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1. 发明申请

WO2010144016A1 MICROELECTRODE AND MULTIPLE MICROELECTRODES COMPRISING MEANS FOR RELEASING DRUGS INTO THE TISSUE 审中-公开
标题翻译：微电解和包含用于将药物释放到组织中的多个微电极
公开(公告)号：WO2010144016A1
公开(公告)日：2010-12-16
申请号：PCT/SE2010/000152
申请日：2010-06-03
申请人： NEURONANO AB , EK, Fredrik , DANIELSEN, Nils , ERIKSSON LINSMEIER, Jenny , PETERSSON, Per , SCHOUENBORG, Jens
发明人： EK, Fredrik , DANIELSEN, Nils , ERIKSSON LINSMEIER, Jenny , PETERSSON, Per , SCHOUENBORG, Jens
IPC分类号： A61N1/05 , A61B5/0478
CPC分类号： A61N1/0531 , A61B5/04001 , A61B5/4094 , A61L31/148 , A61L31/16 , A61L2300/604 , A61N1/0412 , A61N1/0476 , A61N1/05 , A61N1/0536 , A61N1/0551 , A61N1/306 , A61N1/325 , A61N1/327 , A61N1/37205
摘要： A medical microelectrode comprises an elongate electrode body comprising a tip section, a main body section and, optionally, a coupling section. The tip section, the main body section and, optionally, the coupling section are embedded in a first electrode matrix element, which is substantially rigid, biocompatible and soluble or biodegradable in a body fluid. Additionally the microelectrode comprises a dissolution retarding layer on the first electrode matrix element and/or a second electrode matrix element disposed between the first electrode matrix element and the electrode. Upon dissolution or biodegradation of the first electrode matrix element a drug comprised by the first electrode matrix element or the second electrode matrix element is released into the tissue. Also disclosed are bundles and arrays of the electrodes and their use.
摘要翻译：医用微电极包括细长电极体，其包括尖端部分，主体部分和任选的耦合部分。尖端部分，主体部分和任选的联接部分嵌入第一电极矩阵元件，其在体液中基本上是刚性的，生物相容的和可溶解的或可生物降解的。此外，微电极在第一电极矩阵元件上包括溶解阻滞层和/或设置在第一电极矩阵元件和电极之间的第二电极矩阵元件。在溶解或生物降解第一电极基质元件时，由第一电极矩阵元件或第二电极矩阵元素包含的药物释放到组织中。还公开了电极的束和阵列及其用途。

2. 发明申请

WO2022005386A1 MICROELECTRODE FOR INSERTION INTO SOFT TISSUE 审中-公开
公开(公告)号：WO2022005386A1
公开(公告)日：2022-01-06
申请号：PCT/SE2021/050679
申请日：2021-07-05
申请人： NEURONANO AB
发明人： SCHOUENBORG, Jens
IPC分类号： A61N1/05 , A61B5/29 , A61B5/293 , A61N1/36
摘要： The present invention related to a microelectrode, microelectrode probe and array of microelectrodes and/or microelectrode probes useful for implantation into or placing adjacent soft tissue, such as neural tissue. The microelectrode comprises a conductive element having a distal non-insulate portion and a proximal insulated portion. Part of the conductive element is disposed in a casing of electrically insulating non-degradable material said casing encapsulating the non-insulated portion of the conductive element. The casing comprises at least one opening and a first structural component in which the electrically insulated portion of the conductive element can slide in an axial direction.

3. 发明申请

WO2018217147A1 DEVICE FOR INSERTION INTO NERVOUS TISSUE 审中-公开
公开(公告)号：WO2018217147A1
公开(公告)日：2018-11-29
申请号：PCT/SE2018/000013
申请日：2018-05-22
申请人： NEURONANO AB
发明人： SCHOUENBORG, Jens
IPC分类号： A61N1/05 , A61B5/04 , A61N1/36 , A61N1/372
摘要： A device selected from microelectrode, temperature sensor, optical sensor, optical fibre, temperature control element, and microdialysis probe for insertion into soft tissue comprises a body with a distal terminal section and a layer of an agent such as gelatin capable of forming a gel with aqueous body fluid on the terminal section. The terminal section and the gel -forming layer have a temperature of more than 30 °C below body temperature during a period of time prior and up to insertion. Also disclosed is method of insertion, an insertion assembly and a use of the device.

