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1. 发明申请

WO2004042870A3 CARTRIDGE FOR PACKAGING A SENSOR IN A FLUID CALIBRANT 审中-公开
标题翻译：用于在流体校准器中包装传感器的盒子
公开(公告)号：WO2004042870A3
公开(公告)日：2004-09-02
申请号：PCT/US0315777
申请日：2003-05-20
申请人： OPTICAL SENSORS INC
发明人： PIERSKALLA IRVIN T , WINGER KENT R , REYNOLDS BRANDON W , KIMBALL VICTOR E
IPC分类号： G01N33/49 , B01L3/00 , G01N21/27 , G01N27/416 , G01N33/487 , G01N37/00
CPC分类号： B01L3/508 , B01L3/502 , B01L2200/148 , B01L2300/041 , Y10T436/10
摘要： The invention relates to a cartridge for packaging an analyte-containing fluid calibrant. The cartridge is formed from a container having an opening sealed by a sealing member. A septum divides the container into a calibrant compartment and an outer compartment. A probe is provided comprising an analyte-detecting portion and a connecting portion that allows for operative connection to a device for quantitating or determining the concentration of the analyte. The probe may extend sealingly through the septum such that the analyte-detecting portion is located in the calibrant compartment and the connecting portion is located in the outer compartment. The construction of the cartridge provides ease and reduces the likelihood of error in calibrating the probe. The inventionalso relates to a method of manufacturing the cartridge and a method for calibrating a device for analyte concentration determination and quantitation using the inventive cartridge.
摘要翻译：本发明涉及一种用于包装含分析物的流体校准物的盒。盒由具有由密封件密封的开口的容器形成。隔膜将容器分成校准室和外隔室。提供了一种探针，其包括分析物检测部分和连接部分，其允许与用于定量或确定分析物浓度的装置的操作连接。探针可以密封地穿过隔膜，使得分析物检测部分位于校准室中，并且连接部分位于外隔室中。墨盒的结构提供了便利性，并降低了校准探针误差的可能性。本发明还涉及一种制造筒的方法以及使用本发明的盒校准用于分析物浓度测定和定量的装置的方法。

2. 发明申请

WO2004008098A2 NON-INVASIVE MEASUREMENT OF pH 审中-公开
标题翻译：无创测量pH值
公开(公告)号：WO2004008098A2
公开(公告)日：2004-01-22
申请号：PCT/US2003/021488
申请日：2003-07-09
申请人： OPTICAL SENSORS, INC.
发明人： KIMBALL, Victor, E. , FURLONG, Steven, C. , PIERSKALLA, Irvin
IPC分类号： G01N
CPC分类号： G01N21/6486 , A61B5/14539 , A61B5/1455 , G01N21/80
摘要： There is a need within the medical community for non-invasive instruments to measure critical physiologic parameters at the point of care. Such a technique may be applicable to a wide variety of commonly monitored physiologic parameters during critical care patient management. The invention is directed to a method of measuring the pH of a patient's tissue. The method includes measuring the optical signal from a specie whose fluorescence is pH sensitive, such as nicotinamide adenine dinucleotide (NADH) and also measuring the optical signal from a second biological marker, such as FAD, the fluorescence from the second marker being substantially insensitive to pH. The method includes determining the patient's pH by using the first and second optical signals.
摘要翻译：医学界需要非侵入性器械来测量护理点的关键生理参数。这种技术可适用于危重病人护理管理期间的各种常见监测生理参数。本发明涉及测量患者组织的pH值的方法。该方法包括测量来自其荧光对pH敏感的物种如烟酰胺腺嘌呤二核苷酸（NADH）的光信号，并且还测量来自第二生物标志物如FAD的光信号，来自第二标志物的荧光基本上不敏感 pH值。该方法包括通过使用第一和第二光学信号来确定患者的pH。

