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1. 发明申请

WO2012131539A1 NOVEL BICYCLIC PYRIDINONES 审中-公开
标题翻译：新的双相PYRIDINONES
公开(公告)号：WO2012131539A1
公开(公告)日：2012-10-04
申请号：PCT/IB2012/051348
申请日：2012-03-21
申请人： PFIZER INC. , AM ENDE, Chistopher William , FISH, Benjamin Adam , GREEN, Michael Eric , JOHNSON, Douglas Scott , MULLINS, Patrick Bradley , O'DONNELL, Christopher John , PETTERSSON, Martin Youngjin , STIFF, Cory Michael , SUBRAMANYAM, Chakrapani , TRAN, Tuan Phong , NAVARATNAM, Thayalan
发明人： AM ENDE, Chistopher William , FISH, Benjamin Adam , GREEN, Michael Eric , JOHNSON, Douglas Scott , MULLINS, Patrick Bradley , O'DONNELL, Christopher John , PETTERSSON, Martin Youngjin , STIFF, Cory Michael , SUBRAMANYAM, Chakrapani , TRAN, Tuan Phong , NAVARATNAM, Thayalan
IPC分类号： C07D471/04 , A61K31/4985 , A61P25/00
CPC分类号： C07D471/04 , A61K31/4985 , A61K31/695 , A61K45/06 , C07D401/04 , C07D491/048 , C07F7/0812
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要翻译：公开了化合物的化合物和药学上可接受的盐，其中所述化合物具有如本文所定义的式（I）的结构。还公开了相应的药物组合物，治疗方法，合成方法和中间体。

2. 发明申请

WO2006051413A1 AZABENOXAZOLES FOR THE TREATMENT OF CNS DISORDERS 审中-公开
标题翻译：用于治疗CNS病症的AZABENOXAZOLES
公开(公告)号：WO2006051413A1
公开(公告)日：2006-05-18
申请号：PCT/IB2005/003427
申请日：2005-11-04
申请人： PFIZER INC. , DUPLANTIER, Allen, Jacob , O'DONNELL, Christopher, John , ROGERS, Bruce, Nelsen , ZHANG, Lei
发明人： DUPLANTIER, Allen, Jacob , O'DONNELL, Christopher, John , ROGERS, Bruce, Nelsen , ZHANG, Lei
IPC分类号： C07D519/00 , A61K31/551 , A61P25/00 , A61P25/18 , A61P25/28
CPC分类号： C07D471/08
摘要： The present invention relates to a7 nicotinic receptor agonists of formula I as described herein and to a method for treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal an a7 nicotinic receptor agonist of formula I. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant a7 nicotinic receptor agonist of formula (I).
摘要翻译：本发明涉及本文所述的式I的烟碱型受体激动剂和通过向哺乳动物施用a7烟碱样受体来治疗哺乳动物（包括人）中的中枢神经系统（CNS）和其它疾病的疾病的方法其还涉及含有药学上可接受的载体和式（I）的CNS渗透剂α7烟碱受体激动剂的药物组合物。

3. 发明申请

WO2006051394A1 AZABENZOXAZOLES FOR THE TREATMENT OF CNS DISORDERS 审中-公开
标题翻译：用于治疗CNS病症的AZABENZOXAZOLES
公开(公告)号：WO2006051394A1
公开(公告)日：2006-05-18
申请号：PCT/IB2005/003364
申请日：2005-11-03
申请人： PFIZER PRODUCTS INC. , DUPLANTIER, Allen, Jacob , KHASANOV, Alisher, Bakhadirovich , O'DONNELL, Christopher, John , ROGERS, Bruce, Nelsen , ZHANG, Lei
发明人： DUPLANTIER, Allen, Jacob , KHASANOV, Alisher, Bakhadirovich , O'DONNELL, Christopher, John , ROGERS, Bruce, Nelsen , ZHANG, Lei
IPC分类号： C07D519/00 , A61K31/551 , A61P25/18
CPC分类号： C07D519/00 , C07D498/04
摘要： The present invention relates to α7 nicotinic receptor agonists of formula (I) as described herein and to a method for treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal an α7 nicotinic receptor agonist of formula (I). It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant α7 nicotinic receptor agonist of formula (I).
摘要翻译：本发明涉及本文所述的式（I）的烟碱型受体激动剂和通过向哺乳动物施用a7来治疗哺乳动物（包括人）中枢神经系统（CNS）和其它疾病的疾病的方法式（I）的烟碱受体激动剂。它还涉及包含药学上可接受的载体和式（I）的CNS渗透剂a7烟碱受体激动剂的药物组合物。

