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1. 发明申请

WO2003030734A2 PATIENT-SPECIFIC PARAMETER SELECTION FOR NEUROLOGICAL EVENT DETECTION 审中-公开
标题翻译：患者特异性参数选择用于神经事件检测
公开(公告)号：WO2003030734A2
公开(公告)日：2003-04-17
申请号：PCT/US2002/032735
申请日：2002-10-11
申请人： NEUROPACE, INC.
发明人： ECHAUZ, Javier , ESTELLER, Rosana , TCHENG, Thomas, K. , PLESS, Benjamin, D. , KISHAWI, Eyad , GIBB, Barbara
IPC分类号： A61B5/0476
CPC分类号： G06F19/3418 , A61B5/0476 , A61B5/4094 , A61B5/7217 , G06F19/00
摘要： An epileptiform activity patient-specific template creation system permits a user to efficiently develop an optimized set of patient-specific parameters for epileptiform activity detection algorithms. The epileptiform activity patient template creation system is primarily directed for use with an implantable neurostimulator (110) system having EEG storage capability, in conjunction with a computer software program operating within a computer workstation (212) having a processor, disk storage and input/output facilities for storing, processing and displaying patient EEG signals. The implantable neurostimulator is operative to store records of EEG data when neurological events are detected, when it receives external commands to record, or at preset or arbitrary times. The computer workstation operates on stored and uploaded records of EEG data to derive the patient-specific templates via a single local minimum variant of a multidimensional greedy line search process and a feature overlay process.
摘要翻译：癫痫样活动患者特异性模板创建系统允许用户有效地开发用于癫痫样活动检测算法的优化的一组患者特异性参数。癫痫活动患者模板创建系统主要针对与具有EEG存储能力的可植入神经刺激器（110）系统一起使用，结合在具有处理器，磁盘存储和输入/输出的计算机工作站（212）内运行的计算机软件程序用于存储，处理和显示患者EEG信号的设施。可植入式神经刺激器用于在检测到神经事件时，当其接收外部命令进行记录时或在预设或任意时间存储EEG数据的记录。计算机工作站对存储和上传的脑电数据记录进行操作，以通过多维贪婪线搜索过程和特征覆盖过程的单个局部最小变体推导出患者特定模板。

2. 发明申请

WO2004043536A1 SYSTEM FOR ADAPTIVE BRAIN STIMULATION 审中-公开
标题翻译：自适应脑刺激系统
公开(公告)号：WO2004043536A1
公开(公告)日：2004-05-27
申请号：PCT/US2002/036376
申请日：2002-11-12
申请人： NEUROPACE, INC.
发明人： KIRKPATRICK, Bruce , PLESS, Benjamin, D.
IPC分类号： A61N1/36
CPC分类号： A61N1/36135 , A61N1/36064 , A61N1/36082
摘要： An implantable neurostimulator (110) adapted to provide adaptive electrical brain stimulation includes a detection subsystem (422) for isolating an electrographic signal characteristic and a stimulation subsystem (424) for applying an adaptive stimulation signal based at least in part upon the electrographic signal characteristic and correlated with the electrographic signal. Undesired learning of and acclimation to stimulation characteristics are avoided and stimulation efficacy is improved by adapting or otherwise varying the adaptive stimulation signal in relation to the electrographic signal.
摘要翻译：适于提供自适应电脑刺激的可植入神经刺激器（110）包括用于隔离电摄影信号特征的检测子系统（422）和用于至少部分地基于电摄影信号特征施加自适应刺激信号的刺激子系统（424），以及与电图信号相关。避免对刺激特征的不期望的学习和适应，并且通过适应或以其他方式改变与电摄影信号相关的自适应刺激信号来提高刺激功效。

