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1. 发明申请

WO2004052365A2 INHIBITION OF INFLAMATION USING ALPHA 7 RECEPTOR-BINDING CHOLINERGIC AGONISTS 审中-公开
标题翻译：使用ALPHA 7受体结合胆碱酯酸激酶的抑制作用
公开(公告)号：WO2004052365A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/038708
申请日：2003-12-05
申请人： NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE , TRACEY, Kevin, J. , WANG, Hong
发明人： TRACEY, Kevin, J. , WANG, Hong
IPC分类号： A61K31/444
CPC分类号： G01N33/6863 , A61K31/00 , A61K31/439 , A61K31/444 , A61K31/46 , G01N33/9406 , G01N2333/525 , G01N2333/54 , Y02A50/385 , Y02A50/411
摘要： Methods of inhibiting release of a proinflammatory cytokine from a macrophage are provided. The methods comprise treating the macrophage with a cholinergic agonist in an amount sufficient to decrease the amount of the proinflammatory cytokine that is released from the macrophage, wherein the cholinergic agonist is selective for an α7 nicotinic receptor. Methods for inhibiting an inflammatory cytokine cascade in a patient are also provided. The methods comprise treating the patient with a cholinergic agonist in an amount sufficient to inhibit the inflammatory cytokine cascade, wherein the cholinergic agonist is selective for an α7 nicotinic receptor. Methods for determining whether a compound is a cholinergic agonist reactive with an α7 nicotinic receptor are also provided. The methods comprise determining whether the compound inhibits release of a proinflammatory cytokine from a mammalian cell. Additionally, methods for determining whether a compound is a cholinergic antagonist reactive with an α7 nicotinic receptor are provided. These methods comprise determining whether the compound reduces the ability of a cholinergic agonist to inhibit the release of a proinflammatory cytokine from a mammalian cell. Oligonucleotides or mimetics capable of inhibiting attenuation of lipopolysaccharide-induced TNF release from a mammalian macrophage upon exposure of the macrophage to a cholinergic agonist are also provided. The oligonucleotides or mimetics consist essentially of a sequence greater than 5 nucleotides long that is complementary to an mRNA of an α7 receptor. Additionally, methods of inhibiting attenuation of TNF release from a mammalian macrophage upon exposure of the macrophage to a cholinergic agonist are provided. These methods comprise treating the macrophage with the above-described oligonucleotide or mimetic.
摘要翻译：提供了抑制促炎细胞因子从巨噬细胞释放的方法。所述方法包括用足以减少从巨噬细胞释放的促炎细胞因子的量的胆碱能激动剂处理巨噬细胞，其中胆碱能激动剂对α7烟碱受体具有选择性。还提供了用于抑制患者中炎性细胞因子级联的方法。所述方法包括用足以抑制炎性细胞因子级联的量的胆碱能激动剂治疗患者，其中胆碱能激动剂对α7烟碱受体具有选择性。还提供了确定化合物是否是与α7烟碱受体反应的胆碱能激动剂的方法。所述方法包括确定化合物是否抑制来自哺乳动物细胞的促炎细胞因子的释放。另外，提供了确定化合物是否是与α7烟碱受体反应的胆碱能拮抗剂的方法。这些方法包括确定该化合物是否降低胆碱能激动剂抑制促炎细胞因子从哺乳动物细胞释放的能力。还提供了能够抑制巨噬细胞暴露于胆碱能激动剂时从哺乳动物巨噬细胞中减少脂多糖诱导的TNF释放的寡核苷酸或模拟物。寡核苷酸或模拟物基本上由与α7受体的mRNA互补的大于5个核苷酸长的序列组成。此外，提供了在将巨噬细胞暴露于胆碱能激动剂时抑制TNF释放从哺乳动物巨噬细胞的减少的方法。这些方法包括用上述寡核苷酸或模拟物处理巨噬细胞。

2. 发明申请

WO2004046338A2 USE OF HMGB POLYPEPTIDES FOR INCREASING IMMUNE RESPONSES 审中-公开
标题翻译： HMGB多肽用于增加免疫应答
公开(公告)号：WO2004046338A2
公开(公告)日：2004-06-03
申请号：PCT/US2003/036975
申请日：2003-11-19
申请人： NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE , TRACEY, Kevin, J.
发明人： TRACEY, Kevin, J.
IPC分类号： C12N
CPC分类号： C07K14/4702 , C07K14/47 , C07K16/24
摘要： The present invention features polypeptides comprising an HMGB B box or a functional variant thereof that are useful for stimulating or increasing an immune response in an individual. Such polypeptides can be used in vaccine formulations and in cancer therapies.
摘要翻译：本发明的特征在于包含HMGB B盒或其功能性变体的多肽，其用于刺激或增加个体的免疫应答。这样的多肽可以用于疫苗制剂和癌症治疗中。