4. 发明申请

WO2005007655A1 NICOTINE ADDICTION REDUCING HETEROARYL FUSED AZAPOLYCYCLIC COMPOUNDS 审中-公开
标题翻译：尼古丁加入减少异氟醚融合的化合物
公开(公告)号：WO2005007655A1
公开(公告)日：2005-01-27
申请号：PCT/IB2004/002261
申请日：2004-07-08
申请人： PFIZER PRODUCTS INC. , ALLEN, Martin, Patrick , COE, Jotham, Wadsworth , LIRAS, Spiros , O'DONNELL, Christopher, John , O'NEILL, Brian, Thomas
发明人： ALLEN, Martin, Patrick , COE, Jotham, Wadsworth , LIRAS, Spiros , O'DONNELL, Christopher, John , O'NEILL, Brian, Thomas
IPC分类号： C07D471/08
CPC分类号： C07D471/08
摘要： The present invention provides a compound having the structure of formula (I): wherein R 1 is hydrogen, (C 1 -C 6 ) alkyl, unconjugated (C 3 -C 6 ) alkenyl, benzyl, YC(=O)(C 1 -C 6 ) alkyl or -CH 2 CH 2 -O-(C 1 -C 4 ) alkyl; X is CH 2 or CH 2 CH 2 ; Y is (C 2 -C 6 ) alkylene; Z is (CH 2 ) m , CF 2 , or C(=O), where m is 0, 1 or 2; R 2 and R 3 are selected independently from hydrogen, halogen, - (C 1 -C 6 ) alkyl optionally substituted with from 1 to 7 halogen atoms, and -O(C 1 -C 6 ) alkyl optionally substituted with from 1 to 7 halogen atoms, or R 2 and R 3 each together with the atom to which it is connected independently form C(=O), S→O , S(=O) 2 , or N→O; and Het is a 5- to 7- membered monocyclic heteroaryl group selected from pyridinyl, pyridone, pyridazinyl, imidazolyl, pyrimidinyl, pyrazolyl, triazolyl, pyrazinyl, furyl, thienyl, isoxazolyl, thiazolyl, oxazolyl, isothiazolyl, pyrrolyl, cinnolinyl, triazinyl, oxadiazolyl, thiadiazolyl and furazanyl groups. The compounds can be used to treat disease states mediated by neuronal nicotinic acetylcholine specific receptor sites.
摘要翻译：本发明提供具有式（I）结构的化合物：其中R 1是氢，（C 1 -C 6）烷基，未结合的（C 3 -C 6）烯基，苄基，YC（= O）（C 1 -C 6）烷基或-CH 2 CH 2 -O-（C 1 -C 4）烷基; X是CH 2或CH 2 CH 2; Y是（C 2 -C 6）亚烷基; Z是（CH 2）m，CF 2或C（= O），其中m是0,1或2; R 2和R 3独立地选自氢，卤素，任选被1至7个卤素原子取代的 - （C 1 -C 6）烷基和任选被1至7个取代的-O（C 1 -C 6）烷基卤素原子或R 2和R 3各自与其连接的原子一起独立地形成C（= O），S-> O，S（= O）2或N-> O; 吡啶基，咪唑基，嘧啶基，吡唑基，三唑基，吡嗪基，呋喃基，噻唑基，异恶唑基，噻唑基，恶唑基，异噻唑基，吡咯基，噌啉基，三嗪基，恶二唑基，噻二唑基和呋咱基。该化合物可用于治疗由神经元烟碱乙酰胆碱特异性受体位点介导的疾病状态。