3. 发明申请

WO03101277A2 NONINVASIVE DETECTION OF A PHYSIOLOGIC PARAMETER WITHIN A BODY TISSUE OF A PATIENT 审中-公开
标题翻译：病人身体组织中生理参数的无意识检测
公开(公告)号：WO03101277A2
公开(公告)日：2003-12-11
申请号：PCT/US0316033
申请日：2003-05-20
申请人： OPTICAL SENSORS INC
发明人： ANDERSON EDWARD J , REYNOLDS BRANDON W , WINGER KENT R , KIMBALL VICTOR E
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , A61B5/1477 , A61B8/06 , A61B
CPC分类号： A61B5/682 , A61B5/01 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/1473 , A61B5/412 , A61B5/42 , A61B5/6885 , A61B8/06 , A61B8/12 , A61B2562/02 , A61B2562/247
摘要： The invention provides a device for contacting a surface of a tissue within a patient's body to determine a physiologic parameter of the patient. The device typically comprises a sensor responsive to the physiologic parameter and a probe housing the sensor. The probe is constructed to allow the sensor to be secured at a sensing area adjacent to a surface of a patient's tissue, without need for an adhesive and without disturbing the blood flow within the measurement region of the tissue. The device may also include a means for reducing interference in the sensing area. Preferably, the device further comprises an indicating means operably connected to the sensor for indicating an analyte quantity and/or concentration associated with the physiologic parameter. The invention also provides a method for determining a physiologic parameter of a patient.
摘要翻译：本发明提供一种用于接触患者身体内的组织的表面以确定患者的生理参数的装置。该装置通常包括响应生理参数的传感器和容纳传感器的探头。探针被构造成允许传感器固定在与患者组织的表面相邻的感测区域处，而不需要粘合剂并且不会干扰组织测量区域内的血流。该装置还可以包括用于减少感测区域中的干扰的装置。优选地，装置还包括可操作地连接到传感器的指示装置，用于指示与生理参数相关联的分析物量和/或浓度。本发明还提供了一种用于确定患者生理参数的方法。

4. 发明申请

WO2007106455A3 CARDIOGRAPHY SYSTEM AND METHOD USING AUTOMATED RECOGNITION OF HEMODYNAMIC PARAMETERS AND WAVEFORM ATTRIBUTES 审中-公开
标题翻译：使用自动识别血液动力学参数和波形特征的心理学系统和方法
公开(公告)号：WO2007106455A3
公开(公告)日：2008-02-21
申请号：PCT/US2007006253
申请日：2007-03-12
申请人： OPTICAL SENSORS INC , BARTNIK DANIEL J , LAPLANTE PAULITA , SUMMERS RICHARD L , KIMBALL VICTOR E
发明人： BARTNIK DANIEL J , LAPLANTE PAULITA , SUMMERS RICHARD L , KIMBALL VICTOR E
IPC分类号： G06F19/00
CPC分类号： A61B5/02028 , A61B5/0205 , A61B5/0215 , A61B5/0452 , A61B5/053 , A61B7/00 , G06F19/324 , G16H50/70
摘要： A cardiography system and method using automated recognition of hemodynamic parameters and waveform attributes is provided. The cardiography system and method includes at least one sensor, a knowledge base and a processing device. The at least one sensor provides a waveform signal and a hemodynamic parameter input. The knowledge base includes data corresponding to various disease states. The processing device receives the waveform signal and hemodynamic parameter input from the sensor, identifies waveform attributes on the waveform signal, measures the waveform attributes, accesses the knowledge base, cross-references the waveform attributes and the hemodynamic parameters with data in the knowledge base, and outputs a suggested likelihood of a particular disease state. The knowledge base optionally includes goal-directed therapies associated with particular disease states for providing suggested goal-directed therapies based on the cross-referencing of the waveform attributes and the hemodynamic parameters with the knowledge base.
摘要翻译：提供了使用血液动力学参数和波形属性的自动识别的心脏摄影系统和方法。心脏摄影系统和方法包括至少一个传感器，知识库和处理装置。所述至少一个传感器提供波形信号和血液动力学参数输入。知识库包括对应于各种疾病状态的数据。处理装置接收从传感器输入的波形信号和血流动力学参数，识别波形信号上的波形属性，测量波形属性，访问知识库，通过知识库中的数据交叉参考波形属性和血液动力学参数，并输出特定疾病状态的建议可能性。知识库可选地包括与特定疾病状态相关联的目标导向治疗，用于基于与知识库的波形属性和血液动力学参数的交叉参考来提供建议的目标导向疗法。

