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1. 发明申请

WO2010049522A3 DENTAL FILLING MATERIALS WITH SURFACE MODIFIED ZIRCONIA PARTICLES 审中-公开
标题翻译：牙齿填充材料与表面改性ZIRCONIA颗粒
公开(公告)号：WO2010049522A3
公开(公告)日：2011-04-21
申请号：PCT/EP2009064373
申请日：2009-10-30
申请人： DENTOFIT AS , VAN LELIEVELD ALEXANDER , NIELSEN METTE SKOVGAARD
发明人： VAN LELIEVELD ALEXANDER , NIELSEN METTE SKOVGAARD
IPC分类号： A61K6/083
CPC分类号： A61K6/083 , A61K6/0073 , A61K6/087 , C08L33/04 , C08L63/00
摘要： The present application discloses a dental filling material comprising fillers and a polymerizable resin base, the fillers comprising metastable zirconia particles in the tetragonal and/or cubic crystalline phase with less than 30 % (v/v) in the monoclinic phase, and having surface functionalities of the formula: -Zr-O-Zr-O-C(=O)-X-C(R1)(R2)(R3), wherein X = -O-, -NH-, -S-; R1 / R2 = hydrogen, opt.subst. C1-30-alkyl, a (meth)acrylate moiety moiety, a (meth)acrylate-C1-12-alkyl moiety, opt.subst. C2-30-alkenyl, opt.subst. C5-30-alkadienyl, opt.subst. C8-30-alkatrienyl, or when X = -NH-, R1 / R2 = =O; R3 = hydrogen, C1-6-alkyl, hydroxy, halogen. A method of controlling the volumetric shrinkage of a dental filling material upon curing, and the dental filling material for use in medicine, in particular in dentistry, are also disclosed.
摘要翻译：本申请公开了一种包含填充剂和可聚合树脂基质的牙科填充材料，所述填料包含在单斜晶相中小于30％（v / v）的四方晶和/或立方晶相中的亚稳态氧化锆颗粒，并且具有表面官能度其中X = -O-，-NH-，-S-; -Zr-O-Zr-OC（= O）-XC（R1）（R2）（R3） R1 / R2 =氢，opt.subst。（甲基）丙烯酸酯部分部分，（甲基）丙烯酸酯-C 1-12烷基部分，优选。 C2-30-烯基，选择性 C5-30-链二烯基，opt.subst。或当X = -NH-时，R 1 / R 2 = = O; R3 =氢，C1-6烷基，羟基，卤素。还公开了一种在固化时控制牙科填充材料的体积收缩率的方法，以及用于医学，特别是牙科用的牙科填充材料。

2. 发明申请

WO2003097574A3 AMINOALKOXY-FUNCTIONAL CHALCONES 审中-公开
公开(公告)号：WO2003097574A3
公开(公告)日：2003-11-27
申请号：PCT/DK2003/000332
申请日：2003-05-19
申请人： LICA PHARMACEUTICALS A/S , NIELSEN, Simon, Feldbæk , BOESEN, Thomas , LARSEN, Mogens , NIELSEN, Mette, Bjerg , KROMANN, Hasse
发明人： NIELSEN, Simon, Feldbæk , BOESEN, Thomas , LARSEN, Mogens , NIELSEN, Mette, Bjerg , KROMANN, Hasse
IPC分类号： C07C217/18
摘要： The invention provides novel alkoxyaminochalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infections, is also disclosed. The invention further relates to a method for detecting inhibitory effects against e.g., bacteria, parasites, fungi, and helminths. The chalcones of the invention carry amino substituents and exhibit enhanced biological effects combined with improved metabolic and physicochemical properties, making the compounds useful as drug substances, in particular as antiparasitic, bacteriostatic, and bacteriocidal agents.

