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1. 发明申请

WO2014159811A1 SALTS AND POLYMORPHS OF A COMPOUND 审中-公开
标题翻译：化合物的盐和多元醇
公开(公告)号：WO2014159811A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/025220
申请日：2014-03-13
申请人： OLIVER, Patricia
发明人： OLIVER, Patricia
IPC分类号： A61K31/192
CPC分类号： A61K31/192
摘要： Disclosed are novel crystalline polymorphic forms of (R)-2-(5-chloro-6-(2,2,2-trifluoroethoxy)-4' -(trifluoromethyl) biphenyl-3-yl)-3-cyclobutylpropanoic acid and salts thereof, methods of preparing the crystalline polymorphic forms, pharmaceutical compositions comprising the crystalline polymorphic forms, and methods of treating Alzheimer's disease using the crystalline polymorphic forms. In particular the potassium and tromethamine salts are provided along with their differential scanning calorimetry (DSC) profile and x-ray powder diffraction pattern. The disclosed compounds are gamma secretase modulators.
摘要翻译：公开了（R）-2-（5-氯-6-（2,2,2-三氟乙氧基）-4' - （三氟甲基）联苯-3-基）-3-环丁基丙酸和其盐的新型结晶多晶型物，制备结晶多晶型物的方法，包含结晶多晶型物的药物组合物，以及使用结晶多晶型形式治疗阿尔茨海默氏病的方法。特别地，提供了钾和氨基丁三醇盐以及它们的差示扫描量热法（DSC）谱和X射线粉末衍射图。所公开的化合物是γ-分泌酶调节剂。

2. 发明申请

WO2014152135A1 POLYMORPHS AND SALTS OF A COMPOUND 审中-公开
标题翻译：化合物的聚合物和盐
公开(公告)号：WO2014152135A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/026988
申请日：2014-03-14
申请人： OLIVER, Patricia
发明人： OLIVER, Patricia
IPC分类号： C07D413/14 , G01N23/207
CPC分类号： C07D487/04 , C07B2200/13
摘要： Disclosed are novel crystalline polymorphic forms of 4-(4-(imidazo[l,2-b]pyridazin- 2-ylmethoxy)phenyl)-2,2-dimethyl-5-(pyridin-4-yl)furan-3(2H)-one and salts thereof, methods of preparing the crystalline polymorphic forms and salts thereof, pharmaceutical compositions comprising the crystalline polymorphic forms and salts thereof, and methods of treating CNS disorders, eating disorders, obesity, compulsive gambling, sexual disorders, narcolepsy, sleep disorders, diabetes, metabolic syndrome, schizophrenia, schizo-affective conditions, Huntington's disease, bipolar disorders, dystonic conditions and tardive dyskinesia, or for use in smoking cessation treatment in a patient using the crystalline polymorphic forms and salts thereof.
摘要翻译：公开了4-（4-（咪唑并[1,2-b]哒嗪-2-基甲氧基）苯基）-2,2-二甲基-5-（吡啶-4-基）呋喃-3（2H ）及其盐，制备结晶多晶型物及其盐的方法，包含结晶多晶型物及其盐的药物组合物和治疗CNS障碍，进食障碍，肥胖症，强迫性赌博，性障碍，发作性睡眠，睡眠的方法疾病，糖尿病，代谢综合征，精神分裂症，分裂症情况，亨廷顿舞蹈病，双相情感障碍，肌张力障碍症状和迟发性运动障碍，或用于使用结晶多晶型及其盐的患者戒烟治疗。

3. 发明申请

WO2007140231A2 LOW MOLECULAR WEIGHT HEPARIN COMPOSITION AND USES THEREOF 审中-公开
标题翻译：低分子量肝素组合物及其用途
公开(公告)号：WO2007140231A2
公开(公告)日：2007-12-06
申请号：PCT/US2007069626
申请日：2007-05-24
申请人： MOMENTA PHARMACEUTICAL INC , SUNDARAM MALLIK , VENKATARAMAN GANESH , OLIVER PATRICIA , YAO YIMING , MAMUWALA ZAINAB SIRAJBHAI , FIER IAN , QI YI WEI , SHRIVER ZACHARY , CAPILA ISHAN , GUNAY NUR SIBEL , BECCATI DANIELA , LIU CUIHUA , BAUER CORINNE , LI YING
发明人： SUNDARAM MALLIK , VENKATARAMAN GANESH , OLIVER PATRICIA , YAO YIMING , MAMUWALA ZAINAB SIRAJBHAI , FIER IAN , QI YI WEI , SHRIVER ZACHARY , CAPILA ISHAN , GUNAY NUR SIBEL , BECCATI DANIELA , LIU CUIHUA , BAUER CORINNE , LI YING
CPC分类号： C08B37/0078
摘要： Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.
摘要翻译：本文提供具有改善性能的低分子量肝素（LMWH）的制备，例如提供临床优势的性质。提供了制备和使用这些制剂的方法以及在生产这种LMWH制剂中分析原料，加工，中间体和最终产品的方法。

4. 发明申请

WO2014159814A1 FORMULATIONS AND TABLETS FOR TREATMENT OR PREVENTION OF NEUROLOGICAL DISORDERS 审中-公开
标题翻译：用于治疗或预防神经疾病的制剂和片剂
公开(公告)号：WO2014159814A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/025226
申请日：2014-03-13
申请人： OLIVER, Patricia , PHAM, Anh, Thu , SINGH, Akaash Kumari
发明人： OLIVER, Patricia , PHAM, Anh, Thu , SINGH, Akaash Kumari
IPC分类号： A61K31/19
CPC分类号： A61K31/192 , A61K9/2846 , A61K9/2886
摘要： Disclosed are pharmaceutical formulations of (R)-2-(5-chloro-6-(2,2,2- trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)-3-cyclobutylpropanoic acid and its pharmaceutically acceptable salts, tablets comprising such formulations, methods of making the formulations and tablets, and methods of treating a neurological disorder such as Alzheimer's disease with same.
摘要翻译：公开了（R）-2-（5-氯-6-（2,2,2-三氟乙氧基）-4' - （三氟甲基）联苯-3-基）-3-环丁基丙酸及其药学上可接受的盐，包含这些制剂的片剂，制备制剂和片剂的方法，以及用它们治疗诸如阿尔茨海默病的神经障碍的方法。

5. 发明申请

WO2007140231A3 LOW MOLECULAR WEIGHT HEPARIN COMPOSITION AND USES THEREOF 审中-公开
公开(公告)号：WO2007140231A3
公开(公告)日：2007-12-06
申请号：PCT/US2007/069626
申请日：2007-05-24
申请人： MOMENTA PHARMACEUTICAL, INC. , SUNDARAM, Mallik , VENKATARAMAN, Ganesh , OLIVER, Patricia , YAO, Yiming , MAMUWALA, Zainab Sirajbhai , FIER, Ian , QI, Yi Wei , SHRIVER, Zachary , CAPILA, Ishan , GUNAY, Nur Sibel , BECCATI, Daniela , LIU, Cuihua , BAUER, Corinne , LI, Ying
发明人： SUNDARAM, Mallik , VENKATARAMAN, Ganesh , OLIVER, Patricia , YAO, Yiming , MAMUWALA, Zainab Sirajbhai , FIER, Ian , QI, Yi Wei , SHRIVER, Zachary , CAPILA, Ishan , GUNAY, Nur Sibel , BECCATI, Daniela , LIU, Cuihua , BAUER, Corinne , LI, Ying
IPC分类号： C08B37/10 , A61K31/727
摘要： Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.

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