类，药物或食品消费的配方
公开(公告)号：WO2009067536A2
公开(公告)日：2009-05-28
申请号：PCT/US2008/084064
申请日：2008-11-19
申请人： XVASIVE, INC. , ORONSKY, Bryan, T. , ORONSKY, Neil, C. , ORONSKY, Arnold, L.
发明人： ORONSKY, Bryan, T. , ORONSKY, Neil, C. , ORONSKY, Arnold, L.
IPC分类号： A61K9/28 , A61K9/00 , A61K47/02 , A61K47/10
CPC分类号： A61K47/34 , A24B15/16 , A61K9/0056 , A61K9/08 , A61K47/02 , A61K47/32 , A61K47/36
摘要： Formulations have been developed which assist individuals having an addiction such as smoking to reduce or quit engaging in the addictive behavior. Representative behaviors include smoking, excessive alcohol or food ingestion, drug addiction, and ingestion of caffeine or junk food providing quick "highs". The formulations assist the smoker to become dissatisfied with smoking, until he or she willingly gives up the habit or at least cuts down on the number of cigarettes smoked per day as an initial step towards quitting in the future. The formulations can also be used in conjunction with other known formulations, such as nicotine gum or patch. The formulations contain hydrophilic polymers, for example, polyethylene glycol (PEG) alone or in combination or polyvinyl pyrrolidone (PVP) (also known as povidone or polyvidone alone or in combination.), sweeteners and/or flavorings, viscosity modifiers/binders, and pH or buffering agents.
摘要翻译：已经开发了帮助患有吸烟等成瘾的个体减少或戒除上瘾行为的制剂。代表性的行为包括吸烟，过度酒精或食物摄入，吸毒成瘾，以及摄取咖啡因或垃圾食品，提供快速“高”。这些配方有助于吸烟者对吸烟不满意，直到他或她愿意放弃习惯，或者至少减少每天吸烟的香烟数量，作为今后戒烟的最初步骤。制剂也可以与其它已知的制剂结合使用，例如尼古丁胶或贴剂。制剂含有亲水性聚合物，例如单独使用或组合使用的聚乙二醇（PEG）或聚乙烯吡咯烷酮（PVP）（也称为聚维酮或聚维酮，单独或组合使用），甜味剂和/或调味剂，粘度调节剂/粘合剂和 pH或缓冲剂。

8. 发明申请

WO2008156646A1 TOPICAL COMPOSITION FOR TREATING PAIN 审中-公开
标题翻译：用于治疗疼痛的主题组合物
公开(公告)号：WO2008156646A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/007354
申请日：2008-06-11
申请人： XVASIVE, INC. , ORONSKY, Neil, Charles , ORONSKY, Bryan, T. , ORONSKY, Arnold, L.
发明人： ORONSKY, Neil, Charles , ORONSKY, Bryan, T. , ORONSKY, Arnold, L.
IPC分类号： A61K31/01 , A61K31/045 , A61K31/19 , A61K31/215 , A61K9/00 , A61P29/00 , A61P29/02 , A61P11/08
CPC分类号： A61K9/0014 , A61K9/0009 , A61K31/01 , A61K31/045 , A61K31/19 , A61K31/215 , A61K31/23 , A61K31/56 , A61K31/685
摘要： Topical compositions having as the active ingredient a lipid, fatty acid ester, natural wax, sterol, or combinations thereof referred to herein as "lipophilic vehicle" or "LV" and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of an ointment, cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The LV may contain a penetration enhancer, most preferably one with membrane disruptive properties. The formulation may be applied to or impregnated into a gauze, wrap, bandage, cotton-tipped stick, adhesive bandage strip, or other support wrap or medical bandage or wound cover. For example, the compositions may be are incorporated onto or into disposables such as hemorrhoid wipes, sponge, mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands, for ease of application. The composition is applied topically to a site at or adjacent to a painful region. The composition is reapplied as necessary. Pain relief is typically obtained within minutes and lasts for periods of variable duration ranging from minutes to several hours and even, in some cases, days. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness.
摘要翻译：已经开发了具有作为活性成分的脂质，脂肪酸酯，天然蜡，甾醇或其组合的称为“亲脂性载体”或“LV”的使用方法的局部组合物，用于改善或预防疼痛或疼痛的后遗症。组合物可以是软膏剂，霜剂，凝胶剂，洗剂，喷雾剂，泡沫剂，糊剂，贴剂，悬浮液或分散体的形式。在优选的实施方案中，制剂是凝胶。 LV可以含有渗透增强剂，最优选的是具有膜破坏性质的渗透增强剂。制剂可以施用于或浸渍在纱布，包裹，绷带，棉花棒，粘合绷带或其它支撑包装或医用绷带或伤口罩中。例如，可以将组合物掺入或放入一次性物品中，例如痔疮巾，海绵，口罩，牙齿托盘; 针或导管; 成人尿布; 手套，袜子或腕带，以方便使用。将组合物局部施用于疼痛区域处或邻近疼痛区域的部位。必要时重新施加组合物。疼痛缓解通常在几分钟内获得，持续时间可变持续时间从几分钟到几小时，甚至在某些情况下也是几天。该组合物可有效治疗急性和慢性的内脏，躯体和神经性疼痛，以及肌肉疼痛和僵硬以及关节疼痛和僵硬。

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