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1. 发明申请

WO2002095019A1 REMOVAL OF PLASMIN(OGEN) FROM PROTEIN SOLUTIONS 审中-公开
标题翻译：从蛋白质溶液中去除血浆（OGEN）
公开(公告)号：WO2002095019A1
公开(公告)日：2002-11-28
申请号：PCT/EP2002/005462
申请日：2002-05-17
申请人： OMRIX BIOPHARMACEUTICALS S.A.
发明人： NUR, Israel , BAR, Liliana , AZACHI, Malkit
IPC分类号： C12N9/68
CPC分类号： C12N9/6435 , C07K1/22 , C12Y304/21007
摘要： A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6 - 8 Angstroms, preferably about 7 Angstroms apart and the rigid amino acid is covalently bound to the support via the amino group of the amino acid.
摘要翻译：一种通过使混合物与刚性氨基酸接触的方法，其特征在于从含有纤维蛋白溶酶（ogen）或纤溶酶的混合物中除去或分离纤维蛋白原（纤维蛋白原）存在下的纤维蛋白溶酶或纤溶酶，其中氨基酸和羧基的氨基氨基酸约6-8埃，优选约7埃，刚性氨基酸通过氨基酸的氨基与载体共价结合。

2. 发明申请

WO1998010703A1 APPLICATOR DEVICE FOR APPLYING A MULTIPLE COMPONENT FLUID 审中-公开
标题翻译：用于应用多种成分流体的施加器装置
公开(公告)号：WO1998010703A1
公开(公告)日：1998-03-19
申请号：PCT/EP1996003975
申请日：1996-09-10
申请人： OMRIX BIOPHARMACEUTICALS S.A. , ZINGER, Freddy
发明人： OMRIX BIOPHARMACEUTICALS S.A.
IPC分类号： A61B17/00
CPC分类号： A61B17/00491 , A61B2017/00495 , A61B2090/037
摘要： The applicator device comprises a plurality of supply containers (112), each of which is mechanically connected via fluid control device (148) to a common connecting headpiece (160). Each fluid control device (148) is provided with a first port (152) connected to said common connecting headpiece (160). A second port (150) of each fluid control device (148) is connected to a syringe body (114). Further, each fluid control device (148) comprises a third port adapted to have a medicinal vessel connected therethrough. Said third port is provided with an adaptor (154) for receiving said medicinal vessel and is further provided with a fluid conduit member which, when the vessel is received in the adaptor (154), extends into the interior of the vessel. Each flow control member is selectively movable from a first flow control position enabling a flow path between a first pair of two ports of the fluid control device and a second flow control position enabling a flow path between a second pair of two ports of the fluid control device, each flow control member being coupled to one of those ports for manipulation between said flow control positions.
摘要翻译：施加器装置包括多个供应容器（112），每个供应容器通过流体控制装置（148）机械地连接到公共连接头盔（160）。每个流体控制装置（148）设置有连接到所述公共连接头盔（160）的第一端口（152）。每个流体控制装置（148）的第二端口（150）连接到注射器主体（114）。此外，每个流体控制装置（148）包括适于具有连接在其中的药物容器的第三端口。所述第三端口设置有用于接收所述药物容器的适配器（154），并且还设置有流体导管构件，当所述容器容纳在所述适配器（154）中时，所述流体导管构件延伸到所述容器的内部。每个流量控制构件可从第一流量控制位置选择性地移动，从而能够实现流体控制装置的第一对两个端口之间的流动路径和第二流量控制位置，从而能够实现流体控制的第二对两个端口之间的流动路径装置，每个流量控制构件联接到这些端口中的一个，用于在所述流量控制位置之间进行操纵。

3. 发明申请

WO2007059801A1 APPLICATOR DEVICE FOR APPLYING A MULTI-COMPONENT FLUID 审中-公开
标题翻译：用于应用多组分流体的应用器件
公开(公告)号：WO2007059801A1
公开(公告)日：2007-05-31
申请号：PCT/EP2005/056154
申请日：2005-11-22
申请人： OMRIX BIOPHARMACEUTICALS S.A. , GOLDBERG, Edit
发明人： GOLDBERG, Edit
IPC分类号： A61B17/00
CPC分类号： A61B17/00491 , A61B2017/00495 , A61B2017/00526 , A61M5/19
摘要： Disclosed is an applicator device ( 10) for applying a multi-component fluid, especially a multi-component tissue glue, comprising a plurality of substantially cylindrical supply containers (12) for respectively one component of the fluid to be applied, each supply container ( 12) having a front end (16) with an out¬ let opening (18), a rear end (22) opposite to the front end ( 16), and a slidably displaceable piston (24) arranged within the supply container ( 12) and having a piston rod (26) extending out of the rear end (22) for operating the piston (24). Moreover, the applicator device includes a manifold (72) having terminal ends (50,58) with a first port for fluid connection with the front ends (16) of the supply containers (12), the manifold (72) further having internal channels (62) extending from the first ports of the terminal ends (50,58) to an outlet site. Finally, also a holding element (38) for holding the supply containers ( 12), and a coupling clement (74) extending from the holding element (38) and having a connection end (76) connected to the manifold (72) arc pro¬ vided, wherein the connection end (76) of the coupling element (74) is bonded to the manifold (72).
摘要翻译：公开了一种用于施加多组分流体，特别是多组分组织胶的施加器装置（10），其包括多个基本上圆柱形的供给容器（12），用于分别被施加的流体的一个部件，每个供应容器 12）具有带有外露开口（18）的前端（16），与前端（16）相对的后端（22）和布置在供给容器（12）内的可滑动位移的活塞（24）并具有延伸出后端（22）的活塞杆（26），用于操作活塞（24）。此外，涂抹器装置包括具有终端（50,58）的歧管（72），其具有用于与供应容器（12）的前端（16）流体连接的第一端口，歧管（72）还具有内部通道（62）从所述终端（50,58）的所述第一端口延伸到出口位置。最后，还有用于保持供应容器（12）的保持元件（38）和从保持元件（38）延伸并具有连接到歧管（72）的连接端（76）的连接件（74）其中联接元件（74）的连接端（76）与歧管（72）结合。