3. 发明申请

WO03001996A3 SEIZURE SENSING AND DETECTION USING AN IMPLANTABLE DEVICE 审中-公开
标题翻译：使用植入式装置进行癫痫发作和检测
公开(公告)号：WO03001996A3
公开(公告)日：2003-09-25
申请号：PCT/US0220630
申请日：2002-06-28
申请人： NEUROPACE INC
发明人： PLESS BENJAMIN D , ARCHER STEPHEN T , BAYSINGER CRAIG M , GIBB BARBARA , GURUNATHAN SURESH K , KIRKPATRICK BRUCE , TCHENG THOMAS K
IPC分类号： A61B5/0476 , A61B5/00 , A61N1/36 , G06F17/00
CPC分类号： A61B5/4094 , A61B5/04012 , A61B5/0476 , A61B5/0478 , A61B5/6868 , A61B5/7203 , A61B5/7242 , A61B5/7246 , A61B5/7264 , A61B5/7275
摘要： A system and method for detecting and predicting neurological events with an implantable device (110) uses a relatively low-power central processing unit (428) in connection with signal processing circuitry (422) to identify features (including half waves) and calculate window-based characteristics (including line lengths and areas under the curve of the waveform) in an electrographic signal received from a patient's brain. The features and window-based characteristics are combinable in various ways according to the invention to detect and predict neurological events in real time, enabling responsive action by the implantable device.
摘要翻译：用于利用可植入设备（110）检测和预测神经事件的系统和方法使用与信号处理电路（422）相关的相对低功率的中央处理单元（428）来识别特征（包括半波）（包括波形曲线下的线长度和面积）在从患者大脑接收的电子照相信号中。这些特征和基于窗口的特征可根据本发明以各种方式组合以实时检测和预测神经事件，从而实现植入式装置的响应动作。

4. 发明申请

WO2003001996A2 SEIZURE SENSING AND DETECTION USING AN IMPLANTABLE DEVICE 审中-公开
标题翻译：使用可移植设备检测和检测
公开(公告)号：WO2003001996A2
公开(公告)日：2003-01-09
申请号：PCT/US2002/020630
申请日：2002-06-28
申请人： NEUROPACE, INC.
发明人： PLESS, Benjamin, D. , ARCHER, Stephen, T. , BAYSINGER, Craig, M. , GIBB, Barbara , GURUNATHAN, Suresh, K. , KIRKPATRICK, Bruce , TCHENG, Thomas, K.
IPC分类号： A61B5/00
CPC分类号： A61B5/4094 , A61B5/04012 , A61B5/0476 , A61B5/0478 , A61B5/6868 , A61B5/7203 , A61B5/7242 , A61B5/7246 , A61B5/7264 , A61B5/7275 , G06F19/00
摘要： A system and method for detecting and predicting neurological events with an implantable device (110) uses a relatively low-power central processing unit (428) in connection with signal processing circuitry (422) to identify features (including half waves) and calculate window-based characteristics (including line lengths and areas under the curve of the waveform) in an electrographic signal received from a patient's brain. The features and window-based characteristics are combinable in various ways according to the invention to detect and predict neurological events in real time, enabling responsive action by the implantable device.
摘要翻译：用可植入装置（110）检测和预测神经病学事件的系统和方法使用与信号处理电路（422）相关联的相对较低功率的中央处理单元（428）来识别特征（包括半波）并计算窗口 - （包括线长度和波形曲线下的面积）在从患者脑部接收的电摄影信号中。根据本发明的特征和基于窗口的特征可以以各种方式组合以实时检测和预测神经病学事件，从而能够实现可植入装置的响应动作。

