专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008105959A3 CEREBROSPINAL FLUID PURIFICATION SYSTEM 审中-公开
标题翻译： CEREBROSPINAL流体净化系统
公开(公告)号：WO2008105959A3
公开(公告)日：2008-12-24
申请号：PCT/US2007080834
申请日：2007-10-09
申请人： NEUROFLUIDICS INC , LAD SHIVANAND P , MOBLEY WILLIAM C , NIKOLICH KAROLY , SAUL THOMAS
发明人： LAD SHIVANAND P , MOBLEY WILLIAM C , NIKOLICH KAROLY , SAUL THOMAS
IPC分类号： A61K39/00
CPC分类号： A61M27/006 , A61M1/3679 , A61M25/0026 , A61M2025/0007 , A61M2027/004 , A61M2202/0021 , A61M2202/0464 , A61M2202/203 , A61M2202/206 , A61M2206/16 , A61M2210/0693 , A61M2210/1003
摘要： The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF). The methods provide for efficiently removing target compounds from CSF. The systems provide for a multilumen flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents. The invention finds use as a diagnostic, therapeutic and drug delivery platform for a variety of diseases affecting the CNS by accessing the CSF space. Exemplified disease conditions treatable by the present CSF processing systems and methods include, but are not limited to: Cerebral Vasospasm, Guillain Barre Syndrome, Alzheimer's, Parkinson's, Huntington's, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Spinal Cord Injury, Traumatic Brain Injury, Stroke, Cancer affecting the brain or spinal cord, Prion disease, Encephalitis from various causes, Meningitis from various causes, diseases secondary to enzymatic or metabolic imbalances, Biological Warfare, etc. For the first time, the present invention offers patients a disease-modifying, disruptive technology treatment platform that addresses the known disease pathogenesis of a number of neurologic conditions to which there are presently limited and ineffective treatment options.
摘要翻译：本发明提供了用于调节脑脊液（CSF）的方法和系统。所述方法提供从CSF中有效地除去目标化合物。该系统提供多空间流动路径并在CSF空间中交换CSF的大部分体积部分。特定化合物的去除和/或递送可以针对特定疾病的病理学来定制。移除是针对性的，特异性的，例如通过使用特定的大小排除阈值，针对特定毒素的抗体和其他色谱技术，以及递送和/或去除靶向治疗剂。本发明用作通过访问CSF空间影响CNS的各种疾病的诊断，治疗和药物递送平台。通过本发明的CSF处理系统和方法可治疗的示例性疾病状况包括但不限于：脑血管痉挛，吉兰巴利综合征，阿尔茨海默病，帕金森病，亨廷顿舞蹈病，多发性硬化症，肌萎缩性侧索硬化症，脊髓损伤，创伤性脑损伤，中风，影响脑或脊髓的癌症，朊病毒病，各种原因的脑炎，各种原因引起的脑膜炎，酶促或代谢紊乱继发的疾病，生物战争等。本发明首次为患者提供疾病修复，破坏性技术治疗平台，解决目前有限和无效治疗方案的许多神经病症的已知疾病发病机制。