3. 发明申请

WO2010049522A2 DENTAL FILLING MATERIALS WITH SURFACE MODIFIED ZIRCONIA PARTICLES 审中-公开
标题翻译：牙齿填充材料与表面改性ZIRCONIA颗粒
公开(公告)号：WO2010049522A2
公开(公告)日：2010-05-06
申请号：PCT/EP2009/064373
申请日：2009-10-30
申请人： DENTOFIT A/S , VAN LELIEVELD, Alexander , NIELSEN, Mette Skovgaard
发明人： VAN LELIEVELD, Alexander , NIELSEN, Mette Skovgaard
IPC分类号： A61K6/083
CPC分类号： A61K6/083 , A61K6/0073 , A61K6/087 , C08L33/04 , C08L63/00
摘要： The present application discloses a dental filling material comprising fillers and a polymerizable resin base, the fillers comprising metastable zirconia particles in the tetragonal and/or cubic crystalline phase with less than 30 % (v/v) in the monoclinic phase, and having surface functionalities of the formula: -Zr-O-Zr-O-C(=O)-X-C(R 1 )(R 2 )(R 3 ), wherein X = -O-, -NH-, -S-; R 1 / R 2 = hydrogen, opt.subst. C 1-30 -alkyl, a (meth)acrylate moiety moiety, a (meth)acrylate-C 1-12 -alkyl moiety, opt.subst. C 2-30 -alkenyl, opt.subst. C 5-30 -alkadienyl, opt.subst. C 8-30 -alkatrienyl, or when X = -NH-, R 1 / R 2 = =O; R 3 = hydrogen, C 1-6 -alkyl, hydroxy, halogen. A method of controlling the volumetric shrinkage of a dental filling material upon curing, and the dental filling material for use in medicine, in particular in dentistry, are also disclosed.
摘要翻译：本申请公开了一种包含填充剂和可聚合树脂基质的牙科填充材料，所述填料包含在单斜晶相中小于30％（v / v）的四方晶和/或立方晶相中的亚稳态氧化锆颗粒，并且具有表面官能度其中X = -O-，-NH-，-S-; -Zr-O-Zr-OC（= O）-XC（R1）（R2）（R3） R1 / R2 =氢，opt.subst。（甲基）丙烯酸酯部分部分，（甲基）丙烯酸酯-C 1-12烷基部分，优选。 C2-30-烯基，选择性 C5-30-链二烯基，opt.subst。或当X = -NH-时，R 1 / R 2 = = O; R3 =氢，C1-6烷基，羟基，卤素。还公开了一种在固化时控制牙科填充材料的体积收缩率的方法，以及用于医学，特别是牙科用的牙科填充材料。

4. 发明申请

WO2008031831A2 PHARMACEUTICAL COMPOSITIONS COMPRISING COMBINATIONS OF AN AMPA/KAINATE ANTAGONISTIC COMPOUND AND AN INHIBITOR OF A MULTIDRUG RESISTANCE PROTEIN 审中-公开
标题翻译：包含AMPA / KAINATE拮抗化合物和多药抗性蛋白抑制剂组合的药物组合物
公开(公告)号：WO2008031831A2
公开(公告)日：2008-03-20
申请号：PCT/EP2007/059548
申请日：2007-09-12
申请人： NEUROSEARCH A/S , WEIKOP, Pia , NIELSEN, Mette, Bjerg , MADSEN, Lars, Siim , MATHIESEN, Claus
发明人： WEIKOP, Pia , NIELSEN, Mette, Bjerg , MADSEN, Lars, Siim , MATHIESEN, Claus
IPC分类号： A61K31/437 , A61K45/06 , A61P25/00 , A61K31/435
CPC分类号： A61K45/06 , A61K31/435 , A61K31/437 , A61K2300/00
摘要： This invention relates to pharmaceutical compositions comprising a combination of an AMPA/kainate antagonistic compound and an inhibitor of a multidrug resistance protein and its use for combating epileptic disorders.
摘要翻译：本发明涉及药物组合物，其包含AMPA /红藻氨酸盐拮抗化合物和多药物抗性蛋白质抑制剂的组合及其用于对抗癫痫病症的用途。