5. 发明申请

WO2004008098A3 NON-INVASIVE MEASUREMENT OF pH 审中-公开
标题翻译：不引入pH的测量
公开(公告)号：WO2004008098A3
公开(公告)日：2004-12-29
申请号：PCT/US0321488
申请日：2003-07-09
申请人： OPTICAL SENSORS INC
发明人： KIMBALL VICTOR E , FURLONG STEVEN C , PIERSKALLA IRVIN
IPC分类号： G01N33/84 , A61B5/00 , G01N21/64 , G01N21/78 , G01N21/80 , G01N37/00
CPC分类号： G01N21/6486 , A61B5/14539 , A61B5/1455 , G01N21/80
摘要： There is a need within the medical community for non-invasive instruments to measure critical physiologic parameters at the point of care. Such a technique may be applicable to a wide variety of commonly monitored physiologic parameters during critical care patient management. The invention is directed to a method of measuring the pH of a patient's tissue. The method includes measuring the optical signal from a specie whose fluorescence is pH sensitive, such as nicotinamide adenine dinucleotide (NADH) and also measuring the optical signal from a second biological marker, such as FAD, the fluorescence from the second marker being substantially insensitive to pH. The method includes determining the patient's pH by using the first and second optical signals.
摘要翻译：医疗界需要非侵入性手段来测量关键生理参数。这种技术可以适用于在关键护理患者管理期间的各种通常监测的生理参数。本发明涉及一种测量患者组织pH值的方法。该方法包括测量来自荧光为pH敏感的物种（例如烟酰胺腺嘌呤二核苷酸（NADH））的光学信号，并且还测量来自第二生物标志物如FAD的光学信号，来自第二标志物的荧光对 pH值。该方法包括通过使用第一和第二光学信号来确定患者的pH。

6. 发明申请

WO2004016169A1 PULSE OXIMETER USING ADDITIONAL PULSATILE SIGNALS 审中-公开
标题翻译：脉冲激光器使用附加脉冲信号
公开(公告)号：WO2004016169A1
公开(公告)日：2004-02-26
申请号：PCT/US2003/025212
申请日：2003-08-12
申请人： OPTICAL SENSORS, INC.
发明人： KIMBALL, Victor, E. , LAPLANTE, Paulita
IPC分类号： A61B5/145
CPC分类号： A61B5/14552 , A61B5/021 , A61B5/02125 , A61B5/0245 , A61B5/0261 , A61B5/0285 , A61B5/0295 , A61B5/0402 , A61B5/0535 , A61B5/14551 , A61B5/1464 , A61B5/6826 , A61B5/6838 , A61B5/721 , A61B5/7285 , A61B7/04 , A61B2562/0233 , A61B2562/043
摘要： There is a need for a technique to compensate for, or eliminate, motion-induced artifacts in patient-attached critical care monitoring instruments. Also, a need exists to extend the accurate operational range of patient-attached pulse oximeters in environments when the patient's blood oxygen saturation is well below the normal physiologic range, or where there is low blood flow. Accordingly, the invention is directed to improving pulse-oximetry by incorporating additional signals to aid in the triggering of the pulse-oximeter or in analyzing the data received by the pulse oximeter. These approaches include measuring a pulsatile characteristic of the patient at a position close to, or at the pulse-oximetry measurement site, or using pulsatile characteristics that result from contraction of the patient's heart.
摘要翻译：需要一种在病人附属的关键监护仪器中补偿或消除运动诱发的人为产生的技术。此外，当患者的血氧饱和度远低于正常生理范围或血液流量低时，需要在患者附近的脉搏血氧计的准确操作范围内扩展。因此，本发明涉及通过并入额外的信号来改善脉搏血氧饱和度以有助于触发脉搏血氧计或分析由脉搏血氧计所接收的数据。这些方法包括测量患者在接近或在脉搏血氧测定位置的位置的脉动特征，或使用由患者心脏收缩引起的脉动特征。