3. 发明申请

WO2002092004A2 USE OF HMG FRAGMENTS AS ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：使用HMG片作为抗炎剂
公开(公告)号：WO2002092004A2
公开(公告)日：2002-11-21
申请号：PCT/US2002/015329
申请日：2002-05-15
申请人： NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE , THE GENERAL HOSPITAL CORPORATION , UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , TRACEY, Kevin, J. , YANG, Huan , WARREN, Howland, Shaw, Jr. , FINK, Mitchell, P.
发明人： TRACEY, Kevin, J. , YANG, Huan , WARREN, Howland, Shaw, Jr. , FINK, Mitchell, P.
IPC分类号： A61K
CPC分类号： C07K14/4702 , A61K38/00 , Y02A50/412
摘要： Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMG A box, and an antibody preparation that specifically binds to a vertebrate HMG B box. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.
摘要翻译：公开了用于抑制促炎细胞因子从脊椎动物细胞中释放并抑制患者炎性细胞因子级联的组合物和方法。组合物包含脊椎动物HMG A盒和特异性结合脊椎动物HMG B盒的抗体制剂。所述方法包括用足够量的组合物治疗细胞或患者以抑制促炎细胞因子的释放或抑制炎性细胞因子级联。

4. 发明申请

WO2005097172A2 ADRENOMEDULLIN AND ADRENOMEDULLIN BINDING PROTEIN FOR ISCHEMIA/REPERFUSION TREATMENT 审中-公开
标题翻译： ADRENOMEDULLIN和ADRENOMEDULLIN结合蛋白进行ISCHEMIA / REPERFUSION治疗
公开(公告)号：WO2005097172A2
公开(公告)日：2005-10-20
申请号：PCT/US2005/010822
申请日：2005-03-30
申请人： NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE , WANG, Ping
发明人： WANG, Ping
IPC分类号： A61K38/22
CPC分类号： A61K38/22 , A61K38/1709 , A61K2300/00
摘要： Methods of treating a mammal at risk for ischemia-reperfusion injury are provided. The methods comprise administering an adrenomedullin binding protein-1 (AMBP-1) to the mammal in sufficient amount to reduce the injury. Also provided are methods of treating a mammal at risk for ischemia-reperfusion injury to the bowel. The methods comprise administering adrenomedullin to the mammal in sufficient amount to reduce the injury.
摘要翻译：提供了治疗处于缺血 - 再灌注损伤风险的哺乳动物的方法。所述方法包括以足够的量向哺乳动物施用肾上腺髓质素结合蛋白-1（AMBP-1）以减少损伤。还提供了治疗对肠的缺血再灌注损伤有风险的哺乳动物的方法。所述方法包括给予哺乳动物足量的肾上腺髓质素以减少损伤。

5. 发明申请

WO2005072713A3 CHOLINESTERASE INHIBITORS FOR TREATING INFLAMMATION 审中-公开
公开(公告)号：WO2005072713A3
公开(公告)日：2005-08-11
申请号：PCT/US2005/003029
申请日：2005-01-27
申请人： NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE , TRACEY, Kevin, J. , PAVLOV, Valentin, A.
发明人： TRACEY, Kevin, J. , PAVLOV, Valentin, A.
IPC分类号： A61K31/00
摘要： A method of treating a subject with a cytokine-mediated inflammatory disorder comprising administering to the subject an effective amount of a pharmaceutically acceptable cholinesterase inhibitor, provided that the inhibitor is not galantamine.

6. 发明申请

WO2003065979A3 METHODS OF DIAGNOSIS, MONITORING AND TREATMENT OF FERTILITY 审中-公开
公开(公告)号：WO2003065979A3
公开(公告)日：2003-08-14
申请号：PCT/US2002/038629
申请日：2002-12-05
申请人： NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE , AI-ABED, Yousef
发明人： AI-ABED, Yousef
IPC分类号： C12N5/00
摘要： The present invention generally relates to methods of using dopachrome tautomerase activity of macrophage migration inhibitory factor (MIF) and related or other proteins present in the seminal fluid (ejaculate) of a male subject to evaluate fertility and other related diseases. Further utilities relate to the diagnosis and treatment of fertility, to new methods of contraception, and to methods of enhancing artificial insemination and in vitro fertilization.