5. 发明申请

WO2007104312A3 COMPOSITE MATERIAL, IN PARTICULAR A DENTAL FILLING MATERIAL 审中-公开
标题翻译：复合材料，特别是牙膏填充材料
公开(公告)号：WO2007104312A3
公开(公告)日：2008-03-06
申请号：PCT/DK2007000124
申请日：2007-03-13
申请人： DENTOFIT AS , VAN LELIEVELD ALEXANDER , NIELSEN METTE SKOVGAARD , ALMDAL KRISTOFFER , LINDEROTH SOEREN
发明人： VAN LELIEVELD ALEXANDER , NIELSEN METTE SKOVGAARD , ALMDAL KRISTOFFER , LINDEROTH SOEREN
IPC分类号： A61K6/083 , A61L27/44
CPC分类号： A61K6/09 , A61K6/0073 , A61K6/083 , A61L27/446 , C08L33/00 , C08L75/16
摘要： The present invention discloses a composite material comprising one or more fillers and a polymerizable resin base, wherein said one or more fillers comprise at least one filler ingredient, said filler ingredient(s) being present in a metastable first phase and being able to undergo a martensitic transformation to a stable second phase, the volume ratio between said stable second phase and said metastable first phase of said filler ingredient(s) being at least 1.005, and wherein said material further comprises one or more water- or acid- releasing agents; as well as a corresponding method of controlling the volumetric shrinkage of a composite material upon curing.
摘要翻译：本发明公开了一种包含一种或多种填料和可聚合树脂基料的复合材料，其中所述一种或多种填料包含至少一种填料成分，所述填料成分存在于亚稳态第一相中，并且能够经历马氏体转化为稳定的第二相，所述稳定的第二相和所述填料成分的所述亚稳态第一相之间的体积比为至少1.005，并且其中所述材料还包含一种或多种水或酸释放剂; 以及在固化时控制复合材料的体积收缩的相应方法。

6. 发明申请

WO2003097574A2 AMINOALKOXY-FUNCTIONAL CHALCONES 审中-公开
标题翻译：氨基酸功能性中间体
公开(公告)号：WO2003097574A2
公开(公告)日：2003-11-27
申请号：PCT/DK2003/000332
申请日：2003-05-19
申请人： LICA PHARMACEUTICALS A/S , NIELSEN, Simon, Feldbæk , BOESEN, Thomas , LARSEN, Mogens , NIELSEN, Mette, Bjerg , KROMANN, Hasse
发明人： NIELSEN, Simon, Feldbæk , BOESEN, Thomas , LARSEN, Mogens , NIELSEN, Mette, Bjerg , KROMANN, Hasse
IPC分类号： C07C217/18
CPC分类号： C07C233/36 , C07C45/00 , C07C45/44 , C07C47/277 , C07C47/55 , C07C47/575 , C07C49/813 , C07C217/22 , C07C225/16 , C07C225/22 , C07C233/33 , C07C237/04 , C07C255/56 , C07C311/21 , C07C323/32 , C07D213/65 , C07D295/088 , C07D295/112 , C07D295/185 , C07D307/79 , C07D309/12 , C07D317/66
摘要： The invention provides novel alkoxyaminochalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infections, is also disclosed. The invention further relates to a method for detecting inhibitory effects against e.g., bacteria, parasites, fungi, and helminths. The chalcones of the invention carry amino substituents and exhibit enhanced biological effects combined with improved metabolic and physicochemical properties, making the compounds useful as drug substances, in particular as antiparasitic, bacteriostatic, and bacteriocidal agents.
摘要翻译：本发明提供新的烷氧基氨基查尔酮衍生物及其类似物。还公开了将化合物或其组合物用于药物活性剂，特别是抗细菌和寄生虫感染的用途。本发明还涉及一种用于检测对例如细菌，寄生虫，真菌和蠕虫的抑制作用的方法。本发明的查尔酮携带氨基取代基并显示出增强的生物效应以及改善的代谢和物理化学性质，使得化合物可用作药物物质，特别是作为抗寄生虫，抑菌剂和杀菌剂。