2. 发明申请

WO2008105959A2 CEREBROSPINAL FLUID PURIFICATION SYSTEM 审中-公开
标题翻译：脑脊液净化系统
公开(公告)号：WO2008105959A2
公开(公告)日：2008-09-04
申请号：PCT/US2007/080834
申请日：2007-10-09
申请人： NEUROFLUIDICS, INC. , LAD, Shivanand P. , MOBLEY, William C. , NIKOLICH, Karoly , SAUL, Thomas
发明人： LAD, Shivanand P. , MOBLEY, William C. , NIKOLICH, Karoly , SAUL, Thomas
IPC分类号： A61K39/00
CPC分类号： A61M27/006 , A61M1/3679 , A61M25/0026 , A61M2025/0007 , A61M2027/004 , A61M2202/0021 , A61M2202/0464 , A61M2202/203 , A61M2202/206 , A61M2206/16 , A61M2210/0693 , A61M2210/1003
摘要： The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF). The methods provide for efficiently removing target compounds from CSF. The systems provide for a multilumen flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents. The invention finds use as a diagnostic, therapeutic and drug delivery platform for a variety of diseases affecting the CNS by accessing the CSF space. Exemplified disease conditions treatable by the present CSF processing systems and methods include, but are not limited to: Cerebral Vasospasm, Guillain Barre Syndrome, Alzheimer's, Parkinson's, Huntington's, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Spinal Cord Injury, Traumatic Brain Injury, Stroke, Cancer affecting the brain or spinal cord, Prion disease, Encephalitis from various causes, Meningitis from various causes, diseases secondary to enzymatic or metabolic imbalances, Biological Warfare, etc. For the first time, the present invention offers patients a disease-modifying, disruptive technology treatment platform that addresses the known disease pathogenesis of a number of neurologic conditions to which there are presently limited and ineffective treatment options.
摘要翻译：本发明提供了用于调节脑脊液（CSF）的方法和系统。该方法提供了从CSF中有效去除目标化合物。这些系统提供多腔流动路径并交换CSF空间中的CSF的大部分体积部分。特定化合物的去除和/或递送可以针对特定疾病的病理而定制。例如，通过使用特定尺寸排阻阈值，针对特定毒素的抗体和其他色谱技术，以及递送和/或去除靶向治疗剂，该去除是针对性和特异性的。本发明通过进入脑脊液空间发现用作影响CNS的各种疾病的诊断，治疗和药物递送平台。可由本发明的CSF加工系统和方法治疗的示例性疾病状况包括但不限于：脑血管痉挛，格林巴利综合征，阿尔茨海默氏病，帕金森氏病，亨廷顿病，多发性硬化症，肌萎缩侧索硬化症，脊髓损伤，创伤性脑损伤，中风，影响脑或脊髓的癌症，朊病毒病，来自各种原因的脑炎，来自各种原因的脑膜炎，继发于酶或代谢失衡的疾病，生物战等等。首次，本发明向患者提供疾病修饰，破坏性技术治疗平台，其解决了目前有限且无效的治疗选择的一些神经病症的已知疾病发病机理。

3. 发明申请

WO2010123558A1 PROGRAMMABLE SYSTEM FOR CONDITIONING OF CEREBROSPINAL FLUID 审中-公开
标题翻译：用于调节脑脊液的可编程系统
公开(公告)号：WO2010123558A1
公开(公告)日：2010-10-28
申请号：PCT/US2010/001186
申请日：2010-04-21
申请人： NEUROFLUIDICS, INC. , PALMER, Olin , BUTTERWICK, Alex , SAUL, Thomas , ALLEN, Richard , LAD, Shivanand, P.
发明人： PALMER, Olin , BUTTERWICK, Alex , SAUL, Thomas , ALLEN, Richard , LAD, Shivanand, P.
IPC分类号： A61M1/36
CPC分类号： A61M27/006 , A61M2027/004 , A61M2205/3331 , A61M2210/0693
摘要： A programmable system (10) to control the extracorporeal circulation and conditioning of cerebrospinal fluid for the treatment of brain maladies. The system (10) includes an extracorporeal fluid circuit (30) with pressure sensors (41, 42, 43), compositional analysis units (45), pumps (65, 72) and medicament dispensers (80) as well as a controller (100) which synchronizes the automated sensing, analysis and conditioning functions with the operation of the pumping system (65, 72) so as to increase the precision of the measurements and optimize the effectiveness of the treatment.
摘要翻译：一种用于控制脑脊液的体外循环和调理用于治疗脑部疾病的可编程系统（10）。系统（10）包括具有压力传感器（41,42,43），成分分析单元（45），泵（65,72）和药物分配器（80）以及控制器（100）的体外流体回路（30）），其将自动感测，分析和调节功能与泵送系统（65,72）的操作同步，以便提高测量的精度并优化治疗的有效性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式