4. 发明申请

WO1998010704A1 MULTICOMPONENT TISSUE ADHESIVE APPLICATION DEVICE AND HOLDER FOR SUCH DEVICE 审中-公开
标题翻译：位装置用于应用多组分胶粘剂面料和支持的命令DEVICE
公开(公告)号：WO1998010704A1
公开(公告)日：1998-03-19
申请号：PCT/EP1997004919
申请日：1997-09-09
申请人： OMRIX BIOPHARMACEUTICALS S.A. , ZINGER, Freddy
发明人： OMRIX BIOPHARMACEUTICALS S.A.
IPC分类号： A61B17/00
CPC分类号： A61B17/00491 , A61B2017/00495
摘要： A multicomponent tissue adhesive device (10) provided with several reservoirs (14) respectively for a liquid component, each reservoir (14) presenting a front end (16,20) with an opening (18) enabling the liquid concerned to be dispensed. The front ends (16,20) of the reservoirs (14) are located in accommodating connecting pieces (42) of a connecting head piece (38).The connecting pieces (42) are provided with radially outward extending projecting parts (92). The reservoirs (14) are held by means of a holding device (52). The application device (10) is also provided with a coupling element (74) for releaseably connecting the holding device to the connecting head piece (38), wherein the coupling element (74) presents an encompassing part (76) with several encompassing areas (82) for at least partial encompassing of the accomodating connecting pieces (42) and mounting on the sides opposite the holding device (52) of the projecting parts (92) of the accomodating connecting pieces (42).
摘要翻译：用于施加多组分组织粘合剂的施用装置（10）设置有设置用于每个流体组件的几个供应容器（14），其特征在于，具有前端（16，20）具有用于输出所述各自的流体组分包括开口（18），每个存储容器（14），该储存容器（14）的前端（16，20）位于容纳连接头戴受话器（38）的颈部（42）。接收连接件（42）设有径向向外指向的突出部（92）。通过安装装置（52）的装置被保持，该储存容器（14）。此外，涂抹器装置（10）具有用于保持器设备（52）可释放地连接到所述连接头部件（38），耦合元件（74），其特征在于具有多个Umgreifzonen（82），用于至少部分地包围所述耦合元件（74）周围部分（76）接收连接件（42）和抵靠安装装置（52）接收连接件（42）的突起（92）的相对两侧。

5. 发明申请

WO1996019940A1 DEVICE FOR APPLYING ONE OR SEVERAL FLUIDS 审中-公开
标题翻译：用于应用一个或多个流体的装置
公开(公告)号：WO1996019940A1
公开(公告)日：1996-07-04
申请号：PCT/EP1995005120
申请日：1995-12-23
申请人： OMRIX BIOPHARMACEUTICALS S.A. , ZINGER, Freddy
发明人： OMRIX BIOPHARMACEUTICALS S.A.
IPC分类号： A61B17/00
CPC分类号： A61M25/01 , A61B1/0055 , A61B17/00491 , A61B2017/00495 , A61C5/64 , A61M35/00 , B05B7/08 , B05B7/0876
摘要： The device for applying one or several fluids, particularly a multi-component fluid, such as medical tissue or dental adhesives, comprises a head piece (9) having channels (25 to 28) for each fluid extending from an inlet side of the head piece (9) to a connection site of the head piece (9). The tubular body (10) comprises an inlet end facing the connection site of the head piece (9) and an outlet end facing away from the inlet end. The tubular body (10) comprises an outer wall, which, at least sectionally, is configured such that the tubular body (10) is plastically deformable, particularly plastically bendable.
摘要翻译：用于施加一种或多种流体，特别是多组分流体（例如医用组织或牙科粘合剂）的装置包括头部件（9），其具有通道（25至28），每个流体从头部件的入口侧延伸（9）连接到头部件（9）的连接部位。管状体（10）包括面向头部件（9）的连接位置的入口端和背离入口端的出口端。管状体（10）包括外壁，其至少部分地构造成使得管状体（10）可塑性变形，特别是塑性可弯曲。

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