7. 发明申请

WO2004096148A2 TISSUE PROTECTIVE CYTOKINE RECEPTOR COMPLEX, ASSAYS FOR IDENTIFYING TISSUE PROTECTIVE COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：组织保护性细胞因子受体复合物，用于鉴定组织保护性化合物的方法及其用途
公开(公告)号：WO2004096148A2
公开(公告)日：2004-11-11
申请号：PCT/US2004/013099
申请日：2004-04-26
申请人： THE KENNETH S. WARREN INSTITUTE, INC. , BRINES, Michael , CERAMI, Anthony , GHEZZI, Pietro , FIORDALISO, Fbio , FRATELLI, Maddalena , LEIST, Marcel , NIELSEN, Mette , SAGER, Thomas , PEDERSEN, Lars, Ostergaard , GERWIEN, Jens , COLEMAN, Thomas
发明人： BRINES, Michael , CERAMI, Anthony , GHEZZI, Pietro , FIORDALISO, Fbio , FRATELLI, Maddalena , LEIST, Marcel , NIELSEN, Mette , SAGER, Thomas , PEDERSEN, Lars, Ostergaard , GERWIEN, Jens , COLEMAN, Thomas
IPC分类号： A61K
CPC分类号： G01N33/5088 , A61K38/00 , G01N33/6863
摘要： The present invention is directed methods for identifying compounds that have a tissue protective activity using a heteromultimer receptor complex that mediates the tissue protective activities. The complex consists of at least one EPO-R in complex with at least one βc Receptor. These compounds used in the assays to identify tissue protective compounds include, but are not limited to, small molecules and biologics. The compounds identified using these assays can be used to treat or prevent various diseases, disorders, or conditions of the central and peripheral nervous systems as well as those of other erythropoietin-responsive or excitable cells, tissues, and organs.
摘要翻译：本发明涉及使用介导组织保护活性的异源多聚体受体复合物来鉴定具有组织保护活性的化合物的方法。复合物由至少一种与至少一种betac受体复合物的EPO-R组成。用于鉴定组织保护性化合物的测定中使用的这些化合物包括但不限于小分子和生物制剂。使用这些测定法鉴定的化合物可用于治疗或预防中枢和周围神经系统以及其它促红细胞生成素反应或兴奋细胞，组织和器官的各种疾病，病症或病症。

8. 发明申请

WO2008031831A3 PHARMACEUTICAL COMPOSITIONS COMPRISING COMBINATIONS OF AN AMPA/KAINATE ANTAGONISTIC COMPOUND AND AN INHIBITOR OF A MULTIDRUG RESISTANCE PROTEIN 审中-公开
标题翻译：包含AMPA / KAINATE ANTAGONISTIC化合物和多重耐药蛋白的抑制剂组合的药物组合物
公开(公告)号：WO2008031831A3
公开(公告)日：2008-09-18
申请号：PCT/EP2007059548
申请日：2007-09-12
申请人： NEUROSEARCH AS , WEIKOP PIA , NIELSEN METTE BJERG , MADSEN LARS SIIM , MATHIESEN CLAUS
发明人： WEIKOP PIA , NIELSEN METTE BJERG , MADSEN LARS SIIM , MATHIESEN CLAUS
IPC分类号： A61K31/437 , A61K31/435 , A61K45/06 , A61P25/00
CPC分类号： A61K45/06 , A61K31/435 , A61K31/437 , A61K2300/00
摘要： This invention relates to pharmaceutical compositions comprising a combination of an AMPA/kainate antagonistic compound and an inhibitor of a multidrug resistance protein and its use for combating epileptic disorders.
摘要翻译：本发明涉及药物组合物，其包含AMPA /红藻氨酸拮抗化合物和多药耐药性蛋白质的抑制剂的组合及其用于对抗癫痫病症的用途。