5. 发明申请

WO2009067323A8 SYSTEMS, METHODS AND DEVICES FOR A SKULL/BRAIN INTERFACE 审中-公开
公开(公告)号：WO2009067323A8
公开(公告)日：2009-05-28
申请号：PCT/US2008/081655
申请日：2008-10-29
申请人： NEUROPACE, INC. , PLESS, Benjamin , CHAO, Daniel , WINGELER, Brett , TCHENG, Thomas
发明人： PLESS, Benjamin , CHAO, Daniel , WINGELER, Brett , TCHENG, Thomas
IPC分类号： A61N1/05
摘要： Disclosed are methods, devices, and systems for inducing neuromodulation by focusing a source of stimulation through a skull/brain interface in the form of an aperture formed in the skull, a naturally occurring fenestration in the skull, or a transcranial channel. Also disclosed are methods, devices, and systems for directing and focusing signals or other energy sensed from the brain for measurement, heat transfer and/or imaging. Further disclosed are methods, devices, and systems for identifying where to locate skull/brain interfaces, accessories that can be used with the interfaces, and features for controlling stimulation delivered through the interfaces. Multiple indications for the skull/brain interfaces are also disclosed, including diagnosis and treatment of neurological disorders and conditions such as epilepsy, movement disorders, depression, Alzheimer's disease, autism, coma, and pain.

6. 发明申请

WO2009067323A1 SYSTEMS, METHODS AND DEVICES FOR A SKULL/BRAIN INTERFACE 审中-公开
标题翻译：用于SKULL / BRAIN接口的系统，方法和设备
公开(公告)号：WO2009067323A1
公开(公告)日：2009-05-28
申请号：PCT/US2008081655
申请日：2008-10-29
申请人： NEUROPACE INC , PLESS BENJAMIN , CHAO DANIEL , WINGELER BRETT , TCHENG THOMAS
发明人： PLESS BENJAMIN , CHAO DANIEL , WINGELER BRETT , TCHENG THOMAS
IPC分类号： A61N1/05
CPC分类号： A61N1/36025 , A61B5/4064 , A61B5/4076 , A61B5/4094 , A61B5/6864 , A61B8/0808 , A61B18/02 , A61B18/14 , A61B90/10 , A61B2018/1807 , A61B2090/103 , A61N1/0484 , A61N1/0492 , A61N1/0529 , A61N1/0534 , A61N1/0536 , A61N1/0539 , A61N1/205 , A61N1/303 , A61N1/36017 , A61N5/0601
摘要： Disclosed are methods, devices, and systems for inducing neuromodulation by focusing a source of stimulation through a skull/brain interface in the form of an aperture formed in the skull, a naturally occurring fenestration in the skull, or a transcranial channel. Also disclosed are methods, devices, and systems for directing and focusing signals or other energy sensed from the brain for measurement, heat transfer and/or imaging. Further disclosed are methods, devices, and systems for identifying where to locate skull/brain interfaces, accessories that can be used with the interfaces, and features for controlling stimulation delivered through the interfaces. Multiple indications for the skull/brain interfaces are also disclosed, including diagnosis and treatment of neurological disorders and conditions such as epilepsy, movement disorders, depression, Alzheimer's disease, autism, coma, and pain.
摘要翻译：公开了用于通过将颅骨/脑界面以颅骨形成的孔的形式聚焦刺激源，颅骨中天然存在的开窗或经颅通道来诱导神经调节的方法，装置和系统。还公开了用于引导和聚焦从大脑感测的信号或其他能量进行测量，传热和/或成像的方法，装置和系统。还公开了用于识别在哪里定位颅骨/脑界面的方法，装置和系统，可以与界面一起使用的附件以及用于控制通过界面传送的刺激的特征。还公开了颅骨/脑界面的多种适应症，包括诊断和治疗诸如癫痫，运动障碍，抑郁症，阿尔茨海默病，孤独症，昏迷和疼痛的神经障碍和病症。