4. 发明申请

WO2013191612A1 MEDICAL MICROELECTRODE, METHOD FOR ITS MANUFACTURE, AND USE THEREOF 审中-公开
标题翻译：医用微电极及其制造方法及其应用
公开(公告)号：WO2013191612A1
公开(公告)日：2013-12-27
申请号：PCT/SE2013/000101
申请日：2013-06-19
申请人： NEURONANO AB
发明人： SCHOUENBORG, Jens
IPC分类号： A61N1/375 , A61N1/05
CPC分类号： A61N1/05 , A61B5/04001 , A61B18/14 , A61B2018/00071 , A61B2018/00107 , A61B2018/00434 , A61M31/002 , A61N1/0536 , A61N1/0558
摘要： A proto microelectrode from which a micro electrode is formed in situ upon insertion into soft tissue comprises a flexible oblong electrode body of electrically conducting material having a front end and a rear end. The electrode body comprises a metal or a metal alloy or an electrically conducting form of carbon or an electrically conducting polymer or a combination thereof. A first coat of a water soluble and/or swellable and/or degradabie material is disposed on the electrode body and extends along is at least over a distal portion thereof. A second coat of electrically insulating, water insoluble flexible polymer material is disposed on the first coat. The second coat comprises one or more through openings at or near its front end. Also disclosed is a corresponding micro electrode and a method of manufacture.
摘要翻译：在插入软组织中原位形成微电极的原微电极包括具有前端和后端的导电材料的柔性长圆形电极体。电极体包括金属或金属合金或导电形式的碳或导电聚合物或其组合。水溶性和/或可溶胀和/或降解材料的第一涂层设置在电极体上并且至少在其远端部分上延伸。在第一层上设置第二层电绝缘的水不溶性柔性聚合物材料。第二涂层在其前端处或附近包括一个或多个通孔。还公开了相应的微电极和制造方法。

5. 发明申请

WO2007075137A1 METHOD AND SYSTEM FOR COMPENSATING A SELF-CAUSED DISPLACEMENT OF TISSUE 审中-公开
标题翻译：用于补偿自身引起的组织位移的方法和系统
公开(公告)号：WO2007075137A1
公开(公告)日：2007-07-05
申请号：PCT/SE2006/001506
申请日：2006-12-28
申请人： NEURONANO AB , SCHOUENBORG, Jens , PETERSSON, Per
发明人： SCHOUENBORG, Jens , PETERSSON, Per
IPC分类号： A61N5/10 , A61B19/00 , A61B5/11 , A61G13/02
CPC分类号： A61B19/203 , A61B5/0402 , A61B5/0488 , A61B5/113 , A61B10/02 , A61B90/14 , A61B2017/00699 , A61B2017/00703 , A61G13/02 , A61G13/06 , A61N2005/1097
摘要： A system for compensating a neurally triggered or other self- caused displacement of a tissue of an animal including man comprises a base provided with a means for immobilizing the animal or body part thereof comprising the tissue, one or more displacement means in contact with the base, a means for sampling position data from a marker disposed in or in the proximity of the tissue, a means for sampling source activity data from one or more sources of displacement, microprocessor means for correlating position data and source activity data to generate a predictive correspondence, a means for controlling the one or more displacement means by source activity data based on the predictive correspondence. Also disclosed is a corresponding method and use.
摘要翻译：用于补偿包括人的动物的神经触发或其他自动引起的移动组织的系统包括设置有用于固定包括组织的动物或身体部分的装置的基部，与基部接触的一个或多个位移装置用于从设置在组织中或其附近的标记物采样位置数据的装置，用于从一个或多个位移源采样源活动数据的装置，用于使位置数据和源活动数据相关联以产生预测对应的微处理器装置，用于基于预测对应来通过源活动数据来控制一个或多个位移装置的装置。还公开了相应的方法和用途。

6. 发明申请

WO2019093936A1 POSITIONAL STABILIZATION OF TISSUE-IMPLANTED MEDICAL DEVICES 审中-公开
公开(公告)号：WO2019093936A1
公开(公告)日：2019-05-16
申请号：PCT/SE2018/000031
申请日：2018-11-06
申请人： NEURONANO AB
发明人： SCHOUENBORG, Jens
IPC分类号： A61N1/05 , A61B5/04 , A61N1/36
摘要： A proto-device for implantation into soft tissue comprises an oblong device body, biodegradable microfibres adhesively attached to the body, a rigid matrix of biocompatible material enclosing the body and the microfibres. The biocompatible material is dissolvable and/or degradable in aqueous body fluid at a rate substantially superior to the rate of microfibre degradation. The proto-device is one of proto-microelectrode, proto-optical fibre, proto-polymer tube for drug delivery, proto-electrical lead, proto-encapsulated electronics. Also disclosed are uses of the proto-device and methods for its implantation and manufacture.

7. 发明申请

WO2018106165A1 MICROELECTRODE ARRAY COMPRISING CONNECTING MICROFIBERS 审中-公开
公开(公告)号：WO2018106165A1
公开(公告)日：2018-06-14
申请号：PCT/SE2017/000048
申请日：2017-11-29
申请人： NEURONANO AB
发明人： SCHOUENBORG, Jens
IPC分类号： A61N1/05 , A61B5/05 , A61B5/042 , A61N1/36
摘要： A microelectrode array comprises three or more flexible oblong, electrically co-operating microelectrodes in wire and/or ribbon form disposed substantially in parallel. The microelectrodes are electrically insulated except for at a distal section thereof. The array further comprises electrically non-conducting microfibres connecting central portions of the microelectrodes in oblique directions in respect of the array axis. In a preferred array variety the microelectrodes are joined by a glue that is dissolvable or degradable in aqueous body fluid. Also disclosed is a combination of two or more arrays of the invention.