7. 发明申请

WO2004006760A1 CALIBRATION TECHNIQUE FOR NON-INVASIVE MEDICAL DEVICES 审中-公开
标题翻译：非入侵医疗器械的校准技术
公开(公告)号：WO2004006760A1
公开(公告)日：2004-01-22
申请号：PCT/US2003/021604
申请日：2003-07-09
申请人： OPTICAL SENSORS, INC.
发明人： KIMBALL, Victor, E. , FURLONG, Steven, C. , PIERSKALLA, Irvin
IPC分类号： A61B5/00
CPC分类号： A61B5/14539 , A61B5/02133 , A61B5/1495 , G06F19/00
摘要： There is a need for a non-invasive method of calibrating medical devices at the point of care, where the calibration is performed without the removal of blood or bodily fluids. The invention is directed to an approach for calibrating a first non-invasive sensor in which the tissue being measured is modulated in some way so as to alter the value of the parameter being measured by the first optical sensor. A second sensor detects another parameter that also changes with the modulation. The second sensor is absolutely calibrated. Where there is a known relationship between the first and second parameters, a calibration may be derived for the first sensor. Such a technique is applicable to calibrating non-invasive sensors for monitoring a wide variety of physiologic parameters including, inter alia , glucose, blood gases, blood electrolytes and blood pH.
摘要翻译：需要在护理点校准医疗器械的非侵入性方法，其中进行校准而不去除血液或体液。本发明涉及用于校准第一非侵入性传感器的方法，其中以某种方式调制被测量的组织，以便改变由第一光学传感器测量的参数的值。第二个传感器检测另外一个参数也随调制而变化。第二个传感器是绝对校准的。在第一和第二参数之间存在已知关系的情况下，可以为第一传感器导出校准。这种技术适用于校准非侵入式传感器，用于监测各种生理参数，特别包括葡萄糖，血液气体，血液电解质和血液pH。

8. 发明申请

WO2004006759A1 METHOD FOR OPTICAL MEASUREMENT OF MULTIPLE PHYSIOLOGIC PARAMETERS 审中-公开
标题翻译：多生理参数光学测量方法
公开(公告)号：WO2004006759A1
公开(公告)日：2004-01-22
申请号：PCT/US2003/021489
申请日：2003-07-09
申请人： OPTICAL SENSORS, INC.
发明人： KIMBALL, Victor, E. , FURLONG, Steven, C. , PIERSKALLA, Irvin
IPC分类号： A61B5/00
CPC分类号： A61B5/682 , A61B5/14539 , A61B5/1459 , A61B5/6885
摘要： Generally, the present invention relates to a method for non-invasive optical measurements at physiologic sites that may reduce or minimize the effects of skin chemistries that optically interfere with the desired optical measurement. An embodiment of the invention is directed to a method of making an optically-based, non-invasive optical measurement of a first physiologic parameter of a patient. The method comprises probing the tissue of a first epithelial site with a first probe light propagating from the optical sensor and detecting a first signal light received from the first assay site with the optical sensor. The method also comprises measuring a value of a second parameter of the patient and determining the level of the first physiologic parameter within the tissue of the first assay site based on the detected first signal light and on the measured second parameter of the patient.
摘要翻译：通常，本发明涉及在生理部位进行非侵入性光学测量的方法，其可以减少或最小化光学干扰所需光学测量的皮肤化学物质的影响。本发明的实施例涉及一种对患者的第一生理参数进行基于光学的非侵入性光学测量的方法。该方法包括利用从光学传感器传播的第一探针光探测第一上皮部位的组织，并用光学传感器检测从第一测定部位接收到的第一信号光。该方法还包括测量患者的第二参数的值，并且基于检测到的第一信号光以及所测量的患者的第二参数来确定第一测定部位的组织内的第一生理参数的水平。