9. 发明申请

WO2007104312A2 COMPOSITE MATERIAL COMPRISING A WATER- OR ACID-RELEASING AGENT 审中-公开
标题翻译：包含水或酸消毒剂的复合材料
公开(公告)号：WO2007104312A2
公开(公告)日：2007-09-20
申请号：PCT/DK2007/000124
申请日：2007-03-13
申请人： DENTOFIT A/S , VAN LELIEVELD, Alexander , NIELSEN, Mette, Skovgaard , ALMDAL, Kristoffer , LINDEROTH, Søren
发明人： VAN LELIEVELD, Alexander , NIELSEN, Mette, Skovgaard , ALMDAL, Kristoffer , LINDEROTH, Søren
IPC分类号： A61K6/083
CPC分类号： A61K6/09 , A61K6/0073 , A61K6/083 , A61L27/446 , C08L33/00 , C08L75/16
摘要： The present invention discloses a composite material comprising one or more fillers and a polymerizable resin base, wherein said one or more fillers comprise at least one filler ingredient, said filler ingredient(s) being present in a metastable first phase and being able to undergo a martensitic transformation to a stable second phase, the volume ratio between said stable second phase and said metastable first phase of said filler ingredient(s) being at least 1.005, and wherein said material further comprises one or more water- or acid- releasing agents; as well as a corresponding method of controlling the volumetric shrinkage of a composite material upon curing.
摘要翻译：本发明公开了一种包含一种或多种填料和可聚合树脂基料的复合材料，其中所述一种或多种填料包含至少一种填料成分，所述填料成分存在于亚稳态第一相中，并且能够经历马氏体转化为稳定的第二相，所述稳定的第二相和所述填料成分的所述亚稳态第一相之间的体积比为至少1.005，并且其中所述材料还包含一种或多种水或酸释放剂; 以及在固化时控制复合材料的体积收缩的相应方法。

10. 发明申请

WO2004096148A3 TISSUE PROTECTIVE CYTOKINE RECEPTOR COMPLEX, ASSAYS FOR IDENTIFYING TISSUE PROTECTIVE COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：组织保护性细胞因子受体复合物，用于鉴定组织保护性化合物的方法及其用途
公开(公告)号：WO2004096148A3
公开(公告)日：2006-03-02
申请号：PCT/US2004013099
申请日：2004-04-26
申请人： KENNETH S WARREN INST INC , BRINES MICHAEL , CERAMI ANTHONY , GHEZZI PIETRO , FIORDALISO FBIO , FRATELLI MADDALENA , LEIST MARCEL , NIELSEN METTE , SAGER THOMAS , PEDERSEN LARS OSTERGAARD , GERWIEN JENS , COLEMAN THOMAS
发明人： BRINES MICHAEL , CERAMI ANTHONY , GHEZZI PIETRO , FIORDALISO FBIO , FRATELLI MADDALENA , LEIST MARCEL , NIELSEN METTE , SAGER THOMAS , PEDERSEN LARS OSTERGAARD , GERWIEN JENS , COLEMAN THOMAS
IPC分类号： A61K20060101 , G01N33/50 , G01N33/68 , A61K38/19 , A61K39/00 , C07K14/505 , C07K14/52 , C12N5/00 , C12N15/00 , G01N33/53
CPC分类号： G01N33/5088 , A61K38/00 , G01N33/6863
摘要： The present invention is directed methods for identifying compounds that have a tissue protective activity using a heteromultimer receptor complex that mediates the tissue protective activities. The complex consists of at least one EPO-R in complex with at least one ßc Receptor. These compounds used in the assays to identify tissue protective compounds include, but are not limited to, small molecules and biologics. The compounds identified using these assays can be used to treat or prevent various diseases, disorders, or conditions of the central and peripheral nervous systems as well as those of other erythropoietin-responsive or excitable cells, tissues, and organs.
摘要翻译：本发明涉及使用介导组织保护活性的异源多聚体受体复合物来鉴定具有组织保护活性的化合物的方法。该复合物由至少一种与至少一种β受体复合物的EPO-R组成。用于鉴定组织保护性化合物的测定中使用的这些化合物包括但不限于小分子和生物制剂。使用这些测定法鉴定的化合物可用于治疗或预防中枢和周围神经系统以及其它促红细胞生成素反应或兴奋细胞，组织和器官的各种疾病，病症或病症。

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