5. 发明申请

WO2005007630A2 ARYL FUSED AZAPOLYCYCLIC COMPOUNDS 审中-公开
公开(公告)号：WO2005007630A2
公开(公告)日：2005-01-27
申请号：PCT/IB2004/002280
申请日：2004-07-09
申请人： PFIZER PRODUCTS INC. , COE, Jotham, Wadsworth , O'DONNELL, Christopher, John
发明人： COE, Jotham, Wadsworth , O'DONNELL, Christopher, John
IPC分类号： C07D223/16
CPC分类号： C07D221/22 , C07D223/14 , C07D471/08 , C07D513/08
摘要： This invention is directed to compounds of the formula (I): and their pharmaceutically acceptable salts, wherein R 1 , R 2 , R 3 and Z are as defined herein ; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such compounds; and methods of using such compounds in the treatment of neurological and psychological disorders.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1，R 2，R 3和Z如本文所定义; 用于合成这些化合物的中间体，含有这些化合物的药物组合物; 以及使用这些化合物治疗神经和心理障碍的方法。

6. 发明申请

WO2011092611A1 AMINOCYCLOHEXANES AND AMINOTETRAHYDROPYRANS AND RELATED COMPOUNDS AS GAMMA-SECRETASE MODULATORS 审中-公开
标题翻译：氨基环己烷和氨基甲酰四氢叶酸及相关化合物作为氨基酸分泌调节剂
公开(公告)号：WO2011092611A1
公开(公告)日：2011-08-04
申请号：PCT/IB2011/050240
申请日：2011-01-19
申请人： PFIZER INC. , AM ENDE, Christopher, William , FISH, Benjamin, Adam , JOHNSON, Douglas, Scott , LIRA, Ricardo , O'DONNELL, Christopher, John , PETTERSSON, Martin, Youngjin , STIFF, Cory, Michael
发明人： AM ENDE, Christopher, William , FISH, Benjamin, Adam , JOHNSON, Douglas, Scott , LIRA, Ricardo , O'DONNELL, Christopher, John , PETTERSSON, Martin, Youngjin , STIFF, Cory, Michael
IPC分类号： C07C229/46 , C07C255/24 , C07D221/20 , C07D221/22 , C07D239/26 , C07D263/32 , C07D271/12 , C07D275/02 , C07D277/28 , C07D307/52 , C07D307/79 , C07D309/04 , C07D309/14 , C07D311/04 , C07D405/04
CPC分类号： C07C229/46 , C07C255/24 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2602/42 , C07D213/55 , C07D221/20 , C07D221/22 , C07D239/26 , C07D263/32 , C07D271/12 , C07D275/02 , C07D277/28 , C07D307/52 , C07D307/79 , C07D309/04 , C07D309/14 , C07D311/04 , C07D405/04
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要翻译：公开了化合物的化合物和药学上可接受的盐，其中所述化合物具有如说明书中定义的式（I）的结构。还公开了相应的药物组合物，治疗方法，合成方法和中间体。

7. 发明申请

WO2011048525A1 NOVEL HETEROARYL IMIDAZOLES AND HETEROARYL TRIAZOLES AS GAMMA-SECRETASE MODULATORS 审中-公开
标题翻译：新型异丙基咪唑和异丙基三唑作为GAMMA-分泌酶调节剂
公开(公告)号：WO2011048525A1
公开(公告)日：2011-04-28
申请号：PCT/IB2010/054616
申请日：2010-10-12
申请人： PFIZER INC. , AM ENDE, Christopher William , JOHNSON, Douglas Scott , O'DONNELL, Christopher John , PETTERSSON, Martin Youngjin , SUBRAMANYAM, Chakrapani
发明人： AM ENDE, Christopher William , JOHNSON, Douglas Scott , O'DONNELL, Christopher John , PETTERSSON, Martin Youngjin , SUBRAMANYAM, Chakrapani
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61K31/4439 , A61K31/497 , A61P25/00 , A61P25/28
CPC分类号： C07D403/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I; (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要翻译：公开了化合物的化合物和药学上可接受的盐，其中所述化合物具有式I的结构; （I）。还公开了相应的药物组合物，治疗方法，合成方法和中间体。