9. 发明申请

WO0059372A9 ASSESSING PERFUSION FAILURE BY MEASURING BLOOD FLOW 审中-公开
标题翻译：通过测量血液流量来评估灌注失败
公开(公告)号：WO0059372A9
公开(公告)日：2001-11-22
申请号：PCT/US0008683
申请日：2000-03-30
申请人： INST CRITICAL CARE MEDICINE , OPTICAL SENSORS INC
发明人： KIMBALL VICTOR E , WEIL MAX HARRY , TANG WANCHUN , BISERA JOSE
IPC分类号： A61B5/00 , A61B5/02 , A61B5/026 , A61B5/0285 , A61B5/05 , A61B5/145 , A61B8/06
CPC分类号： A61B5/14542 , A61B5/0071 , A61B5/0084 , A61B5/0261 , A61B5/14539 , A61B5/1473 , A61B5/412 , A61B5/42 , A61B5/682 , A61B8/06 , A61B8/12
摘要： Methods, and devices are provided for assessing impairment of blood circulation in a patient, such as that in perfusion failure, by measurement of blood flow in the gastro-intestinal tract or upper respiratory/digestive tract of the patient. The method comprises introducing a blood - flow sensor (212) into the gastrointestinal tract or the upper respiratory/digestive tract of a patient, placing the sensor (212) adjacent a mucosal surface therein, and measuring blood flow in adjacent tissue to determine blood flow in that tissue. The method may also involve the measurement of PCO2 and/or pH in combination with the blood flow determination. This invention affords rapid measurement, and detection of perfusion failure.
摘要翻译：提供方法和装置，用于通过测量患者的胃肠道或上呼吸/消化道中的血流量来评估患者血液循环的损伤，例如灌注失败。该方法包括将血液流量传感器（212）引入到患者的胃肠道或上呼吸/消化道中，将传感器（212）放置在其中的粘膜表面附近，并测量相邻组织中的血流量以确定血流量在那个组织。该方法还可以包括与血流测定结合的PCO2和/或pH的测量。本发明提供快速测量和检测灌注失败。

10. 发明申请

WO2005030038A3 ASSESSING SYSTEMIC PERFUSION FAILURE IN A PATIENT 审中-公开
标题翻译：评估患者的系统性灌注失败
公开(公告)号：WO2005030038A3
公开(公告)日：2005-09-15
申请号：PCT/US2004031264
申请日：2004-09-23
申请人： OPTICAL SENSORS INC , KIMBALL VICTOR E
发明人： KIMBALL VICTOR E
IPC分类号： A61B20060101 , A61B5/00 , A61B5/02 , A61B5/026
CPC分类号： A61B5/14542 , A61B5/0261 , A61B5/027 , A61B5/0295 , A61B5/14539 , A61B5/1459 , A61B5/1473 , A61B5/412 , A61B5/42 , A61B5/4233
摘要： A device and method for assessing the degree of systemic perfusion in a patient. The system includes a surface perfusion pressure monitor (E) and a blood pressure monitor (C). The surface perfusion pressure monitor (E) may include laser Doppler sensor or a photoplethysmograph. A surface perfusion pressure index, or alternatively, an optical plethysmography index is derived from the surface perfusion pressure measurement and the blood pressure measurement to allow for assessment of systemic perfusion failure.
摘要翻译：用于评估患者的全身灌注程度的装置和方法。该系统包括表面灌注压力监测器（E）和血压监测器（C）。表面灌注压力监测器（E）可以包括激光多普勒检测器或光电体积描记器。来自表面灌注压力测量和血压测量的表面灌注压力指数，或者替代地，光学体积描记术指数，以允许评估全身灌注失败。

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