7. 发明申请

WO2005092308A2 NEURAL TOURNIQUET 审中-公开
标题翻译： NEURAL TOURNIETET
公开(公告)号：WO2005092308A2
公开(公告)日：2005-10-06
申请号：PCT/US2005/009954
申请日：2005-03-24
申请人： NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE , TRACEY, Kevin, J. , AMELLA, Carol, A. , CZURA, Christopher
发明人： TRACEY, Kevin, J. , AMELLA, Carol, A. , CZURA, Christopher
IPC分类号： A61K31/00
CPC分类号： A61K31/165 , A61K31/4439 , A61K31/4747
摘要： Disclosed is a method of reducing bleed time in a subject by activation of the cholinergic anti-inflammatory pathway in said subject. The cholinergic anti-inflammatory pathway can be activated by direct or indirect stimulation of the vagus nerve. The cholinergic anti-inflammatory pathway can also be activated by administering an effective amount of cholinergic agonist acetylcholinesterase inhibitor to the subject.
摘要翻译：公开了一种通过激活所述受试者中的胆碱能抗炎症途径来减少受试者出血时间的方法。胆碱能抗炎途径可以通过直接或间接刺激迷走神经来激活。胆碱能抗炎途径也可以通过向受试者施用有效量的胆碱能激动剂乙酰胆碱酯酶抑制剂来活化。

8. 发明申请

WO2004041115A2 NOVEL HUMAN ELASTASES AND STRESS URINARY INCONTINENCE 审中-公开
标题翻译：新的人类弹性和压力不均匀性
公开(公告)号：WO2004041115A2
公开(公告)日：2004-05-21
申请号：PCT/US2003/018696
申请日：2003-06-12
申请人： NORTH SHORE - LONG ISLAND JEWISH RESEARCH INSTITUTE , KUSHNER, Leslie , MATHRUBUTHAM, Mahesh , RAO, Srinivasa, K.
发明人： KUSHNER, Leslie , MATHRUBUTHAM, Mahesh , RAO, Srinivasa, K.
IPC分类号： A61F
CPC分类号： C12N9/6448 , A61K38/482 , C12Q1/37 , G01N2333/966
摘要： Novel elastases are provided that are associated with stress urinary incontinence. Also provided are methods for determining whether a woman has stress urinary incontinence, and methods for treating or preventing stress urinary incontinence.
摘要翻译：提供与压力性尿失禁相关的新型弹性蛋白酶。还提供了用于确定女性是否具有压力性尿失禁的方法，以及用于治疗或预防压力性尿失禁的方法。

9. 发明申请

WO2002092004A3 USE OF HMG FRAGMENT AS ANTI-INFLAMMATORY AGENTS 审中-公开
公开(公告)号：WO2002092004A3
公开(公告)日：2002-11-21
申请号：PCT/US2002/015329
申请日：2002-05-15
申请人： NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE , THE GENERAL HOSPITAL CORPORATION , UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , TRACEY, Kevin, J. , YANG, Huan , WARREN, Howland, Shaw, Jr. , FINK, Mitchell, P.
发明人： TRACEY, Kevin, J. , YANG, Huan , WARREN, Howland, Shaw, Jr. , FINK, Mitchell, P.
IPC分类号： C12P21/06
摘要： Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMG A box, and an antibody preparation that specifically binds to a vertebrate HMG B box. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.

10. 发明申请

WO2006073484A3 TREATING INFLAMMATORY DISORDERS BY ELECTRICAL VAGUS NERVE STIMULATION 审中-公开
公开(公告)号：WO2006073484A3
公开(公告)日：2006-07-13
申请号：PCT/US2005/022409
申请日：2005-06-22
申请人： NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE , HUSTON, Jared, M. , TRACEY, Kevin, J.
发明人： HUSTON, Jared, M. , TRACEY, Kevin, J.
IPC分类号： A61N1/36
摘要： A method and an apparatus for treating a patient suffering from, or at risk for, a condition mediated by the inflammatory cytokine cascade, by electrically stimulating vagus nerve activity in an amount sufficient to inhibit the inflammatory cytokine cascade.

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