8. 发明申请

WO2008120093A1 SULFONAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF 审中-公开
标题翻译：磺胺类及其药物组合物
公开(公告)号：WO2008120093A1
公开(公告)日：2008-10-09
申请号：PCT/IB2008/000784
申请日：2008-03-26
申请人： PFIZER INC. , ESTEP, Kimberly Gail , FLIRI, Anton, Franz, Josef , O'DONNELL, Christopher, John
发明人： ESTEP, Kimberly Gail , FLIRI, Anton, Franz, Josef , O'DONNELL, Christopher, John
IPC分类号： C07D211/76 , C07D239/18 , C07D265/10 , C07D279/12 , C07D285/16 , C07D307/32 , C07D333/04 , C07D335/02 , C07D409/10 , A61P35/00 , A61K31/4412 , A61K31/513 , A61K31/5355 , A61K31/357 , A61K31/366
CPC分类号： C07D211/76 , C07D239/18 , C07D265/10 , C07D279/12 , C07D285/16 , C07D307/32 , C07D319/06 , C07D333/04 , C07D335/02 , C07D409/10
摘要： The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula (I), as defined in the specification. The invention is also directed to compositions containing the compounds of formula (I).
摘要翻译：本发明涉及一类化合物，包括具有如说明书中定义的式（I）结构的化合物的药学上可接受的盐。本发明还涉及含有式（I）化合物的组合物。

9. 发明申请

WO2006051413A8 AZABENOXAZOLES FOR THE TREATMENT OF CNS DISORDERS 审中-公开
标题翻译：用于治疗CNS病症的AZABENOXAZOLES
公开(公告)号：WO2006051413A8
公开(公告)日：2007-06-07
申请号：PCT/IB2005003427
申请日：2005-11-04
申请人： PFIZER , DUPLANTIER ALLEN JACOB , O'DONNELL CHRISTOPHER JOHN , ROGERS BRUCE NELSEN , ZHANG LEI
发明人： DUPLANTIER ALLEN JACOB , O'DONNELL CHRISTOPHER JOHN , ROGERS BRUCE NELSEN , ZHANG LEI
IPC分类号： C07D471/08 , A61K31/551 , A61P25/00 , C07D519/00
CPC分类号： C07D471/08
摘要： The present invention relates to a7 nicotinic receptor agonists of formula I as described herein and to a method for treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal an a7 nicotinic receptor agonist of formula I. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant a7 nicotinic receptor agonist of formula (I).
摘要翻译：本发明涉及本文所述的式I的烟碱型受体激动剂和通过向哺乳动物施用a7烟碱样受体来治疗哺乳动物（包括人）中的中枢神经系统（CNS）和其它疾病的疾病的方法其还涉及含有药学上可接受的载体和式（I）的CNS渗透剂α7烟碱受体激动剂的药物组合物。

10. 发明申请

WO2006051410A1 AZABENZOXAZOLES FOR THE TREATMENT OF CNS DISORDERS 审中-公开
标题翻译：用于治疗CNS病症的AZABENZOXAZOLES
公开(公告)号：WO2006051410A1
公开(公告)日：2006-05-18
申请号：PCT/IB2005/003394
申请日：2005-11-04
申请人： PFIZER INC. , BELYANKIN, Andrei, V. , DUPLANTIER, Allen, Jacob , ZHANG, Lei , O'DONNELL, Christopher, John , ROGERS, Bruce, Nelsen , VINCENT, Lawrence, Albert , SVIRIDOV, Sergey, I.
发明人： BELYANKIN, Andrei, V. , DUPLANTIER, Allen, Jacob , ZHANG, Lei , O'DONNELL, Christopher, John , ROGERS, Bruce, Nelsen , VINCENT, Lawrence, Albert , SVIRIDOV, Sergey, I.
IPC分类号： C07D519/00 , A61K31/4995 , A61P3/04 , A61P9/10 , A61P11/06 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/08 , A61P19/10 , A61P25/16 , A61P25/18 , A61P25/28 , A61P35/00
CPC分类号： C07D519/00
摘要： The present invention relates to a7 nicotinic receptor agonists of formula (la) or (lb) as described herein and to a method for treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal an a7 nicotinic receptor agonist of formula (la) or (lb). It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant a7nicotinic receptor agonist of formula (la) or (lb).
摘要翻译：本发明涉及本文所述的式（Ia）或（Ib）的烟碱型受体激动剂，以及涉及通过施用以下方法治疗哺乳动物（包括人）的中枢神经系统（CNS）和其它疾病的疾病的方法哺乳动物是式（Ia）或（1b）的a7烟碱受体激动剂。它还涉及含有药学上可接受的载体和式（Ia）或（Ib）的CNS-渗透剂a7烟酰受体激动剂的药物组合物。

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