7. 发明申请

WO0238031A3 SYSTEM AND METHOD FOR DETERMINING STIMULATION PARAMETERS FOR THE TREATMENT OF EPILEPTIC SEIZURES 审中-公开
标题翻译：用于确定刺激参数的系统和方法用于治疗癫痫发作
公开(公告)号：WO0238031A3
公开(公告)日：2003-10-23
申请号：PCT/US0041704
申请日：2000-10-30
申请人： NEUROPACE INC , FISCHELL ROBERT , FISCHELL DAVID R , MORRELL MARTHA J , GIBB BARBARA
发明人： FISCHELL ROBERT E , FISCHELL DAVID R , MORRELL MARTHA J , GIBB BARBARA
IPC分类号： A61N1/36 , A61B5/0476
CPC分类号： A61N1/36064 , A61N1/36135
摘要： A method for selecting electrical stimulation parameters for controlling epileptiform activity in a patient includes implanting brain electrodes (6, 11, 12) in the patient, connecting the brain electrodes to an EEG analysis system (19) including a display workstation (16) and a stimulator (18), and collecting and analyzing EEG signals to determine whether electrical stimulation applied via the stimulator is effective to initiate or terminate epileptiform activity. If not, parameters are adjusted and stimulation, collection, and analysis steps are repeated.
摘要翻译：用于选择用于控制患者癫痫样活动的电刺激参数的方法包括在患者体内植入脑电极（6,11,12），将脑电极连接到包括显示工作站（16）和刺激器（18），并且收集和分析脑电信号以确定通过刺激器施加的电刺激是否有效起始或终止癫痫样活动。如果没有，则调整参数并重复刺激，收集和分析步骤。

8. 发明申请

WO2003030734A3 PATIENT-SPECIFIC PARAMETER SELECTION FOR NEUROLOGICAL EVENT DETECTION 审中-公开
公开(公告)号：WO2003030734A3
公开(公告)日：2003-04-17
申请号：PCT/US2002/032735
申请日：2002-10-11
申请人： NEUROPACE, INC.
发明人： ECHAUZ, Javier , ESTELLER, Rosana , TCHENG, Thomas, K. , PLESS, Benjamin, D. , KISHAWI, Eyad , GIBB, Barbara
IPC分类号： A61B5/0476
摘要： An epileptiform activity patient-specific template creation system permits a user to efficiently develop an optimized set of patient-specific parameters for epileptiform activity detection algorithms. The epileptiform activity patient template creation system is primarily directed for use with an implantable neurostimulator (110) system having EEG storage capability, in conjunction with a computer software program operating within a computer workstation (212) having a processor, disk storage and input/output facilities for storing, processing and displaying patient EEG signals. The implantable neurostimulator is operative to store records of EEG data when neurological events are detected, when it receives external commands to record, or at preset or arbitrary times. The computer workstation operates on stored and uploaded records of EEG data to derive the patient-specific templates via a single local minimum variant of a multidimensional greedy line search process and a feature overlay process.

9. 发明申请

WO0238217A3 IMPLANTABLE NEUROMUSCULAR STIMULATOR FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS 审中-公开
标题翻译：用于治疗胃肠疾病的可植入神经刺激因子
公开(公告)号：WO0238217A3
公开(公告)日：2002-10-31
申请号：PCT/US0149706
申请日：2001-11-09
申请人： NEUROPACE INC
发明人： FISCHELL DAVID R , UPTON ADRIAN R M
IPC分类号： A61N1/36
CPC分类号： A61N1/36007
摘要： A system and method for treating gastrointestinal and other disorders via electrical stimulation of plural portions of a patient's gastrointestinal tract uses an implantable control module (20), sensors attached to various structures of the gastrointestinal tract, and electrodes (15) also attached to various structures of the gastrointestinal tract. Signals received from the sensors are analyzed to identify events in the gastrointestinal system, and electrical stimulation is applied to structures of the gastrointestinal tract, in sequence, to restore normal function or achieve other clinically desirable results.
摘要翻译：通过对患者胃肠道的多个部分的电刺激来治疗胃肠道和其它疾病的系统和方法使用可植入的控制模块（20），连接到胃肠道的各种结构的传感器，以及也连接到各种结构的电极（15）的胃肠道。分析从传感器接收的信号以识别胃肠系统中的事件，并且依次将电刺激应用于胃肠道的结构，以恢复正常功能或达到其它临床上期望的结果。

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