8. 发明申请

WO2017146627A1 METHOD OF IMPLANTATION OF CELL AGGREGATES AND TISSUE FRAGMENTS 审中-公开
标题翻译：细胞聚集体和组织碎片的植入方法
公开(公告)号：WO2017146627A1
公开(公告)日：2017-08-31
申请号：PCT/SE2017/000014
申请日：2017-02-23
申请人： NEURONANO AB
发明人： SCHOUENBORG, Jens
IPC分类号： A61N1/05 , A61B5/04 , A61N1/36 , A61N1/372
CPC分类号： A61B5/04 , A61N1/0551
摘要： In a method for implantation of a physically stabilized aggregate of living cells or tissue fragment is injected into a channel provided in soft tissue filled with an aqueous gel. Also discloses are methods of stabilizing such aggregates and fragments and of forming such channel in soft tissue as well as means for carrying out the methods.
摘要翻译：在用于植入物理稳定的活细胞或组织片段的集合体的方法中注入设置在充满含水凝胶的软组织中的通道中。还公开了稳定这种聚集体和碎片以及在软组织中形成这种通道的方法以及实施该方法的手段。

9. 发明申请

WO2017095288A8 HAEMORRHAGE AVOIDING MICROELECTRODE 审中-公开
标题翻译：避免使用微电极
公开(公告)号：WO2017095288A8
公开(公告)日：2017-06-08
申请号：PCT/SE2016/000072
申请日：2016-11-21
申请人： NEURONANO AB
发明人： SCHOUENBORG, Jens , MOHAMMED, Mohsin
IPC分类号： A61N1/05 , A61N1/36
摘要： A microelectrode comprises an oblong electrically conducting electrode body covered by distal and proximal sections of a layer of insulating material except for an annular contact section disposed between them, a blunt distal bulge at the distal end of a radial extension substantially greater than that of the proximal section of non-conducting material. For implantation into soft tissue the microelectrode is provided with a support of a material dissolvable in body fluid. Also disclosed is a set of microelectrodes sharing such support, a method of manufacture of the microelectrode and the set, and uses of the microelectrode and the set.
摘要翻译：微电极包括长方形导电电极主体，所述长电导电电极主体由绝缘材料层的远端和近端部分覆盖，除了设置在它们之间的环形接触部分之外，远端的径向钝端基本上大于非导电材料近端部分的延伸范围。为了植入软组织中，微电极配备有可溶于体液的材料的支撑物。还公开了一组共享这种支持的微电极，微电极和套件的制造方法以及微电极和套件的用途。

10. 发明申请

WO2016195587A1 METHOD AND SYSTEM FOR IMPROVING STIMULATION OF EXCITABLE TISSUE 审中-公开
标题翻译：改善可激活组织刺激的方法和系统
公开(公告)号：WO2016195587A1
公开(公告)日：2016-12-08
申请号：PCT/SE2016/050534
申请日：2016-06-03
申请人： NEURONANO AB
发明人： SCHOUENBORG, Jens , BJARTMARZ, Hjalmar
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36132 , A61N1/05 , A61N1/0534 , A61N1/36139 , A61N1/36185 , A61N1/378
摘要： A method for optimization of the stimulation pattern of a set of implanted electrodes in excitable tissue of a patient is disclosed, wherein it comprises the steps of: (a) choosing a first group of a certain number of from said set of implanted electrodes, (b) stimulating the excitable tissue electrically by said first group of electrodes, (c) registering information provided by the patient, (d) assigning each electrode of said first group of electrodes a value related to said information, wherein these steps are repeated for one or more further groups of said certain number of electrodes chosen from said set of implanted electrodes, wherein each electrode may be included in one or several groups, wherein the total assigned value for each electrode is calculated, and wherein electrodes having a total assigned value exceeding a predetermined value or a predetermined number of the electrodes having the highest total assigned value are chosen to be included in said stimulation pattern, as well as a method for treatment or alleviation of a disease or condition by use of a set of electrodes whose stimulation pattern has been optimized with said method, and a system for optimization of the stimulation pattern.
摘要翻译：公开了一种用于优化患者可兴奋组织中的一组植入电极的刺激模式的方法，其中包括以下步骤：（a）从所述植入电极组中选择一定数量的第一组， b）通过所述第一组电极刺激所述可兴奋组织，（c）登记患者提供的信息，（d）将所述第一组电极的每个电极分配给与所述信息相关的值，其中对于一个电极重复这些步骤或更多的所述一定数量的电极组，其中每个电极可以包括在一个或多个组中，其中计算每个电极的总分配值，并且其中总分配值超过的电极选择具有最高总分配值的预定值或预定数量的电极被包括在所述刺激模式中以及通过使用其刺激模式已经利用所述方法优化的一组电极来治疗或减轻疾病或病症的方法，以及用于优化刺激模式的系统。

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